Nothing Special   »   [go: up one dir, main page]

ES8503669A1 - Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos. - Google Patents

Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.

Info

Publication number
ES8503669A1
ES8503669A1 ES523609A ES523609A ES8503669A1 ES 8503669 A1 ES8503669 A1 ES 8503669A1 ES 523609 A ES523609 A ES 523609A ES 523609 A ES523609 A ES 523609A ES 8503669 A1 ES8503669 A1 ES 8503669A1
Authority
ES
Spain
Prior art keywords
hydrogen
cor
alkyl
alkoxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523609A
Other languages
English (en)
Other versions
ES523609A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES523609A0 publication Critical patent/ES523609A0/es
Publication of ES8503669A1 publication Critical patent/ES8503669A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS N-IMIDAZOLILICOS DE COMPUESTOS BICICLICOS.CONSISTE EN SOMETER A REACCION DE BETA-ELIMINACION UN COMPUESTO DE FORMULA (II) PARA OBTENER DERIVADOS N-IMIDAZOLILICOS DE COMPUESTOS BICICLICOS DE FORMULA (I) Y SOMETER A UNA REACCION DE REDUCCION EL COMPUESTO DE FORMULA (I), DONDE EL SIMBOLO REPRESENTA UN ENLACE SIMPLE O DOBLE; Z ES UN ENLACE SIMPLE, UN ATOMO DE O O UN GRUPO -CH2-; R1, R2, R3 Y R4 SON H, HIDROXI, HALOGENO, 5-TETRAZOLILO Y OTROS; R5 Y R6 SON H, ALQUILO C 1 A 6, CICLOALQUILO Y OTROS; Y M ES H O UN DERIVADO ACTIVO DE UN ACIDO. SE REALIZA EN PRESENCIA DE UN DISOLVENTE ORGANICO A TEMPERATURA ENTRE 50JC Y LA TEMPERATURA DE REFLUJO.SE EMPLEAN COMO INHIBIDORES SOBRE LA TXA2-SINTETASA.
ES523609A 1982-07-05 1983-06-27 Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos. Expired ES8503669A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8219412 1982-07-05

Publications (2)

Publication Number Publication Date
ES523609A0 ES523609A0 (es) 1985-03-01
ES8503669A1 true ES8503669A1 (es) 1985-03-01

Family

ID=10531484

Family Applications (1)

Application Number Title Priority Date Filing Date
ES523609A Expired ES8503669A1 (es) 1982-07-05 1983-06-27 Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.

Country Status (33)

Country Link
US (2) US4510149A (es)
JP (1) JPS5927874A (es)
KR (1) KR910000414B1 (es)
AT (1) AT386201B (es)
AU (1) AU557304B2 (es)
BE (1) BE897207A (es)
CA (1) CA1202030A (es)
CH (1) CH655102A5 (es)
CS (1) CS273310B2 (es)
CZ (1) CZ413491A3 (es)
DE (1) DE3324069C2 (es)
DK (1) DK163359C (es)
ES (1) ES8503669A1 (es)
FI (1) FI74466C (es)
FR (1) FR2529547B1 (es)
GR (1) GR77577B (es)
HK (1) HK101187A (es)
HU (1) HU193529B (es)
IE (1) IE55894B1 (es)
IL (1) IL69152A0 (es)
IT (1) IT1163641B (es)
LU (1) LU84895A1 (es)
MY (1) MY104376A (es)
NL (1) NL8302347A (es)
NO (1) NO161439C (es)
NZ (1) NZ204802A (es)
PH (1) PH21115A (es)
PT (1) PT76979B (es)
SE (1) SE461791B (es)
SG (1) SG73487G (es)
SU (1) SU1342414A3 (es)
YU (1) YU43545B (es)
ZA (1) ZA834865B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH22076A (en) * 1983-08-25 1988-05-20 Daiichi Seiyaku Co Benzocycloalkane derivative
JPH062745B2 (ja) * 1984-07-16 1994-01-12 第一製薬株式会社 インダン誘導体
US4659730A (en) * 1984-06-18 1987-04-21 Eli Lilly And Company Aromatase inhibiting imidazole derivatives
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB8612796D0 (en) * 1986-05-27 1986-07-02 Fbc Ltd Fungicides
JPS63310825A (ja) * 1987-06-03 1988-12-19 フアルミタリア・カルロ・エルバ・エツセ・エルレ・エルレ 医薬に有用な二環式化合物のｎ−イミダゾリル誘導体
US4992465A (en) * 1988-09-27 1991-02-12 Ciba-Geigy Corporation 3-amino-dihydro-(1)-benzopyrans
IL91542A0 (en) * 1988-10-06 1990-04-29 Erba Carlo Spa N-imidazolyl-and n-imidazolyl-methyl derivatives of substituted bicyclic compounds,their preparation and pharmaceutical compositions containing them
GB9025848D0 (en) * 1990-11-28 1991-01-09 Erba Carlo Spa Imidazol-2-yl derivatives of substituted bicyclic compounds and process for their preparation
GB9102862D0 (en) * 1991-02-11 1991-03-27 Erba Carlo Spa N-imidazolyl derivatives of substituted or alkoxymino tetrahydronaphthalenes and chromans
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US5559248A (en) * 1995-04-05 1996-09-24 Bristol-Myers Squibb Co. Retinoid-like heterocycles
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
GC0000177A (en) * 1998-12-17 2006-03-29 Smithkline Beecham Thrombopoietin mimetics
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
US20110212054A1 (en) * 2000-05-25 2011-09-01 Glaxosmithkline Llc. Thrombopoietin mimetics
DE10054639B4 (de) * 2000-11-03 2004-05-06 Jenapharm Gmbh & Co. Kg Verwendung von RanBPM als Co-Modulator von Steroidhormonrezeptoren
JP2004527541A (ja) 2001-03-01 2004-09-09 スミスクライン・ビーチャム・コーポレイション トロンボポエチン模倣物
MY142390A (en) * 2002-05-22 2010-11-30 Glaxosmithkline Llc 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine)
WO2004092141A1 (en) * 2003-04-16 2004-10-28 Huntsman Advanced Materials (Switzerland) Gmbh 1-imidazolymethyl-substituted-2-naphtols and their use as accelerators for low-temperature curing
TW200526638A (en) * 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
US9271963B2 (en) * 2005-03-03 2016-03-01 Universitat Des Saarlandes Selective inhibitors of human corticosteroid synthases
CA2672286A1 (en) * 2006-12-18 2008-06-26 Novartis Ag Organic compounds
ECSP077628A (es) * 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
EP3127427B1 (en) 2009-05-29 2020-01-08 Novartis Ag Methods of administration of thrombopoietin agonist compounds
WO2016022448A1 (en) * 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2443671A (en) * 1942-12-03 1948-06-22 Westinghouse Electric Corp Arc welding system
US3485917A (en) * 1966-04-14 1969-12-23 Janssen Pharmaceutica Nv Composition and method for combating fungus with imidazole carboxylates
US3541109A (en) * 1968-06-25 1970-11-17 Du Pont 1-substituted imidazoles useful in acth reserve assay
US3637731A (en) * 1968-07-18 1972-01-25 Du Pont 1-(alkylsubstituted phenyl)imidazoles useful in acth reserve assay
IE40911B1 (en) * 1974-04-11 1979-09-12 Schering Ag Imidazole derivatives and process for their manufacture
DE2418502C3 (de) * 1974-04-11 1980-04-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen Dichlorbenzyl- [2-( a -imidazolylbutyl)-phenyl] -äther und -thioäther, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4284641A (en) * 1977-08-26 1981-08-18 Burroughs Wellcome Co. Pharmaceutically active imidazole derivatives
JPS55313A (en) * 1978-06-13 1980-01-05 Kissei Pharmaceut Co Ltd Imidazole derivative
JPS5681566A (en) * 1979-12-05 1981-07-03 Yoshitomi Pharmaceut Ind Ltd Imidazole derivative
DE3167014D1 (en) * 1980-02-14 1984-12-13 Sandoz Ag A method for the total synthesis of cyclosporins and novel cyclosporins
GB2071655B (en) * 1980-03-04 1983-06-22 Erba Farmitalia N-amidazolyl derivatives of1-chroman and process for their preparation
ZA81980B (en) * 1980-03-04 1982-02-24 Erba Farmitalia N-imidazolyl derivatives of 1-chroman and process for their preparation
IL62122A0 (en) * 1980-03-04 1981-03-31 Erba Farmitalia N-imidazolyl derivatives of 1-chroman,their preparation and pharmaceutical compositions containing them
ZA825142B (en) * 1981-07-23 1983-04-27 Erba Farmitalia N-imidazolyl derivatives of 1,2,3,j-tetrahydro-naphthalene, indan and 2-substituted-1-chroman, and process for their preparation
IL66242A0 (en) * 1981-07-23 1982-11-30 Erba Farmitalia N-imidazolyl derivatives of 1,2,3,4-tetrahydro-naphthalene,indan and 2-substituted-1-chroman,their preparation and pharmaceutical compositions containing them
ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
JPS6081566A (ja) * 1983-10-07 1985-05-09 Nissan Motor Co Ltd ロツクアツプトルクコンバ−タのスリツプ制御装置

Also Published As

Publication number Publication date
US4602022A (en) 1986-07-22
PT76979B (en) 1986-01-09
CZ413491A3 (en) 1993-10-13
DE3324069C2 (de) 1994-08-25
DK307983A (da) 1984-01-06
FI832420L (fi) 1984-01-06
ATA247383A (de) 1987-12-15
HK101187A (en) 1988-01-08
NZ204802A (en) 1986-04-11
US4510149A (en) 1985-04-09
IT8321886A0 (it) 1983-07-01
HU193529B (en) 1987-10-28
SE8303824L (sv) 1984-01-06
SE461791B (sv) 1990-03-26
DK163359B (da) 1992-02-24
DK307983D0 (da) 1983-07-04
IL69152A0 (en) 1983-11-30
FR2529547B1 (fr) 1986-09-05
NO832437L (no) 1984-01-06
NO161439B (no) 1989-05-08
AU557304B2 (en) 1986-12-18
DK163359C (da) 1992-07-13
GR77577B (es) 1984-09-24
SE8303824D0 (sv) 1983-07-04
KR840005433A (ko) 1984-11-12
CS273310B2 (en) 1991-03-12
LU84895A1 (fr) 1983-11-23
AT386201B (de) 1988-07-25
KR910000414B1 (ko) 1991-01-25
CH655102A5 (de) 1986-03-27
CS509483A2 (en) 1990-08-14
MY104376A (en) 1994-03-31
IT1163641B (it) 1987-04-08
ES523609A0 (es) 1985-03-01
BE897207A (fr) 1984-01-04
AU1654083A (en) 1984-01-12
DE3324069A1 (de) 1984-01-26
FI74466B (fi) 1987-10-30
YU43545B (en) 1989-08-31
NO161439C (no) 1989-08-16
JPS5927874A (ja) 1984-02-14
JPH0454662B2 (es) 1992-08-31
PH21115A (en) 1987-07-16
SU1342414A3 (ru) 1987-09-30
YU144283A (en) 1986-10-31
ZA834865B (en) 1984-03-28
FR2529547A1 (fr) 1984-01-06
FI74466C (fi) 1988-02-08
IE55894B1 (en) 1991-02-14
FI832420A0 (fi) 1983-07-01
PT76979A (en) 1983-08-01
CA1202030A (en) 1986-03-18
SG73487G (en) 1988-03-04
IE831564L (en) 1984-01-05
NL8302347A (nl) 1984-02-01

Similar Documents

Publication Publication Date Title
ES8503669A1 (es) Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
TW282466B (es)
NO170280C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive sulfamatderivater
PL275423A1 (en) Method of obtaining novel heterocyclic compounds
HUT52059A (en) Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components
ES8703410A1 (es) Procedimiento para preparar guanidinas anti-inflamatorias
DE3363743D1 (en) Dihydropyridine anti-ischaemic and antihypertensive agents
PH20114A (en) Dihydropyridines,pharmaceutical compositions containing the same and method of use thereof
ES8500233A1 (es) Un metodo para preparar compuestos de piridilo
ATE67193T1 (de) 6-phenyl-pyridazin-verbindungen.
PT87277A (pt) Process for the preparation of new bicyclic compounds and pharmaceutical compositions comprising same
ES8307792A1 (es) Un metodo de produccion de compuesto de dihidropiridina.
ES8403887A1 (es) Procedimiento de obtencion de los 2-amino 5- (aralcoil piperidino alcoil) amino 1,4-diazoles
ES8401755A1 (es) Procedimiento para la preparacion de derivados de tiometilpiridina.
ES2006361A6 (es) Un procedimiento para preparar derivados de insoindolinilo opticamente activos.
ES8604958A1 (es) Un procedimiento de obtencion de imidazoquinolinas
ES8103092A1 (es) Un procedimiento para la preparacion de derivados del acido aminodesoxi-clavulanico

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519