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ES2089097T3 - Procedimiento para la fabricacion de derivados de bencilftalacinona y sales de la misma. - Google Patents

Procedimiento para la fabricacion de derivados de bencilftalacinona y sales de la misma.

Info

Publication number
ES2089097T3
ES2089097T3 ES91120268T ES91120268T ES2089097T3 ES 2089097 T3 ES2089097 T3 ES 2089097T3 ES 91120268 T ES91120268 T ES 91120268T ES 91120268 T ES91120268 T ES 91120268T ES 2089097 T3 ES2089097 T3 ES 2089097T3
Authority
ES
Spain
Prior art keywords
salts
derivatives
chem
general formula
bencilftalacinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91120268T
Other languages
English (en)
Inventor
Kazukata Murakami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Chemical Co Ltd
Original Assignee
Eisai Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Chemical Co Ltd filed Critical Eisai Chemical Co Ltd
Application granted granted Critical
Publication of ES2089097T3 publication Critical patent/ES2089097T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCESO PARA LA PRODUCCION DE DERIVADOS DE BENZILFTALAZINONA REPRESENTADO POR LA FORMULA GENERAL (I): DONDE X ES UN ATOMO DE HALOGENO Y R ELEVADO 1 ES UN GRUPO ALCALINO BAJO, Y SALES DE LA MISMA, QUE COMPRENDE LA REACCION DE UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (II): DONDE X TIENE EL MISMO SIGNIFICADO QUE EL MENCIONADO ANTERIORMENTE, O UNA SAL DE LA MISMA CON UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (III) : DONDE R ELEVADO 1 TIENE EL MISMO SIGNIFICADO QUE EL MENCIONADO ANTERIORMENTE O UNA SAL DE LA MISMA EN PRESENCIA DE UN AGENTE DE DESHIDRATACION/CONDENSACION. LOS DERIVADOS DE BENZILFTALAZINONA SE UTILIZAN COMO AGENTES ANTIHISTAMINICOS.
ES91120268T 1990-11-28 1991-11-27 Procedimiento para la fabricacion de derivados de bencilftalacinona y sales de la misma. Expired - Lifetime ES2089097T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2322399A JPH04198180A (ja) 1990-11-28 1990-11-28 ベンジルフタラゾン誘導体の製造方法

Publications (1)

Publication Number Publication Date
ES2089097T3 true ES2089097T3 (es) 1996-10-01

Family

ID=18143233

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91120268T Expired - Lifetime ES2089097T3 (es) 1990-11-28 1991-11-27 Procedimiento para la fabricacion de derivados de bencilftalacinona y sales de la misma.

Country Status (7)

Country Link
US (1) US5216151A (es)
EP (1) EP0488209B1 (es)
JP (1) JPH04198180A (es)
AT (1) ATE138376T1 (es)
CA (1) CA2056334C (es)
DE (1) DE69119714T2 (es)
ES (1) ES2089097T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4207234A1 (de) * 1992-03-07 1993-09-09 Asta Medica Ag Neue aminocarbonsaeure-derivate mit antiallergischer/antiasthmatischer wirkung und verfahren zu deren herstellung
US20070275921A1 (en) * 1996-06-06 2007-11-29 Isis Pharmaceuticals, Inc. Oligomeric Compounds That Facilitate Risc Loading
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US20070020298A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
ES2493641T3 (es) * 2007-06-28 2014-09-12 Cydex Pharmaceuticals, Inc. Administración nasal de soluciones acuosas de corticosteroides
CN101987844B (zh) * 2009-08-04 2013-04-03 铜陵凯顺生物科技有限公司 一种4-(4-氯苄基)-2-(六氢-1-甲基-1h-氮卓-4-基)-1-(2h)-酞嗪盐酸盐的合成方法
CN118271291A (zh) * 2024-04-01 2024-07-02 广东先强药业有限公司 一种高纯度盐酸氮卓斯汀的制备方法及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813384A (en) * 1972-01-17 1974-05-28 Asta Werke Ag Chem Fab Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
DE3575135D1 (de) * 1984-09-14 1990-02-08 Asta Pharma Ag Substituierte benzylphthalazinon-derivate.
US4939140A (en) * 1985-11-07 1990-07-03 Pfizer Inc. Heterocyclic oxophthalazinyl acetic acids
ES2031813T3 (es) * 1985-11-11 1993-01-01 Asta Pharma Ag Procedimiento para la preparacion de derivados de 4-bencil-1-(2h)-ftalazinona.
EP0289939A1 (de) * 1987-05-08 1988-11-09 ASTA Pharma AG Neue 4-Benzyl-1-(2H)-phthalazinon-Derivate mit einem Aminosäurerest
ATE106883T1 (de) * 1987-11-13 1994-06-15 Asta Medica Ag Azelastin-embonat, verfahren zu seiner herstellung und pharmazeutische zubereitungen, die als wirkstoff azelastin-embonat enthalten.
ATE107643T1 (de) * 1989-05-05 1994-07-15 Asta Medica Ag Salze des azelastins mit verbesserter löslichkeit.

Also Published As

Publication number Publication date
EP0488209B1 (en) 1996-05-22
US5216151A (en) 1993-06-01
ATE138376T1 (de) 1996-06-15
CA2056334A1 (en) 1992-05-29
EP0488209A1 (en) 1992-06-03
JPH04198180A (ja) 1992-07-17
CA2056334C (en) 1999-06-01
DE69119714T2 (de) 1996-10-31
DE69119714D1 (de) 1996-06-27

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