EP2922827A4 - Methods of treating a disease or disorder associated with bruton's tyrosine kinase - Google Patents

Methods of treating a disease or disorder associated with bruton's tyrosine kinase

Info

Publication number: EP2922827A4
Authority: EP; European Patent Office
Prior art keywords: bruton; disease; treating; methods; tyrosine kinase
Prior art date: 2012-11-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP13857254.0A

Other languages

German (de)

French (fr)

Other versions

EP2922827A2 (en

Inventor

Tom Daniel

Kenichi Takeshita

Kenneth Foon

Jay Mei

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Celgene Avilomics Research Inc

Original Assignee

Celgene Avilomics Research Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-11-20

Filing date

2013-11-19

Publication date

2016-06-08

2013-11-19 Application filed by Celgene Avilomics Research Inc filed Critical Celgene Avilomics Research Inc

2015-09-30 Publication of EP2922827A2 publication Critical patent/EP2922827A2/en

2016-06-08 Publication of EP2922827A4 publication Critical patent/EP2922827A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Oncology (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Microbiology (AREA)
Mycology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

EP13857254.0A 2012-11-20 2013-11-19 Methods of treating a disease or disorder associated with bruton's tyrosine kinase Withdrawn EP2922827A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201261728701P	2012-11-20	2012-11-20
US201361870720P	2013-08-27	2013-08-27
PCT/US2013/070772 WO2014081712A2 (en)	2012-11-20	2013-11-19	Methods of treating a disease or disorder associated with bruton's tyrosine kinase

Publications (2)

Publication Number	Publication Date
EP2922827A2 EP2922827A2 (en)	2015-09-30
EP2922827A4 true EP2922827A4 (en)	2016-06-08

Family

ID=50776662

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP13857254.0A Withdrawn EP2922827A4 (en)	2012-11-20	2013-11-19	Methods of treating a disease or disorder associated with bruton's tyrosine kinase

Country Status (3)

Country	Link
EP (1)	EP2922827A4 (en)
TW (1)	TW201427667A (en)
WO (1)	WO2014081712A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY189483A (en)	2010-05-31	2022-02-16	Ono Pharmaceutical Co	Purinone derivative
PL2786996T3 (en)	2011-11-29	2017-01-31	Ono Pharmaceutical Co., Ltd.	Purinone derivative hydrochloride
PE20151274A1 (en)	2013-02-08	2015-09-12	Celgene Avilomics Res Inc	ERK INHIBITORS AND THEIR USES
US9492471B2 (en)	2013-08-27	2016-11-15	Celgene Avilomics Research, Inc.	Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
ES2728350T3 (en) *	2013-11-07	2019-10-23	Hoffmann La Roche	Polytherapy of an antibody to afcosylated CD20 with a BTK inhibitor
ES2806506T3 (en)	2014-03-25	2021-02-17	Ono Pharmaceutical Co	Prophylactic agent and / or therapeutic agent for diffuse large B-cell lymphoma
ES2741785T3 (en)	2014-08-13	2020-02-12	Celgene Car Llc	Forms and compositions of an ERK inhibitor
EP3281943B1 (en)	2015-04-09	2023-06-28	ONO Pharmaceutical Co., Ltd.	Process for producing purinone derivative

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009158571A1 (en) *	2008-06-27	2009-12-30	Avila Therapeutics And Uses Thereof	Heteroaryl compounds and uses thereof
WO2011153514A2 (en) *	2010-06-03	2011-12-08	Pharmacyclics, Inc.	The use of inhibitors of bruton's tyrosine kinase (btk)
WO2013063401A1 (en) *	2011-10-28	2013-05-02	Celgene Avilomics Research, Inc.	Methods of treating a bruton's tyrosine kinase disease or disorder

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000027428A1 (en) *	1998-11-09	2000-05-18	Idec Pharmaceuticals Corporation	Treatment of hematologic malignancies associated with circulating tumor cells using chimeric anti-cd20 antibody
US8338439B2 (en) *	2008-06-27	2012-12-25	Celgene Avilomics Research, Inc.	2,4-disubstituted pyrimidines useful as kinase inhibitors
WO2012021444A1 (en) *	2010-08-10	2012-02-16	Avila Therapeutics, Inc.	Besylate salt of a btk inhibitor
CN102093421B (en) *	2011-01-28	2014-07-02	北京康辰药业有限公司	Phosphorus substituent group-containing quinoline compound and preparation method of quinoline compound as well as pharmaceutical composition containing quinoline compound and application of pharmaceutical composition
WO2012135801A1 (en) *	2011-04-01	2012-10-04	University Of Utah Research Foundation	Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors

2013
- 2013-11-19 EP EP13857254.0A patent/EP2922827A4/en not_active Withdrawn
- 2013-11-19 WO PCT/US2013/070772 patent/WO2014081712A2/en active Application Filing
- 2013-11-19 TW TW102142189A patent/TW201427667A/en unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009158571A1 (en) *	2008-06-27	2009-12-30	Avila Therapeutics And Uses Thereof	Heteroaryl compounds and uses thereof
WO2011153514A2 (en) *	2010-06-03	2011-12-08	Pharmacyclics, Inc.	The use of inhibitors of bruton's tyrosine kinase (btk)
WO2013063401A1 (en) *	2011-10-28	2013-05-02	Celgene Avilomics Research, Inc.	Methods of treating a bruton's tyrosine kinase disease or disorder

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JAN A BURGER ET AL: "The Btk Inhibitor Ibrutinib (PCI-32765) in Combination with Rituximab Is Well Tolerated and Displays Profound Activity in High-Risk Chronic Lymphocytic Leukemia (CLL) Patients", 1 November 2012 (2012-11-01), pages 187, XP002736107, ISSN: 0006-4971, Retrieved from the Internet <URL:https://ash.confex.com/ash/2012/webprogram/Paper47509.html> *
RAJENDRA N DAMLE ET AL: "Changes in immune cell populations in relapsed/refractory CLL patients treated with a Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib (PCI-32765), in combination with Bendamustine and Rituximab (BR)", 15 April 2013 (2013-04-15), pages 3531, XP002736105, ISSN: 1538-7445, Retrieved from the Internet <URL:http://cancerres.aacrjournals.org/content/73/8_Supplement/3531.short> DOI: 10.1158/1538-7445.AM2013-3531 *

Also Published As

Publication number	Publication date
WO2014081712A2 (en)	2014-05-30
WO2014081712A3 (en)	2015-07-16
EP2922827A2 (en)	2015-09-30
TW201427667A (en)	2014-07-16

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IL245042A0 (en)	2016-05-31	Treatment using bruton's tyrosine kinase inhibitors and immunotherapy
EP2809673A4 (en)	2015-07-08	Cyclic molecules as bruton's tyrosine kinase inhibitors
EP2858500A4 (en)	2016-04-06	Inhibitors of bruton's tyrosine kinase
EP2922546A4 (en)	2016-06-08	Methods of treating a disease or disorder associated with bruton's tyrosine kinase
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ZA201400012B (en)	2016-01-27	Inhibitors of bruton's tyrosine kinase
ZA201308397B (en)	2014-07-30	Inhibitors of bruton's tyrosine kinase
ZA201400739B (en)	2016-01-27	Inhibitors of bruton's tyrosine kinase
EP2833886A4 (en)	2015-12-30	Substituted quinolines as bruton's tyrosine kinases inhibitors
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Legal Events

Date	Code	Title	Description
2015-08-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2015-09-30	17P	Request for examination filed	Effective date: 20150615
2015-09-30	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2015-09-30	AX	Request for extension of the european patent	Extension state: BA ME
2016-06-08	A4	Supplementary search report drawn up and despatched	Effective date: 20160511
2016-06-22	DAX	Request for extension of the european patent (deleted)
2017-12-13	17Q	First examination report despatched	Effective date: 20171114
2018-08-03	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2018-09-05	18D	Application deemed to be withdrawn	Effective date: 20180327