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DK214090A - 5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse - Google Patents

5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse Download PDF

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Publication number
DK214090A
DK214090A DK214090A DK214090A DK214090A DK 214090 A DK214090 A DK 214090A DK 214090 A DK214090 A DK 214090A DK 214090 A DK214090 A DK 214090A DK 214090 A DK214090 A DK 214090A
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Prior art keywords
aminosulphonylalkyl
incidental
derivatives
procedure
preparation
Prior art date
Application number
DK214090A
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English (en)
Other versions
DK214090D0 (da
Inventor
Alexander William Oxford
Brian Evans
Michael Dennis Dowle
Ian Harold Coates
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK214090A publication Critical patent/DK214090A/da
Publication of DK214090D0 publication Critical patent/DK214090D0/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16Tryptamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK214090A 1983-12-06 1990-09-06 5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse DK214090D0 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838332435A GB8332435D0 (en) 1983-12-06 1983-12-06 Chemical compounds

Publications (2)

Publication Number Publication Date
DK214090A true DK214090A (da) 1990-09-06
DK214090D0 DK214090D0 (da) 1990-09-06

Family

ID=10552845

Family Applications (2)

Application Number Title Priority Date Filing Date
DK583684A DK583684A (da) 1983-12-06 1984-12-06 Kemiske forbindelser
DK214090A DK214090D0 (da) 1983-12-06 1990-09-06 5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK583684A DK583684A (da) 1983-12-06 1984-12-06 Kemiske forbindelser

Country Status (27)

Country Link
US (1) US4994483A (da)
JP (2) JPH062733B2 (da)
KR (1) KR850004459A (da)
CN (2) CN85104233A (da)
AT (1) AT381934B (da)
AU (1) AU575365B2 (da)
BE (1) BE901224A (da)
CA (1) CA1233183A (da)
CH (1) CH663411A5 (da)
CY (1) CY1562A (da)
DE (1) DE3444572C2 (da)
DK (2) DK583684A (da)
ES (2) ES8607234A1 (da)
FI (1) FI80260C (da)
FR (1) FR2555987B1 (da)
GB (2) GB8332435D0 (da)
HK (1) HK85690A (da)
HU (2) HU196752B (da)
IL (1) IL73756A (da)
IT (1) IT1178268B (da)
NL (1) NL8403719A (da)
NO (1) NO162764C (da)
NZ (1) NZ210469A (da)
PT (1) PT80572B (da)
SE (1) SE458446B (da)
SG (1) SG65790G (da)
ZA (1) ZA849498B (da)

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GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8430624D0 (en) * 1984-12-04 1985-01-09 Glaxo Group Ltd Chemical compounds
AU584142B2 (en) * 1984-12-04 1989-05-18 Glaxo Group Limited Indole derivatives
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
AU611469B2 (en) * 1987-08-13 1991-06-13 Glaxo Group Limited Indole derivatives
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
JPH01312506A (ja) * 1988-06-13 1989-12-18 Mitsui Petrochem Ind Ltd カラーフィルター
DE69127260T2 (de) * 1990-06-07 1997-12-04 Zeneca Ltd., London Therapeutische heterocyclische verbindungen
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
IT1264813B1 (it) * 1993-07-28 1996-10-10 Oxon Italia Spa Procedimento per la preparazione di alcansolfonammidi
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
EP1572647B1 (en) * 2002-12-20 2016-09-21 Basf Se Synthesis of amines and intermediates for the synthesis thereof
WO2004099141A1 (en) * 2003-05-12 2004-11-18 Ramesh Babu Potluri A novel process for preparation of indole derivatives
US20060002989A1 (en) * 2004-06-10 2006-01-05 Ahmed Salah U Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
DK1883451T3 (da) 2005-04-13 2011-03-14 Neuraxon Inc Substituerede indolforbindelser med NOS-hæmmende virkning
US7989447B2 (en) * 2006-04-13 2011-08-02 Neuraxon, Inc. 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity
WO2008056378A2 (en) * 2006-11-09 2008-05-15 Natco Pharma Limited Novel process for the preparation of naratriptan hydrochloride
ES2691033T3 (es) * 2007-02-11 2018-11-23 Map Pharmaceuticals Inc. Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios
EP2220074A4 (en) * 2007-11-16 2012-01-04 Neuraxon Inc 3,5-SUBSTITUTED INDOL COMPOUNDS WITH NOS AND NOREPINEPHRINE RECOVERY-HEMDERING EFFECT
WO2009064505A1 (en) * 2007-11-16 2009-05-22 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for treating visceral pain
KR20100103799A (ko) 2007-11-16 2010-09-28 네우렉슨 인코포레이티드 내장통을 치료하기 위한 인돌 화합물 및 방법
WO2010151804A1 (en) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration of dihydroergotamine mesylate particles using a metered dose inhaler
EP2480197B1 (en) 2009-09-25 2015-11-11 Dr. Reddy's Laboratories Ltd. Formulations comprising triptan compounds
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
EP2716626A4 (en) * 2011-05-27 2014-05-07 Univ Tokushima benzylamine
ES2751388T3 (es) 2011-07-22 2020-03-31 Univ Chicago IGF-1 para su uso en el tratamiento de la jaqueca
CN102827062A (zh) * 2012-09-17 2012-12-19 扬子江药业集团四川海蓉药业有限公司 苹果酸阿莫曲坦的制备方法
CA2895816C (en) 2012-12-21 2021-02-23 Map Pharmaceuticals, Inc. 8'-hydroxy-dihydroergotamine compounds and compositions

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US3322787A (en) * 1964-09-25 1967-05-30 Merck & Co Inc Alpha-hydrazino-beta-(3-indolyl) alkanoic acid derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
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US3730723A (en) * 1971-06-17 1973-05-01 Eastman Kodak Co Direct positive processes utilizing silver halide surface image emulsions containing desensitizers
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CH651551A5 (fr) * 1980-08-12 1985-09-30 Glaxo Group Ltd Derives de l'indole, leur preparation et compositions pharmaceutiques les contenant.
FR2488606A1 (fr) * 1980-08-12 1982-02-19 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
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GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
AU584142B2 (en) * 1984-12-04 1989-05-18 Glaxo Group Limited Indole derivatives

Also Published As

Publication number Publication date
FI80260B (fi) 1990-01-31
ES546631A0 (es) 1987-10-16
BE901224A (fr) 1985-06-06
AU3636784A (en) 1985-06-13
DK583684D0 (da) 1984-12-06
GB2150932A (en) 1985-07-10
GB8332435D0 (en) 1984-01-11
AT381934B (de) 1986-12-10
US4994483A (en) 1991-02-19
CN1015055B (zh) 1991-12-11
CN85106225A (zh) 1987-02-18
FR2555987B1 (fr) 1987-07-17
SE458446B (sv) 1989-04-03
DE3444572A1 (de) 1985-06-20
FI844789A0 (fi) 1984-12-05
IL73756A (en) 1988-02-29
FI844789L (fi) 1985-06-07
FI80260C (fi) 1990-05-10
ES8800150A1 (es) 1987-10-16
HUT40624A (en) 1987-01-28
JPS60155156A (ja) 1985-08-15
FR2555987A1 (fr) 1985-06-07
ZA849498B (en) 1986-09-24
HUT36455A (en) 1985-09-30
NZ210469A (en) 1989-01-27
JPH062733B2 (ja) 1994-01-12
NL8403719A (nl) 1985-07-01
NO844879L (no) 1985-06-07
HU196752B (en) 1989-01-30
AU575365B2 (en) 1988-07-28
DK583684A (da) 1985-06-07
NO162764C (no) 1990-02-14
PT80572A (en) 1985-06-01
IL73756A0 (en) 1985-03-31
CY1562A (en) 1991-05-17
ES8607234A1 (es) 1986-06-01
ES538336A0 (es) 1986-06-01
CA1233183A (en) 1988-02-23
IT1178268B (it) 1987-09-09
ATA387384A (de) 1986-05-15
JPH03184958A (ja) 1991-08-12
KR850004459A (ko) 1985-07-15
NO162764B (no) 1989-11-06
SG65790G (en) 1990-10-26
PT80572B (en) 1986-12-22
IT8449265A0 (it) 1984-12-06
GB8430810D0 (en) 1985-01-16
HK85690A (en) 1990-10-25
GB2150932B (en) 1987-10-28
CN85104233A (zh) 1987-01-07
SE8406200L (sv) 1985-06-07
SE8406200D0 (sv) 1984-12-06
DK214090D0 (da) 1990-09-06
CH663411A5 (fr) 1987-12-15
DE3444572C2 (de) 1993-10-14

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