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FR2323378A1 - Antiarrhythmic dialkyl amino alkyl benzamidines - prepd. from a benzamidine and a primary tertiary alkylene diamine - Google Patents

Antiarrhythmic dialkyl amino alkyl benzamidines - prepd. from a benzamidine and a primary tertiary alkylene diamine

Info

Publication number
FR2323378A1
FR2323378A1 FR7527638A FR7527638A FR2323378A1 FR 2323378 A1 FR2323378 A1 FR 2323378A1 FR 7527638 A FR7527638 A FR 7527638A FR 7527638 A FR7527638 A FR 7527638A FR 2323378 A1 FR2323378 A1 FR 2323378A1
Authority
FR
France
Prior art keywords
benzamidine
prepd
benzamidines
antiarrhythmic
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7527638A
Other languages
French (fr)
Other versions
FR2323378B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7527638A priority Critical patent/FR2323378A1/en
Publication of FR2323378A1 publication Critical patent/FR2323378A1/en
Application granted granted Critical
Publication of FR2323378B1 publication Critical patent/FR2323378B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Amidines of formula (I) and their acid addition salts are newIn (I) R1R2 & R3 = H, halogen, methyl, lower alkoxy, phenoxy, benzyloxy, phenoxypropoxy, nitro, amino or CF3; R4 and R5 = lower alkyl, benzyl or together with the N atom, form a heterocycle such as pyrrolidino, piperidino or morpholino; n = 2-4). (I) are anti-arhythmic agents and loca anaesthetics and have better therapeutic ratio than procainamide. A typical compound is p-nitro-N-(2-diethylaminoethyl) benzamidine dihydrochloride. This was prepd. from 6.045g p-nitro-benzamidine hydrochloride and 3.48g 2-diethylaminoethylamine in ethanol at room temperature or at reflux. The yield was 80% mpt. 202 degrees C.
FR7527638A 1975-09-09 1975-09-09 Antiarrhythmic dialkyl amino alkyl benzamidines - prepd. from a benzamidine and a primary tertiary alkylene diamine Granted FR2323378A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7527638A FR2323378A1 (en) 1975-09-09 1975-09-09 Antiarrhythmic dialkyl amino alkyl benzamidines - prepd. from a benzamidine and a primary tertiary alkylene diamine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7527638A FR2323378A1 (en) 1975-09-09 1975-09-09 Antiarrhythmic dialkyl amino alkyl benzamidines - prepd. from a benzamidine and a primary tertiary alkylene diamine

Publications (2)

Publication Number Publication Date
FR2323378A1 true FR2323378A1 (en) 1977-04-08
FR2323378B1 FR2323378B1 (en) 1979-09-14

Family

ID=9159774

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7527638A Granted FR2323378A1 (en) 1975-09-09 1975-09-09 Antiarrhythmic dialkyl amino alkyl benzamidines - prepd. from a benzamidine and a primary tertiary alkylene diamine

Country Status (1)

Country Link
FR (1) FR2323378A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0093443A1 (en) * 1982-05-05 1983-11-09 Hoechst Aktiengesellschaft Alkyl ester imines of halomethyl benzoic acids and processes for their preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1576553A (en) * 1967-05-30 1969-08-01

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1576553A (en) * 1967-05-30 1969-08-01

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0093443A1 (en) * 1982-05-05 1983-11-09 Hoechst Aktiengesellschaft Alkyl ester imines of halomethyl benzoic acids and processes for their preparation

Also Published As

Publication number Publication date
FR2323378B1 (en) 1979-09-14

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Legal Events

Date Code Title Description
ST Notification of lapse