GB2188932B - Steroidal compounds and process for lengthening the side-chain of certain steroids - Google Patents

Steroidal compounds and process for lengthening the side-chain of certain steroids

Info

Publication number: GB2188932B
Authority: GB; United Kingdom
Prior art keywords: lengthening; chain; steroidal compounds; certain steroids; steroids
Prior art date: 1984-10-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB08709579A

Other versions

GB2188932A (en

GB8709579D0 (en

Inventor

Hector F De Luca

Nobuo Ikekawa

Yoko Tanaka

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wisconsin Alumni Research Foundation

Original Assignee

Wisconsin Alumni Research Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-04

Filing date

1987-04-23

Publication date

1988-09-01

1987-04-23 Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation

1987-05-28 Publication of GB8709579D0 publication Critical patent/GB8709579D0/en

1987-10-14 Publication of GB2188932A publication Critical patent/GB2188932A/en

1988-09-01 Application granted granted Critical

1988-09-01 Publication of GB2188932B publication Critical patent/GB2188932B/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

GB08709579A 1984-10-04 1987-04-23 Steroidal compounds and process for lengthening the side-chain of certain steroids Expired GB2188932B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US65754984A	1984-10-04	1984-10-04

Publications (3)

Publication Number	Publication Date
GB8709579D0 GB8709579D0 (en)	1987-05-28
GB2188932A GB2188932A (en)	1987-10-14
GB2188932B true GB2188932B (en)	1988-09-01

Family

ID=24637652

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GB08524479A Expired GB2167070B (en)	1984-10-04	1985-10-04	Vitamin d derivatives pharmaceutical compositions containing them and precursors thereof
GB08709579A Expired GB2188932B (en)	1984-10-04	1987-04-23	Steroidal compounds and process for lengthening the side-chain of certain steroids

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
GB08524479A Expired GB2167070B (en)	1984-10-04	1985-10-04	Vitamin d derivatives pharmaceutical compositions containing them and precursors thereof

Country Status (13)

Country	Link
EP (1)	EP0197949A1 (en)
JP (3)	JPS62500301A (en)
AU (2)	AU582789B2 (en)
BE (1)	BE903376A (en)
CH (1)	CH672920A5 (en)
DE (2)	DE3590488T (en)
DK (5)	DK154290C (en)
FR (1)	FR2571369B1 (en)
GB (2)	GB2167070B (en)
IE (1)	IE58104B1 (en)
IT (1)	IT1190401B (en)
NL (1)	NL8520265A (en)
WO (1)	WO1986002078A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5206229A (en) *	1988-04-21	1993-04-27	Leo Pharmaceutical Products Ltd	Vitamin d analogues
NL8920392A (en) *	1988-04-29	1990-04-02	Wisconsin Alumni Res Found	1FA-HYDROXYVITAMINE D-HOMOLOGISTS WITH UNSATURATED SIDE CHAIN.
US4927815A (en) *	1988-04-29	1990-05-22	Wisconsin Alumni Research Foundation	Compounds effective in inducing cell differentiation and process for preparing same
US5063221A (en) *	1989-04-05	1991-11-05	Chugai Seiyaku Kabushiki Kaisha	Treatment for hyperparathyroidism with use of vitamin d derivatives
DE3933034A1 (en) *	1989-10-02	1991-04-11	Schering Ag	24-HOMO-VITAMIN-D DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF
US5030772A (en) *	1990-02-14	1991-07-09	Deluca Hector F	Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) *	1990-02-14	1993-11-09	Wisconsin Alumni Research Foundation	Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5891865A (en) *	1996-10-04	1999-04-06	Wisconsin Alumni Research Foundation	Treatment of arthritic disease induced by infectious agents
AU2005303773A1 (en)	2004-11-12	2006-05-18	Bioxell Spa	Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3833622A (en) *	1969-03-17	1974-09-03	Upjohn Co	Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US3880894A (en) *	1974-05-24	1975-04-29	Wisconsin Alumni Res Found	1,25-Dihydroxyergocalciferol
AU527805B2 (en) *	1978-07-27	1983-03-24	Research Institute For Medicine And Chemistry Inc.	1alpha, 1beta dihydroxy steroid-5-enes
US4225596A (en) *	1978-10-13	1980-09-30	Wisconsin Alumni Research Foundation	Method for treating calcium imbalance and improving calcium absorption in mammals
US4448721A (en) *	1982-09-20	1984-05-15	Wisconsin Alumni Research Foundation	Hydroxyvitamin D2 compounds and process for preparing same
US4508651A (en) *	1983-03-21	1985-04-02	Hoffmann-La Roche Inc.	Synthesis of 1α,25-dihydroxyergocalciferol
CH665834A5 (en) *	1983-05-09	1988-06-15	Wisconsin Alumni Res Found	METHOD FOR PRODUCING 1ALPHA, 25-DIHYDROXYLATED VITAMIN D (2) AND RELATED COMPOUNDS.

1985
- 1985-08-19 DE DE19853590488 patent/DE3590488T/en active Pending
- 1985-08-19 EP EP85904336A patent/EP0197949A1/en not_active Withdrawn
- 1985-08-19 DE DE3590488A patent/DE3590488C2/de not_active Expired - Lifetime
- 1985-08-19 JP JP60503924A patent/JPS62500301A/en active Granted
- 1985-08-19 CH CH2351/86A patent/CH672920A5/de not_active IP Right Cessation
- 1985-08-19 NL NL8520265A patent/NL8520265A/en unknown
- 1985-08-19 WO PCT/US1985/001571 patent/WO1986002078A1/en active Application Filing
- 1985-08-19 AU AU47761/85A patent/AU582789B2/en not_active Ceased
- 1985-10-04 GB GB08524479A patent/GB2167070B/en not_active Expired
- 1985-10-04 BE BE0/215682A patent/BE903376A/en not_active IP Right Cessation
- 1985-10-04 IE IE244385A patent/IE58104B1/en not_active IP Right Cessation
- 1985-10-04 IT IT22359/85A patent/IT1190401B/en active
- 1985-10-04 FR FR8514758A patent/FR2571369B1/en not_active Expired
1986
- 1986-06-03 DK DK260086A patent/DK154290C/en active
1987
- 1987-04-23 GB GB08709579A patent/GB2188932B/en not_active Expired
1988
- 1988-03-02 DK DK111188A patent/DK159389C/en active
- 1988-12-29 AU AU27614/88A patent/AU605007B2/en not_active Ceased
1989
- 1989-04-13 DK DK177489A patent/DK158989C/en active
1990
- 1990-01-19 DK DK015290A patent/DK158990C/en active
- 1990-01-19 DK DK015390A patent/DK158991C/en active
1992
- 1992-05-19 JP JP4150045A patent/JPH0689022B2/en not_active Expired - Lifetime
- 1992-05-19 JP JP4150044A patent/JPH0635475B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH0689022B2 (en)	1994-11-09
DK154290C (en)	1989-03-28
DK158989B (en)	1990-08-13
GB8524479D0 (en)	1985-11-06
JPH05178887A (en)	1993-07-20
JPH0569103B2 (en)	1993-09-30
IE852443L (en)	1986-04-04
DK159389B (en)	1990-10-08
JPS62500301A (en)	1987-02-05
DK260086D0 (en)	1986-06-03
WO1986002078A1 (en)	1986-04-10
AU2761488A (en)	1989-06-08
DK177489D0 (en)	1989-04-13
DK111188A (en)	1988-03-02
DK158989C (en)	1991-01-21
JPH05222089A (en)	1993-08-31
JPH0635475B2 (en)	1994-05-11
DE3590488T (en)	1986-10-09
IE58104B1 (en)	1993-06-30
DK154290B (en)	1988-10-31
FR2571369A1 (en)	1986-04-11
DK260086A (en)	1986-06-03
DK177489A (en)	1989-04-13
IT1190401B (en)	1988-02-16
AU605007B2 (en)	1991-01-03
GB2167070B (en)	1988-09-01
AU4776185A (en)	1986-04-17
DE3590488C2 (en)	1992-10-01
IT8522359A0 (en)	1985-10-04
DK111188D0 (en)	1988-03-02
DK158991C (en)	1991-01-21
AU582789B2 (en)	1989-04-13
DK158991B (en)	1990-08-13
DK158990C (en)	1991-01-21
FR2571369B1 (en)	1987-12-04
CH672920A5 (en)	1990-01-15
DK159389C (en)	1991-03-11
DK15390D0 (en)	1990-01-19
DK15390A (en)	1990-01-19
DK15290D0 (en)	1990-01-19
GB2167070A (en)	1986-05-21
EP0197949A1 (en)	1986-10-22
GB2188932A (en)	1987-10-14
NL8520265A (en)	1986-09-01
DK15290A (en)	1990-01-19
BE903376A (en)	1986-02-03
DK158990B (en)	1990-08-13
GB8709579D0 (en)	1987-05-28

Publication	Publication Date	Title
GB2177700B (en)	1988-12-07	Substituted androsta-1,4-diene-3,17-diones and process for their preparation
EP0423842A3 (en)	1991-08-07	Steroids and therapeutic compositions containing same
GR80196B (en)	1985-01-02	Method for the preparation of steroids
PT80783A (en)	1985-08-01	Process for the preparation of benzimidazols bezoxazols and benzothiazols
EP0255246A3 (en)	1989-04-26	Photoconductive device and method of operating the same
GB2188932B (en)	1988-09-01	Steroidal compounds and process for lengthening the side-chain of certain steroids
GR860072B (en)	1986-05-14	New process for the preparation of certain steroids especially intermediates for the preparation of proligestone and related compounds and new intermediates formed in this process
DE3477001D1 (en)	1989-04-13	11-difluoromethyl and 11-fluoromethylene steroids
DE3565122D1 (en)	1988-10-27	Method for the determination of cholesterol
DE3567876D1 (en)	1989-03-02	Process and intermediates for the preparation of 17alpha-hydroxyprogesterones and corticoids from an enol steroid
GB2102805B (en)	1985-09-04	Synthesis of 6-fluoro steroids
GB8516387D0 (en)	1985-07-31	11beta-substituted steroids
GB8525539D0 (en)	1985-11-20	Steroids
AU2685284A (en)	1984-10-18	Steroids of the 20-spiroxane series
GB8325400D0 (en)	1983-10-26	Steroids of androstane series
GB2167078B (en)	1988-04-13	Method and composition for the treatment of pipelines
DE3360856D1 (en)	1985-10-31	Pregnane derivatives and method of producing the same
DE3566678D1 (en)	1989-01-12	Methods of preparing 11 beta, 17 alpha, 20, 21-tetra-hydroxy steroids and corresponding 11 beta, 17 alpha, 21-trihydroxy-20-oxo steroids
GB8605405D0 (en)	1986-04-09	3-deoxo-10beta-alkynyl steroids
HK36196A (en)	1996-03-08	Stabalised monolithium acetylide and the ethynylation of steroids
GB2169900B (en)	1988-02-17	Derivatives of steroids of androstane series
ZA855613B (en)	1988-11-30	Composition and method for the treatment of hemorrhoids
PL280799A1 (en)	1991-02-11	Method of obtaining prednisolone 17-acetate
RO82960B (en)	1984-01-30	Process and installation for the fabrication of cement
GB8402442D0 (en)	1984-03-07	Brackets and fittings

Legal Events

Date	Code	Title	Description
1999-05-26	PCNP	Patent ceased through non-payment of renewal fee	Effective date: 19981004