FI901470A0 - Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo/2,3-b/indol-5-yyli-karbonaattiestereiden valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo/2,3-b/indol-5-yyli-karbonaattiestereiden valmistamiseksi

Info

Publication number: FI901470A0
Authority: FI; Finland
Prior art keywords: trimethylpyrrolo; hexahydro; indol; carbonate esters; preparation
Prior art date: 1989-03-27

Application number

FI901470A

Other languages

English (en)

Swedish (sv)

Other versions

FI92932B (fi

FI92932C (fi

Inventor

Edward J Glamkowski

Yulin Chiang

Barbara E Kurys

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-27

Filing date

1990-03-23

Publication date

1990-03-23

1990-03-23 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1990-03-23 Publication of FI901470A0 publication Critical patent/FI901470A0/fi

1994-10-14 Publication of FI92932B publication Critical patent/FI92932B/fi

1995-01-25 Application granted granted Critical

1995-01-25 Publication of FI92932C publication Critical patent/FI92932C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI901470A 1989-03-27 1990-03-23 Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo/2,3-b/indol-5-yyli-karbonaattiestereiden valmistamiseksi FI92932C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32917189		1989-03-27
US07/329,171 US4971992A (en)	1989-03-27	1989-03-27	Carbonate derivatives of eseroline

Publications (3)

Publication Number	Publication Date
FI901470A0 true FI901470A0 (fi)	1990-03-23
FI92932B FI92932B (fi)	1994-10-14
FI92932C FI92932C (fi)	1995-01-25

Family

ID=23284183

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI901470A FI92932C (fi)	1989-03-27	1990-03-23	Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo/2,3-b/indol-5-yyli-karbonaattiestereiden valmistamiseksi

Country Status (18)

Country	Link
US (1)	US4971992A (fi)
EP (1)	EP0389984B1 (fi)
JP (1)	JPH0737458B2 (fi)
KR (1)	KR0163049B1 (fi)
AT (1)	ATE124044T1 (fi)
AU (1)	AU621208B2 (fi)
CA (1)	CA2013087C (fi)
DE (1)	DE69020205T2 (fi)
DK (1)	DK0389984T3 (fi)
ES (1)	ES2075081T3 (fi)
FI (1)	FI92932C (fi)
HU (1)	HU204053B (fi)
IE (1)	IE67449B1 (fi)
IL (1)	IL93895A (fi)
NO (1)	NO173995C (fi)
NZ (1)	NZ233065A (fi)
PT (1)	PT93535B (fi)
ZA (1)	ZA902307B (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4791107A (en) *	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5077289A (en) *	1989-11-30	1991-12-31	Hoechst Roussel Pharmaceuticals Inc.	Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
US4983616A (en) *	1990-02-01	1991-01-08	Hoechst-Roussel Pharmaceuticals Inc.	Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds
AU634654B2 (en) *	1990-05-11	1993-02-25	Hoechst-Roussel Pharmaceuticals Incorporated	Pyrrolo(2,3-b)indole-ketones and analogs, a process for their preparation and their use as medicaments
US5216017A (en) *	1990-05-11	1993-06-01	Hoechst-Roussel Pharmaceuticals Incorporated	Pyrrolo[2,3-b]indole-ketones and analogs
AU634380B2 (en) *	1990-05-17	1993-02-18	Hoechst-Roussel Pharmaceuticals Incorporated	Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments
DE4139763A1 (de) *	1991-12-03	1993-06-09	Kali-Chemie Pharma Gmbh, 3000 Hannover, De	Kristalline fumarsaure salze von 9,9-alkylen-3,7-diazabicyclononan-verbindungen und diese verbindungen enthaltende arzneimittel
US5409948A (en) *	1992-11-23	1995-04-25	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Method for treating cognitive disorders with phenserine
AT404907B (de) *	1993-07-13	1999-03-25	Andritz Patentverwaltung	Verfahren und anlage zum herstellen von edelstahlband
US5665880A (en) *	1996-10-31	1997-09-09	Hoechst Marion Roussel, Inc.	Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) *	1996-12-19	1997-10-14	Hoechst Marion Roussel, Inc.	Method of preparation of physostigmine carbamate derivatives from eseroline ethers
US20050182044A1 (en) *	2004-02-17	2005-08-18	Bruinsma Gosse B.	Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
CA2508585A1 (en) *	2004-06-01	2005-12-01	Axonyx, Inc.	Transdermal delivery system for treatment of cognitive disorders
CA2509265A1 (en) *	2004-06-08	2005-12-08	Axonyx, Inc.	Methods of delaying alzheimer's disease progression using a beta-amyloid precursor protein inhibitor and hmg coa reductase inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1109003B (it) *	1977-09-20	1985-12-16	Univ Firenze	Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo
US4791107A (en) *	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5077289A (en) *	1989-11-30	1991-12-31	Hoechst Roussel Pharmaceuticals Inc.	Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine

1989
- 1989-03-27 US US07/329,171 patent/US4971992A/en not_active Expired - Lifetime
1990
- 1990-03-22 PT PT93535A patent/PT93535B/pt not_active IP Right Cessation
- 1990-03-23 FI FI901470A patent/FI92932C/fi not_active IP Right Cessation
- 1990-03-23 DE DE69020205T patent/DE69020205T2/de not_active Expired - Lifetime
- 1990-03-23 ES ES90105562T patent/ES2075081T3/es not_active Expired - Lifetime
- 1990-03-23 EP EP90105562A patent/EP0389984B1/en not_active Expired - Lifetime
- 1990-03-23 DK DK90105562.4T patent/DK0389984T3/da active
- 1990-03-23 AT AT90105562T patent/ATE124044T1/de not_active IP Right Cessation
- 1990-03-23 NZ NZ233065A patent/NZ233065A/en unknown
- 1990-03-26 NO NO901385A patent/NO173995C/no unknown
- 1990-03-26 KR KR1019900004027A patent/KR0163049B1/ko not_active IP Right Cessation
- 1990-03-26 CA CA002013087A patent/CA2013087C/en not_active Expired - Lifetime
- 1990-03-26 JP JP2073603A patent/JPH0737458B2/ja not_active Expired - Lifetime
- 1990-03-26 HU HU901832A patent/HU204053B/hu unknown
- 1990-03-26 IL IL9389590A patent/IL93895A/en not_active IP Right Cessation
- 1990-03-26 IE IE109790A patent/IE67449B1/en not_active IP Right Cessation
- 1990-03-26 ZA ZA902307A patent/ZA902307B/xx unknown
- 1990-03-27 AU AU52202/90A patent/AU621208B2/en not_active Ceased

Also Published As

Publication number	Publication date
JPH0737458B2 (ja)	1995-04-26
EP0389984A1 (en)	1990-10-03
FI92932B (fi)	1994-10-14
HUT54159A (en)	1991-01-28
NZ233065A (en)	1992-04-28
NO173995B (no)	1993-11-22
HU204053B (en)	1991-11-28
AU5220290A (en)	1990-11-08
KR900014388A (ko)	1990-10-23
AU621208B2 (en)	1992-03-05
CA2013087A1 (en)	1990-09-27
NO901385L (no)	1990-09-28
KR0163049B1 (ko)	1998-12-01
IL93895A0 (en)	1990-12-23
IE67449B1 (en)	1996-04-03
US4971992A (en)	1990-11-20
NO173995C (no)	1994-03-02
IE901097L (en)	1990-09-27
HU901832D0 (en)	1990-08-28
IL93895A (en)	1995-07-31
DE69020205D1 (de)	1995-07-27
ATE124044T1 (de)	1995-07-15
ZA902307B (en)	1990-12-28
FI92932C (fi)	1995-01-25
CA2013087C (en)	1999-12-28
PT93535B (pt)	1996-03-29
DK0389984T3 (da)	1995-10-30
NO901385D0 (no)	1990-03-26
EP0389984B1 (en)	1995-06-21
JPH02289572A (ja)	1990-11-29
DE69020205T2 (de)	1995-12-07
ES2075081T3 (es)	1995-10-01
PT93535A (pt)	1990-11-07

Publication	Publication Date	Title
FI901470A0 (fi)	1990-03-23	Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo/2,3-b/indol-5-yyli-karbonaattiestereiden valmistamiseksi
AU636351B2 (en)	1993-04-29	N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments
DK0430201T3 (fi)	1997-06-16

Legal Events

Date	Code	Title	Description
1994-09-19	BB	Publication of examined application
1997-06-24	PC	Transfer of assignment of patent	Owner name: HOECHST MARION ROUSSEL, INC.
2004-08-31	FG	Patent granted	Owner name: HOECHST MARION ROUSSEL INC., INC.
2005-09-30	MA	Patent expired