DK1487832T3 - Krystallinsk mikronisat af tiotropiumbromid - Google Patents

Krystallinsk mikronisat af tiotropiumbromid

Info

Publication number: DK1487832T3
Authority: DK; Denmark
Prior art keywords: tiotropium bromide; micronisate; crystalline; crystalline micronisate; tiotropium
Prior art date: 2002-03-20

Application number

DK03708206T

Other languages

English (en)

Other versions

DK1487832T4 (da

Inventor

Helmut Bender

Hagen Graebner

Konrad Schindler

Michael Josef Friedrich Trunk

Michael Walz

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-20

Filing date

2003-03-10

Publication date

2007-11-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27797948&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1487832(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-03-10 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2007-11-05 Publication of DK1487832T3 publication Critical patent/DK1487832T3/da

2018-12-10 Application granted granted Critical

2018-12-10 Publication of DK1487832T4 publication Critical patent/DK1487832T4/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Catalysts (AREA)
Medicinal Preparation (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Glass Compositions (AREA)
Hybrid Cells (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK03708206.2T 2002-03-20 2003-03-10 Krystallinsk mikronisat af tiotropiumbromid DK1487832T4 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10212264A DE10212264A1 (de)	2002-03-20	2002-03-20	Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
PCT/EP2003/002422 WO2003078429A1 (de)	2002-03-20	2003-03-10	Kristallines mikronisat des tiotropiumbromids

Publications (2)

Publication Number	Publication Date
DK1487832T3 true DK1487832T3 (da)	2007-11-05
DK1487832T4 DK1487832T4 (da)	2018-12-10

Family

ID=27797948

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK03708206.2T DK1487832T4 (da)	2002-03-20	2003-03-10	Krystallinsk mikronisat af tiotropiumbromid
DK07102206.5T DK1785422T3 (da)	2002-03-20	2003-03-10	Krystallinsk mikronisat af tiotropiumbromider.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK07102206.5T DK1785422T3 (da)	2002-03-20	2003-03-10	Krystallinsk mikronisat af tiotropiumbromider.

Country Status (37)

Country	Link
EP (3)	EP1487832B9 (da)
JP (1)	JP4331619B2 (da)
KR (2)	KR101021430B1 (da)
CN (2)	CN101220025A (da)
AR (1)	AR039017A1 (da)
AT (1)	ATE369365T1 (da)
AU (1)	AU2003212327B2 (da)
BR (1)	BRPI0308513B8 (da)
CA (1)	CA2479652C (da)
CO (1)	CO5611105A2 (da)
CY (2)	CY1106923T1 (da)
DE (2)	DE10212264A1 (da)
DK (2)	DK1487832T4 (da)
EA (1)	EA007064B1 (da)
EC (1)	ECSP045310A (da)
ES (2)	ES2615460T3 (da)
HK (1)	HK1078871A1 (da)
HR (1)	HRP20040855B1 (da)
HU (1)	HUE031876T2 (da)
IL (2)	IL163841A0 (da)
LT (1)	LT1785422T (da)
ME (1)	ME02764B (da)
MX (1)	MXPA04009056A (da)
MY (1)	MY139720A (da)
NO (2)	NO346754B1 (da)
NZ (1)	NZ535808A (da)
PE (1)	PE20030838A1 (da)
PL (1)	PL220730B1 (da)
PT (2)	PT1785422T (da)
RS (1)	RS57551B1 (da)
SA (1)	SA03240098B1 (da)
SI (1)	SI1487832T2 (da)
TW (1)	TWI345975B (da)
UA (1)	UA78295C2 (da)
UY (1)	UY27725A1 (da)
WO (1)	WO2003078429A1 (da)
ZA (1)	ZA200405636B (da)

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US7056916B2 (en)	2002-11-15	2006-06-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments for the treatment of chronic obstructive pulmonary disease
DK1682543T3 (da)	2003-11-03	2010-12-13	Boehringer Ingelheim Int	Fremgangsmåde til fremstilling af nye tiotropiumsalte
DE502004010885D1 (de)	2003-11-03	2010-04-22	Boehringer Ingelheim Pharma	Verfahren zur herstellung von tiotropiumsalzen
US7220742B2 (en)	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024451A1 (de)	2004-05-14	2005-12-22	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pulverformulierungen für die Inhalation, die Enantiomerenreine Betaagonisten enthalten
CA2606552A1 (en) *	2005-05-02	2006-11-09	Boehringer Ingelheim International Gmbh	Crystalline forms of tiotropium bromide
BRPI0609295A2 (pt)	2005-05-02	2010-03-23	Boehringer Ingelheim Int	formas cristalinas de brometo de tiotràpio, composiÇço farmacÊutica, uso e mÉtodo para preparar as mesmas
PL1917253T3 (pl)	2005-08-15	2015-06-30	Boehringer Ingelheim Int	Sposób wytwarzania betamimetyków
US20070086957A1 (en) *	2005-10-10	2007-04-19	Thierry Bouyssou	Combination of medicaments for the treatment of respiratory diseases
DE102005059602A1 (de) *	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Mikronisierung
JP5086267B2 (ja)	2005-12-19	2012-11-28	シコールインコーポレイティド	臭化チオトロピウムの新規な形態およびそれを製造する方法
US9108962B2 (en)	2005-12-19	2015-08-18	Sicor, Inc.	Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) *	2006-01-13	2010-12-08	江苏正大天晴药业股份有限公司	结晶性抗胆碱药噻托溴铵
GB0716026D0 (en)	2007-08-16	2007-09-26	Norton Healthcare Ltd	An inhalable medicament
WO2011093815A2 (en) *	2010-01-29	2011-08-04	Mahmut Bilgic	Pharmaceutical compositions comprising formoterol and mometasone
GB201200525D0 (en)	2011-12-19	2012-02-29	Teva Branded Pharmaceutical Prod R & D Inc	An inhalable medicament
PT106142B (pt) *	2012-02-10	2014-07-18	Hovione Farmaci Ncia S A	Processo para a preparação de brometo de tiotrópio
WO2014007768A1 (en)	2012-07-05	2014-01-09	Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi	Dry powder inhaler compositions comprising long acting muscorinic antagonists
EP2705838A1 (en) *	2012-09-06	2014-03-12	Xspray Microparticles Ab	Tiotropium preparations
WO2014042605A1 (en) *	2012-09-11	2014-03-20	Mahmut Bilgic	New tiotropium bromide crystalline form
US10034866B2 (en)	2014-06-19	2018-07-31	Teva Branded Pharmaceutical Products R&D, Inc.	Inhalable medicament comprising tiotropium
SI3191081T1 (sl)	2014-09-09	2020-07-31	Vectura Limited	Formulacija, ki vsebuje glikopirolat, postopek in naprava
WO2017068119A1 (en) *	2015-10-23	2017-04-27	Arven Ilac Sanayi Ve Ticaret A.S.	Blister for tiotropium bromide inhalable formulation
BR112018008083A2 (pt) *	2015-10-23	2018-10-23	Arven Ilac Sanayi Ve Ticaret As	blister para formulação inalável de brometo de tiotrópio
CN115737610B (zh) *	2021-12-13	2024-02-27	苏州欧米尼医药有限公司	一种噻托溴铵吸入粉雾剂及其活性成分的气流粉碎方法

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US7309707B2 (en)	2002-03-20	2007-12-18	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
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DE102005059602A1 (de)	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Mikronisierung
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2002
- 2002-03-20 DE DE10212264A patent/DE10212264A1/de not_active Withdrawn
2003
- 2003-03-10 KR KR1020047014831A patent/KR101021430B1/ko active IP Right Grant
- 2003-03-10 ME MEP-2008-467A patent/ME02764B/me unknown
- 2003-03-10 AT AT03708206T patent/ATE369365T1/de active
- 2003-03-10 ES ES07102206.5T patent/ES2615460T3/es not_active Expired - Lifetime
- 2003-03-10 ES ES03708206.2T patent/ES2291619T5/es not_active Expired - Lifetime
- 2003-03-10 BR BRPI0308513A patent/BRPI0308513B8/pt not_active IP Right Cessation
- 2003-03-10 DE DE50307883T patent/DE50307883D1/de not_active Expired - Lifetime
- 2003-03-10 PL PL371799A patent/PL220730B1/pl unknown
- 2003-03-10 RS RS82604A patent/RS57551B1/sr unknown
- 2003-03-10 MX MXPA04009056A patent/MXPA04009056A/es active IP Right Grant
- 2003-03-10 EP EP03708206.2A patent/EP1487832B9/de not_active Expired - Lifetime
- 2003-03-10 PT PT71022065T patent/PT1785422T/pt unknown
- 2003-03-10 AU AU2003212327A patent/AU2003212327B2/en not_active Expired
- 2003-03-10 CN CNA2008100024354A patent/CN101220025A/zh active Pending
- 2003-03-10 IL IL16384103A patent/IL163841A0/xx unknown
- 2003-03-10 DK DK03708206.2T patent/DK1487832T4/da active
- 2003-03-10 LT LTEP07102206.5T patent/LT1785422T/lt unknown
- 2003-03-10 KR KR1020107028543A patent/KR101094091B1/ko active IP Right Grant
- 2003-03-10 EP EP16159836.2A patent/EP3053921A1/de not_active Withdrawn
- 2003-03-10 CN CNB038065169A patent/CN100368410C/zh not_active Ceased
- 2003-03-10 SI SI200330973T patent/SI1487832T2/sl unknown
- 2003-03-10 HU HUE07102206A patent/HUE031876T2/en unknown
- 2003-03-10 PT PT03708206T patent/PT1487832E/pt unknown
- 2003-03-10 DK DK07102206.5T patent/DK1785422T3/da active
- 2003-03-10 EP EP07102206.5A patent/EP1785422B1/de not_active Expired - Lifetime
- 2003-03-10 WO PCT/EP2003/002422 patent/WO2003078429A1/de active IP Right Grant
- 2003-03-10 EA EA200401142A patent/EA007064B1/ru not_active IP Right Cessation
- 2003-03-10 JP JP2003576434A patent/JP4331619B2/ja not_active Expired - Lifetime
- 2003-03-10 NZ NZ535808A patent/NZ535808A/en not_active IP Right Cessation
- 2003-03-10 CA CA2479652A patent/CA2479652C/en not_active Expired - Fee Related
- 2003-03-10 NO NO20190824A patent/NO346754B1/no not_active IP Right Cessation
- 2003-03-18 MY MYPI20030947A patent/MY139720A/en unknown
- 2003-03-18 PE PE2003000268A patent/PE20030838A1/es not_active Application Discontinuation
- 2003-03-18 UY UY27725A patent/UY27725A1/es not_active Application Discontinuation
- 2003-03-18 TW TW092105919A patent/TWI345975B/zh not_active IP Right Cessation
- 2003-03-19 AR ARP030100957A patent/AR039017A1/es not_active Suspension/Interruption
- 2003-04-29 SA SA03240098A patent/SA03240098B1/ar unknown
- 2003-10-03 UA UA20041008391A patent/UA78295C2/uk unknown
2004
- 2004-07-15 ZA ZA2004/05636A patent/ZA200405636B/en unknown
- 2004-08-31 IL IL163841A patent/IL163841A/en not_active IP Right Cessation
- 2004-09-17 HR HR20040855 patent/HRP20040855B1/xx not_active IP Right Cessation
- 2004-09-23 EC EC2004005310A patent/ECSP045310A/es unknown
- 2004-09-23 NO NO20044003A patent/NO344427B1/no not_active IP Right Cessation
- 2004-10-15 CO CO04104123A patent/CO5611105A2/es not_active Application Discontinuation
2005
- 2005-12-01 HK HK05110949A patent/HK1078871A1/xx not_active IP Right Cessation
2007
- 2007-10-10 CY CY20071101300T patent/CY1106923T1/el unknown
2017
- 2017-02-13 CY CY20171100194T patent/CY1118855T1/el unknown

Also Published As

Publication number	Publication date
WO2003078429A1 (de)	2003-09-25
EP1487832B9 (de)	2019-01-23
BR0308513A (pt)	2005-01-04
CA2479652C (en)	2012-07-10
NO344427B1 (no)	2019-12-02
EP1487832A1 (de)	2004-12-22
RS57551B1 (sr)	2018-10-31
KR101094091B1 (ko)	2011-12-15
PL371799A1 (en)	2005-06-27
IL163841A0 (en)	2005-12-18
PT1785422T (pt)	2017-02-17
JP2005526776A (ja)	2005-09-08
EP1785422A8 (de)	2010-06-23
TWI345975B (en)	2011-08-01
CA2479652A1 (en)	2003-09-25
MEP46708A (en)	2011-02-10
LT1785422T (lt)	2017-02-10
ES2291619T5 (es)	2018-12-07
NZ535808A (en)	2005-09-30
DE10212264A1 (de)	2003-10-02
HRP20040855B1 (en)	2012-11-30
DE50307883D1 (de)	2007-09-20
EA200401142A1 (ru)	2005-04-28
DK1487832T4 (da)	2018-12-10
ES2615460T3 (es)	2017-06-07
EA007064B1 (ru)	2006-06-30
KR20100135983A (ko)	2010-12-27
IL163841A (en)	2015-10-29
CO5611105A2 (es)	2006-02-28
AU2003212327A1 (en)	2003-09-29
BRPI0308513B1 (pt)	2016-04-19
SI1487832T2 (sl)	2018-11-30
PE20030838A1 (es)	2003-11-21
EP3053921A1 (de)	2016-08-10
HUE031876T2 (en)	2017-08-28
ZA200405636B (en)	2006-01-25
DK1785422T3 (da)	2017-02-27
HRP20040855A2 (en)	2005-06-30
UY27725A1 (es)	2003-10-31
NO346754B1 (no)	2022-12-12
AR039017A1 (es)	2005-02-02
NO20044003L (no)	2004-10-14
PL220730B1 (pl)	2015-12-31
BRPI0308513B8 (pt)	2021-05-25
MXPA04009056A (es)	2005-01-25
CN1642952A (zh)	2005-07-20
NO20190824A1 (no)	2004-10-14
ECSP045310A (es)	2004-10-26
MY139720A (en)	2009-10-30
ES2291619T3 (es)	2008-03-01
PT1487832E (pt)	2007-08-27
KR20050008662A (ko)	2005-01-21
CY1106923T1 (el)	2012-09-26
CY1118855T1 (el)	2018-01-10
CN101220025A (zh)	2008-07-16
JP4331619B2 (ja)	2009-09-16
UA78295C2 (en)	2007-03-15
EP1785422B1 (de)	2016-11-16
TW200305421A (en)	2003-11-01
EP1487832B2 (de)	2018-08-29
AU2003212327B2 (en)	2009-02-05
HK1078871A1 (en)	2006-03-24
KR101021430B1 (ko)	2011-03-15
ME02764B (me)	2011-05-10
EP1487832B1 (de)	2007-08-08
ATE369365T1 (de)	2007-08-15
SI1487832T1 (sl)	2007-12-31
EP1785422A1 (de)	2007-05-16
CN100368410C (zh)	2008-02-13
SA03240098B1 (ar)	2008-03-24

Publication	Publication Date	Title
DK1487832T3 (da)	2007-11-05	Krystallinsk mikronisat af tiotropiumbromid
IS8348A (is)	2006-03-09	Samrunnin heteróhringasambönd
DK1881980T3 (da)	2012-10-01	Nye krystalline former af tiotropiumbromid
FR16C0004I2 (fr)	2017-01-06	Composes cepheme
FI20021262A (fi)	2003-12-28	Sokerien kiteytys
IS7007A (is)	2003-10-30	Kristallaform af asiþrómýsíni
DK1802579T3 (da)	2014-01-20	Derivater af 3-arylaminopyridin
DK1451192T3 (da)	2011-04-04	Ny krystallinsk forbindelse
IS7879A (is)	2005-06-02	Ný efnasambönd
ATE428701T1 (de)	2009-05-15	Kristalline form von bisä(e)-7-ä4-(4-fluorphenyl)-6-isopropyl-2-
DK1682542T3 (da)	2010-05-10	Nyt krystallinsk anhydrat med anticholinerg effekt
ATE364610T1 (de)	2007-07-15	Kristalline polymorphe form von irinotecan- hyrochlorid
IS7793A (is)	2005-04-11	Nýtt efnasamband
IS7794A (is)	2005-04-11	Nýtt efnasamband
DK1808435T3 (da)	2012-01-16	Teknisk fremstilling af tiotropiumbromid
DK1280803T3 (da)	2005-01-24	Krystallinsk form II af cabergolin
DK1682541T3 (da)	2010-06-28	Fremgangsmåde til fremstilling af tiotropiumsalte
IS7833A (is)	2005-05-02	Efnasambönd með sameinaða heteróhringi
IS7195A (is)	2004-03-23	Ný vatnsfrí kristallaform af gabapentíni
NO20055097D0 (no)	2005-11-01	Krystallinske N-formyl-hydroksylaminforbindelser
DE602004023341D1 (de)	2009-11-12	Chronograph
DK1472412T3 (da)	2008-03-31	Byggesæt af brosten
NO20044364L (no)	2004-12-09	Hydroksykarbamimidoyl-2-hydroksy-benzensulfonamidderivat-krystaller
DE50310893D1 (de)	2009-01-22	Steinbohrer
SE0203348D0 (sv)	2002-11-12	Novel compounds