EP0510066A4 - 1-azetidyl and 1-hexamethylenimine alkyl or aryl bisphosphonic acids and their use as pharmacological agents - Google Patents

1-azetidyl and 1-hexamethylenimine alkyl or aryl bisphosphonic acids and their use as pharmacological agents

Info

Publication number: EP0510066A4
Authority: EP; European Patent Office
Prior art keywords: hexamethylenimine; azetidyl; aryl; alkyl; pharmacological agents
Prior art date: 1990-01-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19910902492

Other versions

EP0510066A1 (en

Inventor

Raymond D. Youssefyeh

Daniel L. Cheney

Christopher J. Burns

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Rhone Poulenc Rorer International Holdings Inc

Original Assignee

Rhone Poulenc Rorer International Holdings Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-12

Filing date

1991-01-03

Publication date

1992-12-02

1991-01-03 Application filed by Rhone Poulenc Rorer International Holdings Inc filed Critical Rhone Poulenc Rorer International Holdings Inc

1992-10-28 Publication of EP0510066A1 publication Critical patent/EP0510066A1/en

1992-12-02 Publication of EP0510066A4 publication Critical patent/EP0510066A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP19910902492 1990-01-12 1991-01-03 1-azetidyl and 1-hexamethylenimine alkyl or aryl bisphosphonic acids and their use as pharmacological agents Withdrawn EP0510066A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US46442390A	1990-01-12	1990-01-12
US464423		1990-01-12

Publications (2)

Publication Number	Publication Date
EP0510066A1 EP0510066A1 (en)	1992-10-28
EP0510066A4 true EP0510066A4 (en)	1992-12-02

Family

ID=23843893

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19910902492 Withdrawn EP0510066A4 (en)	1990-01-12	1991-01-03	1-azetidyl and 1-hexamethylenimine alkyl or aryl bisphosphonic acids and their use as pharmacological agents

Country Status (5)

Country	Link
EP (1)	EP0510066A4 (en)
JP (1)	JPH05507061A (en)
AU (1)	AU7165791A (en)
CA (1)	CA2073448A1 (en)
WO (1)	WO1991010646A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07507317A (en) *	1992-05-29	1995-08-10	プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド	Thio-substituted nitrogen-containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism
ATE168379T1 (en) *	1992-05-29	1998-08-15	Procter & Gamble Pharma	QUATERNARY NITROGEN CONTAINING PHOSPHONATE COMPOUNDS FOR THE TREATMENT OF ABNORMAL CALCIUM AND PHOSPHATE METABOLISM AND TARGET FORMATION
US5763611A (en) *	1992-05-29	1998-06-09	The Procter & Gamble Company	Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5391743A (en) *	1992-05-29	1995-02-21	Procter & Gamble Pharmaceuticals, Inc.	Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
US5753634A (en) *	1992-05-29	1998-05-19	The Procter & Gamble Company	Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
PL175475B1 (en) *	1992-05-29	1999-01-29	Procter & Gamble Pharma	Novel sulphur containing phosphonate compounds
EP1064000B1 (en) *	1998-03-27	2011-07-06	Oregon Health & Science University	Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders
US6214812B1 (en) *	1998-04-02	2001-04-10	Mbc Research, Inc.	Bisphosphonate conjugates and methods of making and using the same
US6750340B2 (en)	1998-04-02	2004-06-15	Mbc Research, Inc.	Bisphosphonate conjugates and methods of making and using the same
US8586781B2 (en)	1998-04-02	2013-11-19	Mbc Pharma, Inc.	Bone targeted therapeutics and methods of making and using the same
US7598246B2 (en)	1998-04-02	2009-10-06	Mbc Pharma, Inc.	Bisphosphonate conjugates and methods of making and using the same
US6896871B2 (en)	1998-04-02	2005-05-24	Mbc Research, Inc.	Biphosphonate conjugates and methods of making and using the same
EP2739154B1 (en)	2011-08-01	2018-06-27	MBC Pharma, Inc.	Vitamin b6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3428524A1 (en) *	1984-08-02	1986-02-13	Boehringer Mannheim Gmbh, 6800 Mannheim	NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3770787D1 (en) *	1986-11-21	1991-07-18	Ciba Geigy Ag	Aromatisch substituierte azacyclo-alkylalkandiphosphonsaeuren.
EP0317505A1 (en) *	1987-11-13	1989-05-24	Ciba-Geigy Ag	Azacycloalkylalkandiphosphonic acids

1991
- 1991-01-03 WO PCT/US1991/000055 patent/WO1991010646A1/en active Search and Examination
- 1991-01-03 JP JP91502976A patent/JPH05507061A/en active Pending
- 1991-01-03 AU AU71657/91A patent/AU7165791A/en not_active Abandoned
- 1991-01-03 CA CA002073448A patent/CA2073448A1/en not_active Abandoned
- 1991-01-03 EP EP19910902492 patent/EP0510066A4/en not_active Withdrawn

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9110646A1 *

Also Published As

Publication number	Publication date
AU7165791A (en)	1991-08-05
WO1991010646A1 (en)	1991-07-25
EP0510066A1 (en)	1992-10-28
CA2073448A1 (en)	1991-07-13
JPH05507061A (en)	1993-10-14

Publication	Publication Date	Title
IL99987A0 (en)	1992-08-18	Aryl derivatives
SG55090A1 (en)	1998-12-21	3-Arylcarbonyl-1H-indoles useful as therapeutic agents
BR8805241A (en)	1989-05-23	CONFORMED ARTICLE
CY99011I2 (en)	2010-07-28	Pyrazolopyrimidinone antianginal agents
EP0510066A4 (en)	1992-12-02	1-azetidyl and 1-hexamethylenimine alkyl or aryl bisphosphonic acids and their use as pharmacological agents
DE59107135D1 (en)	1996-02-08	Phosphonic acid and thionophosphonic acid derivatives
GB2250564B (en)	1993-04-14	Fishplate
EP0472077A3 (en)	1993-03-31	Phosphonate containing hydroxyethylamin- and norstatin-type pseudopeptides
ZA919058B (en)	1992-07-29	Sulfimidoperoxycarboxylic acids
BR9103475A (en)	1992-05-12	COMPLEX PHOSPHATES
GB9122037D0 (en)	1991-11-27	Improvements in or relating to liners
KR100203615B1 (en)	1999-06-15	3'-alkyl or aryl silicaneoxybenzoxazinorifamycin
GB9024409D0 (en)	1991-01-02	Improvements in or relating to vibratable ring-like structures
GB2240993B (en)	1993-12-15	Improvements relating to the handling of hosiery
GB9005411D0 (en)	1990-05-09	Improvements in or relating to the survey of areas
EP0478527A3 (en)	1992-07-08	Phosphate ester plasticizer
GB9315062D0 (en)	1993-09-01	Surface refelctor
GB9015275D0 (en)	1990-08-29	Improvements in or relating to leak location
ZW9390A1 (en)	1990-10-31	Imidazolyl-alkenoic acids
IE900361L (en)	1990-07-31	Saccharoascorbic acids
IE900338L (en)	1990-07-31	Heteroaryl-1-alkyl-pyrrole-2-carboxylic acids
IE900337L (en)	1990-07-31	Heteroaryl-1-alkyl-pyrrole-2-carboxylic acids
GB9000447D0 (en)	1990-03-07	Phosphate composition
GB2265307B (en)	1995-09-13	Improvements in or relating to baths
IE900848L (en)	1990-09-10	Phosphate elimination

Legal Events

Date	Code	Title	Description
1992-09-11	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1992-10-28	17P	Request for examination filed	Effective date: 19920714
1992-10-28	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1992-12-02	A4	Supplementary search report drawn up and despatched	Effective date: 19921016
1992-12-02	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1993-03-04	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1993-04-21	18W	Application withdrawn	Withdrawal date: 19930212