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FR2525108B1 - Medicaments a haut degre de solubilite et procede pour leur obtention - Google Patents

Medicaments a haut degre de solubilite et procede pour leur obtention

Info

Publication number
FR2525108B1
FR2525108B1 FR8206646A FR8206646A FR2525108B1 FR 2525108 B1 FR2525108 B1 FR 2525108B1 FR 8206646 A FR8206646 A FR 8206646A FR 8206646 A FR8206646 A FR 8206646A FR 2525108 B1 FR2525108 B1 FR 2525108B1
Authority
FR
France
Prior art keywords
medicines
solubility
obtaining
solubility medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8206646A
Other languages
English (en)
Other versions
FR2525108A1 (fr
Inventor
Donald E Panoz
Owen I Corrigan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Perrigo Co PLC
Original Assignee
Elan Corp PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Corp PLC filed Critical Elan Corp PLC
Priority to FR8206646A priority Critical patent/FR2525108B1/fr
Priority to IE2610/82A priority patent/IE54084B1/en
Priority to GB08231580A priority patent/GB2119784B/en
Priority to CA000415001A priority patent/CA1225029A/fr
Priority to DE19823241097 priority patent/DE3241097A1/de
Priority to BE1/10635A priority patent/BE894942A/fr
Priority to AR291268A priority patent/AR230183A1/es
Priority to LU84468A priority patent/LU84468A1/fr
Priority to AU90431/82A priority patent/AU555579B2/en
Priority to ES517444A priority patent/ES8505249A1/es
Priority to PT75867A priority patent/PT75867B/fr
Priority to NL8204461A priority patent/NL8204461A/nl
Priority to JP57204422A priority patent/JPS58183615A/ja
Priority to IT24368/82A priority patent/IT1153099B/it
Priority to AT0427282A priority patent/AT389813B/de
Priority to SE8206697A priority patent/SE8206697L/xx
Priority to CH7389/82A priority patent/CH655003A5/fr
Publication of FR2525108A1 publication Critical patent/FR2525108A1/fr
Priority to US06/646,485 priority patent/US4610875A/en
Priority to US06/864,827 priority patent/US4769236A/en
Application granted granted Critical
Publication of FR2525108B1 publication Critical patent/FR2525108B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
FR8206646A 1982-04-19 1982-04-19 Medicaments a haut degre de solubilite et procede pour leur obtention Expired FR2525108B1 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR8206646A FR2525108B1 (fr) 1982-04-19 1982-04-19 Medicaments a haut degre de solubilite et procede pour leur obtention
IE2610/82A IE54084B1 (en) 1982-04-19 1982-11-01 Medicaments with a high degree of solubility and method for their production
GB08231580A GB2119784B (en) 1982-04-19 1982-11-04 Medicaments with a high degree of solubility and method for their production
CA000415001A CA1225029A (fr) 1982-04-19 1982-11-05 Medicaments ultra-solubles, et leur fabrication
DE19823241097 DE3241097A1 (de) 1982-04-19 1982-11-06 Medikamente mit hohem loeslichkeitsgrad und verfahren zu ihrer herstellung
BE1/10635A BE894942A (fr) 1982-04-19 1982-11-08 Medicaments a haut degre de solubilite et procede pour leur obtention
AR291268A AR230183A1 (es) 1982-04-19 1982-11-11 Procedimiento para la preparacion de medicamentos con un alto grado de solubilidad y/o disolucion
AU90431/82A AU555579B2 (en) 1982-04-19 1982-11-12 Highly soluble amorphous medicaments
LU84468A LU84468A1 (fr) 1982-04-19 1982-11-12 Medicaments a haut degre de solubilite et procede pour leur obtention
PT75867A PT75867B (fr) 1982-04-19 1982-11-17 Procede de preparation de medicaments a haut degre de solubilite
ES517444A ES8505249A1 (es) 1982-04-19 1982-11-17 Procedimiento para obtener medicamentos altamente solubles por atomizacion en presencia de un estabilizante y un agente inhibidor de formacion de cristales.
NL8204461A NL8204461A (nl) 1982-04-19 1982-11-18 Geneesmiddelen met een hoge mate van oplosbaarheid en werkwijze voor de bereiding hiervan.
JP57204422A JPS58183615A (ja) 1982-04-19 1982-11-19 高度溶解性医薬及びその製造法
IT24368/82A IT1153099B (it) 1982-04-19 1982-11-23 Medicamenti ad alto grado di solubilita' e procedimento per il loro ottenimento
SE8206697A SE8206697L (sv) 1982-04-19 1982-11-24 Lekemedel med hog loslighet och sett att framstella dessa
AT0427282A AT389813B (de) 1982-04-19 1982-11-24 Verfahren zur herstellung von medikamenten mit hohem loeslichkeitsgrad
CH7389/82A CH655003A5 (fr) 1982-04-19 1982-12-17 Procede pour la preparation de medicaments a haut degre de solubilite et medicaments ainsi obtenus.
US06/646,485 US4610875A (en) 1982-04-19 1984-08-31 Medicaments with a high degree of solubility and method for their production
US06/864,827 US4769236A (en) 1982-04-19 1986-05-19 Medicaments with a high degree of solubility and method for their production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8206646A FR2525108B1 (fr) 1982-04-19 1982-04-19 Medicaments a haut degre de solubilite et procede pour leur obtention

Publications (2)

Publication Number Publication Date
FR2525108A1 FR2525108A1 (fr) 1983-10-21
FR2525108B1 true FR2525108B1 (fr) 1989-05-12

Family

ID=9273120

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8206646A Expired FR2525108B1 (fr) 1982-04-19 1982-04-19 Medicaments a haut degre de solubilite et procede pour leur obtention

Country Status (18)

Country Link
US (2) US4610875A (fr)
JP (1) JPS58183615A (fr)
AR (1) AR230183A1 (fr)
AT (1) AT389813B (fr)
AU (1) AU555579B2 (fr)
BE (1) BE894942A (fr)
CA (1) CA1225029A (fr)
CH (1) CH655003A5 (fr)
DE (1) DE3241097A1 (fr)
ES (1) ES8505249A1 (fr)
FR (1) FR2525108B1 (fr)
GB (1) GB2119784B (fr)
IE (1) IE54084B1 (fr)
IT (1) IT1153099B (fr)
LU (1) LU84468A1 (fr)
NL (1) NL8204461A (fr)
PT (1) PT75867B (fr)
SE (1) SE8206697L (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
JPS60139688A (ja) * 1983-12-28 1985-07-24 Tokyo Tanabe Co Ltd 無定形ジヒドロピリジン粉末製剤
EP0214092A1 (fr) * 1985-08-08 1987-03-11 Ciba-Geigy Ag Absorption d'aryl-2 pyrazoloquinoléines psychoactives sous forme d'une dispersion moléculaire solide dans la polyvinylpyrrolidone
US4798725A (en) * 1986-06-16 1989-01-17 Norwich Eaton Pharmaceuticals, Inc. Sustained release capsule
US4772473A (en) * 1986-06-16 1988-09-20 Norwich Eaton Pharmaceuticals, Inc. Nitrofurantoin dosage form
US4832953A (en) * 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
US5264609A (en) * 1989-11-18 1993-11-23 Schering Agrochemicals Limited Preparation of propenoic acid derivatives
IT1242642B (it) * 1990-04-17 1994-05-16 Alfa Wassermann Spa Formulazioni iniettabili contenenti naproxen sale sodico.
JPH0648937A (ja) * 1992-04-07 1994-02-22 Seitai Kagaku Kenkyusho:Kk 経口投与に適する薬剤およびその製造方法
US5512300A (en) * 1992-09-15 1996-04-30 Warner-Lambert Company Prevention of ibuprofen from forming low melting eutectics with other therapeutic agents in solid dosage forms
FR2722984B1 (fr) * 1994-07-26 1996-10-18 Effik Lab Procede de preparation de formes pharmaceutiques seches et les compositions pharmaceutiques ainsi realisees
US5994348A (en) * 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
FR2736550B1 (fr) * 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
US5686133A (en) * 1996-01-31 1997-11-11 Port Systems, L.L.C. Water soluble pharmaceutical coating and method for producing coated pharmaceuticals
WO1997034601A1 (fr) * 1996-03-18 1997-09-25 Eisai Co., Ltd. Compositions medicamenteuses a solubilite amelioree
US6066339A (en) * 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation
US6086915A (en) * 1998-04-01 2000-07-11 Bioresponse L.L.C. Compositions and methods of adjusting steroid hormone metabolism through phytochemicals
KR100634953B1 (ko) * 1998-07-20 2006-10-17 스미스클라인 비참 코포레이션 에프로사르탄을 포함하는 생물학적으로 강화된 경구 고형투여 형태의 제제
WO2000020033A1 (fr) * 1998-10-05 2000-04-13 Eisai Co., Ltd. Comprimes se delitant immediatement dans la cavite buccale
ATE329579T1 (de) * 1999-11-12 2006-07-15 Abbott Lab Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
ES2299441T3 (es) * 1999-12-08 2008-06-01 Pharmacia Corporation Forma en estado solido de celecoxib con biodisponibilidad potenciada.
EA006402B1 (ru) 1999-12-23 2005-12-29 Пфайзер Продактс Инк. Комбинация лекарства и целлюлозного полимера, повышающего концентрацию; способ введения лекарства и водный раствор (варианты)
IL134701A0 (en) * 2000-02-23 2001-04-30 J P M E D Ltd Homogeneous solid matrix containing vegetable proteins
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
EP1297836A4 (fr) 2000-06-16 2007-06-13 Mitsubishi Pharma Corp Compositions permettant de reguler la plage et/ou la vitesse de liberation du ph
RU2271805C2 (ru) * 2000-10-24 2006-03-20 Адзиномото Ко., Инк. Препарат, содержащий натеглинид
EP1269994A3 (fr) * 2001-06-22 2003-02-12 Pfizer Products Inc. Compositions Pharmaceutiques comprenant un médicament et un polymère permettant d'améliorer la concentration du médicament
EE200400034A (et) * 2001-06-22 2004-06-15 Pfizer Products Inc. Amorfse ravimaine adsorbaatide farmatseutilised kompositsioonid
MXPA03011935A (es) * 2001-06-22 2004-03-26 Pfizer Prod Inc Composiciones farmaceuticas que contienen conjuntos de polimero y farmaco.
SI21223A (sl) * 2002-06-19 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
US20050152932A1 (en) * 2003-06-12 2005-07-14 Valery Normand Non-crystalline perfume or flavor delivery system
US20050048112A1 (en) 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
RU2007123436A (ru) * 2004-12-20 2009-01-27 Др. Редди` Лабораторис Лтд. (IN) Фармацевтическая композиция, содержащая аморфные соединения бензимидазола, и способ ее приготовления
ES2384333T3 (es) * 2005-04-11 2012-07-03 Abbott Laboratories Composiciones farmacéuticas que tienen perfiles de disolución mejorados para fármacos poco solubles
WO2006119779A2 (fr) * 2005-05-10 2006-11-16 Lifecycle Pharma A/S Composition pharmaceutique comprenant un antagoniste de l'aldosterone
AU2007208998A1 (en) * 2006-01-27 2007-08-02 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin A method of producing porous microparticles
PT103743B (pt) * 2007-05-16 2013-01-15 Hovione Farmaciencia S A Processo para preparar derivados de 21-disódio fosfato de pregnanos.
NZ592549A (en) * 2008-11-04 2012-09-28 Cipla Ltd A compex of tiotropium bromide and polyvinylpyrrolidone having a low degree of crystallinity
WO2012085236A1 (fr) 2010-12-23 2012-06-28 Abbott Gmbh & Co. Kg Formulations retard solides à base de dispersions solides
WO2012164575A2 (fr) 2011-05-27 2012-12-06 Hetero Research Foundation Ritonavir amorphe co-précipité

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151273A (en) * 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs
JPS5163925A (ja) * 1974-11-30 1976-06-02 Kyowa Hakko Kogyo Kk Muteikeikuroramufuenikooruno seizoho
US4127647A (en) * 1975-04-08 1978-11-28 Meiji Seika Kaisha, Ltd. Process for preparation of stable amorphous macrolide antibiotic solids
JPS51118816A (en) * 1975-04-08 1976-10-19 Meiji Seika Kaisha Ltd A process for stabilizing non-crystalloidal solid
DE2634004B2 (de) * 1976-07-29 1978-08-10 Bernhard Dr. 8000 Muenchen Lippold Verfahren zur Beschleunigung der Auflösung und Verbesserung der Löslichkeit von schlechtlöslichen zur peroralen Verabreichung bestimmten Arzneistoffen
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
EP0001247A1 (fr) * 1977-09-14 1979-04-04 Kanebo, Ltd. Composition pharmaceutique contenant de la nifédipine et procédé pour sa préparation.
US4128632A (en) * 1978-02-13 1978-12-05 Merck & Co., Inc. Solubilization of Rafoxanide
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
JPS587609B2 (ja) * 1979-06-17 1983-02-10 フロイント産業株式会社 粉体薬剤のコ−テング法
JPS6024768B2 (ja) * 1979-06-16 1985-06-14 フロイント産業株式会社 活性化薬剤の製法
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
JPS55139319A (en) * 1979-04-13 1980-10-31 Furointo Sangyo Kk Activation of drug soluble in alkali and acid
JPS5948810B2 (ja) * 1980-03-22 1984-11-29 山之内製薬株式会社 ニカルジピン持続性製剤用組成物
CA1146866A (fr) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Procede de production d'un compose pharmaceutique a liberation continue sous forme solide
JPS5646837A (en) * 1979-09-27 1981-04-28 Kowa Yakuhin Kogyo Kk Preparation of ibuprofen clathrate compound
JPS5655370A (en) * 1979-10-13 1981-05-15 Kyorin Pharmaceut Co Ltd Amorphous nicomol
US4327080A (en) * 1981-07-13 1982-04-27 E. R. Squibb & Sons, Inc. Novel Bendroflumethiazide formulations and method
FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
DE3318649A1 (de) * 1983-05-21 1984-11-22 Bayer Ag, 5090 Leverkusen Zweiphasenformulierung

Also Published As

Publication number Publication date
FR2525108A1 (fr) 1983-10-21
US4769236A (en) 1988-09-06
AU9043182A (en) 1983-10-27
IE822610L (en) 1983-10-19
BE894942A (fr) 1983-05-09
ATA427282A (de) 1989-07-15
US4610875A (en) 1986-09-09
SE8206697D0 (sv) 1982-11-24
ES517444A0 (es) 1985-05-16
DE3241097A1 (de) 1983-10-20
LU84468A1 (fr) 1983-06-13
AU555579B2 (en) 1986-10-02
CA1225029A (fr) 1987-08-04
JPS58183615A (ja) 1983-10-26
CH655003A5 (fr) 1986-03-27
GB2119784A (en) 1983-11-23
AT389813B (de) 1990-02-12
IT8224368A1 (it) 1984-05-23
NL8204461A (nl) 1983-11-16
JPH0341444B2 (fr) 1991-06-24
IT1153099B (it) 1987-01-14
GB2119784B (en) 1986-04-03
IT8224368A0 (it) 1982-11-23
ES8505249A1 (es) 1985-05-16
PT75867B (fr) 1986-01-21
IE54084B1 (en) 1989-06-07
PT75867A (fr) 1982-12-01
SE8206697L (sv) 1983-10-20
DE3241097C2 (fr) 1989-04-13
AR230183A1 (es) 1984-03-01

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