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ES2523518T3 - Nuevas combinaciones farmacológicas para el tratamiento de enfermedades de las vías respiratorias - Google Patents

Nuevas combinaciones farmacológicas para el tratamiento de enfermedades de las vías respiratorias Download PDF

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Publication number
ES2523518T3
ES2523518T3 ES11187038.2T ES11187038T ES2523518T3 ES 2523518 T3 ES2523518 T3 ES 2523518T3 ES 11187038 T ES11187038 T ES 11187038T ES 2523518 T3 ES2523518 T3 ES 2523518T3
Authority
ES
Spain
Prior art keywords
treatment
respiratory diseases
new pharmacological
pharmacological combinations
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11187038.2T
Other languages
English (en)
Inventor
Thierry Bouyssou
Ingo Konetzki
Sabine Pestel
Andreas Schnapp
Christoph Hoenke
Philipp Lustenberger
Klaus Rudolf
Michael P. Pieper
Michel Pairet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966478&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2523518(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE102004019540A external-priority patent/DE102004019540A1/de
Priority claimed from DE102004052987A external-priority patent/DE102004052987A1/de
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Application granted granted Critical
Publication of ES2523518T3 publication Critical patent/ES2523518T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Combinaciones farmacológicas que, junto a un compuesto 1 (6-hidroxi-8-{1-hidroxi-2-[2-(4-metoxi-fenil)-1,1- dimetil-etilamino]-etil}-4H-benzo[1,4]oxazin-3-ona) eventualmente en forma de los distintos isómeros ópticos, mezclas de los distintos enantiómeros o racematos, de las sales por adición de ácidos con ácidos farmacológicamente inocuos, así como, eventualmente, en forma de los solvatos y/o hidratos; como otro principio activo 2 contienen una sal de tiotropio 2a y ciclesonida 2b.

Description

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Claims (1)

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    imagen2
ES11187038.2T 2004-04-22 2005-04-18 Nuevas combinaciones farmacológicas para el tratamiento de enfermedades de las vías respiratorias Active ES2523518T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE102004019540 2004-04-22
DE102004019540A DE102004019540A1 (de) 2004-04-22 2004-04-22 Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen
DE102004052987 2004-11-03
DE102004052987A DE102004052987A1 (de) 2004-11-03 2004-11-03 Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen
EP05002496 2005-02-07
EP05002496 2005-02-07

Publications (1)

Publication Number Publication Date
ES2523518T3 true ES2523518T3 (es) 2014-11-26

Family

ID=34966478

Family Applications (2)

Application Number Title Priority Date Filing Date
ES05739576T Active ES2380370T3 (es) 2004-04-22 2005-04-18 Combinaciones farmacológicas que contienen benzoxazina para el tratamiento de enfermedades de las vías respiratorias
ES11187038.2T Active ES2523518T3 (es) 2004-04-22 2005-04-18 Nuevas combinaciones farmacológicas para el tratamiento de enfermedades de las vías respiratorias

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES05739576T Active ES2380370T3 (es) 2004-04-22 2005-04-18 Combinaciones farmacológicas que contienen benzoxazina para el tratamiento de enfermedades de las vías respiratorias

Country Status (32)

Country Link
EP (2) EP1781298B1 (es)
JP (1) JP2007533683A (es)
KR (2) KR20130049840A (es)
AR (1) AR049262A1 (es)
AT (1) ATE539754T1 (es)
AU (1) AU2005235419B2 (es)
BE (1) BE2015C065I2 (es)
BR (1) BRPI0510080B8 (es)
CA (1) CA2559699C (es)
CY (3) CY1113890T1 (es)
DK (2) DK2422786T3 (es)
EA (1) EA013157B1 (es)
EC (1) ECSP066947A (es)
ES (2) ES2380370T3 (es)
FI (1) FIC20170005I1 (es)
HU (1) HUS1500058I1 (es)
IL (2) IL177685A (es)
LT (1) LTC1781298I2 (es)
LU (1) LU93066I2 (es)
MY (1) MY148945A (es)
NL (1) NL300779I2 (es)
NO (2) NO337714B1 (es)
NZ (1) NZ550797A (es)
PE (1) PE20060462A1 (es)
PL (2) PL2422786T3 (es)
PT (2) PT1781298E (es)
SG (1) SG152237A1 (es)
SI (2) SI1781298T1 (es)
TW (2) TWI372056B (es)
UY (1) UY28861A1 (es)
WO (1) WO2005102349A1 (es)
ZA (1) ZA200606624B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024452A1 (de) * 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation von Betaagonisten
US7923455B2 (en) * 2005-01-28 2011-04-12 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of heart failure comprising administration of an anticholinergic
WO2006087316A1 (en) * 2005-02-16 2006-08-24 Boehringer Ingelheim International Gmbh Pharmaceutical compositions comprising anticholinergics and etiprednol
BRPI0614410A2 (pt) 2005-08-15 2011-03-29 Boehringer Ingelheim Int processo para preparação de betamiméticos
TWI389692B (zh) 2005-10-10 2013-03-21 Boehringer Ingelheim Int 用以吸入β-共效劑的氣溶膠調配物
US20070086957A1 (en) 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
CA2627982C (en) 2005-11-10 2013-09-10 Nicholas S. Bodor Soft anticholinergic esters
CA2642239A1 (en) * 2006-02-16 2007-08-23 Boehringer Ingelheim International Gmbh Drug combinations for the treatment of respiratory tract diseases
JP2010500318A (ja) * 2006-08-07 2010-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器疾患の治療用医薬組成物
UY30543A1 (es) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int Formulacion de aerosol para la inhalacion de beta- agonistas
UY30542A1 (es) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int Formulacion de aerosol para la inhalacion de agonistas beta
US20100099651A1 (en) * 2006-10-26 2010-04-22 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
EP1921070A1 (de) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
PL2245026T3 (pl) 2008-02-07 2013-01-31 Boehringer Ingelheim Int Spirocykliczne heterocykle, leki zawierające te związki, ich zastosowanie i sposób ich produkcji
JP5539351B2 (ja) 2008-08-08 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法
WO2010060875A1 (de) * 2008-11-27 2010-06-03 Boehringer Ingelheim International Gmbh Neue pulverförmige kristalline arzneimittel zur inhalation
WO2014016548A2 (en) * 2012-07-27 2014-01-30 Cipla Limited Pharmaceutical composition
WO2014056840A1 (en) 2012-10-09 2014-04-17 Boehringer Ingelheim International Gmbh Beta-2-adrenoceptor agonist for the treatment of cough

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460581A (en) * 1982-10-12 1984-07-17 Boehringer Ingelheim Kg (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
FI88112C (fi) 1985-07-30 1993-04-13 Glaxo Group Ltd Anordning foer administrering av laekemedel till patienter
SE453566B (sv) 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
CZ20023537A3 (cs) 2000-04-27 2003-02-12 Boehringer Ingelheim Pharma Kg Betamimetika, způsob jejich výroby a použití jako farmaceutický prostředek
PL207870B1 (pl) 2000-10-12 2011-02-28 Boehringer Ingelheim Pharma Krystaliczny monohydrat bromku tiotropium, sposób jego wytwarzania, środek leczniczy i zastosowanie
AU2002345016B2 (en) 2001-06-22 2008-04-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
DE10130371A1 (de) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika
ES2203327B1 (es) * 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
DE10230751A1 (de) * 2002-07-09 2004-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und EGFR-Kinase-Hemmern
DE10246374A1 (de) * 2002-10-04 2004-04-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika mit verlängerter Wirkungsdauer, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE10253282A1 (de) * 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung

Also Published As

Publication number Publication date
PL1781298T4 (pl) 2017-07-31
IL226562A0 (en) 2013-06-27
IL177685A (en) 2013-10-31
BRPI0510080A (pt) 2007-10-16
NO337714B1 (no) 2016-06-06
PT1781298E (pt) 2012-02-03
EA200601846A1 (ru) 2007-04-27
EP2422786A1 (de) 2012-02-29
NZ550797A (en) 2010-08-27
CA2559699C (en) 2012-06-19
SI2422786T1 (sl) 2014-12-31
NO2016022I2 (no) 2016-12-01
CA2559699A1 (en) 2005-11-03
EP2422786B1 (de) 2014-08-13
ZA200606624B (en) 2008-01-08
NO20065060L (no) 2006-11-21
AU2005235419A1 (en) 2005-11-03
ES2380370T3 (es) 2012-05-11
EP1781298A1 (de) 2007-05-09
BRPI0510080B1 (pt) 2020-08-18
DK1781298T3 (da) 2012-05-07
PL2422786T3 (pl) 2015-02-27
PT2422786E (pt) 2014-11-12
TW201231055A (en) 2012-08-01
HUS1500058I1 (hu) 2016-01-28
LTC1781298I2 (lt) 2018-09-25
SI1781298T1 (sl) 2012-04-30
PE20060462A1 (es) 2006-06-19
CY2017014I2 (el) 2017-11-14
ATE539754T1 (de) 2012-01-15
KR20130049840A (ko) 2013-05-14
TWI374739B (en) 2012-10-21
ECSP066947A (es) 2007-01-26
WO2005102349A1 (de) 2005-11-03
LU93066I2 (fr) 2016-07-11
JP2007533683A (ja) 2007-11-22
CY1115719T1 (el) 2017-01-25
AR049262A1 (es) 2006-07-12
NO2016022I1 (no) 2016-12-01
AU2005235419B2 (en) 2010-11-04
NL300779I2 (nl) 2017-11-02
CY2017014I1 (el) 2017-11-14
TWI372056B (en) 2012-09-11
KR20070015592A (ko) 2007-02-05
CY1113890T1 (el) 2016-07-27
SG152237A1 (en) 2009-05-29
PL1781298T3 (pl) 2012-06-29
EA013157B1 (ru) 2010-02-26
EP1781298B1 (de) 2012-01-04
IL177685A0 (en) 2006-12-31
UY28861A1 (es) 2005-11-30
FIC20170005I1 (fi) 2017-01-13
BE2015C065I2 (es) 2024-08-08
BRPI0510080B8 (pt) 2021-05-25
DK2422786T3 (da) 2014-11-17
MY148945A (en) 2013-06-14
KR101287460B1 (ko) 2013-07-23

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