GB872943A - Improvements in and relating to derivatives of cyclopropane - Google Patents
Improvements in and relating to derivatives of cyclopropaneInfo
- Publication number
- GB872943A GB872943A GB33522/57A GB3352257A GB872943A GB 872943 A GB872943 A GB 872943A GB 33522/57 A GB33522/57 A GB 33522/57A GB 3352257 A GB3352257 A GB 3352257A GB 872943 A GB872943 A GB 872943A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- general formula
- represent
- quaternary ammonium
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises bases of the general formula <FORM:0872943/IV (b)/1> wherein NR2 represents a C2-8 dialkylamino or a piperidino, pyrrolidino or morpholino radical, R1 and R2 represent C1-4 alkyl radicals or hydrogen atoms, R3 represents a hydrogen atom, a C3-5 hydroxyalkyl radical or its ester, or a C2-5 acyl radical, and Ar represents a phenyl radical optionally substituted with C1-4 alkyl or alkoxy radicals or halogen atoms, or Ar2 represents an o-biphenylene radical) and their acid addition and quaternary ammonium salts, and pharmaceutical preparations containing them (see Group VI) and the preparation of the bases by the processes of the examples, which may be summarized as: reacting a diarylddiazomethane Ar2CN2 with an unsaturated carbonyl compound of the general formula <FORM:0872943/IV (b)/2> wherein COZ and Z1 represent groups subsequently converted to CH2NR2 and R3 respectively, or Z1 may also represent hydrogen. Intermediates formed in various embodiments of this process are exemplified by the following formulae:- <FORM:0872943/IV (b)/3> <FORM:0872943/IV (b)/4> Reference is also made to the formation of R3=COCH3 by oxidation of R3=CHOH.CH3.ALSO:Pharmaceutical preparations, useful for the treatment of Parkinsonism or as spasmolytics or analgesics, contain one or more cyclopropane derivatives of the general formula <FORM:0872943/VI/1> or an acid addition salt (e.g. hydrochloride) or quaternary ammonium salt (e.g. methiodide) thereof. They may take the form of injectable solutions or tablets.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US872943XA | 1956-10-26 | 1956-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB872943A true GB872943A (en) | 1961-07-12 |
Family
ID=22204311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB33522/57A Expired GB872943A (en) | 1956-10-26 | 1957-10-28 | Improvements in and relating to derivatives of cyclopropane |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB872943A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3202712A (en) * | 1963-02-05 | 1965-08-24 | American Home Prod | 1-cyclohexene-4-bis (omicron-chlorobenzylaminomethyl) and derivatives |
| US3340268A (en) * | 1964-02-26 | 1967-09-05 | Ciba Geigy Corp | 1-[piperidyl]-2, 2-di(monocyclic hexacyclic aryl)-cyclopropane |
| US3419604A (en) * | 1965-10-19 | 1968-12-31 | Smith Kline French Lab | 2-amino- or -amino-alkylene-spiro [cyclopropane-1,9'-fluorenes] and the salts thereof |
| US4082801A (en) * | 1972-11-27 | 1978-04-04 | Merck & Co., Inc. | 4-Aminomethyldibenzobicyclo[5.1.0]octanes |
-
1957
- 1957-10-28 GB GB33522/57A patent/GB872943A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3202712A (en) * | 1963-02-05 | 1965-08-24 | American Home Prod | 1-cyclohexene-4-bis (omicron-chlorobenzylaminomethyl) and derivatives |
| US3340268A (en) * | 1964-02-26 | 1967-09-05 | Ciba Geigy Corp | 1-[piperidyl]-2, 2-di(monocyclic hexacyclic aryl)-cyclopropane |
| US3419604A (en) * | 1965-10-19 | 1968-12-31 | Smith Kline French Lab | 2-amino- or -amino-alkylene-spiro [cyclopropane-1,9'-fluorenes] and the salts thereof |
| US4082801A (en) * | 1972-11-27 | 1978-04-04 | Merck & Co., Inc. | 4-Aminomethyldibenzobicyclo[5.1.0]octanes |
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