FI963050A0 - Menetelmä klavulaanihapposuolan valmistamiseksi - Google Patents

Menetelmä klavulaanihapposuolan valmistamiseksi

Info

Publication number: FI963050A0
Authority: FI; Finland
Prior art keywords: preparation; acid salt; clavulanic acid; clavulanic; salt
Prior art date: 1994-02-02

Application number

FI963050A

Other languages

English (en)

Swedish (sv)

Other versions

FI111949B (fi

FI963050A (fi

Inventor

Michael Alan Cook

Geoffrey Clive Webb

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-02

Filing date

1996-08-01

Publication date

1996-08-01

1996-08-01 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1996-08-01 Publication of FI963050A0 publication Critical patent/FI963050A0/fi

1996-10-01 Publication of FI963050A publication Critical patent/FI963050A/fi

2003-10-15 Application granted granted Critical

2003-10-15 Publication of FI111949B publication Critical patent/FI111949B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)

FI963050A 1994-02-02 1996-08-01 Menetelmä kaliumklavulanaatin valmistamiseksi FI111949B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB9401969A GB9401969D0 (en)	1994-02-02	1994-02-02	Process
GB9401969		1994-02-02
PCT/GB1995/000191 WO1995021173A1 (en)	1994-02-02	1995-01-31	Process for the preparation of a salt of clavulanic acid
GB9500191		1995-01-31

Publications (3)

Publication Number	Publication Date
FI963050A0 true FI963050A0 (fi)	1996-08-01
FI963050A FI963050A (fi)	1996-10-01
FI111949B FI111949B (fi)	2003-10-15

Family

ID=10749727

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI963050A FI111949B (fi)	1994-02-02	1996-08-01	Menetelmä kaliumklavulanaatin valmistamiseksi

Country Status (32)

Country	Link
US (1)	US5965728A (fi)
EP (1)	EP0741732B1 (fi)
JP (1)	JP4074336B2 (fi)
KR (1)	KR100388769B1 (fi)
CN (1)	CN1065246C (fi)
AP (1)	AP610A (fi)
AT (1)	ATE202358T1 (fi)
AU (1)	AU688849B2 (fi)
BG (1)	BG63307B1 (fi)
BR (1)	BR9506919A (fi)
CA (1)	CA2182504C (fi)
CZ (1)	CZ294005B6 (fi)
DE (1)	DE69521415T2 (fi)
DK (1)	DK0741732T3 (fi)
ES (1)	ES2159626T3 (fi)
FI (1)	FI111949B (fi)
GB (1)	GB9401969D0 (fi)
GR (1)	GR3036602T3 (fi)
HK (1)	HK1012373A1 (fi)
HU (1)	HU226597B1 (fi)
MX (1)	MX9603204A (fi)
NO (1)	NO314505B1 (fi)
NZ (1)	NZ278927A (fi)
OA (1)	OA10587A (fi)
PL (1)	PL181451B1 (fi)
PT (1)	PT741732E (fi)
RO (1)	RO115730B1 (fi)
RU (1)	RU2140418C1 (fi)
SI (1)	SI0741732T1 (fi)
SK (1)	SK282544B6 (fi)
UA (1)	UA48944C2 (fi)
WO (1)	WO1995021173A1 (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT400033B (de)	1992-03-10	1995-09-25	Biochemie Gmbh	Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en)	1994-03-02	1995-10-31	Lek Tovarna Farmacevtskih	New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) *	1995-01-19	1995-03-08	Smithkline Beecham Plc	Novel process
SI9500134B (sl)	1995-04-20	2004-04-30	Lek,	Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) *	1995-08-02	1995-10-04	Smithkline Beecham Plc	Process
AT403375B (de) *	1995-11-15	1998-01-26	Biochemie Gmbh	Verfahren zur fällung von alkalisalzen der clavulansäure
US6414142B1 (en) *	1996-06-13	2002-07-02	Smithkline Beecham Corporation	Process for preparing potassium clavulanate
PT867515E (pt) *	1997-03-24	2000-05-31	Cipan Companhia Ind P De Antib	Processo para isolar um sal de acido clavulanico e de um metal alcalino farmaceuticamente aceitavel
WO1998042858A1 (en) *	1997-03-24	1998-10-01	Cipan-Companhia Industrial Produtora De Antibióticos, S.A.	Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DZ2456A1 (fr)	1997-04-04	2003-01-18	Smithkline Beecham Plc	Procédé de préparation de sels de l'acide clavulanique.
PT1412078E (pt)	2001-08-02	2009-01-08	Lg Life Sciences Ltd	Processos para a produção de derivados amino-protegidos da 4- aminometileno-pirrolidin-3-ona, gemifloxacina ou um seu sal
JP2019527214A (ja)	2016-07-14	2019-09-26	アカオジェンインコーポレイテッド	細菌感染症の処置における使用のためのセフチブテンとクラブラン酸の組み合わせ
CN108822134B (zh) *	2018-04-25	2021-06-25	国药集团威奇达药业有限公司	克拉维酸叔丁胺盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1508977A (en) *	1974-04-20	1978-04-26	Beecham Group Ltd	Beta-lactam antibiotic from streptomyces clavuligerus
GB1563103A (en) *	1975-10-13	1980-03-19	Beecham Group Ltd	Process for the preparation of clavulanic acid
DE3063683D1 (en) *	1979-08-24	1983-07-14	Beecham Group Plc	Amine salt of clavulanic acid, its preparation and use
GB8404749D0 (en) *	1984-02-23	1984-03-28	Atomic Energy Authority Uk	Fluidic contactor

1994
- 1994-02-02 GB GB9401969A patent/GB9401969D0/en active Pending
1995
- 1995-01-31 SK SK1003-96A patent/SK282544B6/sk not_active IP Right Cessation
- 1995-01-31 CA CA002182504A patent/CA2182504C/en not_active Expired - Fee Related
- 1995-01-31 CZ CZ19962294A patent/CZ294005B6/cs not_active IP Right Cessation
- 1995-01-31 CN CN95192179A patent/CN1065246C/zh not_active Expired - Fee Related
- 1995-01-31 KR KR1019960704202A patent/KR100388769B1/ko not_active IP Right Cessation
- 1995-01-31 MX MX9603204A patent/MX9603204A/es not_active IP Right Cessation
- 1995-01-31 EP EP95907075A patent/EP0741732B1/en not_active Expired - Lifetime
- 1995-01-31 PT PT95907075T patent/PT741732E/pt unknown
- 1995-01-31 JP JP52044595A patent/JP4074336B2/ja not_active Expired - Fee Related
- 1995-01-31 SI SI9530525T patent/SI0741732T1/xx unknown
- 1995-01-31 ES ES95907075T patent/ES2159626T3/es not_active Expired - Lifetime
- 1995-01-31 DE DE69521415T patent/DE69521415T2/de not_active Expired - Lifetime
- 1995-01-31 RO RO96-01582A patent/RO115730B1/ro unknown
- 1995-01-31 WO PCT/GB1995/000191 patent/WO1995021173A1/en active IP Right Grant
- 1995-01-31 UA UA96083392A patent/UA48944C2/uk unknown
- 1995-01-31 AU AU15412/95A patent/AU688849B2/en not_active Ceased
- 1995-01-31 NZ NZ278927A patent/NZ278927A/en not_active IP Right Cessation
- 1995-01-31 DK DK95907075T patent/DK0741732T3/da active
- 1995-01-31 US US08/663,158 patent/US5965728A/en not_active Expired - Lifetime
- 1995-01-31 HU HU9602128A patent/HU226597B1/hu not_active IP Right Cessation
- 1995-01-31 PL PL95315782A patent/PL181451B1/pl not_active IP Right Cessation
- 1995-01-31 AT AT95907075T patent/ATE202358T1/de not_active IP Right Cessation
- 1995-01-31 BR BR9506919A patent/BR9506919A/pt not_active Application Discontinuation
- 1995-01-31 RU RU96117347A patent/RU2140418C1/ru not_active IP Right Cessation
- 1995-01-31 AP APAP/P/1996/000838A patent/AP610A/en active
1996
- 1996-08-01 NO NO19963217A patent/NO314505B1/no not_active IP Right Cessation
- 1996-08-01 BG BG100765A patent/BG63307B1/bg unknown
- 1996-08-01 FI FI963050A patent/FI111949B/fi active
- 1996-08-02 OA OA60872A patent/OA10587A/en unknown
1998
- 1998-12-16 HK HK98113569A patent/HK1012373A1/xx not_active IP Right Cessation
2001
- 2001-09-12 GR GR20010401463T patent/GR3036602T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
BG100765A (en)	1997-09-30
NZ278927A (en)	1998-02-26
PT741732E (pt)	2001-11-30
EP0741732B1 (en)	2001-06-20
RO115730B1 (ro)	2000-05-30
MX9603204A (es)	1997-03-29
CA2182504A1 (en)	1995-08-10
SK100396A3 (en)	1996-12-04
CA2182504C (en)	2008-04-08
CN1144528A (zh)	1997-03-05
ATE202358T1 (de)	2001-07-15
JP4074336B2 (ja)	2008-04-09
AP610A (en)	1997-09-04
CZ229496A3 (en)	1997-01-15
CZ294005B6 (cs)	2004-09-15
GB9401969D0 (en)	1994-03-30
US5965728A (en)	1999-10-12
DE69521415T2 (de)	2002-05-29
KR100388769B1 (ko)	2003-09-02
WO1995021173A1 (en)	1995-08-10
DK0741732T3 (da)	2001-10-15
NO963217D0 (no)	1996-08-01
SI0741732T1 (fi)	2001-10-31
NO314505B1 (no)	2003-03-31
SK282544B6 (sk)	2002-10-08
OA10587A (en)	2002-07-10
HK1012373A1 (en)	1999-07-30
AU1541295A (en)	1995-08-21
HU226597B1 (en)	2009-04-28
BG63307B1 (bg)	2001-09-28
EP0741732A1 (en)	1996-11-13
PL315782A1 (en)	1996-12-09
FI111949B (fi)	2003-10-15
AP9600838A0 (en)	1996-07-31
AU688849B2 (en)	1998-03-19
NO963217L (no)	1996-10-01
CN1065246C (zh)	2001-05-02
FI963050A (fi)	1996-10-01
PL181451B1 (en)	2001-07-31
BR9506919A (pt)	1997-09-30
HU9602128D0 (en)	1996-09-30
HUT74885A (en)	1997-02-28
RU2140418C1 (ru)	1999-10-27
DE69521415D1 (de)	2001-07-26
ES2159626T3 (es)	2001-10-16
GR3036602T3 (en)	2001-12-31
UA48944C2 (uk)	2002-09-16
JPH09508411A (ja)	1997-08-26

Publication	Publication Date	Title
FI980630A (fi)	1998-03-20	Menetelmä klavulaanihapon valmistamiseksi
FI945441A (fi)	1994-11-18	Uusi menetelmä 7beta-substituoitu-4-atsa-5alfa-androstan-3-onien valmistamiseksi
FI940769A (fi)	1994-08-20	Menetelmä 2-aminoatsolijohdannaisten valmistamiseksi
FI963050A0 (fi)	1996-08-01	Menetelmä klavulaanihapposuolan valmistamiseksi
FI935791A (fi)	1994-06-26	Menetelmä polyhydroksikarboksyylihapon valmistamiseksi
NO930829D0 (no)	1993-03-08	Fremgangsmaate for fremstilling av klavulansyresalter
FI972065A0 (fi)	1997-05-14	Menetelmä N-fosfonometyyliglysiinin valmistamiseksi
EE03393B1 (et)	2001-04-16	Protsess enantiomeerselt puhta asetidiin-2-karboksüülhappe saamiseks
NO20001777L (no)	2000-05-03	Fremgangsmate for fremstilling av substituerte 4-fenyl-4-cyanocykloheksankarboksylsyrer
FI956058A0 (fi)	1995-12-15	Menetelmä glutaaridialdehydin valmistamiseksi
NO995388D0 (no)	1999-11-04	Fremgangsmåte for fremstilling av formylfosfonsyre
FI962880A0 (fi)	1996-07-17	Menetelmä ja välituotteita naftyridonikarboksyylihapposuolojen valmistusta varten
FI945353A0 (fi)	1994-11-14	Entsymaattinen menetelmä (S)-6-metoksyyli-alfa-metyyli-2-naftaleenietikkahapon valmistamiseksi
NO994793D0 (no)	1999-10-01	FremgangsmÕte for fremstilling av clavulansyre
FR2763942B1 (fr)	2002-09-13	Nouveau procede de preparation de n-acylaminoacides
FI971964A (fi)	1997-05-07	Menetelmä 1-halo-3-trialkyylisilasnyylibentseenijohdannaisten valmistamiseksi
FI943660A0 (fi)	1994-08-05	Menetelmä 3-karbonyyliandrostadieeni-17-karboksamidien valmistamiseksi
ZA988190B (en)	1999-03-09	Process for the preparation of 1-phenylpyrazoline-3-carboxylic acid derivatives
NO991098D0 (no)	1999-03-05	FremgangsmÕte for fremstilling av 2-fenyl-3-naftylpropionsyrederivater
FI960790A (fi)	1996-08-23	Menetelmä fluoreenibisfenolin valmistamiseksi
NO994261D0 (no)	1999-09-02	FremgangsmÕte for fremstilling av trovafloxacinsyresalter
IS4086A (is)	1995-04-21	Aðferð við framleiðslu efnasambanda
IL108884A0 (en)	1994-06-24	Process for the preparation of p-fluoro-alpha-met hyl-cinnamic acid derivatives
NO975150D0 (no)	1997-11-10	Fremgangsmåte for fremstilling av enantiomere former av aminoalkylaminofenylpropansyre
FI960547A0 (fi)	1996-02-06	Adipiinihapon valmistusmenetelmä