EP2787944A1

EP2787944A1 - Set comprising wound dressing and wound filler

Info

Publication number: EP2787944A1
Application number: EP12798721.2A
Authority: EP
Inventors: Birgit Riesinger
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-12-09
Filing date: 2012-12-07
Publication date: 2014-10-15
Also published as: WO2013083800A1; US20140350496A1

Abstract

The invention relates to a set of wound care articles, comprising at least one first planar wound care article comprising hydroactive polymers and at least one second wound care article comprising hydroactive polymers, wherein the second and optionally also any additional wound care articles have a lower liquid retention and/or a lower liquid absorption capacity than the first wound care article.

Description

Set of wound dressing and wound filler

The present invention relates to a wound care article set according to the preamble of claim 1.

The prior art, for example from DE 10059439 of the applicant of the present application, discloses wound care articles having a wound-exudate-absorbing body. In this case, the latter has a substantially flat material portion of absorbent material, consisting of an absorbent fleece with superabsorber particles distributed therein. These wound care articles have proven to be extremely effective in practice, as they are able to absorb exudates from great depths, thus significantly improving wound healing, especially in chronic and / or edema-related wounds.

However, these wound care articles are readily suitable only for relatively shallow wounds, but not for deep wounds that have a high potential for exudates at the bottom.

The term "exudate" refers to a wound fluid derived from the blood plasma via the inflammatory processes of wound edema, and as the blood is responsible for the transport of nutrients and other messengers, and thus for the supply of various parts of the body, the exudate is very similar Way of supplying the Wundbettes and the healing processes occurring therein. To cope with this multitude of functions, it contains a wide range of components, resulting in a specific weight that is slightly above that of water. This is also different from the transudate, which is derived from non-inflammatory processes and has a significantly lower specific gravity with a low cell and protein content. In addition to providing nutrients to the fibroblasts and epithelial cells, the exudate coordinates the various processes of wound healing both temporally and spatially

high content of growth factors and cytokines. These are mainly formed by platelets, keratinocytes, macrophages and fibroblasts. They influence the motility, migration and proliferation of the various cells involved in wound healing. Thus, the infiltration of cells into the wound base is promoted as well as the supply of the newly formed granulation tissue by angiogenesis. The wound cleansing is also supported by the exudate. It contains several serine, cysteine and aspartate proteases as well as matrix metalloproteases, which are tightly regulated in their activity and degrade both existing and newly formed collagen in the wound.

Components of the physiological exudate are in particular salts, glucose, cytokines and growth factors, plasma proteins, proteases (in particular matrix metalloproteases), granulocytes and macrophages.

If it does not occur within a few weeks to a significant progression of the wound healing process according to the different stages of wound healing, it is called a chronic wound. However, exudative episodes lasting more than three days are considered to be a complication, suggesting a pathological exudation that may contribute to chronic wound healing. The underlying causes are usually complex and may well be systemic. However, it is surprising because of the previously explained importance of the exudate for the Wound healing does not mean that complications of wound healing are reflected in a significantly altered composition and effect of the exudate.

Among other things, by a shift in concentration of the individual constituents of the exudate, the normally healing-promoting exudate loses its positive effect in chronic wounds. In particular, the content of inflammatory cytokines and proteases is significantly increased in phalloholic exudate. The content of growth factors is reduced. A particularly serious difference arises with regard to the activity of the previously mentioned matrix metalloproteases. In addition to the preparation of the wound bed, they are also involved in the subsequent remodeling of the granulation to the scar tissue. These enzymes are normally formed as an inactive pre-enzyme and are regulated in their activation by appropriate inhibitors (tissue inhibitors of metalloproteases, TIMPs), which at the same time have a positive effect on cell growth. In chronic exudate, the activity of proteases appears to be increased due to disorders in this regulatory system, possibly contributing to a regression of wound healing. The pathological exudate is in terms of the content of its components from the wound progression-promoting balance. This results in various complications that contribute to further deterioration and chronicity of the wound.

The removal of the exudate from a wound edema is thus an essential prerequisite for the wound caused by the edema to hurry.

The object of the present invention is to provide a wound care article that is particularly suitable for the treatment of deep wounds.

This object is achieved with the features of the submitted main claim. Accordingly, a wound care article set comprising at least one first flat wound care article comprising hydroactive polymers is provided. Furthermore, said set has at least one second wound care article comprising hydroactive polymers, wherein the second and optionally also further further wound care articles have a lower fluid retention and / or a lower fluid absorption capacity than the first wound care article.

The term "hydroactive polymers" is to be understood in the following polymers that are capable of binding large amounts of liquid. Preferably, said polymers are superabsorbent substances comprising polyacrylates, modified cellulose and / or alginates.

Fluid holding capacity and fluid retention refers to the ability of an absorbent material to hold, bind, or hold liquids. It is usually expressed in grams of liquid (eg, distilled water or 0.9% saline) per gram of absorber material. Both parameters are a function of the properties of the hydroactive polymer, its contribution to the overall product as well as the material and technical structure of the overall product. Various configurations of these parameters are conceivable:

Liquid uptake (g / g) over a given time window (eg 15 min) Liquid uptake (g / g) over a given time window upon pressurization of the absorber material (eg 0.3 psi)

Liquid retention (g / g) of an absorber material saturated by dipping or by metered addition

Liquid retention (g / g) of an absorber material saturated by dipping or by metered addition under pressure (for example 0.5 psi) Methods for determining the parameters mentioned are described, for example, in US Pat. No. 4,215,692.

This different fluid retention or fluid absorption capacity contributes to the set of wound care articles according to the invention being able to actively acquire fluid, preferably exudates, from the wound base by means of the second and possibly further wound care articles (wound inserts) and then successively to the first wound care article (Wound dressing), which has a relatively higher fluid retention and / or fluid absorption capacity to deliver. In this way, in the wound base of an overhydration of the wound care article, which could have adverse consequences, prevented, and yet effectively liquid, preferably exudates, discharged from the depth.

It is preferably provided that the first flat wound care article is a wound dressing, while the second and optionally further wound care articles is a wound dressing.

Furthermore, it is preferably provided that the wound inserts, ie the second and further wound care articles, can be divided into at least two groups with different fluid retention and / or fluid absorption capacity.

Due to the different fluid retention or fluid absorption capacities, a retention or capacity gradient is achieved which ensures that fluid is effectively transported further into the second and further wound care articles, namely the wound care articles with relatively less fluid retention and / or the liquid absorption capacity to the wound care articles with relatively higher fluid retention and / or fluid uptake capacity. Finally, the liquid is then delivered to the first wound care article (wound dressing), which, as already described above, has, for the first time, the highest liquid retention and / or liquid absorption capacity. Preferably, it is further provided that the first planar wound care article is larger in area than the second and also larger than any other wound care article. In this way, the second and possibly existing further wound care articles will do a particularly good job of performing your wound care task. For example, they may be in the form of domino-like sections (also referred to as "chips" or "pellets"); they can be designed with or without shell. Other possible embodiments take the form of tamponade-like rollers, cylinders, prisms, tetrahedrons or cuboids.

Preferably, it is further provided that the second and possibly also further wound care articles are designed segmentable. In this case, the second wound care article may have the same size or even larger surface area than the first wound care article. Such a second or further wound care article has, for example, printed cut lines or introduced perforations, by means of which the second or further wound care articles, e.g. can be subdivided by a caregiver into smaller segments, which are then used as wound inserts. In this embodiment, the second wound care article and possibly also other wound care articles preferably have no shell.

Preferably, it is further provided that the first planar wound care article has a flat medial section from the absorbent material and a liquid-permeable cover, wherein the material section also has a surface (F1) in plan view of its flat side its non-wetted state is 3% to 75% smaller than the area (F2) of the flattened shell. The space between shell and material section achieved by this design is also referred to as "expansion edge". In this way it is ensured that the material portion can increase in fluid intake in its volume and is not limited by the shell. Particularly preferred is provided that the shell in plan view of its flat side has a circumferential, projecting beyond the seam top and the absorbent body is free of hard, sharp edges and corners.

It can also be provided that the wound care article has a liquid-impermeable back protection ("backsheet") on its side facing away from the wound.

It is furthermore preferably provided that at least one of the two wound care articles, preferably the first wound care article, has a section of a fleece, preferably of an airlaid.

Preferably, it is further provided that said hydroactive polymers in the first and / or the second and possibly also further wound care articles are superabsorbent polymers (SAP).

It is furthermore particularly preferably provided that the superabsorbent polymers in the second and possibly also further wound care articles are at least partially superabsorbent fibers (SAF).

As a rule, superabsorbent fibers have no wicking effect in pure form, ie once taken up liquid is not actively passed along the fibers, but leads to gelation directly at the location of the take-up. However, by depositing such a wound care article (wound insert) with another wound care article, which has a higher fluid retention or fluid absorption capacity, a retention or capacity gradient can be achieved, which ensures that the former wound care article largely delivers the absorbed fluid to the second-mentioned. In this way, even without a wicking effect, a transfer of the liquid from the wound base to ultimately the first flat wound care article (ie the wound dressing) be guaranteed. Preferably said fibers are in the form of a nonwoven, more preferably in admixture with other fibers (polymer fibers or cellulose).

Since superabsorbent fibers or the products containing them generally have a lower retention or capacity than, for example, cellulose nonwovens which are mixed with a granulate of superabsorbent polymers, the combination in which the former act as wound inserts, and the latter with a relative one, is particularly higher retention and / or capacity than wound dressing, particularly preferred. In this context, the extraordinary softness of many superabsorbent fibers comes into play, which allows a low-pain lining of the wound base and due to the gel formation also allows an atraumatic change of the wound inserts.

Particularly preferably, it is further provided that the second and possibly also further wound care articles have an envelope-free material section having absorbent material. This is particularly useful when the hydroactive polymers are formed in the second and possibly further wound care articles in the form of fibers, for example, form of superabsorbent fibers o in the form of carboxymethyl cellulose fibers. Said fibers can be formed, for example, with other types of fibers, as a nonwoven or as a woven or knitted fabric, wherein it can be ensured that they do not leave the composite even when wetted and swollen.

Furthermore, this may be useful if the superabsorbent polymers are firmly immobilized in the second and possibly also further wound care articles, for example in a nonwoven matrix, wherein it is ensured that they can not detach from this matrix even on wetting and swelling.

Particularly preferably, it is further provided that the second and possibly also further wound care articles have a liquid-conducting material. In this way, the Fluid transport from the wound inserts to the wound dressing, which is also supported by the different fluid retention or absorption is improved.

Preferably liquid-conducting fibers, such as mercerized fibers, hydrophobic fibers or so-called micro fibers, such as

Polyester fibers, such as Trevira Finesse, Diolen Soft, Fortrel Microspun, DuPont Micromattique, Primabelle and / or Shingosen,

Polyamide fibers, such as nylon, Timbrelle, Supplex Microfiber, Tactel® Micro and / or Silky Touch,

• acrylic fibers, such as micro supreme and / or

• polyurethane fibers.

Preferably, it is further provided that the first and / or the second and possibly also further wound care articles have at least one agent selected from the group consisting of

• Hemostatic agents, preferably collagen or gelatin

Antimicrobial agents, preferably chitosan, silver or silver ions, copper or copper ions,

· Agents inhibiting matrix metalloproteases (MMP)

• Wound healing agents, such as hyaluronic acid

• Lactic acid, lactic acid bacteria and / or pre- or probiotic materials

Furthermore, a wound care device is provided for the treatment of wounds by means of atmospheric negative pressure in the wound area, comprising:

At least one wound cover element,

• at least one means for generating atmospheric negative pressure, which is optionally attachable to the wound covering element, as well as At least one wound care article set according to one of the preceding claims.

Such wound care devices are - with the exception of the wound care article set according to one of the preceding claims - known for example from the patent applications WO2006048246, WO2006056294, WO2006048240 and DE 10 2011 050 047.2 the applicant of the present application, which is the subject of negative wound pressure therapy , NWPT), which are fully referenced here.

The combination of the vacuum wound care devices disclosed in the aforementioned applications with the wound care article set discussed herein offers a number of advantages. In this way, the acquisition of wound fluids in the wound base is greatly facilitated, and the therapeutic efficiency of the NWPT, which ultimately aims at removing wound fluids accumulated in the wound base, is considerably increased.

Further, an object of the invention is the use of a wound care article set or a wound care device according to any one of the preceding claims for the treatment of deep wounds.

Furthermore, it is optionally provided that at least one wound care article of the set also has an at least partially liquid-permeable cover. The latter surrounds the absorption body, forms a barrier against solid precipitates forms and allows the passage of other leaked substances to an arranged within the shell material portion of absorbent material. The sheath is preferably at least partially closed by a seam The pores or meshes of the shell are preferably 0.05 mm to 1.0 mm, preferably 0.20 mm to 0.50 mm in size. In principle, it may be provided that the average pore size is smaller than the average size of the particles containing hydroactive polymers. Furthermore, it can preferably be provided that the pores or meshes are delimited by the filament or fiber sections, which are approximately arcuate in section through the envelope and point outwards with their arc crests.

The envelope is preferably made of woven or non-woven composite synthetic fibers, such as polypropylene or polyethylene fibers, but also cotton, silk or viscose. The sheath is preferably made of a fabric or nonwoven having at least a surface specific weight of 20 g / m ² .

The sheath may further consist of a silicone material, for example a silicone mesh or a perforated silicone foil, or a siliconized material, preferably a grid or a perforated foil.

Preferably, the shell is made of hydrophobic material, or the shell material is hydrophobic equipped. The hydrophobic properties of the sheath prevent it from sticking to the wound surface and help the wound exudate particles to enter the sheath more quickly.

It can be provided that the shell has at least partially an elastic material, such. Lycra or spandex fibers. This also ensures that the material portion can increase in fluid intake in its volume and is not limited by the shell.

Absorbent bodies of the type mentioned are disclosed, for example, in WO03094813, WO2007051599 and WO0152780 by the assignee of the present invention. The material of the sheath may be structured such that the sheath has a rough inner surface and a smooth outer surface. Preferably, the rough inner surface of the shell is formed by funnel-shaped perforations, each tapering towards the inner surface and terminating in a free opening edge ("protrusion"), this rough inner surface counteracting the displacements of the contents of the shell, so as to provide adhesion with adhesive dots Accordingly, the smooth outer surface of the casing material may be formed by curved sections of material extending between the perforations Such a casing material may be referred to as "three-dimensional" in contrast to a bilaterally planar one and is for example from DE 102006017194 of the Applicant the present application, the disclosure of which is fully referenced here.

Particularly preferably, it is provided that said three-dimensional shell material is laminated to the aforementioned polypropylene nonwoven. Such a design results in improved fluid absorption properties.

It can also be provided that the wound-care article has a liquid-impermeable backsheet on its side facing away from the wound Superabsorbent polymers (SAP) are plastics which are capable of multiplying their own weight - up to 1000 times - in liquids Chemically, this is a copolymer of acrylic acid (propionic acid, C ₃ H ₄ O ₂ ) and sodium acrylate (sodium salt of acrylic acid, NaC ₃ H ₃ 0 ₂ ), wherein the ratio of the two monomers may vary This core crosslinker (CXL) is added to the monomer solution, which connects the long-chain polymer molecules in some places with each other by chemical bridges ("cross-linked") it swells up the polymer particles and tightens this network at the molecular level, so that the water can not escape without help can. The supernatant-absorbing polymers may be present in the wound care article of the invention in the form of a granulate, a powder, a bed, a compact, a foam, in the form of fibers, a fiber knitted, laid or nonwoven fabric and / or a fiber wadding.

Alternatively, the methylacrylic acid-based superabsorbents, polyvinyl alcohol-maleic anhydride copolymers, polysaccharide-maleic anhydride copolymers, maleic acid derivatives, acrylamidopropanesulfonic acid copolymers, starch-acrylonitrile graft polymers, gelatinized starch derivatives, alkyl- or hydroxyalkylcellulose, carboxymethylcellulose, Starch-acrylic acid graft polymers, vinyl acetate-acrylic acid ester copolymers, acrylonitrile or acrylamide copolymers.

Modified cellulose is preferably derivatives of cellulose, preferably sulfoalkylated cellulose and derivatives thereof, preferably cellulose ethylsulfonates, carboxyalkylated cellulose, preferably carboxymethylcellulose, carboxyethylcellulose and / or carboxypropylcellulose, more complex cellulose derivatives, such as sulphoethylcarboxymethylcellulose, carboxymethylhydroxyethylcellulose, hydroxypropylmethylcellulose, and amidated Cellulose derivatives, such as carboxymethylcellulose amide or carboxypropylcellulose amide. Carboxymethylcellulose in particular is in the form of sodium carboxymethylcellulose and is commercially available under the name "Hydrofiber". In hygiene and wound products, the fibers are transformed into a flat matrix. By absorbing fluid from the wound exudate, the fibers are gradually transformed into a gel pad that holds the fluid and does not release it again. The fibers are constructed so that the wound exudate is absorbed only in the vertical direction. This means that, as long as the capacity is sufficient, the exudate does not flow over the edge of the wound. In this way, wound edge maceration can be effectively prevented.

These hydroactive polymers may also be alginates. Alginates are extracted from brown algae and woven into a fibrous web. Chemically are polysaccharides, namely calcium and / or Natrimsalze the alginic acids. Alginates can absorb up to 20 times their own weight of liquid, while the wound exudate is stored in the cavities. The Ca2 + ions contained in the alginate lattice are exchanged with the Na + ions from the exudate until the degree of saturation of Na ions in the alginate is reached. This leads to a swelling of the wound dressing and the conversion of the alginate fiber into a gel body by swelling of the fibers.

Likewise, said hydroactive polymers may also be hydrogel nanoparticles comprising hydroxy-terminated methacrylate monomers such as 2-hydroxyethyl methacrylate (HEMA) and / or 2-hydroxypropyl methacrylate (HPMA), e.g. marketed as Altrazeal act.

It is particularly preferably provided that at least one wound care article of the set further comprises a nonwoven comprising cellulose fibers, which is also referred to below as absorption body.

The absorbent body may preferably comprise a substantially flat absorbent body of absorbent material consisting of an absorbent web having superabsorbent polymers dispersed therein. These may be in the form of a granulate, a powder, a bed, a compact, a foam, in the form of fibers, a Fasergewirkeses, -laid or -fleece and / or a fiber wadding.

In this case, the absorbent body has at least one material which is selected from the group comprising a mat, in particular an airlaid of said yarns or fibers of superabsorbent polymers with incorporated superabsorbent polymers, and / or a loose filling of superabsorbent polymers. Said Airlaid mat may preferably have a substantially flat material portion of absorbent material, the z. B. consists of an absorbent fleece of said fibers with superabsorbent polymers distributed therein. This absorbent body may correspond to the absorbent pad contained in a wound dressing of the Applicant of the present invention, as disclosed, for example, in WO03094813, WO2007051599 and WO0152780 and sold under the trade name "sorbion sachet." The disclosure of said publications be fully attached to the disclosure of this document.

In another embodiment, the absorbent body can also form a core which - possibly flake-like - fibers or yarns of superabsorbent polymers and superabsorbent polymers in granular form, wherein the granules are glued or welded to the fibers or yarns in several heights, and the granules are distributed over more than 50% of the total height of at least a portion of the core, wherein there are mixed areas of granules and fibers. The proportion by weight of the superabsorbent polymers may preferably be in the range between 10 and 25% by weight. Similar constructions are known from conventional incontinence materials and known as sanitary napkins for their cushioning properties. Around said core may be disposed a sheath which is overlapped in areas and which may be e.g. an adhesive seam is covered or part of the same. The absorption body particularly preferably has a fleece, preferably a nonwoven or airlaid, which consists of superabsorbent fibers ("SAF", preferably polyacrylates) or contains these as constituent. The fibers can be mixed, for example, with fluff pulp (cellulose) or with polyester fibers. Alternatively or additionally, a layer structure may be provided.

The absorbent body, in another embodiment, may also include at least one flat layer comprising fibers or yarns of superabsorbent polymers to which superabsorbent polymers in granular form are adhered. This results in a preferred embodiment, a structure of the body, the at least two layers wherein at least one cover layer underlays a layer comprising superabsorbent polymers. Optionally, a second, flanking cover layer may be provided.

There are no mixtures of fibers and superabsorbent polymers in the plane; but only fixed announcements of both materials. The optionally provided multiple layers can be physically compacted together by rolling, pressing, calendering or similar processes in a preferred embodiment.

Particularly preferably, said absorption body has a surface mass of 5 × 10, 5 × 20, 10 × 20, 10 × 10, 10 × 15 or 15 × 15 cm.

The basis weight may be in the range between> 50 and <2000 g / m ² . Basis weights of 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000, 1050, 1 100 are preferred. 1 150, 1200, 1250, 1300, 1350, 1400, 1450, 1500, 1550, 1600, 1650, 1700, 1750, 1800, 1850, 1900, 1950, and / or 2000 each +/- 25 g / m ² provided.

The thickness can be in the range between> 2 and <50 mm. Preferred are thicknesses of 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46 , 48, and / or 50 are each provided +/- 1 mm.

The absorption capacity can be in the range between> 3 and <30 ml of 0.9% common salt / m ² at 0.2 psi pressure. Values of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 are preferred.

15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, and / or 30 ml of 0.9% saline / m ² . Alternatively, the absorption capacity can be in the range between> 2 and <50 g water / g. Values of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 are preferred.

16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, and / or 50 g of water / g The total content of superabsorbent polymers can be in the range between> 5 and <100% w / w. Values of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 are preferred , 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 , 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 , 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99 and / or 100% w / w.

The tensile strength can be in the range between> 5 and <80 N / 5 cm. Values of 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27 are preferred , 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52 , 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77 , 78, 79 and / or 80 N / 5 cm.

The extensibility can be in the range between> 10 and <80%. Values of 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32 are preferred , 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57 , 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79 and / or 80%. When using superabsorbent fibers, the following types have been found to be particularly advantageous in practice:

Type 1 2 3 4 5 6

Composition 1 layer 40% Bicompone Layer structure: 25% polyester; 40%

au: Polyester ntenfaser Thermo- 75% SAF Polyester

Thermogeb Short cut SAF bonded Airlaid short cut fiber; 60 and one with laminated ser; 60%

Airlaid with% SAF Thermoplas Nonwoven SAF laminated ten

nonwoven

Similar preferred parameter ranges apply as mentioned above. The fluid retention can be between> 5 and <100 g / g. Values of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 are preferred. 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99 and / or 100 g / g In practice, the following types have proven to be particularly advantageous:

Moreover, a wound care article of the set or an absorbent body contained therein may have repeating patterns or grains, such as e.g. a checked pattern, a punching pattern or the like. It is further particularly preferred that said absorbent body has, in addition to a layer of superabsorbent polymers, at least one second flanking layer which has fewer or no superabsorbent polymers and extends in terms of area beyond the former. In this way, it is ensured that the layer comprising superabsorbent polymers can gain volume in accordance with the liquid uptake, without the volume increase being recognizable to the outside, since the latter is laminated by the second layer.

In a further preferred embodiment, the wound care article set further comprises a wound spacer grid.

The term "wound distance grid", a lattice or gauzy structure that - often as a so-called "primary dressing" - is applied directly to a wound before, if necessary, a secondary dressing is applied. Wound distance screens are also often called "Wound gazes" are primarily intended to prevent the entire wound dressing from sticking to the wound, for which wound distance lattices are made of or coated with a material that reduces or prevents adhesion to the wound Wunddistanzgitters be designed so that adhesion to the wound is reduced or prevented.

Commercially available examples of wound spacer meshes are e.g. the products "Mepitel" (silicone-coated, elastic polyamide mesh), "Physiotulle", "Urgotül" (network of polyester fibers soaked with hydrocolloid particles and vaseline) and "ADAPTIC" (smooth viscose knit, impregnated with an oil-in-water emulsion).

The aforementioned products are two-dimensional wound spacer meshes, which therefore essentially take the form of a gauze or a mesh. A three-dimensional wound distance grid is known under the name "sorbion plus" and described in particular in the EP2004116 of the present applicant, the contents of which are hereby fully referenced.

Such a three-dimensional wound spacer grid has a liquid-permeable, pliable material section made of a thermoplastic, which has a first, smooth surface, a surface facing away from the smooth surface and a second rough surface. The latter is produced by a multiplicity of three-dimensional perforations, the walls of which protrude from the first, smooth surface and each run out into a free-edge edge projection, giving the second surface a rough grip.

The perforations are made by punching inserted on one side or by deep drawing over a perforated plate. This creates a rough side with overhangs and a more or less smooth side. A wound spacer grid reliably prevents adhesion of the wound care article to the wound and wound edge maceration. Therefore, unlike the foams known from the prior art, the said active element no longer has to be tailored to the shape of the wound, which considerably reduces the workload of the medical staff.

Furthermore, at least one wound care article preferably has a sheath, which in turn has means that are designed and / or selected such that the sheath can be deformed in a targeted manner at least partially by an increase in volume of the absorption body due to fluid absorption. In principle, such a behavior can be achieved with unidirectionally elastic material, that is to say a material which can be stretched in one direction, but not in the direction orthogonal thereto.

Furthermore, it is preferably provided that at least one wind care article comprises a composition containing at least one nutritive, at least one disinfecting or decontaminating and / or at least one protease inhibiting active substance and / or active substance complex for the external supply and / or treatment of wounds of the human or animal body having. The present invention will be explained in more detail by the figures shown and discussed below. It should be noted that the figures have only descriptive character and are not intended to limit the invention in any way.

FIG. 1 shows a wound care article set 10 in a position applied to a depth wound 11, at the wound base 12 of which exudate 13 has accumulated. The set has a first flat wound care article 14 comprising hydroactive polymers and further wound care articles 15, 16 having hydroactive polymers. The further wound care articles 15, 16 have a lower fluid retention and / or a lower fluid absorption capacity than the first wound care article 14 the first flat wound care article is a wound dressing, while the other wound care articles are a wound dressing.

Fig. 1 shows a preferred embodiment in which there are two sets of wound inserts with different fluid retention and / or fluid uptake capacity, with those with relatively less retention and / or capacity as shown in Fig. 1 being placed close to the wound base, as indicated by Figs gray scale wedge on the left in the figure indicated gradient is symbolized. Due to the different fluid retention or fluid intake capacities, a retention or capacity gradient is achieved which ensures that fluid in the second and further wound care articles is effectively transported further, namely from the wound care articles with relatively less fluid retention and / or fluid absorption capacity to the wound care arti kelnm it rel at iv h eher fluid retention and / or fluid absorption capacity. Finally, the liquid is then delivered to the first wound care article (wound dressing), which, as stated above, preferably has the relatively highest liquid retention and / or liquid absorption capacity.

The said wound inserts are also well suited as fillers for wound bags 17 or for the lining of the wound edge 18. The wound dressing 14 shown in FIG. 1 is a product comprising superabsorbent polymers in a cellulose fleece matrix with a spaced polypropylene fleece sleeve. The grammage of the product, sold under the name "sorbion sachet", for example, has been chosen to achieve high capacity and / or retention. Furthermore, the wound dressing has the expansion edge described above.

The wound inserts 15, 16 shown in Fig. 1 also comprise superabsorbent polymers in a cellulosic nonwoven matrix having a spaced polypropylene fleece sheath from a product. Fig. 2 shows a similar wound care set as in Fig. 1, with the difference that the wound inserts 25, 15 are formed without a shell. Fig. 3 shows a similar wound care set as in Fig. 1, with the difference that here wound inserts are provided with superabsorbent fibers. These are for example in tampon form and are formed without a shell. For the prefaces of this embodiment, reference is made to the description. FIG. 4 shows a similar wound care set as FIG. 1, with the difference that different geometries of the wound inserts are shown by way of example, namely cylindrical (41), cup-shaped (42), tetradedron or pyramidal (43) or tamponade-like (44).

5 shows a further embodiment, according to which the wound care set in addition to the first wound care article 54 also has at least one second wound care article 55, which are designed segmentable. In this case, for example, the second wound care article is of the same size or even larger in size than the first wound care article. The second wound care article has printed cut lines 56 by means of which the second wound care article, e.g. can be subdivided by a caregiver into smaller segments, which are then used as wound inserts. In this embodiment, the second wound care article and possibly also other wound care articles preferably have no shell. Alternatively, the second wound care article may also have introduced perforations.

Claims

claims

1. wound care article set comprising at least a first planar

Wound care article having hydroactive polymers, further comprising at least one second wound care article having hydroactive polymers, wherein the second and possibly also any other wound care article has a lower fluid retention and / or a lower fluid absorption capacity than the first

Wound care products.

2. A wound care article set according to one of the preceding claims, wherein the first flat wound care article is a wound dressing, while the second and optionally further wound care articles is a wound dressing.

3. Wound care article set according to one of the preceding claims, wherein the

Wound inserts, ie the second and further wound care articles, in at least two groups with different fluid retention and / or

Fluid absorption capacity are divisible.

4. Wound care article set according to one of the preceding claims, wherein the first

planar wound care article is larger in area than the second and also larger than possibly existing further wound care article.

5. Wound care article set according to one of claims 1 - 4, wherein the second and possibly also further wound care articles are designed segmentable.

6. Wound care article set according to one of the preceding claims, wherein the first

flat wound care articles comprising a flat material section

Absorbent material and a liquid-permeable shell, wherein further the material section has in plan view on its flat side a surface (Fl) which, in its non-wetted state, is 3% to 75% smaller than the surface (F2) of the flattened casing.

7. Wound care article according to one of the preceding claims, characterized in that at least one of the two wound care articles, preferably the first

Wound care article having a portion of a nonwoven, preferably of an airlaid.

8. A wound care article set according to one of the preceding claims, wherein said hydroactive polymers in the first and / or the second and possibly also further wound care articles are superabsorbent polymers (SAP).

9. Wound care article set according to one of the preceding claims, wherein the

superabsorbent polymers in the second and possibly also further

Wound care articles are at least partially superabsorbent fibers (SAF).

10. A wound care article set according to one of the preceding claims, wherein the second and possibly also further wound care articles have an envelope-free material section having absorption material.

11. A wound care article set according to one of the preceding claims, wherein the second and possibly also further wound care articles have a liquid-conducting material.

12. A wound care article set according to one of the preceding claims, wherein the first

and / or the second and possibly also further wound care articles have at least one agent selected from the group consisting of

• Hemostatic agents, preferably collagen or gelatin Antimicrobial agents, preferably chitosan, silver or silver ions, copper or copper ions,

• Agents inhibiting matrix metalloproteinases (MMPs)

• Wound healing agents, such as hyaluronic acid

• Lactic acid, lactic acid bacteria and / or pre- or probiotic materials

13. Wound care device for the treatment of wounds by means of atmospheric negative pressure in the wound area, comprising:

At least one wound cover element,

• at least one means for generating atmospheric negative pressure, which is optionally attachable to the wound covering element, as well as

At least one wound care article set according to one of the preceding claims.

14. Use of a wound care article set or a wound care device

according to any one of the preceding claims for the treatment of deep

Wounds.