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EP1185622A4 - Methods of making pancreatic islet cells - Google Patents

Methods of making pancreatic islet cells

Info

Publication number
EP1185622A4
EP1185622A4 EP00941645A EP00941645A EP1185622A4 EP 1185622 A4 EP1185622 A4 EP 1185622A4 EP 00941645 A EP00941645 A EP 00941645A EP 00941645 A EP00941645 A EP 00941645A EP 1185622 A4 EP1185622 A4 EP 1185622A4
Authority
EP
European Patent Office
Prior art keywords
methods
islet cells
pancreatic islet
making pancreatic
making
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00941645A
Other languages
German (de)
French (fr)
Other versions
EP1185622A1 (en
Inventor
Susan Bonner-Weir
Monica Taneja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Joslin Diabetes Center Inc
Original Assignee
Joslin Diabetes Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joslin Diabetes Center Inc filed Critical Joslin Diabetes Center Inc
Publication of EP1185622A1 publication Critical patent/EP1185622A1/en
Publication of EP1185622A4 publication Critical patent/EP1185622A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP00941645A 1999-06-23 2000-06-23 Methods of making pancreatic islet cells Withdrawn EP1185622A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14063999P 1999-06-23 1999-06-23
US140639P 1999-06-23
PCT/US2000/017208 WO2000078929A1 (en) 1999-06-23 2000-06-23 Methods of making pancreatic islet cells

Publications (2)

Publication Number Publication Date
EP1185622A1 EP1185622A1 (en) 2002-03-13
EP1185622A4 true EP1185622A4 (en) 2002-09-18

Family

ID=22492159

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00941645A Withdrawn EP1185622A4 (en) 1999-06-23 2000-06-23 Methods of making pancreatic islet cells

Country Status (4)

Country Link
EP (1) EP1185622A4 (en)
AU (1) AU5632600A (en)
CA (1) CA2375509A1 (en)
WO (1) WO2000078929A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610535B1 (en) 2000-02-10 2003-08-26 Es Cell International Pte Ltd. Progenitor cells and methods and uses related thereto
EP1301589A4 (en) * 2000-06-30 2004-06-16 Amcyte Inc Culturing pancreatic stem cells having a specified, intermediate stage of development
FR2814752A1 (en) * 2000-10-02 2002-04-05 Chru Lille METHOD FOR OBTAINING IN VITRO INSULIN-SECRETORY MAMMAL CELLS AND USES THEREOF
GB2399348A (en) 2001-12-07 2004-09-15 Geron Corp Chondrocyte precursors derived from human embryonic stem cells
CA2692325C (en) 2001-12-07 2015-10-20 Geron Corporation Islet cells from human embryonic stem cells
US7101546B2 (en) 2001-12-21 2006-09-05 Amcyte, Inc. In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
AU2003268534A1 (en) 2002-09-06 2004-03-29 Amcyte Inc. Cd56 positive human adult pancreatic endocrine progenitor cells
DE10362002B4 (en) * 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adult pluripotent stem cells
WO2005001073A1 (en) * 2003-06-23 2005-01-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for differentiating stem cells in cells that produce a pancreatic hormone
WO2005046445A2 (en) 2003-11-07 2005-05-26 University Of Connecticut Artificial tissue systems and uses thereof
DE102004017476B4 (en) * 2004-04-08 2009-03-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Process for the preparation of a cell composition containing epithelial cells
WO2005114178A1 (en) * 2004-05-21 2005-12-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Multi-cellular test systems
US9375514B2 (en) 2004-05-21 2016-06-28 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Multicellular tissue and organ culture systems
US8039254B2 (en) 2004-11-22 2011-10-18 Ramot At Tel-Aviv University Ltd. Populations of expanded and re-differentiated adult islet beta cells capable of producing insulin and methods of generating same
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
CN113308433A (en) * 2021-04-27 2021-08-27 立沃生物科技（深圳）有限公司 Method for treating hybrid cells on surface of islet in-vitro culture
CN114196614A (en) * 2021-12-14 2022-03-18 福建省医学科学研究院 Method for promoting transdifferentiation of pAdM3C infected rat pancreatic duct cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040872A1 (en) * 1995-06-07 1996-12-19 Ontogeny, Inc. Bile duct progenitor cells and methods of use
US6326201B1 (en) * 1999-02-10 2001-12-04 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
WO2002029010A2 (en) * 2000-10-02 2002-04-11 Centre Hospitalier Regional Universitaire De Lille Method for obtaining in vitro mammal islet cells and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439521A (en) * 1981-10-21 1984-03-27 Ontario Cancer Institute Method for producing self-reproducing mammalian pancreatic islet-like structures
US5587309A (en) * 1994-04-29 1996-12-24 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating proliferation and differentiation of human fetal pancreatic cells ex vivo
US5681587A (en) * 1995-10-06 1997-10-28 Desmos, Inc. Growth of adult pancreatic islet cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040872A1 (en) * 1995-06-07 1996-12-19 Ontogeny, Inc. Bile duct progenitor cells and methods of use
US6326201B1 (en) * 1999-02-10 2001-12-04 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
WO2002029010A2 (en) * 2000-10-02 2002-04-11 Centre Hospitalier Regional Universitaire De Lille Method for obtaining in vitro mammal islet cells and uses thereof

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BONNER-WEIR SUSAN ET AL: "Partial pancreatectomy as a model of pancreatic regeneration.", PANCREATIC GROWTH AND REGENERATION., 1997, S. Karger AG;S. Karger AG P.O. Box, Allschwilerstrasse 10, CH-4009 Basel, Switzerland; New York, New York, USA, pages 138 - 153, XP001083955, ISBN: 3-8055-6618-2 *
GMYR V ET AL: "EXPANSION OF HUMAN DUCTAL PANCREATIC STEM CELLS OBTAINED FROM MAIN DUCT, PURIFIED ISLET PREPARATION, OR EXOCRINE TISSUE", ACTA DIABETOLOGICA, SPRINGER INTERNATIONAL, BERLIN, DE, vol. 34, no. 2, 1997, pages 107, XP001010264, ISSN: 0940-5429 *
KERR-CONTE J ET AL: "DUCTAL CYST FORMATION IN COLLAGEN-EMBEDDED ADULT HUMAN ISLET PREPARATIONS A MEANS TO THE REPRODUCTION OF NESIDIOBLASTOSIS IN VITRO", DIABETES, NEW YORK, NY, US, vol. 45, no. 8, August 1996 (1996-08-01), pages 1108 - 1114, XP000939167, ISSN: 0012-1797 *
KERR-CONTE J ET AL: "Model for human islet neogenesis in vitro from adult pancreatic preparations.", TRANSPLANTATION PROCEEDINGS, vol. 27, no. 6, 1995, Fifth Congress of the International Pancreas and Islet Transplant Association: Cure of Diabetes by Transplantation;Miami Beach, Florida, USA; June 18-22, 1995, pages 3268, XP002206387, ISSN: 0041-1345 *
KERR-CONTE J ET AL: "Model for islet cell neogenesis from adult human pancreatic ductal epithelium in vitro", EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY AND DIABETES, JOHANN AMBROSIUS BARTH, DE, vol. 105, no. 4, 1997, pages A28 - A29, XP000925803, ISSN: 0947-7349 *
ROSENBERG L: "IN VIVO CELL TRANSFORMATION: NEOGENESIS OF BETA CELLS FROM PANCREATIC DUCTAL CELLS", CELL TRANSPLANTATION, ELSEVIER SCIENCE, US, vol. 4, no. 4, 1995, pages 371 - 383, XP000939136, ISSN: 0963-6897 *
See also references of WO0078929A1 *
WANG R N ET AL: "PANCREATIC DUCT CELLS EXPRESS GASTRIN AND TGF-ALPHA DURING DUCT TO ISLET-CELL DIFFERENTIATION IN DUCT-LIGATED ADULT RATS", DIABETOLOGIA, BERLIN, DE, vol. 39, no. SUPPL 1, 1996, pages A63, XP000925868, ISSN: 0012-186X *
YUAN S ET AL: "TRANSDIFFERENTIATION OF HUMAN ISLETS TO PANCREATIC DUCTAL CELLS IN COLLAGEN MATRIX CULTURE", DIFFERENTIATION, SPRINGER VERLAG, DE, vol. 61, no. 1, 1996, pages 67 - 75, XP000939119, ISSN: 0301-4681 *

Also Published As

Publication number Publication date
EP1185622A1 (en) 2002-03-13
WO2000078929A1 (en) 2000-12-28
CA2375509A1 (en) 2000-12-28
AU5632600A (en) 2001-01-09

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