HK1178053A1 - Argatroban formulation comprising an acid as solubilizer - Google Patents

Argatroban formulation comprising an acid as solubilizer

Info

Publication number: HK1178053A1
Authority: HK; Hong Kong
Prior art keywords: acid; solubilizer; argatroban; formulation; argatroban formulation
Prior art date: 2005-09-01

Application number

HK13105080.5A

Other languages

English (en)

Chinese (zh)

Inventor

George Owoo

Richard A Burgos

Original Assignee

Baxter Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-01

Filing date

2013-04-26

Publication date

2013-09-06

2013-04-26 Application filed by Baxter Int filed Critical Baxter Int

2013-09-06 Publication of HK1178053A1 publication Critical patent/HK1178053A1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

HK13105080.5A 2005-09-01 2013-04-26 Argatroban formulation comprising an acid as solubilizer HK1178053A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71340305P	2005-09-01	2005-09-01

Publications (1)

Publication Number	Publication Date
HK1178053A1 true HK1178053A1 (en)	2013-09-06

Family

ID=37809398

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HK09100496.0A HK1123193A1 (en)	2005-09-01	2009-01-19	Argatroban formulation comprising an acid as solubilizer
HK13105080.5A HK1178053A1 (en)	2005-09-01	2013-04-26	Argatroban formulation comprising an acid as solubilizer

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
HK09100496.0A HK1123193A1 (en)	2005-09-01	2009-01-19	Argatroban formulation comprising an acid as solubilizer

Country Status (23)

Country	Link
US (3)	US7642271B2 (xx)
EP (1)	EP1948133B1 (xx)
JP (1)	JP5189980B2 (xx)
KR (3)	KR101753949B1 (xx)
CN (2)	CN101257890B (xx)
AT (1)	ATE514416T1 (xx)
AU (1)	AU2006285097B2 (xx)
BR (1)	BRPI0616127B8 (xx)
CA (1)	CA2617920C (xx)
CY (1)	CY1112109T1 (xx)
DK (1)	DK1948133T3 (xx)
ES (1)	ES2368758T3 (xx)
HK (2)	HK1123193A1 (xx)
IL (2)	IL189290A (xx)
IN (1)	IN2015DN03947A (xx)
MX (1)	MX2008002177A (xx)
NZ (1)	NZ565821A (xx)
PL (1)	PL1948133T3 (xx)
PT (1)	PT1948133E (xx)
RU (1)	RU2416393C2 (xx)
SI (1)	SI1948133T1 (xx)
WO (1)	WO2007027565A2 (xx)
ZA (1)	ZA200802667B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ565821A (en) *	2005-09-01	2010-05-28	Baxter Int	Argatroban formulation comprising an acid as solubilizer
US7687516B2 (en) *	2006-09-27	2010-03-30	Eagle Pharmaceuticals, Inc.	Alcohol free formulation of argatroban
EP2083823A4 (en) *	2006-09-27	2010-01-13	Eagle Pharmaceuticals Inc	ALCOHOL-FREE FORMULATION OF ARGATROBAN
US20100076019A1 (en) *	2006-10-11	2010-03-25	Eagle Pharmaceuticals, Inc.	Alcohol free formulation of argatroban
US7915290B2 (en)	2008-02-29	2011-03-29	Baxter International Inc.	Argatroban formulations and methods for making and using same
US20090221637A1 (en) *	2008-02-29	2009-09-03	Baxter International Inc.	Solid-state salt argatroban formulations and methods for producing and using the same
CN101598725B (zh) *	2009-06-23	2012-07-18	南通大学附属医院	阿加曲班在血细胞和生化常规分析中的应用
KR20140012029A (ko)	2010-10-21	2014-01-29	알티유 파머수티컬즈, 엘엘시	즉시 사용가능한 케토로락 제제
CN102120026A (zh) *	2011-03-03	2011-07-13	天津市炜杰科技有限公司	以醇作为增溶剂的21(s)阿加曲班静脉注射液
CN102119922A (zh) *	2011-03-03	2011-07-13	天津市炜杰科技有限公司	以酸作为增溶剂的21(s)阿加曲班静脉注射液
CN102228677A (zh) *	2011-06-17	2011-11-02	天津市炜杰科技有限公司	以酸作为增溶剂的21(r)阿加曲班静脉注射液
TWI679977B (zh) *	2011-10-19	2019-12-21	大塚製藥股份有限公司	口服溶液
US10537535B2 (en) *	2015-12-04	2020-01-21	The Regents Of The University Of California	Histone deacetylase inhibitors
CN107773533A (zh) *	2016-08-26	2018-03-09	四川科瑞德制药股份有限公司	一种新型凝血酶抑制剂及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE420919B (sv) *	1973-08-13	1981-11-09	Mitsubishi Chem Ind	Forfarande for framstellning av n?722-dansyl-l-argininderivat och farmaceutiskt godtagbara syradditionssalter derav
US5214052A (en) *	1987-07-28	1993-05-25	Mitsubishi Kasei Corporation	Method for dissolving arginineamides and pharmaceutical compositions containing them
US5506241A (en) *	1992-03-18	1996-04-09	Mitsubishi Chemical Corporation	Argatroban preparations for ophthalmic use
CA2091715A1 (en) *	1992-03-18	1993-09-19	Mitsubishi Kasei Corporation	Argatroban preparations for ophthalmic use
JPH06219948A (ja) *	1993-01-25	1994-08-09	Mitsubishi Kasei Corp	抗トロンビン剤及びその製造方法
JPH06219949A (ja) *	1993-01-25	1994-08-09	Mitsubishi Kasei Corp	抗トロンビン剤及びその製造方法
CA2121723A1 (en)	1993-04-22	1994-10-23	Yoshifumi Ikejiri	Aqueous agent
JPH07228532A (ja) *	1993-04-22	1995-08-29	Senju Pharmaceut Co Ltd	水性液剤、その有効成分の溶解性向上方法および安定化方法
US5849843A (en) *	1993-11-16	1998-12-15	Baxter International Inc.	Polymeric compositions for medical packaging and devices
US5998019A (en) *	1993-11-16	1999-12-07	Baxter International Inc.	Multi-layered polymer structure for medical products
FR2715566B1 (fr) *	1994-02-03	1996-03-08	Synthelabo	Solutions aqueuses concentrées d'argatroban.
US5840733A (en) *	1996-07-01	1998-11-24	Redcell, Canada, Inc.	Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
JPH10316569A (ja) *	1997-05-19	1998-12-02	Mitsubishi Chem Corp	アルガトロバンの可溶化方法及びそれによるアルガトロバン含有外用水性薬剤
KR101010547B1 (ko) *	2003-03-20	2011-01-24	미쓰비시 타나베 파마 코퍼레이션	알기닌아미드류를 함유하는 의약 제제
WO2005009361A2 (en)	2003-07-17	2005-02-03	Smithkline Beecham Corporation	Method of treating hit patients with argatroban
NZ565821A (en) *	2005-09-01	2010-05-28	Baxter Int	Argatroban formulation comprising an acid as solubilizer

2006
- 2006-08-28 NZ NZ565821A patent/NZ565821A/en not_active IP Right Cessation
- 2006-08-28 JP JP2008529147A patent/JP5189980B2/ja not_active Expired - Fee Related
- 2006-08-28 WO PCT/US2006/033432 patent/WO2007027565A2/en active Application Filing
- 2006-08-28 BR BRPI0616127A patent/BRPI0616127B8/pt not_active IP Right Cessation
- 2006-08-28 ES ES06802424T patent/ES2368758T3/es active Active
- 2006-08-28 IN IN3947DEN2015 patent/IN2015DN03947A/en unknown
- 2006-08-28 EP EP06802424A patent/EP1948133B1/en not_active Not-in-force
- 2006-08-28 CN CN2006800322085A patent/CN101257890B/zh not_active Expired - Fee Related
- 2006-08-28 DK DK06802424.9T patent/DK1948133T3/da active
- 2006-08-28 US US11/510,981 patent/US7642271B2/en active Active
- 2006-08-28 KR KR1020147000036A patent/KR101753949B1/ko active IP Right Grant
- 2006-08-28 CN CN201210353437.4A patent/CN102895179B/zh not_active Expired - Fee Related
- 2006-08-28 KR KR1020157025457A patent/KR20150108430A/ko not_active Application Discontinuation
- 2006-08-28 RU RU2008112311/15A patent/RU2416393C2/ru active
- 2006-08-28 PL PL06802424T patent/PL1948133T3/pl unknown
- 2006-08-28 MX MX2008002177A patent/MX2008002177A/es active IP Right Grant
- 2006-08-28 AT AT06802424T patent/ATE514416T1/de active
- 2006-08-28 SI SI200631063T patent/SI1948133T1/sl unknown
- 2006-08-28 CA CA2617920A patent/CA2617920C/en not_active Expired - Fee Related
- 2006-08-28 PT PT06802424T patent/PT1948133E/pt unknown
- 2006-08-28 AU AU2006285097A patent/AU2006285097B2/en not_active Ceased
- 2006-08-28 KR KR1020087007748A patent/KR20080042155A/ko active Application Filing
2008
- 2008-02-05 IL IL189290A patent/IL189290A/en active IP Right Grant
- 2008-03-26 ZA ZA200802667A patent/ZA200802667B/xx unknown
2009
- 2009-01-19 HK HK09100496.0A patent/HK1123193A1/xx not_active IP Right Cessation
- 2009-12-28 US US12/647,854 patent/US8034830B2/en active Active
- 2009-12-28 US US12/647,841 patent/US7985757B2/en active Active
2010
- 2010-09-16 IL IL208183A patent/IL208183A0/en unknown
2011
- 2011-08-30 CY CY20111100825T patent/CY1112109T1/el unknown
2013
- 2013-04-26 HK HK13105080.5A patent/HK1178053A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN101257890B (zh)	2012-10-31
PT1948133E (pt)	2011-08-01
ES2368758T3 (es)	2011-11-22
EP1948133A2 (en)	2008-07-30
DK1948133T3 (da)	2011-10-03
WO2007027565A2 (en)	2007-03-08
JP5189980B2 (ja)	2013-04-24
CA2617920A1 (en)	2007-03-08
BRPI0616127B8 (pt)	2021-05-25
KR101753949B1 (ko)	2017-07-04
CY1112109T1 (el)	2015-11-04
BRPI0616127A2 (pt)	2011-06-07
AU2006285097B2 (en)	2011-08-18
BRPI0616127B1 (pt)	2020-05-12
US8034830B2 (en)	2011-10-11
IN2015DN03947A (xx)	2015-10-02
WO2007027565A3 (en)	2007-10-04
HK1123193A1 (en)	2009-06-12
ZA200802667B (en)	2009-01-28
KR20080042155A (ko)	2008-05-14
EP1948133B1 (en)	2011-06-29
CN102895179A (zh)	2013-01-30
SI1948133T1 (sl)	2011-08-31
AU2006285097A1 (en)	2007-03-08
CN101257890A (zh)	2008-09-03
JP2009507018A (ja)	2009-02-19
PL1948133T3 (pl)	2012-03-30
ATE514416T1 (de)	2011-07-15
MX2008002177A (es)	2008-04-22
US7642271B2 (en)	2010-01-05
IL208183A0 (en)	2010-12-30
US20100099705A1 (en)	2010-04-22
KR20150108430A (ko)	2015-09-25
CA2617920C (en)	2014-05-27
IL189290A (en)	2011-10-31
RU2008112311A (ru)	2009-10-10
RU2416393C2 (ru)	2011-04-20
US7985757B2 (en)	2011-07-26
CN102895179B (zh)	2014-10-22
US20070049617A1 (en)	2007-03-01
KR20140009599A (ko)	2014-01-22
IL189290A0 (en)	2008-06-05
US20100099706A1 (en)	2010-04-22
NZ565821A (en)	2010-05-28

Publication	Publication Date	Title
HK1178053A1 (en)	2013-09-06	Argatroban formulation comprising an acid as solubilizer
CY1121782T1 (el)	2020-07-31	Διαδικασια για ξηρανση της bibw2992, tων αλατων αυτης και στερεων φαρμακευτικων σκευασματων που περιλαμβανουν αυτο το δραστικο συστατικο
AU2013334740A8 (en)	2015-04-09	Stable, low viscosity antibody formulation
EA201170508A1 (ru)	2011-10-31	Производные 1-амино-2-циклобутилэтилбороновой кислоты
HK1138840A1 (en)	2010-09-03	Azabiphenylaminobenzoic acid derivatives as dhodh inhibitors
MY149181A (en)	2013-07-31	Isoxazoline derivative and preparation process thereof
EA201071167A1 (ru)	2011-06-30	Стабилизированные олеосомные композиции и способы их получения
PH12015502802A1 (en)	2016-03-14	Formulation comprising a hypolipidemic agent
ATE485261T1 (de)	2010-11-15	Salicylsäurederivate
EA201171399A1 (ru)	2012-05-30	Способ и композиция для улучшения всасывания лекарственных средств
TNSN07435A1 (en)	2009-03-17	Novel piperidine carboxylic acid amide derivatives
NO20084478L (no)	2008-10-23	Konjugerte lipidderivater
MY148393A (en)	2013-04-15	Malate salts, and polymorphs of (3s, 5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
IN2011KN05169A (xx)	2015-07-17
NO20080650L (no)	2008-05-13	Forbindelser omfattende DMXAA for behandling av kreft
EA201270745A1 (ru)	2013-02-28	Улучшенный стабильный водный состав (e)-4-карбоксистирил-4-хлорбензилсульфона
DE50312458D1 (de)	2010-04-08	Iminosäurederivate als inhibitoren von matrix-metalloproteinasen
EA200701741A1 (ru)	2007-12-28	Композиция, содержащая окаперидон
WO2011162560A3 (ko)	2012-05-03	난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물
WO2007039821A3 (en)	2007-06-21	Novel inhibitors of tyrosinase, their method of preparation and their use in human medicine and in cosmetics
UY30579A1 (es)	2008-03-31	Formulacion acuosa que comprende un agente antitumoral
BR112012022442A2 (pt)	2019-09-24	processo para a preparação de um polimorfo de ranelato de estrôncio
NZ597861A (en)	2013-08-30	2-amino-2-phenyl-alkanol derivatives, preparation thereof, and pharmaceutical compositions containing same
UA95909C2 (xx)	2011-09-26	Амідні похідні піперидинкарбонової кислоти[амидные производные пиперидинкарбоновой кислоты
UA44519U (ru)	2009-10-12	Производные 5-гетерил-1,2,4-триазол-3-илтио-ацетатной кислоты, которые проявляют гипохолестеринемическую активность

Legal Events

Date	Code	Title	Description
2022-03-25	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20210827