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EP0937079A4 - Stabilized carbapenem antibiotic compositions and method of making - Google Patents

Stabilized carbapenem antibiotic compositions and method of making

Info

Publication number
EP0937079A4
EP0937079A4 EP97913772A EP97913772A EP0937079A4 EP 0937079 A4 EP0937079 A4 EP 0937079A4 EP 97913772 A EP97913772 A EP 97913772A EP 97913772 A EP97913772 A EP 97913772A EP 0937079 A4 EP0937079 A4 EP 0937079A4
Authority
EP
European Patent Office
Prior art keywords
making
carbapenem antibiotic
antibiotic compositions
stabilized carbapenem
stabilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97913772A
Other languages
German (de)
French (fr)
Other versions
EP0937079A1 (en
Inventor
Orn Almarsson
Michael J Kaufman
John D Stong
John M Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9626211.8A external-priority patent/GB9626211D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0937079A1 publication Critical patent/EP0937079A1/en
Publication of EP0937079A4 publication Critical patent/EP0937079A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP97913772A 1996-10-28 1997-10-24 Stabilized carbapenem antibiotic compositions and method of making Withdrawn EP0937079A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2952096P 1996-10-28 1996-10-28
US29520P 1996-10-28
GB9626211 1996-12-18
GBGB9626211.8A GB9626211D0 (en) 1996-12-18 1996-12-18 Carbapenem antibiotic, compositions and methods thereof
PCT/US1997/019336 WO1998018800A1 (en) 1996-10-28 1997-10-24 Stabilized carbapenem antibiotic compositions and method of making

Publications (2)

Publication Number Publication Date
EP0937079A1 EP0937079A1 (en) 1999-08-25
EP0937079A4 true EP0937079A4 (en) 2001-01-24

Family

ID=26310661

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97913772A Withdrawn EP0937079A4 (en) 1996-10-28 1997-10-24 Stabilized carbapenem antibiotic compositions and method of making

Country Status (5)

Country Link
EP (1) EP0937079A4 (en)
JP (1) JP2000508343A (en)
AU (1) AU725298B2 (en)
CA (1) CA2268820A1 (en)
WO (1) WO1998018800A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1244444B1 (en) * 1999-10-29 2004-12-29 Merck & Co., Inc. Process for formulation of carbapenem antibiotic compositions
US6548492B1 (en) * 1999-10-29 2003-04-15 Merck & Co., Inc. Process for formulation of carbapenem antibiotic compositions
CN101720326B (en) * 2007-06-28 2012-07-18 山东轩竹医药科技有限公司 Novel carbapenem derivatives
WO2009075309A1 (en) 2007-12-12 2009-06-18 Dainippon Sumitomo Pharma Co., Ltd. Preparation composition
US8691803B2 (en) * 2011-01-24 2014-04-08 Savior Lifetec Corporation Process for the preparation of antibiotic compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0280771A1 (en) * 1986-11-24 1988-09-07 Fujisawa Pharmaceutical Co., Ltd. 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives and processes for the preparation thereof
EP0289801A1 (en) * 1987-04-11 1988-11-09 Lederle (Japan) Ltd. (1R,5S,6S)-2-(substituted thio)-6-[(R)-1-hydroxy-ethyl]-1-methyl-carbapenem-3-carboxylic-acid derivatives
WO1993015078A1 (en) * 1992-02-04 1993-08-05 Zeneca Limited Carbapenems containing a carboxy substituted phenyl group, processes for their preparation, intermediates and use as antibiotics
WO1994014811A1 (en) * 1992-12-21 1994-07-07 Chong Kun Dang Corp. 2-(2-substituted pyrrolidin-4-yl)thio-carbapenem derivatives
WO1997045430A1 (en) * 1996-05-28 1997-12-04 Merck & Co., Inc. Carbapenem antibiotic, composition and method of preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0280771A1 (en) * 1986-11-24 1988-09-07 Fujisawa Pharmaceutical Co., Ltd. 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives and processes for the preparation thereof
EP0289801A1 (en) * 1987-04-11 1988-11-09 Lederle (Japan) Ltd. (1R,5S,6S)-2-(substituted thio)-6-[(R)-1-hydroxy-ethyl]-1-methyl-carbapenem-3-carboxylic-acid derivatives
WO1993015078A1 (en) * 1992-02-04 1993-08-05 Zeneca Limited Carbapenems containing a carboxy substituted phenyl group, processes for their preparation, intermediates and use as antibiotics
WO1994014811A1 (en) * 1992-12-21 1994-07-07 Chong Kun Dang Corp. 2-(2-substituted pyrrolidin-4-yl)thio-carbapenem derivatives
WO1997045430A1 (en) * 1996-05-28 1997-12-04 Merck & Co., Inc. Carbapenem antibiotic, composition and method of preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO9818800A1 *
TAKEUCHI,Y. ET AL.: "Stability of 1-beta-Methylcarbpenem Antibiotic, Meropenem (SM-7338) in Aqueous Solution", CHEM.PHARM.BULL., vol. 43, no. 4, 1995, TOKYO, pages 689 - 692, XP000941598 *

Also Published As

Publication number Publication date
CA2268820A1 (en) 1998-05-07
EP0937079A1 (en) 1999-08-25
AU5088198A (en) 1998-05-22
WO1998018800A1 (en) 1998-05-07
AU725298B2 (en) 2000-10-12
JP2000508343A (en) 2000-07-04

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Legal Events

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