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EA199800096A1 - METHOD OF OBTAINING INTERMEDIATE PRODUCTS FOR CARBAPENEM SYNTHESIS - Google Patents

METHOD OF OBTAINING INTERMEDIATE PRODUCTS FOR CARBAPENEM SYNTHESIS

Info

Publication number
EA199800096A1
EA199800096A1 EA199800096A EA199800096A EA199800096A1 EA 199800096 A1 EA199800096 A1 EA 199800096A1 EA 199800096 A EA199800096 A EA 199800096A EA 199800096 A EA199800096 A EA 199800096A EA 199800096 A1 EA199800096 A1 EA 199800096A1
Authority
EA
Eurasian Patent Office
Prior art keywords
intermediate products
obtaining intermediate
carbapenem synthesis
carbapenem
synthesis
Prior art date
Application number
EA199800096A
Other languages
Russian (ru)
Inventor
Чунхуа Янг
Нобуйоси Ясуда
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602921.0A external-priority patent/GB9602921D0/en
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA199800096A1 publication Critical patent/EA199800096A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Описан способ синтеза соединения формулы (1) или (2)где R представляет собой водород или метил, а P представляет собой триэтилсилил или триметилсилил. Соединение формулы (3) или (4) реагирует в присутствии основания и по существу инертного растворителя с P-Cl, где P определен выше, с образованием (1) или (2).Международная заявка была опубликована вместе с отчетом о международном поиске.A method of synthesizing a compound of formula (1) or (2) is described, wherein R is hydrogen or methyl, and P is triethylsilyl or trimethylsilyl. The compound of formula (3) or (4) reacts in the presence of a base and a substantially inert solvent with P-Cl, where P is defined above, to form (1) or (2). The international application was published along with an international search report.

EA199800096A 1995-06-28 1996-06-24 METHOD OF OBTAINING INTERMEDIATE PRODUCTS FOR CARBAPENEM SYNTHESIS EA199800096A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58595P 1995-06-28 1995-06-28
GBGB9602921.0A GB9602921D0 (en) 1996-02-13 1996-02-13 Improved process for synthesizing carbapenem intermediates
PCT/US1996/010783 WO1997001564A1 (en) 1995-06-28 1996-06-24 Improved process for synthesizing carbapenem intermediates

Publications (1)

Publication Number Publication Date
EA199800096A1 true EA199800096A1 (en) 1998-08-27

Family

ID=26308678

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800096A EA199800096A1 (en) 1995-06-28 1996-06-24 METHOD OF OBTAINING INTERMEDIATE PRODUCTS FOR CARBAPENEM SYNTHESIS

Country Status (13)

Country Link
EP (1) EP0836607A1 (en)
JP (1) JPH11513979A (en)
KR (1) KR19990028406A (en)
CN (1) CN1193322A (en)
AR (1) AR002507A1 (en)
AU (1) AU696543B2 (en)
BR (1) BR9609338A (en)
CA (1) CA2224439A1 (en)
CZ (1) CZ419097A3 (en)
EA (1) EA199800096A1 (en)
HU (1) HUP9903016A3 (en)
SK (1) SK176597A3 (en)
WO (1) WO1997001564A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2326648T3 (en) 2008-07-30 2012-10-15 Ranbaxy Lab Ltd Process for the preparation of carbapenem compounds
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
JP2675625B2 (en) * 1989-01-12 1997-11-12 鐘淵化学工業株式会社 Method for producing enol silyl ether compound
NZ234411A (en) * 1989-07-18 1991-05-28 Merck & Co Inc Preparation of 2-diazo-3-silyloxy-3-butenoate esters
DE3934100A1 (en) * 1989-10-12 1991-04-18 Bayer Ag METHOD FOR PRODUCING 0-SILYLATED HYDROXYL COMPOUNDS AND THE USE THEREOF FOR PRODUCING ISOCYANATES HAVING ESTER GROUPS

Also Published As

Publication number Publication date
SK176597A3 (en) 1998-07-08
BR9609338A (en) 1999-05-11
AR002507A1 (en) 1998-03-25
CA2224439A1 (en) 1997-01-16
HUP9903016A3 (en) 2000-04-28
WO1997001564A1 (en) 1997-01-16
MX9800041A (en) 1998-08-30
AU696543B2 (en) 1998-09-10
CN1193322A (en) 1998-09-16
CZ419097A3 (en) 1998-07-15
EP0836607A1 (en) 1998-04-22
KR19990028406A (en) 1999-04-15
AU6392196A (en) 1997-01-30
JPH11513979A (en) 1999-11-30
HUP9903016A2 (en) 2000-03-28

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