Nothing Special   »   [go: up one dir, main page]

EP1673041B1 - Dispositif de retenue de systeme de deploiement de prothese - Google Patents

Dispositif de retenue de systeme de deploiement de prothese Download PDF

Info

Publication number
EP1673041B1
EP1673041B1 EP04794823A EP04794823A EP1673041B1 EP 1673041 B1 EP1673041 B1 EP 1673041B1 EP 04794823 A EP04794823 A EP 04794823A EP 04794823 A EP04794823 A EP 04794823A EP 1673041 B1 EP1673041 B1 EP 1673041B1
Authority
EP
European Patent Office
Prior art keywords
prosthesis
introducer
retention device
stent
distal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP04794823A
Other languages
German (de)
English (en)
Other versions
EP1673041A2 (fr
Inventor
Erik E. Rasmussen
Jens Vejby Schultz
Bent Ohlenschlaeger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cook Inc
Original Assignee
Cook Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cook Inc filed Critical Cook Inc
Priority to EP10001503.1A priority Critical patent/EP2204141B1/fr
Publication of EP1673041A2 publication Critical patent/EP1673041A2/fr
Application granted granted Critical
Publication of EP1673041B1 publication Critical patent/EP1673041B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/9517—Instruments specially adapted for placement or removal of stents or stent-grafts handle assemblies therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9505—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9505—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
    • A61F2002/9511—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument the retaining means being filaments or wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
    • A61F2002/9665—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod with additional retaining means

Definitions

  • This invention relates to a medical device and, in particular, an introducer for retaining and releasing an expandable, intraluminal prosthesis for the endovascular repair of a diseased or damaged vessel.
  • proximal and proximally are used for a position or direction towards the patient's heart and the terms distal and distally are used for a position or direction away from the patient's heart.
  • United States Patent No. 4,950,227 entitled “Stent Delivery System” proposes the delivery of a stent by mounting the stent to the outside of an inflatable catheter and retaining the ends of the unexpanded stent by fitting a sleeve over either end of the stent. Expansion of the stent is caused by inflation of the catheter between the sleeves so that the ends of the stent are withdrawn from the respective sleeves and the stent released and expanded into position.
  • United States Patent No. 6,206,931 entitled "Graft Prosthesis Materials” discloses graft prosthesis materials and a method for implanting, transplanting replacing and repairing a part of a patient and particularly the manufacture and use of a purified, collagen based matrix structure removed from a submucosa tissue source. These features and other features disclosed in US Patent No. 6,206,931 could be used with the present invention.
  • PCT Patent Publication Number No. WO99/29262 entitled “Endoluminal Aortic Stents” discloses a fenestrated prosthesis for placement where there are intersecting arteries. This feature and other features disclosed in PCT Patent Publication Number No. WO99/29262 could be used with the present invention,
  • PCT Patent Publication Number No. WO03/034948 entitled “Prostheses for Curved Lumens” discloses prostheses with arrangements for bending the prosthesis for placement into curved lumens. This feature and other features disclosed in PCT Patent Publication Number No. WO03/034948 could be used with the present invention,
  • United States Utility Patent Application Serial No. 10/447,406 entitled “Trigger Wire System” discloses release wire systems for the release of stent grafts retained on introducer devices. This feature and other features disclosed in United States Utility Patent Application Serial No. 10/447,406 could be used with the present invention.
  • United States Utility Patent Application Serial No. 10/609,846 entitled “Thoracic Aortic Stent Graft Deployment Device” discloses introducer devices adapted for deployment of stent grafts particularly in the thoracic arch. This feature and other features disclosed in United States Utility Patent Application No. 10/609,846 could be used with the present invention.
  • United States Utility Patent Application Serial No. 10/602,930 entitled “Stent-Graft Fastening” discloses arrangements for fastening stents onto grafts particularly for exposed stents. This feature and other features disclosed in United States Utility Patent Application Serial No. 10/602,930 could be used with the present invention.
  • PCT Patent Publication Number No. WO03/053287 entitled “Stent Graft with Improved Graft Adhesion” discloses arrangements on stent grafts for enhancing the adhesion of such stent grafts into walls of vessels in which they are deployed. This feature and other features disclosed in PCT Patent Publication Number No. WO03/053287 could be used with the present invention.
  • PCT Patent Publication Number No. WO98/53761 entitled “A Prosthesis and a Method and Means of Deploying a Prosthesis”, discloses various embodiments of an introducer for positioning an expandable endovascular prosthesis in a lumen of a patient.
  • Some prosthetic devices may have shorter bare wire stents or bare wire stents that comprise thinner wire. Smaller wire diameter causes the stent to have a lower radial force while in a hollow retention device, and allow more free space for stent struts to move relative to each other. This lower radial force and increased free movement of the stent struts may allow barbs as well as stent eyelets to catch adjacent stent struts and become entangled. It may be desirable to provide a method and apparatus to deploy a graft prosthesis that provides a controlled release of a proximal bare wire stent of the prosthesis that decreases the likelihood of entanglement.
  • a control mechanism such as a trigger wire, may prevent a graft prosthesis having a proximal bare wire stent from being released prematurely from a proximal retention device of an introducer.
  • Many introducers utilize a single connection point to retain the graft prosthesis in the retention device. This single-point connection may allow the bare wire stent of the graft prosthesis to rotate within the retention device, which could cause the struts of a bare wire stent to tangle. It may be desirable to keep the bare wire stent from rotating within the retention device to lessen the likelihood of entanglement.
  • An introducer for an expandable endovascular prosthesis having a self-expanding stent includes a proximal prosthesis positioning mechanism that has a retention device to retain the self-expanding stent and a control member to selectively release the retention device from the prosthesis.
  • the retention device includes an opening to a cavity that may have a width which tapers from the opening inward.
  • the control member may include a plurality of loops coupled to the prosthesis and a trigger wire. The trigger wire may pass through a first aperture of the retention device, through the plurality of loops, and through and a second aperture of the retention device to retain the loops between the trigger wire and the retention device.
  • the cavity of the retention device may have a linear, circular, or a parabolic cross section.
  • the cavity may taper so that the maximum width is at least 5% to 10% greater than the minimum width.
  • the introducer may also include a control arrangement for controlling the length of the prosthesis. Additionally, the introducer may include a rotational control arrangement by which the relative angular orientation of the proximal and distal portions of the prosthesis can be adjusted.
  • An introducer according to the preamble of claim 1 is known from the document WO-A-98/53761 .
  • a method for placing a prosthesis into an internal lumen using an insertion assembly may include inserting the insertion assembly with the prosthesis into the internal lumen and withdrawing a sheath from the insertion assembly to expose the prosthesis.
  • a stent of the prosthesis may be retained in a retention device with a plurality of loops coupled to the prosthesis and a trigger wire that passes through a first aperture of the retention device, through the plurality of loops, and through a second aperture of the retention device to retain the loops between the trigger wire and the retention device.
  • the method may include removing the trigger wire and moving the retention device proximally away from the prosthesis to release the stent.
  • the method may also include replacing the sheath onto the insertion assembly and retracting the insertion assembly. The method does not form, part of the present invention.
  • FIG 1 is a perspective view of selected segments of an introducer of the present invention with a prosthesis partially deployed.
  • FIG 2 is a sectional detail view of a portion of the introducer around the distal end of the prosthesis.
  • FIG 3 is a sectional detail view of a portion of the introducer around the proximal end of the prosthesis.
  • FIG 4 is a sectional view of a proximal retention device of the introducer.
  • FIG 4a is a plan view of the proximal retention device of the introducer.
  • FIG 5 is a sectional view of a portion of the introducer around the haemostatic seal.
  • FIG 6 is a sectional view of a portion of the introducer around the trigger wire release mechanism.
  • FIG 7 is a sectional view of a portion of the introducer around the pin vise clamp and the medical reagent introduction tube.
  • FIG 8 is a segmented sectional view of the introducer of FIG 1 fully loaded and ready for introduction into a patient.
  • FIG 9 is a view similar to FIG 8 showing an initial stage of deployment of the prosthesis.
  • FIG 10 is a view similar to FIG 8 showing release of the prosthesis proximal end during deployment.
  • FIG 11 is a view similar to FIG 8 showing release of the prosthesis distal end during deployment.
  • FIG 12 is a view similar to FIG 8 showing the advancement of the distal attachment mechanism to the proximal attachment mechanism.
  • FIG 13 is a view similar to FIG 8 showing the withdrawal of the introducer.
  • FIG 1 shows a prosthesis 20, and an endovascular deployment system, also known as an introducer, for deploying the prosthesis 20 in a lumen of a patient during a medical procedure.
  • the introducer includes an external manipulation section 1, a distal positioning mechanism or attachment region 2 and a proximal positioning mechanism or attachment region 3.
  • the external manipulation section 1 which is acted upon by a user to manipulate the introducer, remains outside of the patient throughout the procedure.
  • the prosthesis 20 can comprise a tubular graft material, such as Dacron, with self-expanding stents 19 attached thereto as shown in FIGs 2 and 3 .
  • the self-expanding stents 19 cause the prosthesis 20 to expand following its release from the introducer.
  • the prosthesis 20 also includes an exposed self-expanding zigzag stent 21 shown in FIGs 1 and 3 , which is a bare wire stent having barbs 26 that extend from the stent proximal end. When the self-expanding stent 21 is released, the barbs 26 anchor the proximal end of the prosthesis 20 to the surrounding lumen, not shown.
  • FIG 3 shows the proximal attachment region 3 in greater detail.
  • the proximal attachment region 3 includes a retention device 10.
  • the retention device 10 has at its proximal end a long tapered flexible extension 11.
  • the flexible extension 11 has an internal longitudinal aperture 12.
  • the longitudinal aperture 12 facilitates advancement of the tapered flexible extension 11 along a previously inserted insertion wire 13.
  • the longitudinal aperture 12 also provides a channel for the introduction of medical reagents. For example, it may be desirable to supply a contrast agent to allow angiography to be performed during placement and deployment phases of the medical procedure.
  • a thin walled tube 15 generally made of metal is fastened to the extension 11.
  • the thin walled tube 15 is flexible so that the introducer can be advanced within a relatively tortuous vessel, such as a femoral artery.
  • the thin walled tube also allows manipulation longitudinally and rotationally of the proximal attachment region 3.
  • the thin walled tube 15 extends through the introducer to the manipulation section 1, terminating at a connection means 16, as shown in FIG 7 .
  • connection means 16 is adapted to accept a syringe to facilitate the introduction of reagents into the metal tube 15.
  • the metal tube 15 is in fluid communication with the aperture 12 of the flexible extension 11. Therefore, reagents introduced into connection means 16 can flow through the aperture 12 and can emanate from the lateral apertures 14.
  • a tube 41 which can be made of plastic, is coaxial with and radially outside the thin walled tube 15.
  • the tube 41 is "thick walled", which is to say the thickness of the wall of tube 41 is several times that of the thin walled tube 15.
  • the tube 41 is five or more times thicker than the thin walled tube 15.
  • a sheath 30 is coaxial with and radially outside the thick walled tube 41. The thick walled tube 41 and the sheath 30 extend distally to the manipulation region 1, as shown in FIG 5 .
  • FIGS 2 and 3 illustrate distal and proximal retention and release mechanisms of the introducer, respectively.
  • the prosthesis 20 is retained in a compressed condition by the sheath 30.
  • the sheath 30 extends distally to a gripping and haemostatic sealing means 35 of the external manipulation section 1, shown in FIG 5 .
  • FIG 5 shows the haemostatic sealing means 35 of the external manipulation section 1 shown in greater detail.
  • the haemostatic sealing means 35 can include a haemostatic seal 27 a side tube 29.
  • the haemostatic seal 27 can also include a clamping collar 26 that clamps the sheath 30 to the haemostatic seal 27.
  • the haemostatic seal 27 can also include a silicone seal ring 28.
  • the silicone seal ring 28 forms a haemostatic seal around the thick walled tube 41.
  • the side tube 29 facilitates the introduction of medical reagents between the thick walled tube 41 and the sheath 30.
  • the sheath 30 is advanced over the retention device 10 of the proximal attachment region 3 while the prosthesis 20 is held in a compressed state by an external force.
  • the proximal self-expanding zigzag stent 21 is retained in the retention device 10 by suture loops 66 and a proximal trigger wire 22 shown in FIG 3 .
  • FIG 4 shows a detailed cross section of the retention device 10.
  • the retention device 10 includes apertures 62 and 64 to accommodate the proximal trigger wire 22.
  • the retention device 10 includes an opening that extends longitudinally to form the surface of a conical cavity 70, rather than a straight cavity as is the case with some proximal retention devices.
  • the conical cavity 70 decreases in diameter from a maximum diameter A near the distal opening to a minimum diameter B near the proximal end.
  • the conical cavity 70 is shown decreasing as a straight line, but could also decrease as a parabola or some other shape.
  • the maximum diameter A is between about 5% and about 20% greater than the minimum diameter B .
  • the conical shape of the cavity 70 forces the struts of the self-expanding stent 21 closer together, and decreases the amount of free space in the cavity 70. Because the struts of the stent 21 are harder pressed against the walls of the cavity 70, and because there is less free space in the cavity 70, the struts of the stent 21 are less likely to move and tangle.
  • FIG 4A is a plan view of the retention device 10 showing the prosthesis 20 partially deployed, with the self-expanding zigzag stent 21 still retained in a compressed state.
  • the suture loops 66 shown in detail in FIG 4A , are coupled to the body of the prosthesis 20, and hold the self-expanding zigzag stent 21 in the retention device 10 until the trigger wire 22 is removed. While the trigger wire 22 is in place, the suture loops 66 prevent the retention device 10 and the prosthesis 20 from separating. The trigger wire 22 retains the suture loops 66 between itself and an outer surface of the retention device 10.
  • the suture loops 66 are attached to opposing sides of the prosthesis 20, for example separated by 90 to 180 degrees. Since the suture loops 66 do not stretch, they provide opposing torques that prevent the prosthesis 20 from rotating. When the trigger wire 22 is removed, the suture loops 66 are free to move, and the retention device 10 may be released from the self-expanding zigzag stent 21.
  • This configuration differs from introducers that have a single point of attachment securing a bare wire self-expanding zigzag stent in a retention device, which may allow the stent to rotate within the retention device and lead to entanglement of the stent's struts.
  • the proximal trigger wire 22 extends through the annular space between the thick walled tube 41 and the thin walled tube 15 to the manipulation region 1.
  • the proximal trigger wire 22 exits the annular space at a proximal wire release mechanism 24.
  • the self-expanding stent 21 is released by retracting the sheath 30, removing the trigger wire 22, and then sliding the proximal attachment region 3, including the retention device 10, proximally away from the stent 21. Once the retention device 10 has cleared the self-expanding stent 21, the stent 21 will expand.
  • the suture loops 66, the trigger wire 22, and the proximal wire release mechanism 24 form a control member to selectively release the retention device 10 from the prosthesis 20 by holding the self-expanding stent 21 in the retention device 10 until the prosthesis 20 is positioned at a desired site in the lumen.
  • a distal attachment or retention section 40 is coupled to the thick walled tube 41.
  • the distal attachment or retention section 40 may be formed in the thick walled tube 41.
  • the distal attachment section 40 retains a distal end 42 of the prosthesis 20 during the procedure.
  • the distal end 42 of the prosthesis 20 includes a loop 43.
  • a distal trigger wire 44 extends through the loop 43.
  • the distal trigger wire 44 also extends through an aperture 45 in the distal attachment section 40 and into the annular region between the thin walled tube 15 and the thick walled tube 41.
  • FIG 6 shows a proximal portion of the external manipulation section 1.
  • the release wire actuation section has a body 36 that is mounted onto the thick walled plastic tube 41.
  • the thin walled tube 15 passes through the body 36.
  • the distal wire release mechanism 25 is mounted for slidable movement on the body 36.
  • a clamping screw 37 prevents inadvertent early release of the distal end 42 of the prosthesis 20.
  • the proximal wire release mechanism 24 is mounted for slidable movement on the body 36.
  • a clamping screw 37 prevents inadvertent early release of the self-expanding zigzag stent 21 of the prosthesis 20.
  • the distal trigger wire 44 extends through the annular space between the thick walled tube 41 and the thin walled tube 15 to the manipulation region 1.
  • the distal trigger wire 44 exits the annular space at a distal wire release mechanism 25.
  • the distal trigger wire 44 and the distal wire release mechanism 25 form a control member to selectively release the distal retention section 40 from the prosthesis 20 when the prosthesis is positioned at a desired site in the lumen.
  • the positioning of the proximal and distal wire release mechanisms 24 and 25 is such that the proximal wire release mechanism 24 must be moved before the distal wire release mechanism 25 can be moved. Therefore, the distal end 42 of the prosthesis 20 cannot be released until the self-expanding zigzag stent 21 has been released and anchored to the lumen.
  • a haemostatic seal 38 is provided so the release wire 44 can extend out through the body 36 to the release mechanism 25 without unnecessary blood loss during the medical procedure.
  • FIG 7 shows a distal portion of the external manipulation section 1.
  • a pin vise 39 is mounted onto the distal end of the body 36.
  • the pin vise 39 has a screw cap 46.
  • the vise jaws 47 clamp against (engage) the thin walled metal tube 15.
  • the thin walled tube 15 can only move with the body 36, and hence the thin walled tube 15 can only move with the thick walled tube 41 (not shown).
  • the screw cap 46 tightened, the entire assembly, except for the external sleeve 30, can be moved as one.
  • FIGS 8 through 13 show the various stages of the deployment of the prosthesis 20 during the medical procedure.
  • a guide wire 13 is introduced, for example, into the femoral artery and advanced until the tip of the guide wire 13 is beyond the region into which the prosthesis 20 is to be deployed.
  • the introducer assembly is shown fully assembled ready for introduction into a patient.
  • the ends of the prosthesis 20 are retained by the proximal and distal retaining assemblies respectively, while the external sleeve 30 compresses the middle portion of the prosthesis intermediate the ends.
  • the introducer assembly can be inserted through a femoral artery over the guide wire 13 as shown in FIG 8 , and positioned by radiographic techniques (not discussed here).
  • the introducer assembly is in a desired position for deployment of the prosthesis 20.
  • the external sheath 30 is withdrawn to just proximal of the distal attachment section 40. This action releases the middle portion of the prosthesis 20 so that the middle portion can expand radially.
  • the proximal self-expanding stent 21, however, is still retained within the retention device 10.
  • the distal end 42 of the prosthesis 20 is still retained within the external sheath 30.
  • the prosthesis 20 may be lengthened or shortened or rotated or compressed for accurate placement in the desired location within the lumen.
  • X-ray opaque markers may be placed along the prosthesis 20 to assist with placement of the prosthesis.
  • the "proximal" trigger wire 22 has been removed, allowing the retention device 10 to be separated from the self-expanding zigzag stent 21, as explained above.
  • the proximal trigger wire release mechanism 24 and the "proximal" trigger wire 22 can be removed completely.
  • the screw cap 46 of the pin vise 39 has been loosened so that the thin walled tubing 15 can be pushed in a proximal direction to move the proximal attachment means 10 in a proximal direction.
  • the proximal attachment means 10 no longer surrounds the self-expanding stent 21 at the proximal end of the prosthesis 20, the self-expanding stent 21 expands.
  • the hooks or barbs 26 on the self-expanding stent 21 grip into the walls of the lumen to hold the proximal end of the prosthesis 20 in place.
  • the distal end 42 of the prosthesis 20 is still retained by the distal attachment means 40, with the loop 43 retained therein.
  • the external sheath 30 is then withdrawn to distal of the distal attachment section 40 to allow the distal end 42 of the prosthesis 20 to expand.
  • the distal end 42 of the prosthesis 20 may still be moved. Consequently, the prosthesis 20 can still be rotated or lengthened or shortened or otherwise moved for accurate positioning.
  • the prosthesis 20 to be deployed is a bifurcated graft
  • the movement at this stage may ensure that the shorter leg is directed in the direction of the contra-iliac artery.
  • the distal end 42 of the prosthesis 20 has been released by removal of the distal trigger wire 44.
  • the distal trigger wire release mechanism 25 and the distal trigger wire 44 can be removed completely. This removal may be accomplished by passing the distal wire release mechanism 25 over the pin vise 39 and the connection means 16.
  • the loop 43 of the terminal distal self-expanding zigzag stent 19 is hence released, and the prosthesis 20 is now free to expand to the walls of the vessel. At this point, the introducer is ready to be removed.
  • FIG 12 the first stage of removal is shown. First, the distal attachment section 40 is advanced until it is received in the rear of the proximal attachment device 10. The proximal attachment device 10, the tapered flexible extension 11, and the distal attachment device 40 are then removed together, as shown in FIG 12 .
  • the sheath 30 has been advanced to uncover the joint between the proximal attachment device 10 and the distal attachment section 40.
  • the sheath 30 may be removed with the proximal attachment device 10, the tapered flexible extension 11 and the distal attachment device 40. Alternatively, these items could be removed separately, followed by removal of the external sleeve 30.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Claims (9)

  1. Dispositif d'introduction pour une prothèse endovasculaire extensible (20) ayant une portion proximale, une portion distale et un stent auto-extenseur (21), le dispositif d'introduction comprenant :
    un mécanisme de positionnement de prothèse distal (2) comportant une section de retenue de stent distale et un premier organe de commande pour détacher de manière sélective la section de retenue distale de la prothèse ; et
    un mécanisme de positionnement de prothèse proximal (3) comportant un dispositif de retenue de stent (10) pour retenir le stent auto-extenseur (21) et un deuxième organe de commande pour détacher de manière sélective le dispositif de retenue (10) de la prothèse (20) ;
    le dispositif de retenue (10) comportant une ouverture de réception de stent qui s'étend longitudinalement pour former la surface d'une cavité de réception de stent (70), caractérisé en ce que la cavité (70) a une première largeur au niveau de l'ouverture et une deuxième largeur à une distance longitudinale de l'ouverture le long de la surface, la première largeur étant supérieure à la deuxième largeur et étant dimensionnée de manière à recevoir une portion proximale dudit stent (21).
  2. Dispositif d'introduction selon la revendication 1, dans lequel la surface a une section transversale linéaire.
  3. Dispositif d'introduction selon la revendication 1, dans lequel la surface a une section transversale parabolique.
  4. Dispositif d'introduction selon la revendication 1, dans lequel la surface a une section transversale circulaire.
  5. Dispositif d'introduction selon l'une quelconque des revendications précédentes, dans lequel la première largeur est au moins cinq pour cent plus grande que la deuxième largeur.
  6. Dispositif d'introduction selon l'une quelconque des revendications précédentes, dans lequel la première largeur est au moins dix pour cent plus grande que la deuxième largeur.
  7. Dispositif d'introduction selon l'une quelconque des revendications précédentes, comportant un agencement de contrôle pour contrôler la longueur de la prothèse.
  8. Dispositif d'introduction selon l'une quelconque des revendications précédentes, comportant un agencement de contrôle de rotation (39) permettant d'ajuster l'orientation angulaire relative des portions proximale et distale de la prothèse.
  9. Dispositif d'introduction selon l'une quelconque des revendications précédentes, dans lequel le deuxième organe de contrôle comporte une pluralité de boucles (66) couplées à la prothèse et un fil de déclenchement (22) qui passe à travers une première ouverture (62) du dispositif de retenue, à travers la pluralité de boucles (66), et à travers une deuxième ouverture (64) du dispositif de retenue pour retenir les boucles entre le fil de déclenchement et le dispositif de retenue tandis que le stent auto-extenseur (21) est retenu dans le dispositif de retenue (10).
EP04794823A 2003-10-15 2004-10-12 Dispositif de retenue de systeme de deploiement de prothese Expired - Lifetime EP1673041B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10001503.1A EP2204141B1 (fr) 2003-10-15 2004-10-12 Dispositif de retenue de système de déploiement de prothèse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51160803P 2003-10-15 2003-10-15
PCT/US2004/033571 WO2005037142A2 (fr) 2003-10-15 2004-10-12 Dispositif de retenue de systeme de deploiement de prothese

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP10001503.1 Division-Into 2010-02-15

Publications (2)

Publication Number Publication Date
EP1673041A2 EP1673041A2 (fr) 2006-06-28
EP1673041B1 true EP1673041B1 (fr) 2010-04-21

Family

ID=34465251

Family Applications (2)

Application Number Title Priority Date Filing Date
EP04794823A Expired - Lifetime EP1673041B1 (fr) 2003-10-15 2004-10-12 Dispositif de retenue de systeme de deploiement de prothese
EP10001503.1A Expired - Lifetime EP2204141B1 (fr) 2003-10-15 2004-10-12 Dispositif de retenue de système de déploiement de prothèse

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10001503.1A Expired - Lifetime EP2204141B1 (fr) 2003-10-15 2004-10-12 Dispositif de retenue de système de déploiement de prothèse

Country Status (5)

Country Link
US (1) US7666219B2 (fr)
EP (2) EP1673041B1 (fr)
AT (1) ATE464864T1 (fr)
DE (1) DE602004026756D1 (fr)
WO (1) WO2005037142A2 (fr)

Families Citing this family (207)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8016877B2 (en) 1999-11-17 2011-09-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US7749245B2 (en) 2000-01-27 2010-07-06 Medtronic, Inc. Cardiac valve procedure methods and devices
US6692513B2 (en) 2000-06-30 2004-02-17 Viacor, Inc. Intravascular filter with debris entrapment mechanism
US20020022860A1 (en) 2000-08-18 2002-02-21 Borillo Thomas E. Expandable implant devices for filtering blood flow from atrial appendages
US7544206B2 (en) 2001-06-29 2009-06-09 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US8771302B2 (en) 2001-06-29 2014-07-08 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US8623077B2 (en) 2001-06-29 2014-01-07 Medtronic, Inc. Apparatus for replacing a cardiac valve
FR2826863B1 (fr) 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
FR2828091B1 (fr) 2001-07-31 2003-11-21 Seguin Jacques Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
US7097659B2 (en) 2001-09-07 2006-08-29 Medtronic, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US8721713B2 (en) 2002-04-23 2014-05-13 Medtronic, Inc. System for implanting a replacement valve
US9579194B2 (en) 2003-10-06 2017-02-28 Medtronic ATS Medical, Inc. Anchoring structure with concave landing zone
US7186265B2 (en) * 2003-12-10 2007-03-06 Medtronic, Inc. Prosthetic cardiac valves and systems and methods for implanting thereof
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US20120041550A1 (en) 2003-12-23 2012-02-16 Sadra Medical, Inc. Methods and Apparatus for Endovascular Heart Valve Replacement Comprising Tissue Grasping Elements
US7748389B2 (en) 2003-12-23 2010-07-06 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
EP2529696B1 (fr) 2003-12-23 2014-01-29 Sadra Medical, Inc. Valvule cardiaque repositionnable
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US7381219B2 (en) 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US8828078B2 (en) 2003-12-23 2014-09-09 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US7445631B2 (en) * 2003-12-23 2008-11-04 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US11278398B2 (en) 2003-12-23 2022-03-22 Boston Scientific Scimed, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US7824442B2 (en) * 2003-12-23 2010-11-02 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US20050137694A1 (en) * 2003-12-23 2005-06-23 Haug Ulrich R. Methods and apparatus for endovascularly replacing a patient's heart valve
US20050137696A1 (en) * 2003-12-23 2005-06-23 Sadra Medical Apparatus and methods for protecting against embolization during endovascular heart valve replacement
US20050137686A1 (en) * 2003-12-23 2005-06-23 Sadra Medical, A Delaware Corporation Externally expandable heart valve anchor and method
US7329279B2 (en) * 2003-12-23 2008-02-12 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US7824443B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Medical implant delivery and deployment tool
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US20050137687A1 (en) 2003-12-23 2005-06-23 Sadra Medical Heart valve anchor and method
ITTO20040135A1 (it) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa Protesi valvolare cardiaca
WO2005102015A2 (fr) 2004-04-23 2005-11-03 3F Therapeutics, Inc. Valvule prothetique pouvant etre implantee
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
US8562672B2 (en) 2004-11-19 2013-10-22 Medtronic, Inc. Apparatus for treatment of cardiac valves and method of its manufacture
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
ITTO20050074A1 (it) 2005-02-10 2006-08-11 Sorin Biomedica Cardio Srl Protesi valvola cardiaca
US7962208B2 (en) 2005-04-25 2011-06-14 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
US7712606B2 (en) 2005-09-13 2010-05-11 Sadra Medical, Inc. Two-part package for medical implant
EP1945142B1 (fr) 2005-09-26 2013-12-25 Medtronic, Inc. Valve cardiaque prothétique et valvules veineuses
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
AU2012211487B2 (en) * 2005-12-23 2013-04-04 Cook Medical Technologies Llc Introducer for a prosthesis
EP2359777B1 (fr) 2005-12-23 2015-09-02 Cook Medical Technologies LLC Système de déploiement de prothèse
US9078781B2 (en) 2006-01-11 2015-07-14 Medtronic, Inc. Sterile cover for compressible stents used in percutaneous device delivery systems
WO2007097983A2 (fr) 2006-02-14 2007-08-30 Sadra Medical, Inc. Systemes et procedes pour installer un implant medical
US8518098B2 (en) * 2006-02-21 2013-08-27 Cook Medical Technologies Llc Split sheath deployment system
US20080114435A1 (en) * 2006-03-07 2008-05-15 Med Institute, Inc. Flexible delivery system
US8075615B2 (en) 2006-03-28 2011-12-13 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US7740655B2 (en) * 2006-04-06 2010-06-22 Medtronic Vascular, Inc. Reinforced surgical conduit for implantation of a stented valve therein
US7524331B2 (en) * 2006-04-06 2009-04-28 Medtronic Vascular, Inc. Catheter delivered valve having a barrier to provide an enhanced seal
US20070239269A1 (en) * 2006-04-07 2007-10-11 Medtronic Vascular, Inc. Stented Valve Having Dull Struts
US20070244544A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Seal for Enhanced Stented Valve Fixation
US20070244545A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Prosthetic Conduit With Radiopaque Symmetry Indicators
US20070244546A1 (en) * 2006-04-18 2007-10-18 Medtronic Vascular, Inc. Stent Foundation for Placement of a Stented Valve
US9308105B2 (en) * 2006-04-19 2016-04-12 Cook Medical Technologies Llc Delivery device for an endoluminal prosthesis
EP2015706B1 (fr) * 2006-04-27 2016-08-03 Cook Medical Technologies LLC Déploiement d'implants médicaux
US8118853B2 (en) * 2006-06-19 2012-02-21 Cook Medical Technologies Llc Prosthesis delivery and deployment device
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US8348995B2 (en) 2006-09-19 2013-01-08 Medtronic Ventor Technologies, Ltd. Axial-force fixation member for valve
US11304800B2 (en) 2006-09-19 2022-04-19 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
JP2010504820A (ja) * 2006-09-28 2010-02-18 クック・インコーポレイテッド 胸部大動脈瘤を修復するための装置および方法
WO2008047354A2 (fr) 2006-10-16 2008-04-24 Ventor Technologies Ltd. Système d'administration transapicale avec dérivation de débordement ventriculo-artérielle
DE602007008281D1 (de) * 2006-11-30 2010-09-16 Cook William Europ Schubschlauch für Stent-Implantationsvorrichtung
CN101641061B (zh) 2006-12-06 2013-12-18 美顿力科尔瓦有限责任公司 用于环锚固的自膨胀瓣膜的经心尖递送的系统和方法
WO2008100600A1 (fr) 2007-02-16 2008-08-21 Medtronic, Inc. Valvules cardiaques prothétiques de remplacement, et procédés d'implantation
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
FR2915087B1 (fr) 2007-04-20 2021-11-26 Corevalve Inc Implant de traitement d'une valve cardiaque, en particulier d'une valve mitrale, materiel inculant cet implant et materiel de mise en place de cet implant.
US7766953B2 (en) * 2007-05-16 2010-08-03 Med Institute, Inc. Deployment system for an expandable stent
US9149379B2 (en) * 2007-07-16 2015-10-06 Cook Medical Technologies Llc Delivery device
US9119742B2 (en) * 2007-07-16 2015-09-01 Cook Medical Technologies Llc Prosthesis delivery and deployment device
US8092510B2 (en) * 2007-07-25 2012-01-10 Cook Medical Technologies Llc Retention wire for self-expanding stent
US8747458B2 (en) 2007-08-20 2014-06-10 Medtronic Ventor Technologies Ltd. Stent loading tool and method for use thereof
US10856970B2 (en) 2007-10-10 2020-12-08 Medtronic Ventor Technologies Ltd. Prosthetic heart valve for transfemoral delivery
US9848981B2 (en) 2007-10-12 2017-12-26 Mayo Foundation For Medical Education And Research Expandable valve prosthesis with sealing mechanism
US8858608B2 (en) * 2007-12-10 2014-10-14 Cook Medical Technologies Llc Lubrication apparatus for a delivery and deployment device
MX2010008171A (es) 2008-01-24 2010-12-07 Medtronic Inc Endoprotesis para valvulas cardiacas protesicas.
US8157852B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US9393115B2 (en) 2008-01-24 2016-07-19 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
WO2009094197A1 (fr) 2008-01-24 2009-07-30 Medtronic, Inc. Stents pour valvules cardiaques prothétiques
US9149358B2 (en) * 2008-01-24 2015-10-06 Medtronic, Inc. Delivery systems for prosthetic heart valves
US9089422B2 (en) 2008-01-24 2015-07-28 Medtronic, Inc. Markers for prosthetic heart valves
WO2011104269A1 (fr) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent pour le positionnement et l'ancrage d'une prothèse valvulaire dans un site d'implantation dans le cœur d'un patient
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
WO2009108355A1 (fr) 2008-02-28 2009-09-03 Medtronic, Inc. Systèmes de prothèse de valve cardiaque
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
US8430927B2 (en) 2008-04-08 2013-04-30 Medtronic, Inc. Multiple orifice implantable heart valve and methods of implantation
US8312825B2 (en) 2008-04-23 2012-11-20 Medtronic, Inc. Methods and apparatuses for assembly of a pericardial prosthetic heart valve
US8696743B2 (en) 2008-04-23 2014-04-15 Medtronic, Inc. Tissue attachment devices and methods for prosthetic heart valves
ES2386239T3 (es) 2008-05-16 2012-08-14 Sorin Biomedica Cardio S.R.L. Prótesis cardiovalvular atraumática
US20100049293A1 (en) * 2008-06-04 2010-02-25 Zukowski Stanislaw L Controlled deployable medical device and method of making the same
US8876879B2 (en) 2008-06-04 2014-11-04 Cook Medical Technologies Llc Introducer
EP2323595B1 (fr) 2008-06-04 2019-07-31 W.L. Gore & Associates, Inc. Dispositif médical déployable contrôlé
WO2010002931A1 (fr) 2008-07-01 2010-01-07 Endologix, Inc. Système de cathéter
US8998981B2 (en) 2008-09-15 2015-04-07 Medtronic, Inc. Prosthetic heart valve having identifiers for aiding in radiographic positioning
US8721714B2 (en) 2008-09-17 2014-05-13 Medtronic Corevalve Llc Delivery system for deployment of medical devices
EP3238661B1 (fr) 2008-10-10 2019-05-22 Boston Scientific Scimed, Inc. Dispositifs médicaux et systèmes de délivrance destinés à délivrer des dispositifs médicaux
US8137398B2 (en) 2008-10-13 2012-03-20 Medtronic Ventor Technologies Ltd Prosthetic valve having tapered tip when compressed for delivery
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
GB2464977B (en) 2008-10-31 2010-11-03 William Cook Europe As Introducer for deploying a stent graft in a curved lumen and stent graft therefor
US11376114B2 (en) 2008-10-31 2022-07-05 Cook Medical Technologies Llc Introducer for deploying a stent graft in a curved lumen and stent graft therefor
ES2551694T3 (es) 2008-12-23 2015-11-23 Sorin Group Italia S.R.L. Válvula protésica expansible dotada de apéndices de anclaje
JP5602151B2 (ja) * 2008-12-30 2014-10-08 クック メディカル テクノロジーズ エルエルシー 給送器具
EP2628465A1 (fr) 2009-04-27 2013-08-21 Sorin Group Italia S.r.l. Conduit vasculaire prothétique
WO2010126889A1 (fr) 2009-04-27 2010-11-04 Med Institute, Inc. Stent avec des barbelures protégées
US20100292779A1 (en) * 2009-05-15 2010-11-18 Helmut Straubinger Device for compressing a stent and a system as well as a method for loading a stent into a medical delivery system
US8808369B2 (en) 2009-10-05 2014-08-19 Mayo Foundation For Medical Education And Research Minimally invasive aortic valve replacement
GB2474252B (en) 2009-10-07 2012-01-25 Cook Medical Technologies Llc Deployment handle for an introducer
EP2493428B1 (fr) * 2009-10-29 2015-11-25 Cook Medical Technologies LLC Système de pose de stent avec fil de déclenchement en nitinol
WO2011094527A1 (fr) * 2010-01-29 2011-08-04 Cook Medical Technologies Llc Systèmes de pose et de dilatation mécaniquement extensibles
US9226826B2 (en) 2010-02-24 2016-01-05 Medtronic, Inc. Transcatheter valve structure and methods for valve delivery
US8652204B2 (en) 2010-04-01 2014-02-18 Medtronic, Inc. Transcatheter valve with torsion spring fixation and related systems and methods
IT1400327B1 (it) 2010-05-21 2013-05-24 Sorin Biomedica Cardio Srl Dispositivo di supporto per protesi valvolari e corrispondente corredo.
JP2013526388A (ja) 2010-05-25 2013-06-24 イエナバルブ テクノロジー インク 人工心臓弁、及び人工心臓弁とステントを備える経カテーテル搬送体内プロテーゼ
JP5874727B2 (ja) 2010-09-01 2016-03-02 メドトロニック ヴァスキュラー ゴールウェイ 補綴弁支持構造
US9333075B2 (en) 2010-09-10 2016-05-10 Symetis Sa Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device
US9095466B2 (en) 2010-11-16 2015-08-04 W. L. Gore & Associates, Inc. Apposition fiber for use in endoluminal deployment of expandable devices in tortuous anatomies
US9198787B2 (en) 2010-12-31 2015-12-01 Cook Medical Technologies Llc Conformable prosthesis delivery system and method for deployment thereof
EP2486894B1 (fr) 2011-02-14 2021-06-09 Sorin Group Italia S.r.l. Dispositif d'ancrage sans suture pour prothèses valvulaires cardiaques
ES2641902T3 (es) 2011-02-14 2017-11-14 Sorin Group Italia S.R.L. Dispositivo de anclaje sin sutura para prótesis valvulares cardiacas
JP6294669B2 (ja) 2011-03-01 2018-03-14 エンドロジックス、インク カテーテルシステムおよびその使用方法
WO2012127309A1 (fr) 2011-03-21 2012-09-27 Ontorfano Matteo Appareil pour valvule à disques et procédé de traitement du dysfonctionnement de la valvule
US9744033B2 (en) 2011-04-01 2017-08-29 W.L. Gore & Associates, Inc. Elastomeric leaflet for prosthetic heart valves
EP2520251A1 (fr) 2011-05-05 2012-11-07 Symetis SA Procédé et appareil pour compresser des valvules d'endoprothèse
US10117765B2 (en) * 2011-06-14 2018-11-06 W.L. Gore Associates, Inc Apposition fiber for use in endoluminal deployment of expandable implants
EP2535025A1 (fr) 2011-06-17 2012-12-19 Cook Medical Technologies LLC Mécanisme de libération à fil déclencheur
CA2835893C (fr) 2011-07-12 2019-03-19 Boston Scientific Scimed, Inc. Systeme de couplage pour dispositifs medicaux
US10010412B2 (en) * 2011-07-27 2018-07-03 Edwards Lifesciences Corporation Conical crimper
EP2564811B1 (fr) 2011-08-31 2021-03-10 The Cleveland Clinic Foundation Système d'introduction d'un dispositif endoluminal
US9554806B2 (en) 2011-09-16 2017-01-31 W. L. Gore & Associates, Inc. Occlusive devices
US9131926B2 (en) 2011-11-10 2015-09-15 Boston Scientific Scimed, Inc. Direct connect flush system
US9877858B2 (en) 2011-11-14 2018-01-30 W. L. Gore & Associates, Inc. External steerable fiber for use in endoluminal deployment of expandable devices
US9782282B2 (en) 2011-11-14 2017-10-10 W. L. Gore & Associates, Inc. External steerable fiber for use in endoluminal deployment of expandable devices
US8940014B2 (en) 2011-11-15 2015-01-27 Boston Scientific Scimed, Inc. Bond between components of a medical device
US8951243B2 (en) 2011-12-03 2015-02-10 Boston Scientific Scimed, Inc. Medical device handle
US9278018B2 (en) * 2011-12-14 2016-03-08 Cook Medical Technologies Llc Circumferential trigger wire for deploying an endoluminal prosthesis
US9510945B2 (en) 2011-12-20 2016-12-06 Boston Scientific Scimed Inc. Medical device handle
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
EP2842517A1 (fr) 2011-12-29 2015-03-04 Sorin Group Italia S.r.l. Kit pour l'implantation de conduits vasculaires prosthétiques
WO2013112547A1 (fr) 2012-01-25 2013-08-01 Boston Scientific Scimed, Inc. Ensemble de valvule avec un joint bioabsorbant et un implant de valvule remplaçable
US9375308B2 (en) 2012-03-13 2016-06-28 W. L. Gore & Associates, Inc. External steerable fiber for use in endoluminal deployment of expandable devices
US9883941B2 (en) 2012-06-19 2018-02-06 Boston Scientific Scimed, Inc. Replacement heart valve
US9622893B2 (en) 2012-12-20 2017-04-18 Cook Medical Technologies Llc Apparatus and method for improved deployment of endovascular grafts
US9308108B2 (en) 2013-03-13 2016-04-12 Cook Medical Technologies Llc Controlled release and recapture stent-deployment device
US10265202B2 (en) 2013-03-14 2019-04-23 Cook Medical Technologies Llc Prosthesis having an everting pivoting fenestration
JP6561044B2 (ja) 2013-05-03 2019-08-14 メドトロニック，インコーポレイテッド 弁搬送ツール
US11911258B2 (en) 2013-06-26 2024-02-27 W. L. Gore & Associates, Inc. Space filling devices
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
EP3038567B1 (fr) 2013-08-30 2022-09-07 JenaValve Technology, Inc. Cadre radialement repliable pour valvule prothétique et procédé de fabrication dudit cadre
EP3046511B1 (fr) * 2013-09-16 2018-03-28 Symetis SA Procédé et appareil pour comprimer/charger des endoprothèses valvulaires
EP2907485B1 (fr) 2014-02-16 2020-01-08 Cook Medical Technologies LLC Système de pose de prothèse
US9901445B2 (en) 2014-11-21 2018-02-27 Boston Scientific Scimed, Inc. Valve locking mechanism
EP4306080A3 (fr) 2014-12-09 2024-04-10 Cephea Valve Technologies, Inc. Valvules cardiaques de remplacement et procédé de fabrication
US10449043B2 (en) 2015-01-16 2019-10-22 Boston Scientific Scimed, Inc. Displacement based lock and release mechanism
US9861477B2 (en) 2015-01-26 2018-01-09 Boston Scientific Scimed Inc. Prosthetic heart valve square leaflet-leaflet stitch
WO2016126524A1 (fr) 2015-02-03 2016-08-11 Boston Scientific Scimed, Inc. Valve cardiaque prothétique à joint tubulaire
US9788942B2 (en) 2015-02-03 2017-10-17 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US10426617B2 (en) 2015-03-06 2019-10-01 Boston Scientific Scimed, Inc. Low profile valve locking mechanism and commissure assembly
US10285809B2 (en) 2015-03-06 2019-05-14 Boston Scientific Scimed Inc. TAVI anchoring assist device
US10080652B2 (en) 2015-03-13 2018-09-25 Boston Scientific Scimed, Inc. Prosthetic heart valve having an improved tubular seal
EP3270825B1 (fr) 2015-03-20 2020-04-22 JenaValve Technology, Inc. Système de pose de prothèse de valvule cardiaque
CN107530168B (zh) 2015-05-01 2020-06-09 耶拿阀门科技股份有限公司 在心脏瓣膜替换中具有降低的起搏器比例的装置和方法
US10849746B2 (en) 2015-05-14 2020-12-01 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
JP2018515246A (ja) 2015-05-14 2018-06-14 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティドＷ．Ｌ． Ｇｏｒｅ ＆ Ａｓｓｏｃｉａｔｅｓ， Ｉｎｃｏｒｐｏｒａｔｅｄ 心耳の閉塞のためのデバイスおよび方法
EP3294221B1 (fr) 2015-05-14 2024-03-06 Cephea Valve Technologies, Inc. Valvules mitrales de remplacement
EP3139860B1 (fr) 2015-06-30 2024-06-12 Endologix LLC Ensemble de verrouillage pour accoupler un fil-guide à un système de distribution
US10335277B2 (en) 2015-07-02 2019-07-02 Boston Scientific Scimed Inc. Adjustable nosecone
US10195392B2 (en) 2015-07-02 2019-02-05 Boston Scientific Scimed, Inc. Clip-on catheter
US10136991B2 (en) 2015-08-12 2018-11-27 Boston Scientific Scimed Inc. Replacement heart valve implant
US10179041B2 (en) 2015-08-12 2019-01-15 Boston Scientific Scimed Icn. Pinless release mechanism
US10779940B2 (en) 2015-09-03 2020-09-22 Boston Scientific Scimed, Inc. Medical device handle
US10342660B2 (en) 2016-02-02 2019-07-09 Boston Scientific Inc. Tensioned sheathing aids
US10610393B2 (en) 2016-03-24 2020-04-07 Cook Medical Technologies Llc Wire retention and release mechanisms
EP4183371A1 (fr) 2016-05-13 2023-05-24 JenaValve Technology, Inc. Système de pose de prothèse de valvule cardiaque et procédé de pose de prothèse de valvule cardiaque avec gaine d'introduction et système de chargement
US10583005B2 (en) 2016-05-13 2020-03-10 Boston Scientific Scimed, Inc. Medical device handle
US10245136B2 (en) 2016-05-13 2019-04-02 Boston Scientific Scimed Inc. Containment vessel with implant sheathing guide
US10201416B2 (en) 2016-05-16 2019-02-12 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets
WO2017218877A1 (fr) 2016-06-17 2017-12-21 Cephea Valve Technologies, Inc. Dispositifs et systèmes de mise en place de valve cardiaque
EP3570779B1 (fr) 2017-01-23 2023-02-15 Cephea Valve Technologies, Inc. Valves mitrales de remplacement
EP4209196A1 (fr) 2017-01-23 2023-07-12 Cephea Valve Technologies, Inc. Valvules mitrales de remplacement
EP3573579B1 (fr) 2017-01-27 2023-12-20 JenaValve Technology, Inc. Mimétisme de valve cardiaque
US10709541B2 (en) 2017-04-28 2020-07-14 Cook Medical Technologies Llc Systems and methods for adjusting the diameter of an endoluminal prosthesis and an endoluminal prosthesis configured for the same
US10828154B2 (en) 2017-06-08 2020-11-10 Boston Scientific Scimed, Inc. Heart valve implant commissure support structure
EP3661458A1 (fr) 2017-08-01 2020-06-10 Boston Scientific Scimed, Inc. Mécanisme de verrouillage d'implant médical
US10939996B2 (en) 2017-08-16 2021-03-09 Boston Scientific Scimed, Inc. Replacement heart valve commissure assembly
US11173023B2 (en) 2017-10-16 2021-11-16 W. L. Gore & Associates, Inc. Medical devices and anchors therefor
WO2019144069A2 (fr) 2018-01-19 2019-07-25 Boston Scientific Scimed, Inc. Capteurs de déploiement de mode d'inductance de système de valve transcathéter
EP3740170A1 (fr) 2018-01-19 2020-11-25 Boston Scientific Scimed, Inc. Système de pose de dispositif médical à boucle de rétroaction
EP3749252A1 (fr) 2018-02-07 2020-12-16 Boston Scientific Scimed, Inc. Système de pose de dispositif médical avec élément d'alignement
US11439732B2 (en) 2018-02-26 2022-09-13 Boston Scientific Scimed, Inc. Embedded radiopaque marker in adaptive seal
US11229517B2 (en) 2018-05-15 2022-01-25 Boston Scientific Scimed, Inc. Replacement heart valve commissure assembly
CN112437649B (zh) 2018-05-23 2024-10-11 恪心有限责任公司 心脏瓣膜假体
US11241310B2 (en) 2018-06-13 2022-02-08 Boston Scientific Scimed, Inc. Replacement heart valve delivery device
WO2020123486A1 (fr) 2018-12-10 2020-06-18 Boston Scientific Scimed, Inc. Système d'administration de dispositif médical comprenant un élément de résistance
US11439504B2 (en) 2019-05-10 2022-09-13 Boston Scientific Scimed, Inc. Replacement heart valve with improved cusp washout and reduced loading
GB2605559B (en) 2021-01-07 2023-04-05 Cook Medical Technologies Llc Stent graft

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562596A (en) 1984-04-25 1986-01-07 Elliot Kornberg Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair
US4665918A (en) 1986-01-06 1987-05-19 Garza Gilbert A Prosthesis system and method
US4950227A (en) 1988-11-07 1990-08-21 Boston Scientific Corporation Stent delivery system
US5720776A (en) 1991-10-25 1998-02-24 Cook Incorporated Barb and expandable transluminal graft prosthesis for repair of aneurysm
US5387235A (en) 1991-10-25 1995-02-07 Cook Incorporated Expandable transluminal graft prosthesis for repair of aneurysm
US5693084A (en) 1991-10-25 1997-12-02 Cook Incorporated Expandable transluminal graft prosthesis for repair of aneurysm
SK22499A3 (en) 1996-08-23 1999-10-08 Cook Biotech Inc Graft prosthesis, materials and methods
US5830229A (en) * 1997-03-07 1998-11-03 Micro Therapeutics Inc. Hoop stent
AUPO700897A0 (en) 1997-05-26 1997-06-19 William A Cook Australia Pty Ltd A method and means of deploying a graft
AUPP083597A0 (en) 1997-12-10 1998-01-08 William A Cook Australia Pty Ltd Endoluminal aortic stents
US6569193B1 (en) * 1999-07-22 2003-05-27 Advanced Cardiovascular Systems, Inc. Tapered self-expanding stent
AU2001245696B2 (en) * 2000-03-14 2006-06-29 Cook Incorporated Endovascular stent graft
US6585747B1 (en) * 2000-04-14 2003-07-01 Advanced Cardiovascular Systems, Inc. Interdigitating polymeric endcap for enhanced stent retention
US20030074044A1 (en) * 2001-10-16 2003-04-17 Randby John H. Stent delivery system
AUPR847301A0 (en) 2001-10-26 2001-11-15 Cook Incorporated Endoluminal prostheses for curved lumens
AUPR961701A0 (en) 2001-12-19 2002-01-24 Cook Incorporated Improving graft adhesion
WO2003101518A1 (fr) * 2002-05-29 2003-12-11 William A. Cook Australia Pty. Ltd. Systeme de fils de declenchement pour un dispositif de deploiement de prothese
ATE533433T1 (de) 2002-06-26 2011-12-15 Cook Medical Technologies Llc Stent-graft befestigung
EP1779810B1 (fr) 2002-06-28 2011-11-16 Cook Medical Technologies LLC Dispositif de déploiement thoracique
EP1691720B1 (fr) * 2003-10-10 2011-06-08 William Cook Europe ApS Systeme de retenue d'endoprothese

Also Published As

Publication number Publication date
EP1673041A2 (fr) 2006-06-28
WO2005037142A2 (fr) 2005-04-28
EP2204141A1 (fr) 2010-07-07
US20050085890A1 (en) 2005-04-21
ATE464864T1 (de) 2010-05-15
EP2204141B1 (fr) 2013-06-05
US7666219B2 (en) 2010-02-23
DE602004026756D1 (de) 2010-06-02
WO2005037142A3 (fr) 2005-07-21

Similar Documents

Publication Publication Date Title
EP1673041B1 (fr) Dispositif de retenue de systeme de deploiement de prothese
EP1667606B1 (fr) Systeme de deploiement de prothese
AU736368B2 (en) A prosthesis and a method and means of deploying a prosthesis
US8523934B2 (en) Fenestrated intraluminal stent system
EP1517652B1 (fr) Introducteur thoracique
EP1763327B1 (fr) Greffe de stent autodéployable / à ballon
EP1729684B1 (fr) Le dispositif de deploiement de stent

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20060403

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: A61F 2/84 20060101AFI20090925BHEP

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: COOK INCORPORATED

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 602004026756

Country of ref document: DE

Date of ref document: 20100602

Kind code of ref document: P

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20100421

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100801

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100722

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100428

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100823

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

26N No opposition filed

Effective date: 20110124

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101031

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101031

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101031

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101102

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20110630

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

Free format text: REGISTERED BETWEEN 20110804 AND 20110810

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101022

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101012

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100421

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100721

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230602

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20230925

Year of fee payment: 20

Ref country code: GB

Payment date: 20230914

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20230915

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 602004026756

Country of ref document: DE

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20241011