DK0902789T3 - Androstenderivater - Google Patents

Androstenderivater

Info

Publication number: DK0902789T3
Authority: DK; Denmark
Prior art keywords: beta; androstene; hydroxyandrosta; androstenes; dichloroacetoxy
Prior art date: 1996-05-09

Application number

DK97921345T

Other languages

English (en)

Inventor

Nicholas S Bodor

Original Assignee

Soft Drugs Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-09

Filing date

1997-05-01

Publication date

2002-05-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21780726&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0902789(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-05-01 Application filed by Soft Drugs Inc filed Critical Soft Drugs Inc

2002-05-06 Application granted granted Critical

2002-05-06 Publication of DK0902789T3 publication Critical patent/DK0902789T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK97921345T 1996-05-09 1997-05-01 Androstenderivater DK0902789T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1710296P	1996-05-09	1996-05-09
PCT/US1997/006812 WO1997042214A1 (en)	1996-05-09	1997-05-01	Androstene derivatives

Publications (1)

Publication Number	Publication Date
DK0902789T3 true DK0902789T3 (da)	2002-05-06

Family

ID=21780726

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97921345T DK0902789T3 (da)	1996-05-09	1997-05-01	Androstenderivater

Country Status (20)

Country	Link
US (1)	US5981517A (da)
EP (1)	EP0902789B1 (da)
JP (1)	JP3328938B2 (da)
CN (1)	CN1144812C (da)
AT (1)	ATE212351T1 (da)
AU (1)	AU721622B2 (da)
BR (1)	BR9709062A (da)
CA (1)	CA2254079C (da)
CZ (1)	CZ292860B6 (da)
DE (1)	DE69710065T2 (da)
DK (1)	DK0902789T3 (da)
ES (1)	ES2171933T3 (da)
HK (1)	HK1021539A1 (da)
HU (1)	HUP9902449A3 (da)
NO (2)	NO311646B1 (da)
NZ (1)	NZ332608A (da)
PL (1)	PL186637B1 (da)
PT (1)	PT902789E (da)
RU (1)	RU2194053C2 (da)
WO (1)	WO1997042214A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001066561A1 (fr) *	2000-03-09	2001-09-13	Kissei Pharmaceutical Co., Ltd.	Medicaments preventifs ou therapeutiques contre des maladies des yeux
US6777399B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) *	2000-08-05	2000-09-27	Glaxo Group Ltd	Novel compounds
US6759398B2 (en) *	2000-08-05	2004-07-06	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative
US6858593B2 (en) *	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6750210B2 (en) *	2000-08-05	2004-06-15	Smithkline Beecham Corporation	Formulation containing novel anti-inflammatory androstane derivative
US6858596B2 (en) *	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivative
US6777400B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6787532B2 (en) *	2000-08-05	2004-09-07	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivatives
AU7576001A (en) *	2000-08-05	2002-02-18	Glaxo Group Ltd	6.alpha., 9.alpha.-difluoro-17.alpha.-`(2-furanylcarboxyl) oxy]-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothioic acid s-fluoromethyl ester as an anti-inflammatory agent
CA2427569C (en) *	2000-11-03	2010-07-27	Matrix Therapeutics Limited	Selective glucocorticoid receptor agonists
UA77656C2 (en) *	2001-04-07	2007-01-15	Glaxo Group Ltd	S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
MY137522A (en) *	2001-04-30	2009-02-27	Glaxo Group Ltd	Novel anti-inflammatory androstane derivatives.
US20040248867A1 (en) *	2001-06-12	2004-12-09	Keith Biggadike	Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives
US20050175545A1 (en) *	2002-02-04	2005-08-11	Keith Biggadike	Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) *	2002-02-05	2002-03-20	Glaxo Wellcome Mfg Pte Ltd	Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en)	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
WO2005000317A1 (en) *	2003-06-19	2005-01-06	Bodor Nicholas S	Enhancement of activity and/or duration of action of soft anti-inflammatory steroids for topical or other local application
CA2558941C (en) *	2003-06-19	2012-05-15	Nicholas S. Bodor	Enhancement of activity and/or duration of action of selected anti-inflammatory steroids
EP1684767A1 (en) *	2003-11-03	2006-08-02	Norton Healthcare Limited	Soft steroid compositions for use in dry powder inhalers
GB0507165D0 (en) *	2005-04-08	2005-05-18	Glaxo Group Ltd	Novel crystalline pharmaceutical product
TWI374147B (en) *	2006-01-27	2012-10-11	Sun Pharma Advance Res Company Ltd	Novel 11β-hydroxyandrosta-4-ene-3-ones
US7691811B2 (en) *	2006-05-25	2010-04-06	Bodor Nicholas S	Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
US7687484B2 (en) *	2006-05-25	2010-03-30	Bodor Nicholas S	Transporter enhanced corticosteroid activity
GB0615108D0 (en) *	2006-07-28	2006-09-06	Glaxo Group Ltd	Novel formulations
EP3638249A1 (en) *	2017-06-13	2020-04-22	Bodor Laboratories, Inc.	Potent soft anti-inflammatory corticosteroid compounds and uses thereof
CN111100176A (zh) *	2019-12-20	2020-05-05	重庆华邦胜凯制药有限公司	一种化合物的制备方法
WO2024149093A1 (zh) *	2023-01-10	2024-07-18	四川科伦博泰生物医药股份有限公司	糖皮质激素受体激动剂及其偶联物

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE135476C (da) *
US3258473A (en) *	1963-10-04	1966-06-28	Syntex Corp	17-dihaloacetate esters of 17alpha-hydroxy-21-desoxypregnane derivatives
US3636010A (en) *	1968-12-23	1972-01-18	Ciba Geigy Corp	Esters of steroid-17-carboxylic acids
GB1384372A (en) *	1971-01-20	1975-02-19	Glaxo Lab Ltd	Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
US3828080A (en) *	1972-01-20	1974-08-06	Glaxo Lab Ltd	Androstane-17beta-carboxylic acids and processes for the preparation thereof
GB1438940A (en) *	1972-07-19	1976-06-09	Glaxo Lab Ltd	17beta-haloalkoxycarbonyl-17alpha-oxysteroids
US4093721A (en) *	1974-08-30	1978-06-06	Glaxo Laboratories Limited	Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof
CH628355A5 (de) *	1976-02-24	1982-02-26	Ciba Geigy Ag	Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.
GB2014579B (en) *	1978-02-08	1982-08-25	Glaxo Group Ltd	Chloromethyl 17 acetoxy fluoro hydroxy 16 methyl 3 oxoandrosta 1,4 diene 17 carboxylate
US4198403A (en) *	1978-04-05	1980-04-15	Syntex (U.S.A.) Inc.	17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes
US4263289A (en) *	1978-04-05	1981-04-21	Syntex (U.S.A.) Inc.	Thio etianic acid derivatives
US4188385A (en) *	1978-04-05	1980-02-12	Syntex (U.S.A.) Inc.	Thioetianic acid derivatives
JPS56138200A (en) *	1980-02-15	1981-10-28	Glaxo Group Ltd	Androstane carbothioate compound
US4578221A (en) *	1980-04-23	1986-03-25	Glaxo Group Limited	Androstane carbothioic acids
US4996335A (en) *	1980-07-10	1991-02-26	Nicholas S. Bodor	Soft steroids having anti-inflammatory activity
US4710495A (en) *	1980-07-10	1987-12-01	Otsuka Pharmaceutical Co., Ltd.	Soft steroids having anti-inflammatory activity
US4607028A (en) *	1983-08-18	1986-08-19	Ciba-Geigy Corporation	Novel carboxylic acid esters
FR2551069B1 (fr) *	1983-08-26	1986-07-25	Jouveinal Sa	17-oxo-21-thioesters d'hydrocortisone, leur preparation et leurs applications comme medicament
JPS617291A (ja) *	1984-06-20	1986-01-13	Mitsubishi Chem Ind Ltd	新規なコルチコイド誘導体およびその製法
PT78973A (en) *	1984-07-25	1984-08-01	Joao Emerico Villax	New preparation process of the 9alpha-fluoro 17,21-acylates or hidroxilades in 17 and 21 chloro-corticosteroid
US5223493A (en) *	1984-12-28	1993-06-29	Alcon Laboratories, Inc.	Anti-inflammatory compounds for ophthalmic use
DE4025342A1 (de) *	1990-08-10	1992-02-13	Hoechst Ag	In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel

1997
- 1997-04-24 US US08/840,038 patent/US5981517A/en not_active Expired - Fee Related
- 1997-05-01 CA CA002254079A patent/CA2254079C/en not_active Expired - Fee Related
- 1997-05-01 PL PL97329802A patent/PL186637B1/pl not_active IP Right Cessation
- 1997-05-01 HU HU9902449A patent/HUP9902449A3/hu unknown
- 1997-05-01 AU AU27407/97A patent/AU721622B2/en not_active Ceased
- 1997-05-01 RU RU98122210/04A patent/RU2194053C2/ru not_active IP Right Cessation
- 1997-05-01 JP JP53994997A patent/JP3328938B2/ja not_active Expired - Fee Related
- 1997-05-01 BR BR9709062-0A patent/BR9709062A/pt not_active IP Right Cessation
- 1997-05-01 EP EP97921345A patent/EP0902789B1/en not_active Expired - Lifetime
- 1997-05-01 NZ NZ332608A patent/NZ332608A/xx unknown
- 1997-05-01 DE DE69710065T patent/DE69710065T2/de not_active Expired - Fee Related
- 1997-05-01 ES ES97921345T patent/ES2171933T3/es not_active Expired - Lifetime
- 1997-05-01 CN CNB971960755A patent/CN1144812C/zh not_active Expired - Fee Related
- 1997-05-01 DK DK97921345T patent/DK0902789T3/da active
- 1997-05-01 PT PT97921345T patent/PT902789E/pt unknown
- 1997-05-01 AT AT97921345T patent/ATE212351T1/de not_active IP Right Cessation
- 1997-05-01 WO PCT/US1997/006812 patent/WO1997042214A1/en active IP Right Grant
- 1997-05-01 CZ CZ19983616A patent/CZ292860B6/cs not_active IP Right Cessation
1998
- 1998-11-09 NO NO19985232A patent/NO311646B1/no unknown
2000
- 2000-01-27 HK HK00100515A patent/HK1021539A1/xx not_active IP Right Cessation
2001
- 2001-11-27 NO NO20015790A patent/NO315425B1/no unknown

Also Published As

Publication number	Publication date
WO1997042214A1 (en)	1997-11-13
CN1224429A (zh)	1999-07-28
CA2254079C (en)	2004-09-14
EP0902789B1 (en)	2002-01-23
CZ292860B6 (cs)	2003-12-17
NZ332608A (en)	2000-01-28
NO311646B1 (no)	2001-12-27
DE69710065T2 (de)	2002-08-29
US5981517A (en)	1999-11-09
HUP9902449A3 (en)	2000-03-28
DE69710065D1 (de)	2002-03-14
HUP9902449A2 (hu)	1999-11-29
RU2194053C2 (ru)	2002-12-10
JP2000509716A (ja)	2000-08-02
AU2740797A (en)	1997-11-26
CZ361698A3 (cs)	1999-03-17
NO985232D0 (no)	1998-11-09
PT902789E (pt)	2002-07-31
ES2171933T3 (es)	2002-09-16
BR9709062A (pt)	2000-01-04
NO20015790L (no)	1998-05-04
JP3328938B2 (ja)	2002-09-30
PL186637B1 (pl)	2004-02-27
CN1144812C (zh)	2004-04-07
EP0902789A1 (en)	1999-03-24
NO985232L (no)	1998-12-04
AU721622B2 (en)	2000-07-13
EP0902789A4 (da)	1999-04-14
NO20015790D0 (no)	2001-11-27
HK1021539A1 (en)	2000-06-16
PL329802A1 (en)	1999-04-12
ATE212351T1 (de)	2002-02-15
NO315425B1 (no)	2003-09-01
CA2254079A1 (en)	1997-11-13

Publication	Publication Date	Title
DK0902789T3 (da)	2002-05-06	Androstenderivater
NO971889D0 (no)	1997-04-24	Forbindelser og sammensetninger for levering av aktive midler
SE9504661D0 (sv)	1995-12-22	New compounds
FI973828A0 (fi)	1997-09-29	Yhdisteitä ja koostumuksia aktiivisten aineiden annostelemiseksi
EE9800223A (et)	1998-12-15	Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine
TR199901417T2 (xx)	1999-10-21	Analjezik etkisi olan yeni bile�imler.
ATE308327T1 (de)	2005-11-15	Verwendung von 2-hydroxy-5-phenylazobenzoesäure- derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs
FI972308A0 (fi)	1997-05-30	2-substituoituja 1,2,5-tiadiatsolidin-3-oni-1,1-dioksideja ja niitä sisältäviä koostumuksia ja menetelmiä niiden käyttämiseksi
DE69919179D1 (de)	2004-09-09	Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen
SE9201628D0 (sv)	1992-05-22	Pharmaceutical composition
SE9802208D0 (sv)	1998-06-22	Novel compounds
HUP9602498A2 (hu)	1998-04-28	Antimikrobiális hatású gyógyászati készítmények
ATE267187T1 (de)	2004-06-15	Als entzündungshemmende mittel nützliche dihydrobenzofurane und verwandte verbindungen
DK0556322T3 (da)	1996-10-14	Aminosulfonylurinstof-ACAT-inhibitorer
DK0773782T3 (da)	2001-06-25	Terpenderivater (sarcodictyiner) anvendelse som antitumormidler
SE9802209D0 (sv)	1998-06-22	Novel compounds
SE9504662D0 (sv)	1995-12-22	New compounds
PL339073A1 (en)	2000-12-04	Derivatives of benzoxazine and benzothiazine and their application in therapeutic agents
GEP20032975B (en)	2003-05-27	Echinocandin Derivatives, Preparation Method and Pharmaceutical Composition