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ES474130A1 - Procedimiento para la obtencion de derivados de 6-tiatetra- ciclina - Google Patents

Procedimiento para la obtencion de derivados de 6-tiatetra- ciclina

Info

Publication number
ES474130A1
ES474130A1 ES474130A ES474130A ES474130A1 ES 474130 A1 ES474130 A1 ES 474130A1 ES 474130 A ES474130 A ES 474130A ES 474130 A ES474130 A ES 474130A ES 474130 A1 ES474130 A1 ES 474130A1
Authority
ES
Spain
Prior art keywords
thiatetracyclinracemates
preparing
optical antipodes
natural configuration
thianaphtha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES474130A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES474130A1 publication Critical patent/ES474130A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Procedimiento para la obtención de derivados de 6-tiatetraciclina, caracterizado porque mezclas de epímero de 1,44a 5,5a,6,11,12a-octahidro-3,12-dihidroxi-1,11-dioxo-6-tia- natacen-2-carboxamidas se transforman por tratamiento con una base, en caso dado en presencia de un disolvente inerte a temperaturas entre 15 y 120º con una relación de tiempo que a 20º asciende a 12 horas y a 50º aproximadamente 1 hora.
ES474130A 1977-10-13 1978-10-11 Procedimiento para la obtencion de derivados de 6-tiatetra- ciclina Expired ES474130A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2746044A DE2746044C2 (de) 1977-10-13 1977-10-13 Verfahren zur Herstellung von e-Thiatetracyclinracematen mit natürlicher Konfiguration und ihren optischen Antipoden

Publications (1)

Publication Number Publication Date
ES474130A1 true ES474130A1 (es) 1980-01-16

Family

ID=6021351

Family Applications (1)

Application Number Title Priority Date Filing Date
ES474130A Expired ES474130A1 (es) 1977-10-13 1978-10-11 Procedimiento para la obtencion de derivados de 6-tiatetra- ciclina

Country Status (9)

Country Link
US (1) US4229582A (es)
EP (1) EP0001558A1 (es)
JP (1) JPS5466681A (es)
AU (1) AU4069178A (es)
DE (1) DE2746044C2 (es)
ES (1) ES474130A1 (es)
HU (1) HU176135B (es)
IL (1) IL55704A0 (es)
IT (1) IT1109315B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2318580A1 (en) * 1998-01-23 1999-07-29 Mark L. Nelson Pharmaceutically active compounds and methods of use thereof
EP1713457A2 (de) * 2004-02-11 2006-10-25 Max-Delbrück-Centrum Für Molekulare Medizin Neue arzneimittel und diagnostische zusammensetzungen f r be handlung und diagnose von neurodegenerativen erkrankungen und amyloid-krankheiten

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437487A1 (de) * 1974-08-03 1976-02-19 Merck Patent Gmbh 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung
DE2442829A1 (de) * 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
HU176135B (en) 1980-12-28
DE2746044B1 (de) 1979-01-04
AU4069178A (en) 1980-04-17
JPS5466681A (en) 1979-05-29
IT1109315B (it) 1985-12-16
DE2746044C2 (de) 1979-09-06
IT7851481A0 (it) 1978-10-12
IL55704A0 (en) 1978-12-17
EP0001558A1 (de) 1979-05-02
US4229582A (en) 1980-10-21

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