ES8506605A1 - Process for the preparation of basic oxime ethers - Google Patents
Process for the preparation of basic oxime ethersInfo
- Publication number
- ES8506605A1 ES8506605A1 ES529566A ES529566A ES8506605A1 ES 8506605 A1 ES8506605 A1 ES 8506605A1 ES 529566 A ES529566 A ES 529566A ES 529566 A ES529566 A ES 529566A ES 8506605 A1 ES8506605 A1 ES 8506605A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- image
- lower alkyl
- phenyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 oxime ethers Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000004703 alkoxides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
An improved process for the preparation of basic oxime ethers of the general Formula I < IMAGE > /wherein R is a phenyl group optionally substituted by one to three halogen atom/s/ and/or lower alkoxy group/s/ R<1> and R<2> each are hydrogen or together from a valence bond A is lower alkylene R<3> and R<4> each stand for hydrogen or lower alkyl or together with the adjacent nitrogen atom they are attached to form a 5-8 membered heterocyclic ring which may optionally contain a further oxygen or nitrogen atom and/or may be optionally substituted by lower alkyl, phenyl or phenyl-lower alkyl, and n is 3, 4, 5, 6 or 7/ and acid addition salts thereof comprises reacting an oxime of the general Formula II < IMAGE > with a compound of the general Formula III < IMAGE > (where Hal is a halogen atom) or an acid addition salt thereof in the presence of an alkali metal lower alkoxide and an aromatic organic hydrocarbon solvent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU83415A HU189226B (en) | 1983-02-08 | 1983-02-08 | Process for producing basic oxime-ethers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES529566A0 ES529566A0 (en) | 1985-08-01 |
| ES8506605A1 true ES8506605A1 (en) | 1985-08-01 |
Family
ID=10949516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES529566A Expired ES8506605A1 (en) | 1983-02-08 | 1984-02-08 | Process for the preparation of basic oxime ethers |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS59172453A (en) |
| AT (1) | AT385508B (en) |
| BE (1) | BE898834A (en) |
| CH (1) | CH659063A5 (en) |
| DE (1) | DE3404424A1 (en) |
| ES (1) | ES8506605A1 (en) |
| FR (1) | FR2540492B1 (en) |
| GB (1) | GB2135994B (en) |
| HU (1) | HU189226B (en) |
| IT (1) | IT1196016B (en) |
| SU (1) | SU1299502A3 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU197205B (en) * | 1984-07-10 | 1989-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of medical compositions against angine |
| HU202195B (en) * | 1987-12-31 | 1991-02-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing new substituted styrene derivatives and medical compositions comprising such compounds |
| US5071853A (en) * | 1989-03-23 | 1991-12-10 | Bigge Christopher F | Polycyclic amines useful as cerebrovascular agents |
| US5180736A (en) * | 1989-03-23 | 1993-01-19 | Warner-Lambert Company | Polycyclic amines useful as cerebrovascular agents |
| HU212415B (en) * | 1989-08-25 | 1996-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing new cyclic oxym derivatives and pharmaceutical compositions containing them as active components |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4083978A (en) * | 1976-01-27 | 1978-04-11 | Egyt Gyogyszervegyeszeti Gyar | Oxime ethers |
| DK149043C (en) * | 1976-01-27 | 1986-05-26 | Egyt Gyogyszervegyeszeti Gyar | METHOD OF ANALOGUE FOR THE PREPARATION OF 2-BENZAL OR 2-BENZYL-1- (AMINOALCOXYIMINO) -CYCLOALKANES OR SALTS OR QUATERNARY AMMONIUM DERIVATIVES THEREOF |
| HU178518B (en) * | 1978-12-19 | 1982-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing cyclododekanone oxime ethers |
-
1983
- 1983-02-08 HU HU83415A patent/HU189226B/en not_active IP Right Cessation
-
1984
- 1984-02-02 CH CH480/84A patent/CH659063A5/en not_active IP Right Cessation
- 1984-02-03 BE BE1/010951A patent/BE898834A/en not_active IP Right Cessation
- 1984-02-07 GB GB08403234A patent/GB2135994B/en not_active Expired
- 1984-02-07 IT IT19469/84A patent/IT1196016B/en active
- 1984-02-07 AT AT0038784A patent/AT385508B/en not_active IP Right Cessation
- 1984-02-07 FR FR8401832A patent/FR2540492B1/en not_active Expired
- 1984-02-08 ES ES529566A patent/ES8506605A1/en not_active Expired
- 1984-02-08 JP JP59021514A patent/JPS59172453A/en active Pending
- 1984-02-08 SU SU843703074A patent/SU1299502A3/en active
- 1984-02-08 DE DE19843404424 patent/DE3404424A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59172453A (en) | 1984-09-29 |
| HU189226B (en) | 1986-06-30 |
| GB2135994A (en) | 1984-09-12 |
| AT385508B (en) | 1988-04-11 |
| ES529566A0 (en) | 1985-08-01 |
| IT1196016B (en) | 1988-11-10 |
| GB8403234D0 (en) | 1984-03-14 |
| GB2135994B (en) | 1986-08-20 |
| BE898834A (en) | 1984-08-03 |
| IT8419469A0 (en) | 1984-02-07 |
| FR2540492A1 (en) | 1984-08-10 |
| FR2540492B1 (en) | 1988-02-19 |
| ATA38784A (en) | 1987-09-15 |
| CH659063A5 (en) | 1986-12-31 |
| DE3404424A1 (en) | 1984-08-16 |
| SU1299502A3 (en) | 1987-03-23 |
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