DK1007520T3 - 2-aminopyridiner som indeholder sammensluttede ringsubstituenter som NOS inhibitorer - Google Patents

2-aminopyridiner som indeholder sammensluttede ringsubstituenter som NOS inhibitorer

Info

Publication number: DK1007520T3
Authority: DK; Denmark
Prior art keywords: ring substituents; nos inhibitors; linked ring; containing linked; aminopyridines containing
Prior art date: 1997-08-27

Application number

DK98935249T

Other languages

Danish (da)

English (en)

Inventor

John Adams Lowe Iii

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-27

Filing date

1998-08-11

Publication date

2003-11-24

1998-08-11 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2003-11-24 Application granted granted Critical

2003-11-24 Publication of DK1007520T3 publication Critical patent/DK1007520T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Immunology (AREA)
Psychology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK98935249T 1997-08-27 1998-08-11 2-aminopyridiner som indeholder sammensluttede ringsubstituenter som NOS inhibitorer DK1007520T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5709497P	1997-08-27	1997-08-27
PCT/IB1998/001229 WO1999010339A1 (fr)	1997-08-27	1998-08-11	2-aminopyridines contenant des substituants a noyau condense en tant qu'inhibiteurs des nos

Publications (1)

Publication Number	Publication Date
DK1007520T3 true DK1007520T3 (da)	2003-11-24

Family

ID=22008463

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98935249T DK1007520T3 (da)	1997-08-27	1998-08-11	2-aminopyridiner som indeholder sammensluttede ringsubstituenter som NOS inhibitorer

Country Status (40)

Country	Link
EP (1)	EP1007520B1 (fr)
JP (1)	JP3411271B2 (fr)
KR (1)	KR100367277B1 (fr)
CN (1)	CN1268133A (fr)
AP (1)	AP1213A (fr)
AR (1)	AR014110A1 (fr)
AT (1)	ATE248161T1 (fr)
AU (1)	AU8458898A (fr)
BG (1)	BG104138A (fr)
BR (1)	BR9811555A (fr)
CA (1)	CA2296313C (fr)
CO (1)	CO4970728A1 (fr)
DE (1)	DE69817584T2 (fr)
DK (1)	DK1007520T3 (fr)
DZ (1)	DZ2594A1 (fr)
EA (1)	EA003839B1 (fr)
ES (1)	ES2203976T3 (fr)
GT (1)	GT199800128A (fr)
HN (1)	HN1998000118A (fr)
HR (1)	HRP980470A2 (fr)
HU (1)	HUP0003700A3 (fr)
ID (1)	ID24087A (fr)
IL (1)	IL133958A0 (fr)
IS (1)	IS5344A (fr)
MA (1)	MA26537A1 (fr)
NO (1)	NO20000958L (fr)
NZ (1)	NZ502281A (fr)
OA (1)	OA11288A (fr)
PA (1)	PA8456901A1 (fr)
PE (1)	PE106599A1 (fr)
PL (1)	PL338987A1 (fr)
PT (1)	PT1007520E (fr)
SK (1)	SK1402000A3 (fr)
TN (1)	TNSN98154A1 (fr)
TR (1)	TR200000535T2 (fr)
UA (1)	UA55461C2 (fr)
UY (1)	UY25158A1 (fr)
WO (1)	WO1999010339A1 (fr)
YU (1)	YU10900A (fr)
ZA (1)	ZA987726B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20010049379A1 (en)	1997-08-27	2001-12-06	Lowe John Adams	2-aminopyridines containing fused ring substituents
SK15072000A3 (sk)	1998-04-10	2001-08-06	Japan Tobacco Inc.	Amidové zlúčeniny
EA003991B1 (ru) *	1998-06-03	2003-12-25	Пфайзер Продактс Инк.	Производные 2-аминопиридинов, способ ингибирования синтазы оксида азота, фармацевтические композиции и способы лечения
KR20010085364A (ko) *	1998-08-11	2001-09-07	데이비드 존 우드	Ｎｏｓ 억제제에 대한 신규 제약 용도
SK12022001A3 (sk)	1999-02-25	2002-07-02	Pfizer Products Inc.	2-aminopyridíny obsahujúce ako substituenty kondenzované kruhové skupiny
GB0004149D0 (en)	2000-02-23	2000-04-12	Astrazeneca Uk Ltd	Novel compounds
GB0004153D0 (en)	2000-02-23	2000-04-12	Astrazeneca Uk Ltd	Novel use
GB0004152D0 (en) *	2000-02-23	2000-04-12	Astrazeneca Uk Ltd	Novel compounds
GB0004151D0 (en) *	2000-02-23	2000-04-12	Astrazeneca Uk Ltd	Novel use
FR2805818B1 (fr) *	2000-03-03	2002-04-26	Aventis Pharma Sa	Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant
CZ200380A3 (cs) *	2000-08-16	2004-01-14	Pharmacia & Upjohn Company	Sloučeniny pro léčbu poruch spojených se závislostmi
WO2002092084A1 (fr)	2001-05-15	2002-11-21	F. Hoffmann-La Roche Ag	Derives d'oxazole substitues par de l'acide carboxylique utiles en tant qu'activateurs ppar-alpha et gamma dans le traitement du diabete
SE0102640D0 (sv)	2001-07-31	2001-07-31	Astrazeneca Ab	Novel compounds
US20030045449A1 (en) *	2001-08-15	2003-03-06	Pfizer, Inc.	Pharmaceutical combinations for the treatment of neurodegenerative diseases
DE10159922A1 (de) *	2001-12-06	2003-06-26	Gruenenthal Gmbh	Substituierte 2-Pyrrolidin-2-yl-1H-indol-Derivate
EP1519925B1 (fr)	2002-07-03	2007-09-12	F. Hoffmann-La Roche Ag	Derives oxazole et utilisation de ceux-ci en tant que sensibilisateurs a l'insuline
JP2005538187A (ja) *	2002-08-14	2005-12-15	ニューロサーチ、アクティーゼルスカブ	新規キヌクリジン誘導体及びその使用方法
BR0313946A (pt)	2002-08-30	2005-07-12	Hoffmann La Roche	Compostos, processo para a manufatura destes compostos, composições farmacêuticas que compreendem os mesmos, métodos para o tratamento e/ou prevenção de enfermidades que são moduladas por agonistas ppara(alfa) e/ou ppary, utilização dos compostos e/ou do método
CN100577660C (zh)	2002-09-12	2010-01-06	霍夫曼-拉罗奇有限公司	作为ppar激动剂用于治疗糖尿病的n-取代-1h-吲哚-5-丙酸化合物
US20040092741A1 (en) *	2002-11-08	2004-05-13	Pfizer Inc	Substituted pyridines via boronic acid coupling
BR0316556A (pt)	2002-11-25	2005-10-04	Hoffmann La Roche	Compostos, processo para a preparação de um composto, composição farmacêutica que compreende esse composto, sua utilização e método para o tratamento e/ou profilaxia de enfermidades que são moduladas por agonistas ppar(alfa) e/ou ppary
US7160876B2 (en) *	2003-12-22	2007-01-09	Abbott Laboratories	Fused bicycloheterocycle substituted quinuclidine derivatives
EP1824848A1 (fr) *	2004-12-10	2007-08-29	Abbott Laboratories	Derives polycycliques de quinuclidine substitues par un bicycloheterocycle condense
US7655657B2 (en)	2003-12-22	2010-02-02	Abbott Laboratories	Fused bicycloheterocycle substituted quinuclidine derivatives
WO2006010040A2 (fr) *	2004-07-09	2006-01-26	Glaxo Group Limited	Agents antibacteriens
WO2009029617A1 (fr) *	2007-08-27	2009-03-05	Kalypsys, Inc.	Quinolones substituées par diarylamine utiles comme inhibiteurs de l'oxyde nitrique synthase inductible.
WO2009029592A1 (fr) *	2007-08-27	2009-03-05	Kalypsys, Inc.	Quinolones à substitution par reste hétérobicyclique utiles comme inhibiteurs de l'oxyde nitrique synthase.
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
DE102008054141A1 (de)	2008-10-31	2010-05-06	Merck Patent Gmbh	Neue Materialien für organische Elektrolumineszenzvorrichtungen
DE102009033371A1 (de)	2009-07-16	2011-05-12	Merck Patent Gmbh	Materialien für elektronische Vorrichtungen
US9120750B2 (en)	2013-03-07	2015-09-01	Northwestern University	2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
CN104725249B (zh) *	2013-12-20	2019-02-12	广东东阳光药业有限公司	苄胺类衍生物及其在药物上的应用
US10759791B2 (en)	2014-11-04	2020-09-01	Northwestern University	Mammalian and bacterial nitric oxide synthase inhibitors
WO2016073623A2 (fr)	2014-11-04	2016-05-12	Northwestern University	Inhibiteurs d'oxyde nitrique synthase d'origine bactérienne et mammalienne
CN106478376A (zh) *	2016-10-08	2017-03-08	贵州大学	一种4‑氟萘‑1‑醇的制备工艺
US20220073501A1 (en) *	2018-12-17	2022-03-10	Godavari Biorefineries Limited	Compounds for the inhibition of unregulated cell growth
CN114560779B (zh) *	2022-01-25	2024-06-25	杭州华东医药集团浙江华义制药有限公司	一种米拉贝隆关键中间体的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT400845B (de) *	1993-12-06	1996-03-25	Chem Pharm Forsch Gmbh	Neue thienothiazinderivate, ein verfahren zu ihrer herstellung und ihre verwendung
WO1996018616A1 (fr) *	1994-12-12	1996-06-20	Merck & Co., Inc.	2-aminopyridines substituees utilisees comme inhibiteurs de synthase d'oxyde d'azote
JPH08311028A (ja) *	1995-05-17	1996-11-26	Japan Tobacco Inc	２−アミノピリジン誘導体及びそれら化合物を含有してなる一酸化窒素合成酵素阻害剤
JPH09132529A (ja) *	1995-11-09	1997-05-20	Ono Pharmaceut Co Ltd	一酸化窒素合成酵素阻害剤
DK0891332T3 (da) *	1996-03-29	2004-07-05	Pfizer	6-phenylpyridyl-2-aminderivater
HN1997000027A (es) *	1996-12-06	1997-06-05	Pfizer Prod Inc	Derivados de 6-fenil piridil - 2 amina

1998
- 1998-07-29 HN HN1998000118A patent/HN1998000118A/es unknown
- 1998-08-10 PA PA19988456901A patent/PA8456901A1/es unknown
- 1998-08-10 GT GT199800128A patent/GT199800128A/es unknown
- 1998-08-11 AT AT98935249T patent/ATE248161T1/de not_active IP Right Cessation
- 1998-08-11 CN CN98808577A patent/CN1268133A/zh active Pending
- 1998-08-11 YU YU10900A patent/YU10900A/sh unknown
- 1998-08-11 DE DE69817584T patent/DE69817584T2/de not_active Expired - Fee Related
- 1998-08-11 HU HU0003700A patent/HUP0003700A3/hu unknown
- 1998-08-11 DK DK98935249T patent/DK1007520T3/da active
- 1998-08-11 EA EA200000171A patent/EA003839B1/ru not_active IP Right Cessation
- 1998-08-11 EP EP98935249A patent/EP1007520B1/fr not_active Expired - Lifetime
- 1998-08-11 BR BR9811555-3A patent/BR9811555A/pt not_active Application Discontinuation
- 1998-08-11 AU AU84588/98A patent/AU8458898A/en not_active Abandoned
- 1998-08-11 JP JP2000507668A patent/JP3411271B2/ja not_active Expired - Fee Related
- 1998-08-11 CA CA002296313A patent/CA2296313C/fr not_active Expired - Fee Related
- 1998-08-11 ID IDW20000198A patent/ID24087A/id unknown
- 1998-08-11 WO PCT/IB1998/001229 patent/WO1999010339A1/fr not_active Application Discontinuation
- 1998-08-11 PL PL98338987A patent/PL338987A1/xx unknown
- 1998-08-11 IL IL13395898A patent/IL133958A0/xx unknown
- 1998-08-11 ES ES98935249T patent/ES2203976T3/es not_active Expired - Lifetime
- 1998-08-11 NZ NZ502281A patent/NZ502281A/xx unknown
- 1998-08-11 SK SK140-2000A patent/SK1402000A3/sk unknown
- 1998-08-11 PT PT98935249T patent/PT1007520E/pt unknown
- 1998-08-11 KR KR10-2000-7001017A patent/KR100367277B1/ko not_active IP Right Cessation
- 1998-08-11 TR TR2000/00535T patent/TR200000535T2/xx unknown
- 1998-08-24 PE PE1998000772A patent/PE106599A1/es not_active Application Discontinuation
- 1998-08-25 AR ARP980104224A patent/AR014110A1/es not_active Application Discontinuation
- 1998-08-26 ZA ZA9807726A patent/ZA987726B/xx unknown
- 1998-08-26 TN TNTNSN98154A patent/TNSN98154A1/fr unknown
- 1998-08-26 DZ DZ980204A patent/DZ2594A1/fr active
- 1998-08-26 MA MA25229A patent/MA26537A1/fr unknown
- 1998-08-26 UY UY25158A patent/UY25158A1/es unknown
- 1998-08-27 HR HR60/057,094A patent/HRP980470A2/hr not_active Application Discontinuation
- 1998-08-27 CO CO98049140A patent/CO4970728A1/es unknown
- 1998-08-27 AP APAP/P/1998/001330A patent/AP1213A/en active
- 1998-11-08 UA UA2000010298A patent/UA55461C2/uk unknown
2000
- 2000-01-14 IS IS5344A patent/IS5344A/is unknown
- 2000-02-08 BG BG104138A patent/BG104138A/xx unknown
- 2000-02-18 OA OA1200000037A patent/OA11288A/en unknown
- 2000-02-25 NO NO20000958A patent/NO20000958L/no unknown

Also Published As

Publication number	Publication date
EP1007520B1 (fr)	2003-08-27
HN1998000118A (es)	1999-02-09
GT199800128A (es)	2000-02-01
JP2001514176A (ja)	2001-09-11
HUP0003700A3 (en)	2002-09-30
ID24087A (id)	2000-07-06
BR9811555A (pt)	2000-09-12
JP3411271B2 (ja)	2003-05-26
TR200000535T2 (tr)	2000-11-21
HRP980470A2 (en)	1999-06-30
DE69817584D1 (de)	2003-10-02
KR20010022433A (ko)	2001-03-15
AU8458898A (en)	1999-03-16
UA55461C2 (uk)	2003-04-15
IS5344A (is)	2000-01-14
ZA987726B (en)	2000-02-28
KR100367277B1 (ko)	2003-01-09
SK1402000A3 (en)	2000-07-11
AP1213A (en)	2003-10-07
EA003839B1 (ru)	2003-10-30
TNSN98154A1 (fr)	2005-03-15
CN1268133A (zh)	2000-09-27
EA200000171A1 (ru)	2000-10-30
PE106599A1 (es)	1999-11-02
HUP0003700A2 (hu)	2001-10-28
YU10900A (sh)	2002-12-10
CO4970728A1 (es)	2000-11-07
WO1999010339A1 (fr)	1999-03-04
IL133958A0 (en)	2001-04-30
DZ2594A1 (fr)	2003-02-22
EP1007520A1 (fr)	2000-06-14
PT1007520E (pt)	2003-12-31
DE69817584T2 (de)	2004-04-01
NZ502281A (en)	2002-09-27
MA26537A1 (fr)	2004-12-20
NO20000958D0 (no)	2000-02-25
UY25158A1 (es)	2000-12-29
ATE248161T1 (de)	2003-09-15
PA8456901A1 (es)	2000-05-24
ES2203976T3 (es)	2004-04-16
AP9801330A0 (en)	1998-09-30
BG104138A (en)	2000-11-30
NO20000958L (no)	2000-04-14
AR014110A1 (es)	2001-02-07
PL338987A1 (en)	2000-12-04
OA11288A (en)	2003-08-22
CA2296313C (fr)	2004-11-02
CA2296313A1 (fr)	1999-03-04

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