EP1881823A4 - Compositions and methods for treatment of eye disorders - Google Patents
Compositions and methods for treatment of eye disordersInfo
- Publication number
- EP1881823A4 EP1881823A4 EP06770607A EP06770607A EP1881823A4 EP 1881823 A4 EP1881823 A4 EP 1881823A4 EP 06770607 A EP06770607 A EP 06770607A EP 06770607 A EP06770607 A EP 06770607A EP 1881823 A4 EP1881823 A4 EP 1881823A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- treatment
- methods
- eye disorders
- disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000030533 eye disease Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- A61B3/101—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the tear film
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EP11181066.9A EP2444079B1 (en) | 2005-05-17 | 2006-05-17 | Compositions and Methods for Treatment of Eye Disorders |
EP16201157.1A EP3195861A1 (en) | 2005-05-17 | 2006-05-17 | Compositions and methods for treatment of dry eye disorders |
SI200631898T SI1881823T1 (en) | 2005-05-17 | 2006-05-17 | Compositions and methods for treatment of eye disorders |
DK11181066.9T DK2444079T3 (en) | 2005-05-17 | 2006-05-17 | Compositions and Methods for the Treatment of Eye Diseases |
PL06770607T PL1881823T3 (en) | 2005-05-17 | 2006-05-17 | Compositions and methods for treatment of eye disorders |
SI200632151A SI2444079T1 (en) | 2005-05-17 | 2006-05-17 | Compositions and Methods for Treatment of Eye Disorders |
CY20151100187T CY1116045T1 (en) | 2005-05-17 | 2015-02-20 | COMPOSITIONS AND METHODS FOR EYE DISORDER TREATMENT |
CY20171100257T CY1118660T1 (en) | 2005-05-17 | 2017-02-24 | COMPOSITIONS AND METHODS FOR EYE DISORDER TREATMENT |
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PCT/US2006/019327 WO2006125119A1 (en) | 2005-05-17 | 2006-05-17 | Compositions and methods for treatment of eye disorders |
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EP11181066.9A Division-Into EP2444079B1 (en) | 2005-05-17 | 2006-05-17 | Compositions and Methods for Treatment of Eye Disorders |
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EP16201157.1A Division EP3195861A1 (en) | 2005-05-17 | 2006-05-17 | Compositions and methods for treatment of dry eye disorders |
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EP11181066.9A Active EP2444079B1 (en) | 2005-05-17 | 2006-05-17 | Compositions and Methods for Treatment of Eye Disorders |
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WO2005044817A1 (en) * | 2003-11-05 | 2005-05-19 | Sunesis Pharmaceuticals, Inc. | Modulators of cellular adhesion |
PT2332909E (en) | 2005-04-13 | 2014-12-17 | Astex Therapeutics Ltd | Hydroxybenzamide derivatives and their use as inhibitors of hsp90 |
PL1881823T3 (en) | 2005-05-17 | 2015-05-29 | Sarcode Bioscience Inc | Compositions and methods for treatment of eye disorders |
US7202209B2 (en) * | 2005-07-13 | 2007-04-10 | Allergan, Inc. | Cyclosporin compositions |
US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
JP5518478B2 (en) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | Pharmaceutical compounds |
WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
EP2073803B1 (en) | 2006-10-12 | 2018-09-19 | Astex Therapeutics Limited | Pharmaceutical combinations |
GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
KR100930467B1 (en) * | 2007-06-07 | 2009-12-08 | 동아제약주식회사 | 3 ', 4', 5-trimethoxy flavone derivative compound for promoting mucus secretion, preparation method thereof and pharmaceutical use |
ES2830024T3 (en) * | 2007-10-19 | 2021-06-02 | Novartis Ag | Compositions and methods for the treatment of macular edema |
EP2265124A4 (en) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | Aerosolized lfa-1 antagonists for use in localized treatment of immune related disorders |
CN105943534A (en) * | 2008-04-15 | 2016-09-21 | 萨可德生物科学公司 | Topical LFA-1 antagonists for use in localized treatment of immune related disorders |
US20090258070A1 (en) * | 2008-04-15 | 2009-10-15 | John Burnier | Topical LFA-1 antagonists for use in localized treatment of immune related disorders |
WO2009139817A2 (en) * | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
WO2009128932A1 (en) * | 2008-04-15 | 2009-10-22 | Sarcode Corporation | Delivery of lfa-1 antagonists to the gastrointestinal system |
EP2285783B1 (en) | 2008-04-29 | 2014-05-21 | Boehringer Ingelheim International GmbH | Indazole compounds as ccr1 receptor antagonists |
EP2297112B1 (en) * | 2008-05-06 | 2013-04-03 | Boehringer Ingelheim International GmbH | Pyrazole compounds as ccr1 antagonists |
LT2915529T (en) | 2008-05-07 | 2018-10-25 | The Regents Of The University Of California | Therapeutic replenishment and enrichment of ocular surface lubrication |
US8506944B2 (en) | 2008-05-07 | 2013-08-13 | The Regents Of The University Of California | Replenishment and enrichment of ocular surface lubrication |
NZ591115A (en) | 2008-09-26 | 2012-10-26 | Boehringer Ingelheim Int | Azaindazole compounds as ccr1 receptor antagonists |
CN102459249A (en) | 2009-05-22 | 2012-05-16 | 埃克塞里艾克西斯公司 | Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases |
AU2010276537B2 (en) | 2009-07-27 | 2015-04-16 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
PT2491028E (en) | 2009-10-21 | 2014-02-04 | Boehringer Ingelheim Int | Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists |
US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
JP5542214B2 (en) | 2009-10-27 | 2014-07-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Heterocyclic compounds as CCR1 receptor antagonists |
CA2782384A1 (en) * | 2009-12-08 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds |
EP2563787B1 (en) | 2010-04-30 | 2014-11-26 | Boehringer Ingelheim International GmbH | Azaindazole amide compounds as ccr1 receptor antagonists |
AU2011272787B2 (en) | 2010-07-02 | 2015-06-18 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
EP2655371B1 (en) | 2010-12-23 | 2015-02-25 | Boehringer Ingelheim International GmbH | Pyrazolopiperidine compounds as ccr1 receptor antagonists |
US10640464B2 (en) | 2011-01-03 | 2020-05-05 | The William M. Yarbrough Foundation | Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases |
US10273205B2 (en) | 2011-01-03 | 2019-04-30 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating isothiocyanate functional surfactants and associated methods for treating biofilms |
US10308599B2 (en) | 2011-01-03 | 2019-06-04 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
US11279674B2 (en) | 2011-01-03 | 2022-03-22 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactant and associated method of use |
US8933119B2 (en) | 2011-01-03 | 2015-01-13 | The William M. Yarbrough Foundation | Method for treating phytophotodermatitis |
US11407713B2 (en) | 2011-01-03 | 2022-08-09 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
US10647668B2 (en) | 2011-01-03 | 2020-05-12 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactant and associated method of use |
US9962361B2 (en) | 2011-01-03 | 2018-05-08 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
US8865765B2 (en) | 2011-01-12 | 2014-10-21 | The William M. Yarbrough Foundation | Method for treating eczema |
US9532969B2 (en) | 2011-02-08 | 2017-01-03 | The William M. Yarbrough Foundation | Method for treating psoriasis |
CA2834164A1 (en) | 2011-05-10 | 2012-11-15 | Gilead Sciences, Inc. | Fused benzoxazinones as ion channel modulators |
TW201837023A (en) | 2011-07-01 | 2018-10-16 | 美商基利科學股份有限公司 | Fused heterocyclic compounds as ion channel modulators |
NO3175985T3 (en) | 2011-07-01 | 2018-04-28 | ||
US20130197059A1 (en) * | 2012-01-27 | 2013-08-01 | Hoffmann-La Roche Inc. | Integrin antagonist conjugates for targeted delivery to cells expressing lfa-1 |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
CN104797574B (en) | 2012-07-25 | 2019-11-22 | 原生质生物科学股份有限公司 | LFA-1 inhibitor and its polymorph |
US10335387B2 (en) | 2012-07-26 | 2019-07-02 | The William M. Yarbrough Foundation | Method for treating infectious diseases with isothiocyanate functional compounds |
US9949943B2 (en) | 2012-07-26 | 2018-04-24 | The William M. Yarbrough Foundation | Method for treating neurodegenerative diseases |
US10434081B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Inhibitors of macrophage migration inhibitory factor |
US10441561B2 (en) | 2012-07-26 | 2019-10-15 | The William M. Yanbrough Foundation | Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer |
WO2014018874A1 (en) | 2012-07-26 | 2014-01-30 | The William M. Yarbrough Foundation | Method for treating skin cancer |
US9839621B2 (en) | 2012-07-26 | 2017-12-12 | The William M. Yarbrough Foundation | Method for treating bladder cancer |
US10080734B2 (en) | 2012-07-26 | 2018-09-25 | The William M. Yarbrough Foundation | Method for treating autism and other neurodevelopmental disorders |
US10434082B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms |
WO2014092958A1 (en) * | 2012-12-10 | 2014-06-19 | Molecular Targeting Technologies, Inc. | Compositions and methods of diagnosing ocular diseases |
BR112015014367B1 (en) * | 2012-12-19 | 2022-11-22 | Novartis Ag | LFA-1-INHIBITOR COMPOSITION, METHOD FOR STABILIZING SAID COMPOSITION, AND USE THEREOF TO TREAT AN EYE DISEASE |
US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
EP3244851B1 (en) | 2015-01-12 | 2024-10-16 | Bausch + Lomb Ireland Limited | Micro-droplet delivery device |
CN107921136A (en) | 2015-07-08 | 2018-04-17 | 艾克瑟罗视觉股份有限公司 | The pharmaceutical composition for containing integrin alpha 4 antagonists for treating ophthalmic inflammatory illness |
CN106995439B (en) * | 2016-01-26 | 2019-09-20 | 镇江圣安医药有限公司 | Deuterium replaces 3- (mesyl)-L-phenylalanine derivative and its pharmaceutical composition, pharmaceutical preparation and purposes |
US10799447B2 (en) | 2016-03-04 | 2020-10-13 | James M. Rynerson | Method of treating an eye disorder by inhibiting or disrupting bacterial biofilm formation |
SG11201901137UA (en) | 2016-08-12 | 2019-03-28 | Silk Technologies Ltd | Silk-derived protein for treating inflammation |
CA3032695C (en) | 2016-08-19 | 2021-11-23 | Akrivista, LLC | Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye |
US9981041B2 (en) * | 2016-08-23 | 2018-05-29 | Ira Jason Salzman | Ophthalmic lubricating spray |
WO2018048789A1 (en) * | 2016-09-07 | 2018-03-15 | Glia, Llc | Treatment of symptoms related to neurodegenerative disorders through pharmacological dermal activation of cranial nerves |
KR102412086B1 (en) | 2017-01-20 | 2022-06-22 | 켄달리온 테라퓨틱스 인코포레이티드 | piezoelectric fluid dispenser |
CN109134533B (en) | 2017-06-27 | 2020-08-11 | 维眸生物科技(上海)有限公司 | Phosphorus-containing compound and preparation and application thereof |
WO2019020580A1 (en) | 2017-07-24 | 2019-01-31 | Interquim, S.A. | Process for preparing and purifying the lfa-1 antagonist lifitegrast |
EP3668474A4 (en) | 2017-08-18 | 2021-05-26 | Akrivista, LLC | Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye |
AU2018336171B2 (en) | 2017-09-22 | 2023-01-05 | Jubilant Epipad LLC | Heterocyclic compounds as PAD inhibitors |
AU2018362046B2 (en) | 2017-11-06 | 2023-04-13 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
WO2019097547A1 (en) | 2017-11-15 | 2019-05-23 | Cipla Limited | An improved process for the preparation of lifitegrast or salts thereof |
WO2019096996A1 (en) | 2017-11-17 | 2019-05-23 | Medichem, S.A. | A process to obtain a tetrahydroisoquinoline derivative |
US11459338B2 (en) | 2017-11-24 | 2022-10-04 | Jubilant Episcribe Llc | Heterocyclic compounds as PRMT5 inhibitors |
WO2019175897A1 (en) | 2018-03-13 | 2019-09-19 | Jubilant Biosys Limited | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
CN111989325A (en) | 2018-04-18 | 2020-11-24 | 星座制药公司 | Modulators of methyl-modified enzymes, compositions and uses thereof |
CA3100977A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US11166910B2 (en) * | 2019-01-25 | 2021-11-09 | Nordiccan A/S | Cannabinoid chewing gum with sugar alcohols |
US12097145B2 (en) | 2019-03-06 | 2024-09-24 | Bausch + Lomb Ireland Limited | Vented multi-dose ocular fluid delivery system |
US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
JP2022530322A (en) | 2019-04-18 | 2022-06-29 | アズーラ オフサルミックス エルティーディー. | Compounds and methods for treating eye disorders |
CN114040783A (en) * | 2019-04-22 | 2022-02-11 | 阿雷格罗眼科有限责任公司 | Compositions and methods useful for treating dry eye |
JP2022541840A (en) * | 2019-07-25 | 2022-09-27 | ノース カロライナ ステート ユニバーシティ | Crosslinking compound and method of using same |
EP4120973A4 (en) | 2020-04-17 | 2024-04-17 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
CN115768384A (en) | 2020-04-17 | 2023-03-07 | 科达隆治疗公司 | Fluid power actuated preservative-free dispensing system |
US11213551B1 (en) | 2021-04-05 | 2022-01-04 | Korb Research, Llc. | Ocular treatment compositions and methods of use thereof |
US11459351B1 (en) | 2021-04-05 | 2022-10-04 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
CN115707698A (en) * | 2021-08-18 | 2023-02-21 | 辽宁何氏医学院 | 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-formamide compound, and preparation method and application thereof |
WO2023201283A2 (en) * | 2022-04-13 | 2023-10-19 | The Regents Of The University Of California | Methods of producing plasma or serum and uses thereof |
WO2024058212A1 (en) * | 2022-09-15 | 2024-03-21 | 日油株式会社 | Solution for contact lenses |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040006236A1 (en) * | 1998-10-13 | 2004-01-08 | Nader Fotouhi | Diaminopropionic acid derivatives |
US20040058968A1 (en) * | 2000-11-28 | 2004-03-25 | Genentech, Inc. | LFA-1 antagonist compounds |
WO2005044817A1 (en) * | 2003-11-05 | 2005-05-19 | Sunesis Pharmaceuticals, Inc. | Modulators of cellular adhesion |
Family Cites Families (117)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US423439A (en) * | 1890-03-18 | Stove-pipe guard and register | ||
US744A (en) * | 1838-05-17 | Mode of cutting off steam in steam-engines | ||
GB138135A (en) * | 1918-08-13 | 1920-02-05 | Hugh William Gabbett Fairfax | Improvements in automatic firearms |
US1680610A (en) * | 1926-09-16 | 1928-08-14 | Mary Y Harmon | Batik-frame support |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US3876444A (en) * | 1970-04-24 | 1975-04-08 | Gen Electric | Method of treating high strength carbon fibers |
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4668506A (en) | 1985-08-16 | 1987-05-26 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
US4713244A (en) | 1985-08-16 | 1987-12-15 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent |
US4931279A (en) * | 1985-08-16 | 1990-06-05 | Bausch & Lomb Incorporated | Sustained release formulation containing an ion-exchange resin |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
US4992445A (en) * | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
GB2209937B (en) * | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
DE3852374T2 (en) | 1987-11-02 | 1995-05-04 | Baylor College Medicine | Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation. |
ES2058351T3 (en) | 1988-01-29 | 1994-11-01 | Sumitomo Pharma | A PROCEDURE FOR PRODUCING A SUSTAINED RELEASE FORMULATION THAT IS SUITABLE FOR HUMAN AND VETERINARY USE. |
DE3802996A1 (en) | 1988-02-02 | 1989-08-10 | Cassella Ag | USE OF 2-OXO-PYRROLIDIN-1-ACETAMIDE FOR DETERMINING GLOMERULAR FILTRATION RATE IN HUMANS |
US5424399A (en) * | 1988-06-28 | 1995-06-13 | The Children's Medical Center Corporation | Human CR3α/β heterodimers |
ATE123810T1 (en) | 1988-08-23 | 1995-06-15 | Dana Farber Cancer Inst Inc | ALPHA SUBUNITY OF THE LFA-1 LEUKOCYTE ADHESION RECEPTOR. |
ES2141076T3 (en) | 1988-09-01 | 2000-03-16 | Bayer Ag | HUMAN RHINOVIRUS RECEPTOR PROTEIN INHIBITING VIRUS INFECTIVITY. |
KR900701846A (en) | 1988-09-28 | 1990-12-04 | 원본미기재 | Intercellular adhesion molecule and its binding ligand |
US5149780A (en) * | 1988-10-03 | 1992-09-22 | The Scripps Research Institute | Peptides and antibodies that inhibit integrin-ligand binding |
CA2050329A1 (en) | 1989-03-09 | 1990-09-10 | Timothy A. Springer | Method of treating viral infections using lfa-1 |
AU5553290A (en) | 1989-04-28 | 1990-11-29 | Baylor College Of Medicine | Dissemination of hiv-1 infected cells |
CH679207A5 (en) | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
WO1991019511A1 (en) | 1990-06-18 | 1991-12-26 | The General Hospital Corporation | CONTROLLING CELLULAR IMMUNE/INFLAMMATORY RESPONSES WITH β2 INTEGRINS |
CA2046830C (en) | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
US5318965A (en) | 1990-08-24 | 1994-06-07 | Abbott Laboratories | Quinobenzoxazine, antineoplastic agents |
CA2090427A1 (en) | 1990-08-27 | 1992-02-28 | Cetus Oncology Corporation | Cd18 peptide medicaments for the treatment of disease |
JP2995860B2 (en) | 1990-11-27 | 1999-12-27 | 味の素株式会社 | New peptide |
US5288854A (en) * | 1990-11-28 | 1994-02-22 | Center For Blood Research, Inc. | Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1 |
CH683149A5 (en) * | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Process for the preparation of microspheres of a biodegradable polymeric material. |
DE69229275T2 (en) * | 1991-10-04 | 1999-12-30 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville | PRODUCTION OF A MEDICINAL PRODUCT FOR TREATING EYE INFLAMMATION BY BLOCKING CELL ADHESION MOLECULES |
GB9211268D0 (en) | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
US5298492A (en) | 1992-08-04 | 1994-03-29 | Schering Corporation | Diamino acid derivatives as antihypertensives |
CA2140933A1 (en) * | 1992-08-21 | 1994-02-22 | Paula M. Jardieu | Method for treating an lfa-1 mediated disorder |
WO1994011400A1 (en) | 1992-11-18 | 1994-05-26 | Helsinki University Licensing Ltd. Oy | Peptides from human icam-2 and from human icam-1 and their analogs for use in therapy and diagnosis |
CZ293425B6 (en) | 1993-01-06 | 2004-04-14 | Kinerton Limited | Polyester containing one or more free carboxylic groups and composition containing such polyester |
US5672659A (en) * | 1993-01-06 | 1997-09-30 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
US5424289A (en) * | 1993-07-30 | 1995-06-13 | Alza Corporation | Solid formulations of therapeutic proteins for gastrointestinal delivery |
US5397791A (en) | 1993-08-09 | 1995-03-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
DE59409322D1 (en) * | 1993-12-03 | 2000-06-08 | Hoffmann La Roche | Acetic acid derivatives as medicines |
US5470953A (en) * | 1993-12-23 | 1995-11-28 | Icos Corporation | Human β2 integrin α subunit |
AU698406B2 (en) | 1994-04-19 | 1998-10-29 | University Of Kansas, The | ICAM-1/LFA-1 short-chain peptides and method of using same |
US5849327A (en) | 1994-07-29 | 1998-12-15 | Advanced Polymer Systems, Inc. | Delivery of drugs to the lower gastrointestinal tract |
US5585359A (en) | 1994-09-29 | 1996-12-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
DK0710657T3 (en) * | 1994-11-02 | 1999-05-25 | Merck Patent Gmbh | Adhesion receptor antagonists |
US5612052A (en) * | 1995-04-13 | 1997-03-18 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
US5747035A (en) | 1995-04-14 | 1998-05-05 | Genentech, Inc. | Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor |
WO1996038471A1 (en) | 1995-05-29 | 1996-12-05 | Pfizer Inc. | Dipeptides which promote release of growth hormone |
US5877224A (en) | 1995-07-28 | 1999-03-02 | Rutgers, The State University Of New Jersey | Polymeric drug formulations |
US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
US5840332A (en) | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
HUP0000732A3 (en) | 1996-04-23 | 2000-11-28 | Ipsen Mfg Ireland Ltd | Acidic polylactic polymers |
HRP970493A2 (en) | 1996-09-23 | 1998-08-31 | Wienman E. Phlips | Oral delayed immediate release medical formulation and method for preparing the same |
CA2217134A1 (en) | 1996-10-09 | 1998-04-09 | Sumitomo Pharmaceuticals Co., Ltd. | Sustained release formulation |
DE69736812T2 (en) * | 1996-11-27 | 2007-08-09 | Bristol-Myers Squibb Pharma Co. | NEW INTEGRIN RECEPTOR ANTAGONISTS |
US5968895A (en) | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
US5893985A (en) * | 1997-03-14 | 1999-04-13 | The Lincoln Electric Company | Plasma arc torch |
AR012443A1 (en) | 1997-04-16 | 2000-10-18 | Uriach & Cia Sa J | NEW CARBOXAMIDS AS INHIBITORS OF THE PLATELET AGGREGATION, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME IN THE MANUFACTURE OF MEDICINES |
US6630492B1 (en) | 1997-08-28 | 2003-10-07 | Novartis Ag | Lymphocyte function antigen-1 antagonists |
EA007852B1 (en) * | 1998-03-27 | 2007-02-27 | Джинентех, Инк. | Compounds for treatment of cd11/cd18 adhesion receptor mediated disorders |
CA2306393C (en) * | 1998-07-14 | 2008-12-23 | Alcon Laboratories, Inc. | Use of 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid for the manufacture of a medicament for treating non-allergic ophthalmic inflammatory disorders and for the prevention of ocular neovascularization |
ATE279914T1 (en) | 1998-11-27 | 2004-11-15 | Kanji Takada | ORALLY APPLICABLE MEDICINAL PRODUCT FOR ADMINISTRATION OF ACTIVE INGREDIENTS IN THE GITRIC INTESTINAL TRACT |
IT1304152B1 (en) | 1998-12-10 | 2001-03-08 | Mediolanum Farmaceutici Srl | COMPOSITIONS INCLUDING A PEPTIDE AND POLYLACTIC-GLYCOLIC ACID FOR THE PREPARATION OF SUBCUTANEOUS IMPLANTS HAVING A PROLONGED |
US6670321B1 (en) * | 1998-12-30 | 2003-12-30 | The Children's Medical Center Corporation | Prevention and treatment for retinal ischemia and edema |
DE69932084T2 (en) * | 1999-01-05 | 2007-06-28 | The Flinders University Of South Australia, Bedford Park | Antibody fragments for the local treatment of eye diseases |
AU2847200A (en) | 1999-01-27 | 2000-08-18 | G.D. Searle & Co. | Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors |
EP1028114A1 (en) * | 1999-02-13 | 2000-08-16 | Aventis Pharma Deutschland GmbH | Novel guanidine derivatives as inhibitors of cell adhesion |
EP1611881A1 (en) * | 1999-03-31 | 2006-01-04 | Janssen Pharmaceutica N.V. | Pregelatinized starch in a controlled release formulation |
US6645525B1 (en) | 1999-06-23 | 2003-11-11 | Sedum Laboratories, Inc. | Ionically formulated biomolecule microcarriers |
PL354120A1 (en) | 1999-08-18 | 2003-12-29 | Societe De Conseils De Recherches Et D'applicationsociete De Conseils De Recherches Et D'applications Scientifiques S.A.S.S Scientifiques S.A.S. | Sustained release formulation of a peptide |
ECSP003707A (en) | 1999-10-13 | 2002-05-23 | Novartis Ag | DIAZEPANES |
EP1223981B1 (en) | 1999-10-22 | 2008-01-16 | Biogen Idec MA Inc. | Use of a cd40:cd154 binding interruptor to treat immunological complications of the eye |
US6605597B1 (en) * | 1999-12-03 | 2003-08-12 | Cv Therapeutics, Inc. | Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives |
US6294522B1 (en) * | 1999-12-03 | 2001-09-25 | Cv Therapeutics, Inc. | N6 heterocyclic 8-modified adenosine derivatives |
PT1237575E (en) * | 1999-12-14 | 2008-11-17 | Genentech Inc | Tnf-alpha antagonist and lfa-1 antagonist for treating rheumatoid arthritis |
US7326425B2 (en) * | 1999-12-31 | 2008-02-05 | Rutgers, The State University | Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release |
US7521061B2 (en) | 1999-12-31 | 2009-04-21 | Rutgers, The State University Of New Jersey | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
AU784226B2 (en) | 1999-12-31 | 2006-02-23 | Rutgers, The State University | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
ATE294188T1 (en) | 2000-01-14 | 2005-05-15 | Richard S Larson | PEPTIDIC INHIBITORS OF LFA-1/ICAM-1 INTERACTION |
US20030064105A1 (en) | 2000-08-25 | 2003-04-03 | Myung-Jin Kim | Lipophilic-coated microparticle containing a protein drug and formulation comprising same |
US6515124B2 (en) | 2000-02-09 | 2003-02-04 | Hoffman-La Roche Inc. | Dehydroamino acids |
JP2003532703A (en) * | 2000-05-05 | 2003-11-05 | ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・(エス.セー.エール.アー.エス) | Novel amino acid derivatives and their use as pharmaceuticals |
GB0011817D0 (en) | 2000-05-16 | 2000-07-05 | Pharmacia & Upjohn Spa | Antagonists of integrin receptors |
JP2004502681A (en) * | 2000-06-29 | 2004-01-29 | アボット・ラボラトリーズ | Arylphenyl heterocyclic sulfide derivatives and their use as anti-inflammatory and immunosuppressive substances that inhibit cell adhesion |
PE20020420A1 (en) | 2000-10-02 | 2002-06-27 | Novartis Ag | DERIVATIVES OF DIAZACICLOALKANODIONA AS ANTAGONISTS OF ANTIGEN ASSOCIATED WITH LYMPHOCYTE-1 FUNCTION (LFA-1) |
GB0025208D0 (en) | 2000-10-13 | 2000-11-29 | Euro Celtique Sa | Delayed release pharmaceutical formulations |
US6653478B2 (en) * | 2000-10-27 | 2003-11-25 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators |
DE10055857A1 (en) | 2000-11-10 | 2002-08-22 | Creative Peptides Sweden Ab Dj | New pharmaceutical depot formulation |
GB0028367D0 (en) * | 2000-11-21 | 2001-01-03 | Celltech Chiroscience Ltd | Chemical compounds |
US20030008848A1 (en) | 2000-12-19 | 2003-01-09 | Fleck Roman Wolfgang | Small molecules useful in the treatment of inflammatory disease |
WO2002058672A2 (en) | 2001-01-26 | 2002-08-01 | Debio Recherche Pharmaceutique S.A. | Microparticles of biodegradable polymer encapsulating a biologically active substance |
DE60216830T2 (en) * | 2001-02-06 | 2007-06-14 | Pfizer Products Inc., Groton | Pharmaceutical compositions for the treatment of disorders of the CNS or other diseases |
US20030068320A1 (en) * | 2001-03-02 | 2003-04-10 | Christine Dingivan | Methods of administering/dosing CD2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders |
AU2002258563A1 (en) | 2001-03-19 | 2002-10-03 | Praecis Pharmaceuticals Incorporated | Pharmaceutical formulations for sustained release |
US6872382B1 (en) * | 2001-05-21 | 2005-03-29 | Alcon, Inc. | Use of selective PDE IV inhibitors to treat dry eye disorders |
AU2002302783B2 (en) | 2001-06-06 | 2006-11-16 | Aventis Pharma Limited | Substituted tetrahydroisoquinolines for use in the treatment of inflammatory diseases |
JP2005519884A (en) | 2001-12-19 | 2005-07-07 | アルザ・コーポレーシヨン | Formulations and dosage forms for improving the oral bioavailability of hydrophilic polymers |
MXPA04008240A (en) | 2002-03-04 | 2004-12-07 | Sod Conseils Rech Applic | Sustained release drug formulations containing a carrier peptide. |
WO2004014365A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Phthalimide derivatives as matrix metalloproteinase inhibitors |
AU2003278727A1 (en) | 2002-09-20 | 2004-04-08 | Alcon, Inc. | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders |
US7785578B2 (en) * | 2002-10-11 | 2010-08-31 | Aciont, Inc. | Non-invasive ocular drug delivery |
CA2531796A1 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
WO2005014534A1 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
WO2005042710A1 (en) | 2003-10-28 | 2005-05-12 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of statin to kill ebv-transformed b cells |
GT200500139A (en) | 2004-06-08 | 2005-07-25 | METHOD FOR THE PREPARATION OF HYDROXAMIC ACIDS | |
PL1881823T3 (en) | 2005-05-17 | 2015-05-29 | Sarcode Bioscience Inc | Compositions and methods for treatment of eye disorders |
US7541420B2 (en) * | 2006-06-30 | 2009-06-02 | Sabic Innovative Plastics Ip B.V. | Method for making molded polycarbonate articles with improved color |
JP4193895B2 (en) | 2006-10-12 | 2008-12-10 | 横河電機株式会社 | Defect inspection equipment |
ES2830024T3 (en) * | 2007-10-19 | 2021-06-02 | Novartis Ag | Compositions and methods for the treatment of macular edema |
WO2009128932A1 (en) * | 2008-04-15 | 2009-10-22 | Sarcode Corporation | Delivery of lfa-1 antagonists to the gastrointestinal system |
WO2009139817A2 (en) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
US20090258070A1 (en) * | 2008-04-15 | 2009-10-15 | John Burnier | Topical LFA-1 antagonists for use in localized treatment of immune related disorders |
US8337942B2 (en) * | 2009-08-28 | 2012-12-25 | Minsek David W | Light induced plating of metals on silicon photovoltaic cells |
US8378105B2 (en) * | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
CN104797574B (en) * | 2012-07-25 | 2019-11-22 | 原生质生物科学股份有限公司 | LFA-1 inhibitor and its polymorph |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040006236A1 (en) * | 1998-10-13 | 2004-01-08 | Nader Fotouhi | Diaminopropionic acid derivatives |
US20050080119A1 (en) * | 1998-10-13 | 2005-04-14 | Nader Fotouhi | Diaminopropionic acid derivatives |
US20040058968A1 (en) * | 2000-11-28 | 2004-03-25 | Genentech, Inc. | LFA-1 antagonist compounds |
WO2005044817A1 (en) * | 2003-11-05 | 2005-05-19 | Sunesis Pharmaceuticals, Inc. | Modulators of cellular adhesion |
Non-Patent Citations (6)
Title |
---|
GADEK T R ET AL: "Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.", SCIENCE (NEW YORK, N.Y.) 8 FEB 2002, vol. 295, no. 5557, 8 February 2002 (2002-02-08), pages 1086 - 1089, XP002522872, ISSN: 1095-9203 * |
GAO JIANPING ET AL: "ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjogrens syndrome-like MRL/lpr mice.", EXPERIMENTAL EYE RESEARCH, vol. 78, no. 4, April 2004 (2004-04-01), pages 823 - 835, XP002522789, ISSN: 0014-4835 * |
KEATING SUSAN M ET AL: "Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.", PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY FEB 2006, vol. 15, no. 2, February 2006 (2006-02-01), pages 290 - 303, XP002522873, ISSN: 0961-8368 * |
See also references of WO2006125119A1 * |
SHIMAOKA M ET AL: "Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other", IMMUNITY, CELL PRESS, US, vol. 19, no. 3, 1 September 2003 (2003-09-01), pages 391 - 402, XP008091510, ISSN: 1074-7613 * |
SUSAN M. KEATING, JIM MARSTERS, MAUREEN BERESINI, CARMEN LADNER, KIM ZIONCHECK, KEVIN CLARK, FRED ARELLANO, SARAH BODARY: "Putting the pieces together: contribution of fluorescence polarization assays to small-molecule lead optimization", PROC. SPIE, vol. 3913, no. 128, 2 July 2003 (2003-07-02), pages 137, XP002522871, Retrieved from the Internet <URL:10.1117/12.382026> [retrieved on 20090407] * |
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