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EA201170154A1 - Производные пиридинопиридинонов, способ их получения и применение в терапии - Google Patents

Производные пиридинопиридинонов, способ их получения и применение в терапии

Info

Publication number
EA201170154A1
EA201170154A1 EA201170154A EA201170154A EA201170154A1 EA 201170154 A1 EA201170154 A1 EA 201170154A1 EA 201170154 A EA201170154 A EA 201170154A EA 201170154 A EA201170154 A EA 201170154A EA 201170154 A1 EA201170154 A1 EA 201170154A1
Authority
EA
Eurasian Patent Office
Prior art keywords
therapy
derivatives
pyridinopiridinones
reception
application
Prior art date
Application number
EA201170154A
Other languages
English (en)
Other versions
EA019362B1 (ru
Inventor
Патрис Белльверг
Жильбер Лассалль
Гари Маккорт
Валери Мартен
Пьер Сави
Сесиль Волль-Шаллье
Original Assignee
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of EA201170154A1 publication Critical patent/EA201170154A1/ru
Publication of EA019362B1 publication Critical patent/EA019362B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Изобретение относится к производным пиридинопиридинонов общей формулы (I)в которой Rl, R2, R3, R4, R5, R6, R7, V, W, Y, Z, m имеют значения, указанные в описании. Изобретение относится к способу получения соединений и к применению их в терапии.
EA201170154A 2008-07-08 2009-07-06 Производные пиридино-пиридинонов, способ их получения и применение в терапии EA019362B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0803862A FR2933700B1 (fr) 2008-07-08 2008-07-08 Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
PCT/FR2009/051321 WO2010004197A2 (fr) 2008-07-08 2009-07-06 Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
EA201170154A1 true EA201170154A1 (ru) 2011-08-30
EA019362B1 EA019362B1 (ru) 2014-03-31

Family

ID=40219672

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170154A EA019362B1 (ru) 2008-07-08 2009-07-06 Производные пиридино-пиридинонов, способ их получения и применение в терапии

Country Status (32)

Country Link
US (1) US8436011B2 (ru)
EP (1) EP2315767B1 (ru)
JP (1) JP5606434B2 (ru)
KR (1) KR20110031372A (ru)
CN (1) CN102149713B (ru)
AR (1) AR072798A1 (ru)
AU (1) AU2009267827B2 (ru)
BR (1) BRPI0915438A2 (ru)
CA (1) CA2729833A1 (ru)
CL (1) CL2011000048A1 (ru)
CO (1) CO6341476A2 (ru)
CR (1) CR11866A (ru)
DO (1) DOP2011000008A (ru)
EA (1) EA019362B1 (ru)
EC (1) ECSP11010742A (ru)
ES (1) ES2438540T3 (ru)
FR (1) FR2933700B1 (ru)
HK (1) HK1159108A1 (ru)
HN (1) HN2011000076A (ru)
IL (1) IL210514A (ru)
MA (1) MA32544B1 (ru)
MX (1) MX2011000330A (ru)
MY (1) MY149705A (ru)
NI (1) NI201100011A (ru)
NZ (1) NZ590862A (ru)
PE (1) PE20110405A1 (ru)
SV (1) SV2011003800A (ru)
TW (1) TW201004955A (ru)
UA (1) UA102858C2 (ru)
UY (1) UY31971A (ru)
WO (1) WO2010004197A2 (ru)
ZA (1) ZA201100210B (ru)

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FR2952934B1 (fr) * 2009-11-23 2012-06-22 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2954943B1 (fr) * 2010-01-07 2013-03-01 Sanofi Aventis Derives de pyridino-pyridinones arylsulfonamides, leur preparation et leur application en therapeutique
FR2955109B1 (fr) * 2010-01-08 2012-09-07 Sanofi Aventis Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
EP2524915A1 (en) * 2011-05-20 2012-11-21 Sanofi 2-Amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors
ES2635105T3 (es) * 2012-07-17 2017-10-02 Sanofi Uso de inhibidores de VEGFR-3 para tratar carcinoma hepatocelular
UA110688C2 (uk) * 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
JP2018052878A (ja) * 2016-09-29 2018-04-05 第一三共株式会社 ピリジン化合物
EP3709986B1 (en) 2017-11-14 2023-11-01 Merck Sharp & Dohme LLC Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
MX2020004930A (es) 2017-11-14 2020-08-27 Merck Sharp & Dohme Compuestos de biarilo sustituido novedosos como inhibidores de indolamina 2,3-dioxigenasa (ido).
CN111727042A (zh) * 2017-12-06 2020-09-29 仁新医药私人有限公司 微管蛋白抑制剂

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Also Published As

Publication number Publication date
HK1159108A1 (en) 2012-07-27
MX2011000330A (es) 2011-04-05
NI201100011A (es) 2011-08-05
CN102149713B (zh) 2013-12-11
EP2315767A2 (fr) 2011-05-04
CO6341476A2 (es) 2011-11-21
PE20110405A1 (es) 2011-07-04
US8436011B2 (en) 2013-05-07
MY149705A (en) 2013-09-30
CR11866A (es) 2011-03-14
JP2011527320A (ja) 2011-10-27
WO2010004197A2 (fr) 2010-01-14
UA102858C2 (ru) 2013-08-27
IL210514A (en) 2013-11-28
ES2438540T3 (es) 2014-01-17
CL2011000048A1 (es) 2011-07-15
NZ590862A (en) 2012-06-29
WO2010004197A3 (fr) 2010-03-11
SV2011003800A (es) 2011-04-29
FR2933700A1 (fr) 2010-01-15
IL210514A0 (en) 2011-03-31
AU2009267827A1 (en) 2010-01-14
UY31971A (es) 2010-02-26
BRPI0915438A2 (pt) 2015-11-10
JP5606434B2 (ja) 2014-10-15
EP2315767B1 (fr) 2013-09-04
ZA201100210B (en) 2012-03-28
ECSP11010742A (es) 2011-02-28
CA2729833A1 (fr) 2010-01-14
DOP2011000008A (es) 2011-02-15
CN102149713A (zh) 2011-08-10
FR2933700B1 (fr) 2010-07-30
US20110124643A1 (en) 2011-05-26
HN2011000076A (es) 2013-07-22
AU2009267827B2 (en) 2014-01-09
AR072798A1 (es) 2010-09-22
TW201004955A (en) 2010-02-01
KR20110031372A (ko) 2011-03-25
EA019362B1 (ru) 2014-03-31
MA32544B1 (fr) 2011-08-01

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