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FR2396749A1 - Analogues de prostacycline - Google Patents

Analogues de prostacycline

Info

Publication number
FR2396749A1
FR2396749A1 FR7819950A FR7819950A FR2396749A1 FR 2396749 A1 FR2396749 A1 FR 2396749A1 FR 7819950 A FR7819950 A FR 7819950A FR 7819950 A FR7819950 A FR 7819950A FR 2396749 A1 FR2396749 A1 FR 2396749A1
Authority
FR
France
Prior art keywords
analogs
analogues
prostacyclin
prostacycline
prostacycline analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7819950A
Other languages
English (en)
Other versions
FR2396749B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2396749A1 publication Critical patent/FR2396749A1/fr
Application granted granted Critical
Publication of FR2396749B1 publication Critical patent/FR2396749B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention est relative à de nouveaux analogues de prostacycline. Ces analogues sont des composés du type prostaglandine E, dans la formule desquels l'atome de carbone en C-6 est substitué Par le radical hydroxy. Ces nouveaux analogues ont des activités semblables mais supérieures à celles de la prostacycline.
FR7819950A 1977-07-05 1978-07-04 Analogues de prostacycline Granted FR2396749A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/812,794 US4131738A (en) 1977-07-05 1977-07-05 6-Hydroxy-PGE1 compounds

Publications (2)

Publication Number Publication Date
FR2396749A1 true FR2396749A1 (fr) 1979-02-02
FR2396749B1 FR2396749B1 (fr) 1981-12-11

Family

ID=25210648

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7819950A Granted FR2396749A1 (fr) 1977-07-05 1978-07-04 Analogues de prostacycline

Country Status (9)

Country Link
US (6) US4131738A (fr)
JP (1) JPS5416453A (fr)
BE (1) BE868767A (fr)
CH (1) CH635827A5 (fr)
DE (1) DE2828075A1 (fr)
FR (1) FR2396749A1 (fr)
GB (1) GB2002346B (fr)
IT (1) IT7824772A0 (fr)
NL (1) NL7807016A (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008077A2 (fr) * 1978-08-04 1980-02-20 Hoechst Aktiengesellschaft Prostaglandines de type delta-2-PGF2 et delta-2-PGE2, procédé pour leur préparation et leur application dans des compositions thérapeutiques
EP0038613A1 (fr) * 1979-05-18 1981-10-28 Teijin Limited Prostaglandines de type E1 et leurs compositions anti-thrombocytices

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181808A (en) * 1976-08-23 1980-01-01 The Upjohn Company 5-Keto prostaglandin Fα analogs
US4251466A (en) * 1976-12-30 1981-02-17 The Upjohn Company 2-Decarboxy-2-hydroxymethyl-6-keto-PGE1 compounds
DE2834249A1 (de) * 1978-08-04 1980-02-28 Hoechst Ag Neue prostaglandinderivate in der delta 2-11-desoxy-pgf tief 2 bzw. pge tief 2 -reihe
US4311707A (en) * 1979-02-12 1982-01-19 American Cyanamid Company Process for topically producing cutaneous vasodilation for the treatment of vasospastic or ischemic conditions
JPS55153725A (en) * 1979-05-18 1980-11-29 Teijin Ltd Production of ketone bearing substituent in adjacent position
US4456613A (en) * 1982-12-27 1984-06-26 E. I. Du Pont De Nemours And Company 6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof
US4755531A (en) * 1986-08-11 1988-07-05 Syntex (U.S.A.) Inc. Thiol esters of 4,5-allenyl prostaglandins and use thereof as antigastric secretion agents
US5221763A (en) * 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5591887A (en) * 1987-04-30 1997-01-07 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5236907A (en) * 1988-10-01 1993-08-17 R-Tech Ueno Ltd. Ocular hypotensive agents
US6420422B1 (en) 1987-09-18 2002-07-16 Sucampo Pharmaceuticals, Inc. Ocular hypotensive agents
US5321128A (en) * 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US6187813B1 (en) 1990-04-10 2001-02-13 Pharmacia & Upjohn Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
ES2193901T1 (es) 1988-09-06 2003-11-16 Pharmacia Ab Derivados de prostaglandina para el tratamiento de glaucoma o hipertension ocular.
US5194429A (en) * 1988-10-01 1993-03-16 K.K. Ueno Seiyaku Oyo Kenkyujo Ocular hypotensive agents
US5972991A (en) 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
WO1994008960A1 (fr) * 1992-10-20 1994-04-28 Taisho Pharmaceutical Co., Ltd. Analogue de prostaglandine e¿1?
CA2147461A1 (fr) * 1992-10-21 1994-04-28 Takehiro Amano Analogues de la prostaglandine e1
US5428884A (en) * 1992-11-10 1995-07-04 Tns Mills, Inc. Yarn conditioning process
US5410788A (en) * 1992-11-10 1995-05-02 Tns Mills, Inc. Yarn conditioning process & apparatus
AU6513294A (en) * 1993-05-26 1994-12-20 Taisho Pharmaceutical Co., Ltd. Prostaglandin e1 analog
WO2000061550A1 (fr) 1999-04-09 2000-10-19 Taisho Pharmaceutical Co., Ltd. Derives de prostaglandine e1
EP1211241A4 (fr) 1999-09-06 2004-10-27 Taisho Pharmaceutical Co Ltd Analogues de la prostaglandine e
CN1190417C (zh) 1999-09-10 2005-02-23 大正制药株式会社 前列腺素衍生物
US7101906B2 (en) * 2004-11-16 2006-09-05 Allergan, Inc. 2,3,4-substituted cyclopentanones as therapeutic agents
US7183324B2 (en) 2004-11-23 2007-02-27 Allergan, Inc. 2,3,4-substituted cyclopentanones as therapeutic agents
RU2440338C2 (ru) * 2005-01-27 2012-01-20 Сукампо Аг Способ и композиция для лечения заболеваний центральной нервной системы
EP4055007A4 (fr) * 2019-11-07 2024-02-14 Lifex Biolabs, Inc. Analogues de la prostaglandine et leurs utilisations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950363A (en) * 1975-03-10 1976-04-13 The Upjohn Company Prostaglandin cyclic ethers
US4049648A (en) * 1975-06-23 1977-09-20 The Upjohn Company PG-type, 1,9-lactones
US4013695A (en) * 1975-10-02 1977-03-22 The Upjohn Company 4,4,5,5-Tetradehydro-PGE1 analogs
US4060534A (en) * 1976-01-23 1977-11-29 The Upjohn Company 9-Deoxy-9-methylene-PGF compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/76 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008077A2 (fr) * 1978-08-04 1980-02-20 Hoechst Aktiengesellschaft Prostaglandines de type delta-2-PGF2 et delta-2-PGE2, procédé pour leur préparation et leur application dans des compositions thérapeutiques
EP0008077A3 (en) * 1978-08-04 1980-04-16 Hoechst Aktiengesellschaft Prostaglandin derivatives with a delta-2-pgf2 structure or a delta-2-pge2 structure, process for their preparation and their use as medicaments
EP0038613A1 (fr) * 1979-05-18 1981-10-28 Teijin Limited Prostaglandines de type E1 et leurs compositions anti-thrombocytices

Also Published As

Publication number Publication date
US4131738A (en) 1978-12-26
US4150053A (en) 1979-04-17
US4156092A (en) 1979-05-22
US4156091A (en) 1979-05-22
NL7807016A (nl) 1979-01-09
US4147877A (en) 1979-04-03
GB2002346A (en) 1979-02-21
GB2002346B (en) 1982-01-27
FR2396749B1 (fr) 1981-12-11
CH635827A5 (de) 1983-04-29
JPS5416453A (en) 1979-02-07
DE2828075A1 (de) 1979-01-25
US4159997A (en) 1979-07-03
BE868767A (fr) 1979-01-05
IT7824772A0 (it) 1978-06-20

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Legal Events

Date Code Title Description
ST Notification of lapse