DK1351703T3 - Anvendelse af et polypeptid omfattende det ekstracellulære domæne af IL-20RA og IL-20RB til behandling af inflammation - Google Patents
Anvendelse af et polypeptid omfattende det ekstracellulære domæne af IL-20RA og IL-20RB til behandling af inflammationInfo
- Publication number
- DK1351703T3 DK1351703T3 DK01970886T DK01970886T DK1351703T3 DK 1351703 T3 DK1351703 T3 DK 1351703T3 DK 01970886 T DK01970886 T DK 01970886T DK 01970886 T DK01970886 T DK 01970886T DK 1351703 T3 DK1351703 T3 DK 1351703T3
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptide
- inflammation
- treatment
- extracellular domain
- seq
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23330500P | 2000-09-15 | 2000-09-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1351703T3 true DK1351703T3 (da) | 2006-11-27 |
Family
ID=22876714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01970886T DK1351703T3 (da) | 2000-09-15 | 2001-09-13 | Anvendelse af et polypeptid omfattende det ekstracellulære domæne af IL-20RA og IL-20RB til behandling af inflammation |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7855269B2 (de) |
| EP (2) | EP1351703B1 (de) |
| JP (1) | JP4908723B2 (de) |
| AT (2) | ATE460429T1 (de) |
| AU (1) | AU2001290837A1 (de) |
| CA (1) | CA2422033A1 (de) |
| DE (2) | DE60121808T2 (de) |
| DK (1) | DK1351703T3 (de) |
| ES (1) | ES2267814T3 (de) |
| WO (1) | WO2002022153A2 (de) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965704A (en) * | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
| ES2381650T3 (es) * | 2000-08-08 | 2012-05-30 | Zymogenetics, Inc. | Receptores de citoquinas Zcytor11 solubles |
| CA2422033A1 (en) * | 2000-09-15 | 2002-03-21 | Zymogenetics, Inc. | Method for treating inflammation |
| KR20110091598A (ko) * | 2003-03-24 | 2011-08-11 | 지모제넥틱스, 인코포레이티드 | 항-ｉｌ-22ｒａ 항체 및 결합 파트너 및 염증에 있어서의 사용 방법 |
| US20040248097A1 (en) * | 2003-05-23 | 2004-12-09 | Ming-Shi Chang | Interleukin-20 variants and promoters |
| WO2005014028A1 (en) * | 2003-08-08 | 2005-02-17 | Novo Nordisk A/S | Interleukin-20 for treating and diagnosing conditions associated with neovascularisation |
| PT1725249E (pt) | 2003-11-06 | 2014-04-10 | Seattle Genetics Inc | Compostos de monometilvalina capazes de conjugação a ligandos |
| WO2005052001A2 (en) * | 2003-11-21 | 2005-06-09 | Zymogenetics, Inc. | Anti-il-20 receptor antibodies and binding partners and methods of using in inflammation |
| EP2286844A3 (de) | 2004-06-01 | 2012-08-22 | Genentech, Inc. | Antikörper-Arzneimittelkonjugate und Verfahren |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| AU2005286607B2 (en) | 2004-09-23 | 2011-01-27 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| DE602005022475D1 (de) * | 2004-10-22 | 2010-09-02 | Zymogenetics Inc | Anti-il-22ra-antikörper und bindungspartner und verfahren zur anwendung bei entzündungen |
| EP1856156A2 (de) * | 2005-02-08 | 2007-11-21 | ZymoGenetics, Inc. | Anti-il-20-, anti-il-22- und anti-il-22ra-antikörper und bindungspartner sowie verwendungsverfahren bei entzündungen |
| EP2035452B1 (de) | 2006-06-22 | 2012-04-25 | Novo Nordisk A/S | Lösliche heterodimere rezeptoren und ihre verwendung |
| WO2011031870A1 (en) | 2009-09-09 | 2011-03-17 | Centrose, Llc | Extracellular targeted drug conjugates |
| ES2430567T3 (es) | 2010-04-15 | 2013-11-21 | Spirogen Sàrl | Pirrolobenzodiacepinas y conjugados de las mismas |
| CA3220104A1 (en) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| CN103313990B (zh) | 2010-11-17 | 2016-07-20 | 基因泰克公司 | 丙氨酰美登醇抗体偶联物 |
| EP2707723B1 (de) | 2011-05-12 | 2016-02-10 | Genentech, Inc. | Lc-ms/ms-verfahren mit mehrfachreaktionsüberwachung zur erkennung therapeutischer antikörper in tierischen proben mittels rahmensignaturpeptiden |
| CA2850371C (en) | 2011-10-14 | 2020-06-30 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
| WO2014057120A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| MX364328B (es) | 2012-10-12 | 2019-04-23 | Medimmune Ltd | Conjugados del anticuerpo pirrolobenzodiazepina. |
| US10736903B2 (en) | 2012-10-12 | 2020-08-11 | Medimmune Limited | Pyrrolobenzodiazepine-anti-PSMA antibody conjugates |
| HUE041274T2 (hu) | 2012-10-12 | 2019-05-28 | Adc Therapeutics Sa | Pirrolobenzodiazepin-anti-PSMA-antitest konjugátumok |
| ES2530968T3 (es) | 2012-10-12 | 2015-03-09 | Spirogen Sarl | Pirrolobenzodiazepinas y conjugados de las mismas |
| DK2906251T3 (da) | 2012-10-12 | 2017-11-20 | Adc Therapeutics Sa | Pyrrolobenzodiazepin-anti-CD22-antistofkonjugater |
| DK2906298T3 (en) | 2012-10-12 | 2018-12-17 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| CA2894961C (en) | 2012-12-21 | 2020-09-15 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EA032986B1 (ru) | 2012-12-21 | 2019-08-30 | Медимьюн Лимитед | Пирролобензодиазепины |
| WO2014159981A2 (en) | 2013-03-13 | 2014-10-02 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| US20160031887A1 (en) | 2013-03-13 | 2016-02-04 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| AU2014229529B2 (en) | 2013-03-13 | 2018-02-15 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| TWI636792B (zh) | 2013-08-12 | 2018-10-01 | 建南德克公司 | １－（氯甲基）－２，３－二氫－１ｈ－苯并［ｅ］吲哚二聚體抗體－藥物結合物化合物及使用與治療方法 |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| WO2015052532A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
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| PE20161394A1 (es) | 2013-12-16 | 2017-01-06 | Genentech Inc | Compuestos peptidomimeticos y sus conjugados de anticuerpo-farmaco |
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| EP4198059A1 (de) | 2014-05-27 | 2023-06-21 | The University of Queensland | Modulation von zellulärem stress |
| JP6449338B2 (ja) | 2014-06-06 | 2019-01-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | グルココルチコイド誘導腫瘍壊死因子受容体（ｇｉｔｒ）に対する抗体およびその使用 |
| CN106687141A (zh) | 2014-09-10 | 2017-05-17 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其缀合物 |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| KR20170052600A (ko) | 2014-09-12 | 2017-05-12 | 제넨테크, 인크. | 시스테인 가공된 항체 및 콘주게이트 |
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| BR112017005393A2 (pt) | 2014-09-17 | 2017-12-05 | Genentech Inc | composto de fórmula i, método de preparação de um conjugado de fórmula a, conjugado de fórmula a1, composição compreendendo uma mistura dos compostos de conjugado de anticorpo-fármaco, composição farmacêutica, e uso de um conjugado ou de uma composição |
| BR112017011111A2 (pt) | 2014-11-25 | 2017-12-26 | Adc Therapeutics Sa | conjugados de pirrolobenzodiazepina-anticorpo |
| KR20170086121A (ko) | 2014-12-03 | 2017-07-25 | 제넨테크, 인크. | 4급 아민 화합물 및 그의 항체-약물 접합체 |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| WO2016196792A1 (en) | 2015-06-03 | 2016-12-08 | Bristol-Myers Squibb Company | Anti-gitr antibodies for cancer diagnostics |
| MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
| MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| MA45326A (fr) | 2015-10-20 | 2018-08-29 | Genentech Inc | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
| WO2017087678A2 (en) | 2015-11-19 | 2017-05-26 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
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| EP3458101B1 (de) | 2016-05-20 | 2020-12-30 | H. Hoffnabb-La Roche Ag | Protac-antikörper-konjugate und verfahren zur verwendung |
| JP7022080B2 (ja) | 2016-05-27 | 2022-02-17 | ジェネンテック， インコーポレイテッド | 部位特異的抗体－薬物複合体の特徴付けのための生化学分析的方法 |
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| WO2018031662A1 (en) | 2016-08-11 | 2018-02-15 | Genentech, Inc. | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof |
| EP3522933B1 (de) | 2016-10-05 | 2021-12-15 | F. Hoffmann-La Roche AG | Verfahren zur herstellung von antikörperarzneimittelkonjugaten |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| KR20200032243A (ko) | 2017-02-08 | 2020-03-25 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항체 컨주게이트 |
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| EP3612234B1 (de) | 2017-04-20 | 2024-03-13 | ADC Therapeutics SA | Kombinationstherapie mit anti-axl-antikörper-arzneimittel-konjugat |
| US11685787B2 (en) | 2017-05-16 | 2023-06-27 | Bristol-Myers Squibb Company | Treatment of cancer with anti-GITR agonist antibodies |
| MX2019015042A (es) | 2017-06-14 | 2020-08-06 | Adc Therapeutics Sa | Regimen de dosificacion. |
| EA039276B1 (ru) | 2017-08-18 | 2021-12-27 | Медимьюн Лимитед | Пирролобензодиазепиновые конъюгаты |
| TW201920192A (zh) | 2017-09-20 | 2019-06-01 | 韓商Ｐｈ製藥公司 | 泰蘭他汀（ｔｈａｉｌａｎｓｔａｔｉｎ）類似物 |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| TW202037381A (zh) | 2018-10-24 | 2020-10-16 | 瑞士商赫孚孟拉羅股份公司 | 綴合化學降解誘導劑及使用方法 |
| JP2022513198A (ja) | 2018-12-10 | 2022-02-07 | ジェネンテック， インコーポレイテッド | Ｆｃ含有タンパク質への部位特異的コンジュゲーションのための光架橋性ペプチド |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| WO2024138128A2 (en) | 2022-12-23 | 2024-06-27 | Genentech, Inc. | Cereblon degrader conjugates, and uses thereof |
| WO2024220546A2 (en) | 2023-04-17 | 2024-10-24 | Peak Bio, Inc. | Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates |
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-
2001
- 2001-09-13 CA CA002422033A patent/CA2422033A1/en not_active Abandoned
- 2001-09-13 DE DE60121808T patent/DE60121808T2/de not_active Expired - Lifetime
- 2001-09-13 EP EP01970886A patent/EP1351703B1/de not_active Expired - Lifetime
- 2001-09-13 US US09/951,268 patent/US7855269B2/en not_active Expired - Fee Related
- 2001-09-13 AT AT05028379T patent/ATE460429T1/de not_active IP Right Cessation
- 2001-09-13 EP EP05028379A patent/EP1803733B1/de not_active Expired - Lifetime
- 2001-09-13 DE DE60141546T patent/DE60141546D1/de not_active Expired - Lifetime
- 2001-09-13 JP JP2002526403A patent/JP4908723B2/ja not_active Expired - Fee Related
- 2001-09-13 ES ES01970886T patent/ES2267814T3/es not_active Expired - Lifetime
- 2001-09-13 AU AU2001290837A patent/AU2001290837A1/en not_active Abandoned
- 2001-09-13 DK DK01970886T patent/DK1351703T3/da active
- 2001-09-13 AT AT01970886T patent/ATE333888T1/de active
- 2001-09-13 WO PCT/US2001/028557 patent/WO2002022153A2/en active IP Right Grant
-
2010
- 2010-11-09 US US12/942,302 patent/US20110077207A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110077207A1 (en) | 2011-03-31 |
| CA2422033A1 (en) | 2002-03-21 |
| WO2002022153A3 (en) | 2003-06-19 |
| EP1803733A2 (de) | 2007-07-04 |
| EP1351703B1 (de) | 2006-07-26 |
| DE60121808D1 (de) | 2006-09-07 |
| ATE460429T1 (de) | 2010-03-15 |
| EP1351703A2 (de) | 2003-10-15 |
| US20020085992A1 (en) | 2002-07-04 |
| DE60141546D1 (de) | 2010-04-22 |
| WO2002022153A2 (en) | 2002-03-21 |
| ATE333888T1 (de) | 2006-08-15 |
| JP2004525074A (ja) | 2004-08-19 |
| JP4908723B2 (ja) | 2012-04-04 |
| EP1803733B1 (de) | 2010-03-10 |
| ES2267814T3 (es) | 2007-03-16 |
| US7855269B2 (en) | 2010-12-21 |
| EP1803733A3 (de) | 2007-10-31 |
| DE60121808T2 (de) | 2007-03-29 |
| AU2001290837A1 (en) | 2002-03-26 |
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