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GB1437895A - Thiazolylurea derivatives and process for the preparation thereof - Google Patents

Thiazolylurea derivatives and process for the preparation thereof

Info

Publication number
GB1437895A
GB1437895A GB4768974A GB4768974A GB1437895A GB 1437895 A GB1437895 A GB 1437895A GB 4768974 A GB4768974 A GB 4768974A GB 4768974 A GB4768974 A GB 4768974A GB 1437895 A GB1437895 A GB 1437895A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
group
reacted
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4768974A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of GB1437895A publication Critical patent/GB1437895A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1437895 Thiazolyl-ureas and -thioureas EGYT GYOGYSZERVEGYESZETI GYAR 4 Nov 1974 [9 Nov 1973] 47689/74 Heading C2C Novel compounds of Formula I wherein R<SP>1</SP> stands for a pyridyl group, R<SP>2</SP> and R<SP>3</SP> each stand for hydrogen or a lower alkyl group, Y stands for oxygen or sulphur, and R<SP>4</SP> and R<SP>5</SP> each stand for hydrogen, a lower alkyl group, allyl group, a C 3-6 cycloalkyl group, phenyl group or a halophenyl group, or R<SP>4</SP> and R<SP>5</SP> may form together with the adjacent nitrogen atom a heterocyclic group of the general Formulµ (X) or (XI) wherein n represents an integer of from 4 to 7, and Z stands for oxygen, or an =NH, =N-CH 3 or =N-C 6 H 5 group are prepared by one of the following methods (a) a compound of Formula II wherein X is halogen is reacted with a compound of Formula III or (b) a compound of Formula IV is reacted with R<SP>5</SP>(R<SP>6</SP>)N.C=Y, a compound of Formula XIII or an alkali metal cyanate or thiocyanate and a strong acid or (c) a compound of Formula VI wherein R<SP>6</SP> is C 1-4 alkyl or phenyl is reacted with an amine R<SP>4</SP>NHR<SP>5</SP> or (d) a compound of Formula IX is reacted with an amine R<SP>4</SP>NHR<SP>5</SP> (e) a compound of Formula XII is reacted with an amine R<SP>4</SP>NHR<SP>5</SP>. Intermediates of Formula IX above are prepared either by reacting a compound of Formula IV above with CS 2 and dicyclohexyl carbodiimide or by heating a compound of Formula VIII Cyclopropyl isothiocyanate is prepared by reacting cyclopropylamine with CS 2 and NaOH. 4 - (3<SP>1 </SP>- Pyridyl) - thiazole - 2 - carboxylic acid azide is prepared by action of aqueous NaNO 2 on 4 - (3<SP>1</SP> - pyridyl)thiazole - 2 - carboxylic acid hydroxide obtained by action of hydrazine hydrate on the ethyl ester of the acid. Pharmaceutical compositions in conventional forms for oral, rectal or parenteral administration and having anti-inflammatory and antiulcer activity comprises an above novel compound and a carrier or diluent.
GB4768974A 1973-11-09 1974-11-04 Thiazolylurea derivatives and process for the preparation thereof Expired GB1437895A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUGO1249A HU168393B (en) 1973-11-09 1973-11-09

Publications (1)

Publication Number Publication Date
GB1437895A true GB1437895A (en) 1976-06-03

Family

ID=10996753

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4768974A Expired GB1437895A (en) 1973-11-09 1974-11-04 Thiazolylurea derivatives and process for the preparation thereof

Country Status (8)

Country Link
BE (1) BE822029A (en)
CS (2) CS183797B2 (en)
DE (1) DE2453082A1 (en)
FR (1) FR2250525B1 (en)
GB (1) GB1437895A (en)
HU (1) HU168393B (en)
IL (1) IL45970A (en)
NL (1) NL7414583A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196104B2 (en) 2000-08-15 2007-03-27 Amgen, Inc. Thiazolyl urea compounds and methods of uses
US9233951B2 (en) 2010-07-15 2016-01-12 Bayer Intellectual Property Gmbh Heterocyclic compounds as pesticides

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
GB9823873D0 (en) 1998-10-30 1998-12-30 Pharmacia & Upjohn Spa 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196104B2 (en) 2000-08-15 2007-03-27 Amgen, Inc. Thiazolyl urea compounds and methods of uses
US9233951B2 (en) 2010-07-15 2016-01-12 Bayer Intellectual Property Gmbh Heterocyclic compounds as pesticides

Also Published As

Publication number Publication date
CS183797B2 (en) 1978-07-31
CS183768B2 (en) 1978-07-31
DE2453082A1 (en) 1975-05-22
IL45970A (en) 1977-08-31
AU7512374A (en) 1976-05-13
FR2250525A1 (en) 1975-06-06
IL45970A0 (en) 1974-12-31
HU168393B (en) 1976-04-28
NL7414583A (en) 1975-05-13
BE822029A (en) 1975-03-03
FR2250525B1 (en) 1978-07-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee