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GB665675A - Process for the manufacture of derivatives of hydroxy acids - Google Patents

Process for the manufacture of derivatives of hydroxy acids

Info

Publication number
GB665675A
GB665675A GB31229/48A GB3122948A GB665675A GB 665675 A GB665675 A GB 665675A GB 31229/48 A GB31229/48 A GB 31229/48A GB 3122948 A GB3122948 A GB 3122948A GB 665675 A GB665675 A GB 665675A
Authority
GB
United Kingdom
Prior art keywords
copper
derivatives
prepared
salicylic acid
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31229/48A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALAN AUGUST GOLDBURG
NORMAN LESLIE THOMAS
Ward Blenkinsop and Co Ltd
Original Assignee
ALAN AUGUST GOLDBURG
NORMAN LESLIE THOMAS
Ward Blenkinsop and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALAN AUGUST GOLDBURG, NORMAN LESLIE THOMAS, Ward Blenkinsop and Co Ltd filed Critical ALAN AUGUST GOLDBURG
Priority to GB31229/48A priority Critical patent/GB665675A/en
Publication of GB665675A publication Critical patent/GB665675A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Acylamido-salicylic acids of the formula <FORM:0665675/IV (b)/1> where R1 and R2 are hydrogen or alkyl and n is an integer are prepared by treating the halogen compounds <FORM:0665675/IV (b)/2> where X is a halogen, with ammonia or primary or secondary amines. Suitable amines are ethylamine, diethylamine, isopropylamine, butylamines, amylamines, laurylamine, stearylamine and palmitylamine; when a secondary amine is used R1 and R2 may be the same or different. The halogen compounds may be the a -chloro- or bromo-acetamido, propionamido or butyramido derivatives. The reaction is preferably carried out at low temperatures to minimise hydrolysis of the acylamido group. A solvent such as alcohol may be present, together with copper, copper-bronze, or a copper salt as catalyst. The product is conveniently isolated as a salt such as the hydrochloride. The starting materials can be prepared as in Specification 664,363. Examples show the preparation of 4-glycylamido-salicylic acid and 4-diethylaminoacetamido-salicylic acid.
GB31229/48A 1948-12-02 1948-12-02 Process for the manufacture of derivatives of hydroxy acids Expired GB665675A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB31229/48A GB665675A (en) 1948-12-02 1948-12-02 Process for the manufacture of derivatives of hydroxy acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB31229/48A GB665675A (en) 1948-12-02 1948-12-02 Process for the manufacture of derivatives of hydroxy acids

Publications (1)

Publication Number Publication Date
GB665675A true GB665675A (en) 1952-01-30

Family

ID=10319970

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31229/48A Expired GB665675A (en) 1948-12-02 1948-12-02 Process for the manufacture of derivatives of hydroxy acids

Country Status (1)

Country Link
GB (1) GB665675A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2427327A1 (en) * 1978-06-01 1979-12-28 Nitto Boseki Co Ltd NEW L-LEUCYL-4-HYDROXYANILIDE DERIVATIVES AND THEIR APPLICATION FOR DETERMINING THE ACTIVITY OF L-LEUCIN AMINOPEPTIDASE
FR2644697A1 (en) * 1989-03-24 1990-09-28 Poudres & Explosifs Ste Nale ANESTHETIC COMPOUNDS WITH CONTROLLED ACTION PERIOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2427327A1 (en) * 1978-06-01 1979-12-28 Nitto Boseki Co Ltd NEW L-LEUCYL-4-HYDROXYANILIDE DERIVATIVES AND THEIR APPLICATION FOR DETERMINING THE ACTIVITY OF L-LEUCIN AMINOPEPTIDASE
FR2644697A1 (en) * 1989-03-24 1990-09-28 Poudres & Explosifs Ste Nale ANESTHETIC COMPOUNDS WITH CONTROLLED ACTION PERIOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
WO1990011292A2 (en) * 1989-03-24 1990-10-04 Societe Nationale Des Poudres Et Explosifs Controlled-action anesthetic compounds and pharmaceutical compositions containing same
WO1990011292A3 (en) * 1989-03-24 1990-11-15 Poudres & Explosifs Ste Nale Controlled-action anesthetic compounds and pharmaceutical compositions containing same

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