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ES8506326A1 - Procedimiento para la preparacion de derivados de estrano y androstano - Google Patents

Procedimiento para la preparacion de derivados de estrano y androstano

Info

Publication number
ES8506326A1
ES8506326A1 ES536649A ES536649A ES8506326A1 ES 8506326 A1 ES8506326 A1 ES 8506326A1 ES 536649 A ES536649 A ES 536649A ES 536649 A ES536649 A ES 536649A ES 8506326 A1 ES8506326 A1 ES 8506326A1
Authority
ES
Spain
Prior art keywords
group
carbon
hydrogen
carbon atoms
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536649A
Other languages
English (en)
Other versions
ES536649A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES536649A0 publication Critical patent/ES536649A0/es
Publication of ES8506326A1 publication Critical patent/ES8506326A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ESTRANO Y ANDOSTRANO, DE FORMULA GENERAL (I), EN LA QUE X SIGNIFICA UN ATOMO DE BROMO, DE YODO, UN GRUPO TRIFENILESTAN/O O TRIALQUILESTAN/O CON 1 A 6 ATOMOS DE CARBONO POR CADA RADICAL ALQUILO; Y SIGNIFICA DOS ATOMOS DE HIDROGENO O UN GRUPO METILENO; Z SIGNIFICA DOS ATOMOS DE HIDROGENO O UN GRUPO OXO; Y V SIGNIFICA UN GRUPO ETILENO O UN GRUPO VINILENO.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R1 SIGNIFICA HIDROGENO O UN RADICAL HIDROCARBONADO; R2 SIGNIFICA UN GRUPO METILO O ETILO; R3 SIGNIFICA HIDROGENO; Y R4 SIGNIFICA UN ENLACE CARBONO- CARBONO, CON HIDRURO DE TRIFENILESTAN/O O CON UN HIDRUTO DE TRIALQUILESTAN/O.DE APLICACION EN MEDICINA PARA DESCUBRIR TUMORES Y METASTASIS EN LOS TEJIDOS.
ES536649A 1983-10-10 1984-10-10 Procedimiento para la preparacion de derivados de estrano y androstano Expired ES8506326A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3337179A DE3337179A1 (de) 1983-10-10 1983-10-10 Estran- und androstan-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende praeparate

Publications (2)

Publication Number Publication Date
ES536649A0 ES536649A0 (es) 1985-07-16
ES8506326A1 true ES8506326A1 (es) 1985-07-16

Family

ID=6211683

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536649A Expired ES8506326A1 (es) 1983-10-10 1984-10-10 Procedimiento para la preparacion de derivados de estrano y androstano

Country Status (12)

Country Link
US (1) US4945064A (es)
EP (1) EP0137434B1 (es)
JP (1) JPH0635476B2 (es)
AT (1) ATE72247T1 (es)
AU (1) AU3406684A (es)
CA (1) CA1300601C (es)
DE (2) DE3337179A1 (es)
DK (1) DK484584A (es)
ES (1) ES8506326A1 (es)
GR (1) GR80583B (es)
IE (1) IE58642B1 (es)
NZ (1) NZ209811A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3427795A1 (de) * 1984-07-25 1986-02-06 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 17(alpha)-halogenvinyl-estran-derivate, ihre herstellung und verwendung in der medizin
IE58562B1 (en) * 1985-07-24 1993-10-06 Akzo Nv Novel 11-methylene-oestr-15-enes, processes for their preparation, and pharmaceutical compositions
US4780420A (en) * 1985-09-30 1988-10-25 Yale University Progesterone receptor ligands
DE3627154A1 (de) * 1986-08-11 1988-02-25 Schering Ag Verfahren zur herstellung von (z)-17(alpha)-halogenvinyl-steroiden und (z)-17(alpha)-chlorvinyl-steroide
JPH01500903A (ja) * 1986-08-11 1989-03-30 シエーリング　アクチエンゲゼルシヤフト （Ｚ）‐１７α‐ハロゲンビニル‐ステロイドの製造法
FR2613937B1 (fr) * 1987-04-17 1989-07-21 Ire Celltarg Sa Ligands specifiques de recepteurs d'hormones steroides utiles pour la therapie ciblee ou l'imagerie medicale notamment du cancer
FR2637803B1 (fr) * 1988-10-19 1993-07-09 Ire Celltarg Sa Ligands specifiques de recepteurs d'hormones steroides estrogenes et progestagenes, application et produits intermediaires de synthese
US5427766A (en) * 1993-11-15 1995-06-27 The Dow Chemical Company Radiolabeled steroids for use in radiochemical-guided surgery
PL356465A1 (en) * 2002-10-04 2004-04-05 ANPHARM Przedsiębiorstwo Farmaceutyczne S.A. METHOD OF MANUFACTURE OF 17beta-HYDROXY-7alpha-METHYL-19-NOR-17alpha-PREGN-5(10)-ENE-20-YNE-3-ONE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3498975A (en) * 1960-09-30 1970-03-03 Merck & Co Inc Haloethisterone compounds
US3498978A (en) * 1967-04-10 1970-03-03 Geigy Chem Corp 3-pipecoline derivatives
US4321208A (en) * 1976-09-27 1982-03-23 Velayudhan Sahadevan Preparation of directly iodinated steroid hormones and related compounds
US4541957A (en) * 1983-09-07 1985-09-17 The George Washington University Process for preparing iodovinyl-estradiol

Also Published As

Publication number Publication date
EP0137434A2 (de) 1985-04-17
JPH0635476B2 (ja) 1994-05-11
IE842575L (en) 1985-04-10
IE58642B1 (en) 1993-10-20
US4945064A (en) 1990-07-31
EP0137434B1 (de) 1992-01-29
DE3337179A1 (de) 1985-05-23
ATE72247T1 (de) 1992-02-15
DE3485490D1 (de) 1992-03-12
GR80583B (en) 1985-02-04
DK484584A (da) 1985-04-11
EP0137434A3 (en) 1986-01-08
CA1300601C (en) 1992-05-12
NZ209811A (en) 1988-02-29
AU3406684A (en) 1986-09-11
ES536649A0 (es) 1985-07-16
DK484584D0 (da) 1984-10-10
JPS60155193A (ja) 1985-08-15

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