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FR2391215A1 - Nouvelles imidazoazines et imidazodiazines, leur preparation et leur application en tant que medicaments - Google Patents

Nouvelles imidazoazines et imidazodiazines, leur preparation et leur application en tant que medicaments

Info

Publication number
FR2391215A1
FR2391215A1 FR7814248A FR7814248A FR2391215A1 FR 2391215 A1 FR2391215 A1 FR 2391215A1 FR 7814248 A FR7814248 A FR 7814248A FR 7814248 A FR7814248 A FR 7814248A FR 2391215 A1 FR2391215 A1 FR 2391215A1
Authority
FR
France
Prior art keywords
imidazodiazines
imidazoazines
preparation
new
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7814248A
Other languages
English (en)
Other versions
FR2391215B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2391215A1 publication Critical patent/FR2391215A1/fr
Application granted granted Critical
Publication of FR2391215B1 publication Critical patent/FR2391215B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne de nouvelles imidazoazines et imidazodiazines. L'invention concerne en particulier les composés de formule :
FR7814248A 1977-05-16 1978-05-12 Nouvelles imidazoazines et imidazodiazines, leur preparation et leur application en tant que medicaments Granted FR2391215A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/796,958 US4166851A (en) 1977-05-16 1977-05-16 Certain imidazo(1,2a)pyridine derivatives

Publications (2)

Publication Number Publication Date
FR2391215A1 true FR2391215A1 (fr) 1978-12-15
FR2391215B1 FR2391215B1 (fr) 1981-12-11

Family

ID=25169498

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7814248A Granted FR2391215A1 (fr) 1977-05-16 1978-05-12 Nouvelles imidazoazines et imidazodiazines, leur preparation et leur application en tant que medicaments

Country Status (13)

Country Link
US (1) US4166851A (fr)
JP (1) JPS53141292A (fr)
BE (1) BE866841A (fr)
CH (1) CH639662A5 (fr)
DE (1) DE2820938A1 (fr)
DK (1) DK180878A (fr)
FR (1) FR2391215A1 (fr)
GB (1) GB1601041A (fr)
IE (1) IE46882B1 (fr)
IT (1) IT1156737B (fr)
LU (1) LU79651A1 (fr)
NL (1) NL7804345A (fr)
SE (1) SE7804777L (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233301A (en) * 1977-05-16 1980-11-11 Merck & Co., Inc. Novel imidazoazines and imidazodiazines
US4210653A (en) * 1978-06-27 1980-07-01 Merck & Co., Inc. Pyridyloxypropanolamines
US4330543A (en) * 1978-12-14 1982-05-18 Merck & Co., Inc. Imidazoazines and imidazodiazines
US4656168A (en) * 1980-12-23 1987-04-07 Merck & Co., Inc. (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation
US4442094A (en) * 1980-12-23 1984-04-10 Merck & Co., Inc. (3-Aralkylamino-2-or-propoxy)heterocyclic compounds
US4331679A (en) * 1980-12-23 1982-05-25 Merck Sharp & Dohme (I.A.) Corp. (3-Aralkylamino-2-or-propoxy) heterocyclic compounds
US4349673A (en) * 1980-12-23 1982-09-14 Merck & Co., Inc. Benzoxazines
US4391806A (en) * 1982-07-12 1983-07-05 The Dow Chemical Company Substituted tetrahydropyridazino-(1,6-A)benzimidazoles and use as bronchodilators
US4537889A (en) * 1982-12-27 1985-08-27 Eli Lilly And Company Inotropic agents
ZA839398B (en) * 1982-12-27 1985-08-28 Lilly Co Eli Substituted imidazopyrimidines-pyrazines,and-triazines
US4636502A (en) * 1982-12-27 1987-01-13 Eli Lilly And Company Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines
DE3446778A1 (de) * 1984-12-21 1986-07-03 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
PH27291A (en) * 1989-01-31 1993-05-04 Takeda Chemical Industries Ltd Imidazolpyrimidazines their production and use
EP0440119A1 (fr) * 1990-01-31 1991-08-07 Takeda Chemical Industries, Ltd. Composés de imidazopyridazine, leur préparation et utilisation
DK0471236T3 (da) * 1990-07-30 1995-07-24 Takeda Chemical Industries Ltd Imidazopyridinderivater og deres anvendelse
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
DE10145457A1 (de) * 2001-09-14 2003-04-03 Basf Ag Substituierte Imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-one, Verfahren zu ihrer Herstellung, sowie deren Verwendung zur Herstellung von Imidazo[1,2,-a]pyridinen
US20070078136A1 (en) 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
EP2320907A4 (fr) * 2008-08-05 2012-09-05 Merck Sharp & Dohme Composés thérapeutiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208397A1 (es) * 1973-02-20 1976-12-27 Ciba Geigy Ag Procedimiento para la elaboracion de compuestos de 1-piridiloxi-2-hidroxi-3-amino-propano1-piraziniloxi-2-hidroxi-3-amino-propano y 1-pirimidiniloxi-2-hidroxi-3-amino-propan
US4071630A (en) * 1975-04-08 1978-01-31 Sandoz Ltd. 1-Substituted-amino-3-(4-furo[3,2-c]pyridinyloxy)-2-propanols
CH614711A5 (fr) * 1975-04-08 1979-12-14 Sandoz Ag

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NV2054/72 *

Also Published As

Publication number Publication date
DK180878A (da) 1978-11-17
DE2820938A1 (de) 1978-11-23
IE46882B1 (en) 1983-10-19
CH639662A5 (de) 1983-11-30
IE780923L (en) 1978-11-16
IT7849338A0 (it) 1978-05-12
SE7804777L (sv) 1978-11-17
JPS623153B2 (fr) 1987-01-23
IT1156737B (it) 1987-02-04
BE866841A (fr) 1978-11-09
NL7804345A (nl) 1978-11-20
FR2391215B1 (fr) 1981-12-11
US4166851A (en) 1979-09-04
GB1601041A (en) 1981-10-21
LU79651A1 (fr) 1979-02-02
JPS53141292A (en) 1978-12-08

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