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DK2132326T3 - Fremgangsmåder - Google Patents

Fremgangsmåder

Info

Publication number
DK2132326T3
DK2132326T3 DK08718997.3T DK08718997T DK2132326T3 DK 2132326 T3 DK2132326 T3 DK 2132326T3 DK 08718997 T DK08718997 T DK 08718997T DK 2132326 T3 DK2132326 T3 DK 2132326T3
Authority
DK
Denmark
Prior art keywords
approaches
Prior art date
Application number
DK08718997.3T
Other languages
English (en)
Inventor
Dario Alessi
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of DK2132326T3 publication Critical patent/DK2132326T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK08718997.3T 2007-04-05 2008-04-07 Fremgangsmåder DK2132326T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91024207P 2007-04-05 2007-04-05
GBGB0706709.3A GB0706709D0 (en) 2007-04-05 2007-04-05 Methods
PCT/GB2008/001211 WO2008122789A2 (en) 2007-04-05 2008-04-07 Methods for modulating lrrk2

Publications (1)

Publication Number Publication Date
DK2132326T3 true DK2132326T3 (da) 2012-12-17

Family

ID=38090954

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08718997.3T DK2132326T3 (da) 2007-04-05 2008-04-07 Fremgangsmåder

Country Status (8)

Country Link
US (1) US7947468B2 (da)
EP (1) EP2132326B1 (da)
JP (1) JP2010523101A (da)
CN (1) CN101688234A (da)
CA (1) CA2718580A1 (da)
DK (1) DK2132326T3 (da)
GB (1) GB0706709D0 (da)
WO (1) WO2008122789A2 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8206942B2 (en) 2007-04-05 2012-06-26 Medical Research Council Methods of identifying LRRK2 inhibitors
GB0706709D0 (en) 2007-04-05 2007-05-16 Medical Res Council Methods
GB2463656B (en) * 2008-09-18 2010-10-13 Medical Res Council Substrate of LRRK2 and methods of assessing LRRK2 activity
JP2012254937A (ja) * 2009-09-11 2012-12-27 Kyushu Univ Ｒｈｏ−キナーゼの新規基質ペプチド
WO2011036211A1 (en) * 2009-09-23 2011-03-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides and nucleic acids for treating erbb2-dependent cancers
US8367349B2 (en) 2010-04-19 2013-02-05 Medical Research Council Methods for identifying modulators of LRRK2
KR101687060B1 (ko) * 2010-10-08 2016-12-15 상하이 켁신 바이오테크 씨오., 엘티디. 모에신 조절제 및 그의 용도
KR101571940B1 (ko) 2010-10-08 2015-11-25 상하이 켁신 바이오테크 씨오., 엘티디. 면역성 혈소판 감소증과 관련된 모에신 단편
CA2814023C (en) * 2010-10-08 2018-01-16 Shanghai Kexin Biotech Co., Ltd. Moesin fragments and uses thereof
CA2814030C (en) * 2010-10-08 2019-04-30 Shanghai Kexin Biotech Co., Ltd. Diagnostic and therapeutic uses of moesin fragments
WO2012045275A1 (en) * 2010-10-08 2012-04-12 Shanghai Kexin Biotech Co., Ltd. Moesin fragments associated with aplastic anemia
RU2013129818A (ru) * 2010-11-30 2015-01-10 Дженентек, Инк. Способы анализа и биомаркеры для гена lrrk2
CN105732639A (zh) 2012-06-29 2016-07-06 辉瑞大药厂 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类
ES2663622T3 (es) 2013-12-17 2018-04-16 Pfizer Inc. Novedosas 1H-pirrolo[2,3-b]piridinas 3,4-disustituidas y 7H-pirrolo[2,3-c]piridacinas 4,5-disustituidas como inhibidores de LRRK2
US10058559B2 (en) 2014-05-15 2018-08-28 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Treatment or prevention of an intestinal disease or disorder
RU2722149C1 (ru) 2015-09-14 2020-05-27 Пфайзер Инк. Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2
US20180179594A1 (en) * 2016-10-31 2018-06-28 Parkinson's Institute Multiple system atrophy and the treatment thereof
CN108709997B (zh) * 2018-05-28 2020-09-18 中国林业科学研究院林业研究所 Lrr受体激酶的底物寻找方法
CN112843067B (zh) * 2019-11-26 2023-01-06 兰州大学 人源lrrk2蛋白小分子抑制剂及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166222A1 (en) * 2002-01-02 2003-09-04 Millennium Pharmaceuticals, Inc. 39267, human kinase family members and uses therefor
US20040265849A1 (en) * 2002-11-22 2004-12-30 Applera Corporation Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof
JP2006174701A (ja) * 2003-02-24 2006-07-06 Research Association For Biotechnology 新規タンパク質およびそれをコードするｄｎａ
US8163511B2 (en) 2006-03-14 2012-04-24 Cellzome Ag Methods for the identification of LRRK2 interacting molecules
WO2008091799A2 (en) 2007-01-22 2008-07-31 The Trustees Of Columbia University In The City Of New York Cell-based methods for identifying inhibitors of parkinson's disease-associated lrrk2 mutants
GB0706709D0 (en) 2007-04-05 2007-05-16 Medical Res Council Methods

Also Published As

Publication number Publication date
WO2008122789A2 (en) 2008-10-16
CN101688234A (zh) 2010-03-31
WO2008122789A3 (en) 2008-12-04
JP2010523101A (ja) 2010-07-15
CA2718580A1 (en) 2008-10-16
US7947468B2 (en) 2011-05-24
US20090142784A1 (en) 2009-06-04
EP2132326B1 (en) 2012-10-31
GB0706709D0 (en) 2007-05-16
EP2132326A2 (en) 2009-12-16

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