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ES2175087T3 - Compuestos triciclicos utiles en el tratamiento de trastornos de proliferacion celular. - Google Patents

Compuestos triciclicos utiles en el tratamiento de trastornos de proliferacion celular.

Info

Publication number
ES2175087T3
ES2175087T3 ES96911439T ES96911439T ES2175087T3 ES 2175087 T3 ES2175087 T3 ES 2175087T3 ES 96911439 T ES96911439 T ES 96911439T ES 96911439 T ES96911439 T ES 96911439T ES 2175087 T3 ES2175087 T3 ES 2175087T3
Authority
ES
Spain
Prior art keywords
useful
treatment
cell proliferation
proliferation disorders
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96911439T
Other languages
English (en)
Inventor
Ronald J Doll
Alan K Mallams
Adriano Afonso
Dinanath F Rane
F George Njoroge
Randall R Rossman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2175087T3 publication Critical patent/ES2175087T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE DESCRIBEN NUEVOS COMPUESTOS DE FORMULA (1.0). TAMBIEN SE DESCRIBE UN PROCEDIMIENTO PARA INHIBIR LA FUNCION RAS Y POR TANTO PARA INHIBIR EL CRECIMIENTO ANORMAL DE CELULAS. EL PROCEDIMIENTO INCLUYE LA ADMINISTRACION DE UN COMPUESTO CON ESTA FORMULA A UN SISTEMA BIOLOGICO. EN CONCRETO, EL PROCEDIMIENTO INHIBE EL CRECIMIENTO ANORMAL DE CELULAS EN UN MAMIFERO, TAL COMO UN SER HUMANO.
ES96911439T 1995-04-07 1996-04-03 Compuestos triciclicos utiles en el tratamiento de trastornos de proliferacion celular. Expired - Lifetime ES2175087T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41898295A 1995-04-07 1995-04-07

Publications (1)

Publication Number Publication Date
ES2175087T3 true ES2175087T3 (es) 2002-11-16

Family

ID=23660318

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96911439T Expired - Lifetime ES2175087T3 (es) 1995-04-07 1996-04-03 Compuestos triciclicos utiles en el tratamiento de trastornos de proliferacion celular.

Country Status (11)

Country Link
US (1) US5891872A (es)
EP (1) EP0819128B1 (es)
JP (1) JPH11503157A (es)
AT (1) ATE220400T1 (es)
AU (1) AU5432596A (es)
CA (1) CA2217680A1 (es)
DE (1) DE69622265T2 (es)
ES (1) ES2175087T3 (es)
IL (1) IL117782A0 (es)
MX (1) MX9707732A (es)
WO (1) WO1996031111A1 (es)

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US11098059B2 (en) 2017-11-08 2021-08-24 Merck Sharp & Dohme Corp. PRMT5 inhibitors
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Also Published As

Publication number Publication date
WO1996031111A1 (en) 1996-10-10
EP0819128B1 (en) 2002-07-10
DE69622265D1 (de) 2002-08-14
MX9707732A (es) 1997-12-31
JPH11503157A (ja) 1999-03-23
US5891872A (en) 1999-04-06
DE69622265T2 (de) 2003-03-20
IL117782A0 (en) 1996-08-04
AU5432596A (en) 1996-10-23
CA2217680A1 (en) 1996-10-10
ATE220400T1 (de) 2002-07-15
EP0819128A1 (en) 1998-01-21

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