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DOP2011000061A - Compuestos de pirrol - Google Patents

Compuestos de pirrol

Info

Publication number
DOP2011000061A
DOP2011000061A DO2011000061A DO2011000061A DOP2011000061A DO P2011000061 A DOP2011000061 A DO P2011000061A DO 2011000061 A DO2011000061 A DO 2011000061A DO 2011000061 A DO2011000061 A DO 2011000061A DO P2011000061 A DOP2011000061 A DO P2011000061A
Authority
DO
Dominican Republic
Prior art keywords
halogen
group optionally
optionally substituted
alkyl group
hydrogen atom
Prior art date
Application number
DO2011000061A
Other languages
English (en)
Inventor
Haruyuki Nishida
Yasuyoshi Arikawa
Ikuo Fujimori
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41508823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2011000061(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of DOP2011000061A publication Critical patent/DOP2011000061A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a un compuesto representado por la fórmula: en donde A es grupo piridilo que tiene al menos un sustituyente en donde R1, R2 y R3 son cada uno un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C1_6 opcionalmente sustituido con halógeno o un grupo alcoxi C1_6 opcionalmente sustituido con halógeno, R4 y R6 son cada uno un átomo de hidrógeno, un átomo de halógeno o un grupo alquilo C1_6 opcionalmente sustituido con halógeno, R5 es un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C1_6 opcionalmente sustituido con halógeno o un grupo alcoxi C1_6 opcionalmente sustituido con halógeno y R7 es un átomo de hidrógeno o un grupo alquilo C1_6 opcionalmente sustituido con halógeno o una de sus sales o una composición farmacéutica que los contie ne.
DO2011000061A 2008-08-27 2011-02-25 Compuestos de pirrol DOP2011000061A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008218851 2008-08-27
JP2008269099 2008-10-17

Publications (1)

Publication Number Publication Date
DOP2011000061A true DOP2011000061A (es) 2011-04-15

Family

ID=41508823

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2011000061A DOP2011000061A (es) 2008-08-27 2011-02-25 Compuestos de pirrol

Country Status (39)

Country Link
US (3) US8592597B2 (es)
EP (1) EP2318390B1 (es)
JP (1) JP5638515B2 (es)
KR (1) KR101629181B1 (es)
CN (1) CN102197033B (es)
AR (1) AR073136A1 (es)
AU (1) AU2009284867B2 (es)
BR (1) BRPI0917705A2 (es)
CA (1) CA2735162C (es)
CL (1) CL2011000402A1 (es)
CO (1) CO6321166A2 (es)
CR (1) CR20110169A (es)
CY (1) CY1114452T1 (es)
DK (1) DK2318390T3 (es)
DO (1) DOP2011000061A (es)
EA (1) EA019741B1 (es)
EC (1) ECSP11010912A (es)
ES (1) ES2423289T3 (es)
GE (1) GEP20135786B (es)
HK (1) HK1157756A1 (es)
HR (1) HRP20130653T1 (es)
IL (1) IL211335A (es)
JO (1) JO2871B1 (es)
MA (1) MA32647B1 (es)
ME (1) ME01598B (es)
MX (1) MX2011001955A (es)
MY (1) MY152008A (es)
NZ (1) NZ591793A (es)
PE (2) PE20110300A1 (es)
PL (1) PL2318390T3 (es)
PT (1) PT2318390E (es)
RS (1) RS52872B (es)
SI (1) SI2318390T1 (es)
SM (1) SMT201300085B (es)
TW (1) TWI473798B (es)
UA (1) UA105185C2 (es)
UY (1) UY32074A (es)
WO (1) WO2010024451A1 (es)
ZA (1) ZA201101774B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA105185C2 (uk) * 2008-08-27 2014-04-25 Такеда Фармасьютікал Компані Лімітед Піроли
US20110229879A1 (en) * 2010-03-19 2011-09-22 University Of Rochester Methods and compositions for nuclear staining
CN102452979B (zh) * 2010-11-03 2015-04-01 天津药明康德新药开发有限公司 5-氟-3-吡啶磺酰氯的合成方法
CN102863371B (zh) * 2011-07-06 2016-04-13 中国科学院上海有机化学研究所 氟代二氢吡咯或氟代吡咯
WO2013119800A1 (en) 2012-02-07 2013-08-15 Massachusetts Institute Of Technology Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
MX2014015269A (es) 2012-06-27 2015-02-20 Takeda Pharmaceutical Preparaciones liquidas de aminas y acidos organicos estabilizados por sales.
MY176887A (en) * 2013-02-28 2020-08-25 Takeda Pharmaceuticals Co Method for producing sulfonyl chloride compound
WO2014144231A1 (en) 2013-03-15 2014-09-18 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
KR102084185B1 (ko) 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
CN105367550A (zh) * 2014-08-11 2016-03-02 江苏柯菲平医药股份有限公司 四氢环戊二烯并[c]吡咯类衍生物、其制备方法及其在医药上的应用
UY36547A (es) 2015-02-05 2016-06-01 Bayer Cropscience Ag Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas
US10317418B2 (en) 2015-02-24 2019-06-11 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
ES2977953T3 (es) 2015-07-30 2024-09-03 Takeda Pharmaceuticals Co Comprimido
MX2018001417A (es) 2015-08-07 2018-03-15 Bayer Cropscience Ag Derivados heterociclicos condensados sustituidos por 2-(het)-arilo como pesticidas.
CN106430006B (zh) * 2016-08-18 2018-06-12 国网湖南省电力公司带电作业中心 配电线路移动式绝缘登高作业装置及方法
CN108203430A (zh) * 2016-12-16 2018-06-26 天地人和生物科技有限公司 一种新型可逆性质子泵抑制剂及其制备方法和用途
SG11202000136YA (en) 2017-07-10 2020-02-27 Takeda Pharmaceuticals Co Preparation comprising vonoprazan
KR102126576B1 (ko) 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
CN113527536B (zh) * 2020-04-21 2024-03-22 杭州德柯医疗科技有限公司 一种含氟多糖高分子化合物及其制备方法
BR112022025613A2 (pt) * 2020-06-17 2023-01-17 Ildong Pharmaceutical Co Ltd Novo inibidor de secreção de ácido e uso do mesmo
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
CN113620930B (zh) * 2021-07-12 2022-08-16 南京烁慧医药科技有限公司 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用
KR20240119083A (ko) * 2021-12-15 2024-08-06 일동제약(주) 1-설포닐 피롤 유도체의 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물
CN118401510A (zh) * 2021-12-15 2024-07-26 日东制药株式会社 1-磺酰基吡咯衍生物的新颖盐类、其制备方法及包含其的药物组合物
KR20230102353A (ko) * 2021-12-30 2023-07-07 주식회사 대웅제약 삼중음성유방암의 예방 또는 치료용 약학적 조성물

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3772301D1 (de) 1986-08-29 1991-09-26 Pfizer 2-guanidino-4-aryl-thiazole fuer die behandlung von peptischen geschwueren.
US5128366A (en) 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
AU8653891A (en) 1990-08-31 1992-03-30 Warner-Lambert Company Amino acid analogs as cck antagonists
US5331006A (en) 1990-08-31 1994-07-19 Warner-Lambert Company Amino acid analogs as CCK antagonists
AU664392B2 (en) 1991-10-18 1995-11-16 Monsanto Technology Llc Fungicides for the control of take-all disease of plants
ZA927272B (en) 1991-10-29 1994-03-23 Du Pont Herbicidal triazolecarboxamides
JPH06135961A (ja) 1992-10-23 1994-05-17 Nippon Iyakuhin Kogyo Kk 新規ジフェニルピロリルフラン誘導体
US5286742A (en) 1992-11-03 1994-02-15 American Cyanamid Company Pyrrole thiocarboxamide insecticidal and acaricidal agents
US5480902A (en) 1993-08-31 1996-01-02 American Cyanamid Company Thienylpyrrole fungicidal agents
JPH08119936A (ja) 1994-10-18 1996-05-14 Fujisawa Pharmaceut Co Ltd 複素環式誘導体
JPH0930967A (ja) 1995-07-17 1997-02-04 Chugai Pharmaceut Co Ltd 抗潰瘍剤
AU741893B2 (en) 1996-08-28 2001-12-13 Procter & Gamble Company, The Substituted cyclic amine metalloprotease inhibitors
WO1998028269A1 (en) 1996-12-23 1998-07-02 Du Pont Pharmaceuticals Company NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS
JPH11209344A (ja) 1998-01-26 1999-08-03 Kyowa Hakko Kogyo Co Ltd 含窒素複素環化合物
GB9817548D0 (en) * 1998-08-12 1998-10-07 Novartis Ag Organic compounds
US7105564B1 (en) 1999-03-10 2006-09-12 Shionogi & Co., Ltd. Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton
TW575561B (en) 1999-03-25 2004-02-11 Hoffmann La Roche 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives
AU3783100A (en) 1999-06-14 2000-12-21 Dow Agrosciences Llc Substituted triazoles, imidazoles and pyrazoles as herbicides
AU7812900A (en) * 1999-08-26 2001-03-19 Aventis Pharmaceuticals Inc. Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benozopyrans
EP1284260A4 (en) 2000-05-22 2004-03-31 Takeda Chemical Industries Ltd TYROSINE PHOSPHATASE INHIBITORS
US6589978B2 (en) 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
GB0016453D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
WO2003028641A2 (en) 2001-10-01 2003-04-10 Taisho Pharmaceutical Co., Ltd. Mch receptor antagonists
US6919359B2 (en) * 2001-11-08 2005-07-19 Pfizer Inc Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
CA2464314A1 (en) 2001-11-22 2003-05-30 Ciba Specialty Chemicals Holding Inc. Pyrrole synthesis
WO2003057669A1 (fr) 2001-12-28 2003-07-17 Takeda Chemical Industries, Ltd. Antagonistes du recepteur androgene
WO2003068738A1 (en) 2002-02-11 2003-08-21 Neurocrine Biosciences, Inc. Pyrrole derivatives as ligands of melanocortin receptors
WO2003068740A1 (en) 2002-02-14 2003-08-21 Wyeth Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
TW200306191A (en) 2002-02-22 2003-11-16 Teijin Ltd Pyrrolopyrimidine derivatives
BR0311707A (pt) 2002-06-13 2005-03-15 Du Pont Composto, composição e método de controle de pelo menos uma praga invertebrada
WO2004014368A1 (en) 2002-08-12 2004-02-19 Sugen, Inc. 3-pyrrolyl-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
JP2004315511A (ja) 2003-03-31 2004-11-11 Taisho Pharmaceut Co Ltd Ｍｃｈ受容体アンタゴニスト
US7612064B2 (en) 2003-05-26 2009-11-03 Takeda Pharmaceutical Company Limited Sulfopyrroles
JP5173192B2 (ja) 2004-09-30 2013-03-27 武田薬品工業株式会社 プロトンポンプ阻害薬
EP1655284A1 (en) 2004-10-26 2006-05-10 Aponetics AG 2-Phenylsulfopyrroles
ES2364498T3 (es) * 2005-08-30 2011-09-05 Takeda Pharmaceutical Company Limited Inhibidor de la secreción ácida.
US8512761B2 (en) 2006-01-27 2013-08-20 Yale University Fast acting inhibitor of gastric acid secretion
WO2007114338A1 (ja) 2006-03-31 2007-10-11 Takeda Pharmaceutical Company Limited 酸分泌抑制薬
US8933105B2 (en) * 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
AR068538A1 (es) 2007-09-28 2009-11-18 Takeda Pharmaceutical Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido
US20090318429A1 (en) * 2008-04-28 2009-12-24 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives
MY152749A (en) 2008-05-16 2014-11-28 Takeda California Inc Pyrazole and fused pyrazole glucokinase activators
UA105185C2 (uk) * 2008-08-27 2014-04-25 Такеда Фармасьютікал Компані Лімітед Піроли

Also Published As

Publication number Publication date
EA201170384A1 (ru) 2011-10-31
EA019741B1 (ru) 2014-05-30
HK1157756A1 (en) 2012-07-06
GEP20135786B (en) 2013-03-11
US8993598B2 (en) 2015-03-31
RS52872B (en) 2013-12-31
EP2318390A1 (en) 2011-05-11
US8969387B2 (en) 2015-03-03
CL2011000402A1 (es) 2011-07-29
DK2318390T3 (da) 2013-07-08
MX2011001955A (es) 2011-03-29
IL211335A0 (en) 2011-04-28
UY32074A (es) 2010-03-26
ECSP11010912A (es) 2011-04-29
JO2871B1 (en) 2015-03-15
SI2318390T1 (sl) 2013-08-30
CA2735162A1 (en) 2010-03-04
CA2735162C (en) 2015-06-23
US8592597B2 (en) 2013-11-26
KR101629181B1 (ko) 2016-06-13
AR073136A1 (es) 2010-10-13
CO6321166A2 (es) 2011-09-20
PE20141174A1 (es) 2014-09-19
SMT201300085B (it) 2013-09-06
ME01598B (me) 2014-09-20
US20100056577A1 (en) 2010-03-04
TWI473798B (zh) 2015-02-21
JP5638515B2 (ja) 2014-12-10
PL2318390T3 (pl) 2013-09-30
PT2318390E (pt) 2013-07-10
ZA201101774B (en) 2012-06-27
CY1114452T1 (el) 2016-10-05
MY152008A (en) 2014-08-15
WO2010024451A1 (en) 2010-03-04
PE20110300A1 (es) 2011-06-16
UA105185C2 (uk) 2014-04-25
CN102197033A (zh) 2011-09-21
AU2009284867A1 (en) 2010-03-04
EP2318390B1 (en) 2013-05-01
US20140031393A1 (en) 2014-01-30
AU2009284867B2 (en) 2014-08-28
NZ591793A (en) 2012-11-30
AU2009284867A2 (en) 2011-04-21
KR20110071067A (ko) 2011-06-28
TW201010993A (en) 2010-03-16
US20110172275A1 (en) 2011-07-14
MA32647B1 (fr) 2011-09-01
CN102197033B (zh) 2014-07-16
BRPI0917705A2 (pt) 2016-02-16
JP2012501296A (ja) 2012-01-19
HRP20130653T1 (en) 2013-08-31
CR20110169A (es) 2011-05-16
IL211335A (en) 2013-12-31
ES2423289T3 (es) 2013-09-19

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