DK2922872T3 - Bispecifikke egfr/c-met-antistoffer - Google Patents

Bispecifikke egfr/c-met-antistoffer Download PDF

Info

Publication number: DK2922872T3
Authority: DK; Denmark
Prior art keywords: met antibodies; bispecific egfr; bispecific; egfr; antibodies
Prior art date: 2012-11-21

Application number

DK13856592.4T

Other languages

English (en)

Inventor

Mark Chiu

Sheri Moores

Joost Neijssen

Paul Parren

Janine Schuurman

Original Assignee

Janssen Biotech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-11-21

Filing date

2013-11-21

Publication date

2019-01-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50728148&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2922872(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-11-21 Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc

2019-01-02 Application granted granted Critical

2019-01-02 Publication of DK2922872T3 publication Critical patent/DK2922872T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Mycology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Inorganic Chemistry (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Oncology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK13856592.4T 2012-11-21 2013-11-21 Bispecifikke egfr/c-met-antistoffer DK2922872T3 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US201261728912P	2012-11-21	2012-11-21
US201361782550P	2013-03-14	2013-03-14
US201361809541P	2013-04-08	2013-04-08
US201361864717P	2013-08-12	2013-08-12
US201361892797P	2013-10-18	2013-10-18
PCT/US2013/071288 WO2014081954A1 (en)	2012-11-21	2013-11-21	BISPECIFIC EGFR/c-Met ANTIBODIES

Publications (1)

Publication Number	Publication Date
DK2922872T3 true DK2922872T3 (da)	2019-01-02

Family

ID=50728148

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK13856592.4T DK2922872T3 (da)	2012-11-21	2013-11-21	Bispecifikke egfr/c-met-antistoffer
DK18199421.1T DK3447069T3 (da)	2012-11-21	2013-11-21	Bispecifikke egfr/c-met-antistoffer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK18199421.1T DK3447069T3 (da)	2012-11-21	2013-11-21	Bispecifikke egfr/c-met-antistoffer

Country Status (33)

Country	Link
US (3)	US9593164B2 (da)
EP (4)	EP4420727A3 (da)
JP (5)	JP6423357B2 (da)
KR (3)	KR20240005211A (da)
CN (2)	CN113201073A (da)
AU (4)	AU2013347962B2 (da)
BR (1)	BR112015011717B1 (da)
CA (2)	CA3182876A1 (da)
CL (1)	CL2015001356A1 (da)
CY (2)	CY1121270T1 (da)
DK (2)	DK2922872T3 (da)
EA (1)	EA031184B1 (da)
ES (3)	ES2831374T3 (da)
FI (1)	FIC20220016I1 (da)
FR (1)	FR22C1018I2 (da)
HR (2)	HRP20182128T1 (da)
HU (3)	HUE052548T2 (da)
IL (1)	IL238796B (da)
LT (3)	LT2922872T (da)
MX (1)	MX361088B (da)
NI (1)	NI201500069A (da)
NL (1)	NL301173I2 (da)
NO (1)	NO2022012I1 (da)
NZ (1)	NZ708352A (da)
PE (1)	PE20151181A1 (da)
PH (1)	PH12015501118A1 (da)
PL (1)	PL2922872T3 (da)
PT (2)	PT2922872T (da)
RS (2)	RS61057B1 (da)
SG (1)	SG11201503938VA (da)
SI (2)	SI2922872T1 (da)
UA (1)	UA117121C2 (da)
WO (1)	WO2014081954A1 (da)

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US20140255408A1 (en)	2014-09-11
PT2922872T (pt)	2019-01-18
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JP7019771B2 (ja)	2022-02-15
FR22C1018I2 (fr)	2023-05-05
KR102373193B1 (ko)	2022-03-10
NL301173I1 (nl)	2022-05-04
AU2019200441A1 (en)	2019-02-07
HUS2200016I1 (hu)	2022-05-28
CA2893505C (en)	2023-02-21
EP3808767C0 (en)	2023-12-06
BR112015011717B1 (pt)	2023-12-12
WO2014081954A1 (en)	2014-05-30
KR20240005211A (ko)	2024-01-11
JP2024026236A (ja)	2024-02-28
KR20150087365A (ko)	2015-07-29
NL301173I2 (nl)	2022-06-15
CN113201073A (zh)	2021-08-03
SG11201503938VA (en)	2015-06-29
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NZ708352A (en)	2019-10-25
AU2021202394A1 (en)	2021-05-20
AU2024203417A1 (en)	2024-06-13
EP2922872B1 (en)	2018-10-10
MX2015006387A (es)	2015-12-03
PH12015501118B1 (en)	2016-02-01
JP2022062155A (ja)	2022-04-19
LTPA2022507I1 (da)	2022-06-27
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BR112015011717A2 (pt)	2017-08-15
ES2700231T3 (es)	2019-02-14
PL2922872T3 (pl)	2019-03-29
CN104955838B (zh)	2021-02-02
RS58192B1 (sr)	2019-03-29
AU2013347962B2 (en)	2018-10-25
LT3447069T (lt)	2020-12-10
ES2831374T3 (es)	2021-06-08
EP3808767B1 (en)	2023-12-06
JP6423357B2 (ja)	2018-11-14
EP3447069B1 (en)	2020-09-23
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SI2922872T1 (sl)	2019-01-31
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JP2016505537A (ja)	2016-02-25
KR20220032654A (ko)	2022-03-15
CA3182876A1 (en)	2014-05-30
PT3447069T (pt)	2020-11-13
CY1123550T1 (el)	2022-03-24
JP7397105B2 (ja)	2023-12-12
IL238796B (en)	2019-06-30
EP4420727A3 (en)	2024-10-23
NO2022012I1 (no)	2022-05-06
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IL238796A0 (en)	2015-06-30
AU2019200441B2 (en)	2021-01-28
EP2922872A1 (en)	2015-09-30
HRP20182128T1 (hr)	2019-02-08
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CY1121270T1 (el)	2020-05-29
DK3447069T3 (da)	2020-11-16
AU2021202394B2 (en)	2024-03-07
ES2971536T3 (es)	2024-06-05
JP2019048817A (ja)	2019-03-28
MX361088B (es)	2018-11-26
EA201590985A1 (ru)	2015-11-30
PH12015501118A1 (en)	2016-02-01
EP3808767A1 (en)	2021-04-21
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UA117121C2 (uk)	2018-06-25
CA2893505A1 (en)	2014-05-30
HUE052548T2 (hu)	2021-05-28
RS61057B1 (sr)	2020-12-31
NI201500069A (es)	2015-10-19
US9695242B2 (en)	2017-07-04
SI3447069T1 (sl)	2021-02-26
HUE041499T2 (hu)	2019-05-28
US9580508B2 (en)	2017-02-28
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