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ES2176359T3 - Liberacion localizada de factores que favorecen la supervivencia de celulas transplantadas. - Google Patents

Liberacion localizada de factores que favorecen la supervivencia de celulas transplantadas.

Info

Publication number
ES2176359T3
ES2176359T3 ES95943823T ES95943823T ES2176359T3 ES 2176359 T3 ES2176359 T3 ES 2176359T3 ES 95943823 T ES95943823 T ES 95943823T ES 95943823 T ES95943823 T ES 95943823T ES 2176359 T3 ES2176359 T3 ES 2176359T3
Authority
ES
Spain
Prior art keywords
egf
survival
microspheres
factors
hepatocits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95943823T
Other languages
English (en)
Inventor
David J Mooney
Robert S Langer
Joseph P Vacanti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Medical Center Corp
Massachusetts Institute of Technology
Original Assignee
Childrens Medical Center Corp
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center Corp, Massachusetts Institute of Technology filed Critical Childrens Medical Center Corp
Application granted granted Critical
Publication of ES2176359T3 publication Critical patent/ES2176359T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C12N5/0075—General culture methods using substrates using microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Materials For Medical Uses (AREA)

Abstract

SE ADMINISTRAN FACTORES DE CRECIMIENTO Y/O FACTORES ANGIOGENICOS EN COMBINACION CON LAS CELULAS DISOCIADAS A TRASPLANTAR, PREFERENTEMENTE EN MICROESFERAS CON LAS CELULAS ENCIMA O EN UNA MATRIZ POLIMERICA, PARA AUMENTAR LA SUPERVIVENCIA Y PROLIFERACION DE LAS CELULAS TRASPLANTADAS. LOS EJEMPLOS DEMUESTRAN QUE EL FACTOR DE CRECIMIENTO EPIDERMAL (EGF) SE INCORPORO EN MICROESFERAS FABRICADAS A PARTIR DE UN COPOLIMERO DE ACIDO LACTICO O GLICOLICO UTILIZANDO UNA TECNICA DE DOBLE EMULSION, EL EGF INCORPORADO SE LIBERO DE FORMA REGULAR TRAS HABER ESTADO UN MES IN VITRO Y PERMANECIO BIOLOGICAMENTE ACTIVO, PUES SEGUIA TENIENDO SU CAPACIDAD DE ESTIMULAR LA SINTESIS DE ADN, DIVISION Y SUPERVIVENCIA A LARGO PLAZO DE HEPATOCITOS CULTIVADOS. LAS MICROESFERAS QUE CONTENIAN EL EGF SE MEZCLARON CON UNA SUSPENSION DE HEPATOCITOS, SE NUCLEARON SOBRE ESPONJAS POROSAS E IMPLANTARON EN EL MESENTERIO DE DOS GRUPOS DE RATAS LEWIS, PARA DEMOSTRAR LA EFICACIA IN VIVO. DOS SEMANAS DESPUES DE LA IMPLANTACION EN ANIMALES PCS, DISPOSITIVOS QUE INCLUIAN MICROESFERAS QUE CONTENIAN EGF PRESENTABAN UN AUMENTO DOS VECES MAYOR DEL NUMERO DE HEPATOCITOS INJERTADOS, EN COMPARACION A LOS IMPLANTES QUE RECIBIERON MICROESFERAS SOLAS.
ES95943823T 1994-12-16 1995-12-14 Liberacion localizada de factores que favorecen la supervivencia de celulas transplantadas. Expired - Lifetime ES2176359T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/358,235 US6281015B1 (en) 1994-12-16 1994-12-16 Localized delivery of factors enhancing survival of transplanted cells

Publications (1)

Publication Number Publication Date
ES2176359T3 true ES2176359T3 (es) 2002-12-01

Family

ID=23408836

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95943823T Expired - Lifetime ES2176359T3 (es) 1994-12-16 1995-12-14 Liberacion localizada de factores que favorecen la supervivencia de celulas transplantadas.

Country Status (10)

Country Link
US (1) US6281015B1 (es)
EP (1) EP0794790B1 (es)
JP (2) JP4361134B2 (es)
AT (1) ATE216255T1 (es)
CA (1) CA2207286C (es)
DE (1) DE69526448T2 (es)
DK (1) DK0794790T3 (es)
ES (1) ES2176359T3 (es)
PT (1) PT794790E (es)
WO (1) WO1996018411A1 (es)

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Also Published As

Publication number Publication date
US6281015B1 (en) 2001-08-28
EP0794790A1 (en) 1997-09-17
DE69526448D1 (de) 2002-05-23
ATE216255T1 (de) 2002-05-15
CA2207286C (en) 2003-10-07
EP0794790B1 (en) 2002-04-17
DE69526448T2 (de) 2002-11-07
JP4361134B2 (ja) 2009-11-11
WO1996018411A1 (en) 1996-06-20
PT794790E (pt) 2002-09-30
JPH10510816A (ja) 1998-10-20
CA2207286A1 (en) 1996-06-20
DK0794790T3 (da) 2002-07-22
JP2008011863A (ja) 2008-01-24

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