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DE68905365D1 - BENZODIAZEPINES, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE. - Google Patents

BENZODIAZEPINES, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE.

Info

Publication number
DE68905365D1
DE68905365D1 DE8989400969T DE68905365T DE68905365D1 DE 68905365 D1 DE68905365 D1 DE 68905365D1 DE 8989400969 T DE8989400969 T DE 8989400969T DE 68905365 T DE68905365 T DE 68905365T DE 68905365 D1 DE68905365 D1 DE 68905365D1
Authority
DE
Germany
Prior art keywords
benzodiazepines
production
methods
therapeutic use
intermediate products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989400969T
Other languages
German (de)
Other versions
DE68905365T2 (en
Inventor
Alain Pierre Calvet
Jean-Louis Junien
Yves Robert Alain Pascal
Xavier Bernard Louis Pascaud
Francois Joseph Roman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jouveinal SA
Original Assignee
Jouveinal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jouveinal SA filed Critical Jouveinal SA
Publication of DE68905365D1 publication Critical patent/DE68905365D1/en
Application granted granted Critical
Publication of DE68905365T2 publication Critical patent/DE68905365T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)

Abstract

Benzodiazepines of formula <IMAGE> (I) in which R1 is H of halogen, R2 is H or halogen, Ar is indolyl, phenyl, naphthyl, indolyl monosubstituted with a halogen or with a methoxy or phenyl mono-, di- or trisubstituted with a halogen or with a methoxy or with a trifluoromethyl group, and n is 2 or 3; and their optical isomers.
DE89400969T 1988-04-25 1989-04-07 Benzodiazepines, processes and intermediates for their preparation and their therapeutic use. Expired - Fee Related DE68905365T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8805443A FR2630440B1 (en) 1988-04-25 1988-04-25 BENZODIAZEPINES, THEIR PREPARATION PROCESS AND INTERMEDIATES AND THEIR THERAPEUTIC APPLICATIONS

Publications (2)

Publication Number Publication Date
DE68905365D1 true DE68905365D1 (en) 1993-04-22
DE68905365T2 DE68905365T2 (en) 1993-10-14

Family

ID=9365634

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89400969T Expired - Fee Related DE68905365T2 (en) 1988-04-25 1989-04-07 Benzodiazepines, processes and intermediates for their preparation and their therapeutic use.

Country Status (19)

Country Link
US (1) US4929614A (en)
EP (1) EP0340064B1 (en)
JP (1) JP2805634B2 (en)
KR (1) KR0142328B1 (en)
AT (1) ATE86995T1 (en)
AU (1) AU618086B2 (en)
CA (1) CA1340074C (en)
DE (1) DE68905365T2 (en)
DK (1) DK172664B1 (en)
ES (1) ES2054045T3 (en)
FI (1) FI91409C (en)
FR (1) FR2630440B1 (en)
HK (1) HK95496A (en)
IE (1) IE62663B1 (en)
IS (1) IS3454A7 (en)
NO (1) NO169653C (en)
NZ (1) NZ228650A (en)
PT (1) PT90339B (en)
ZA (1) ZA892682B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5248679A (en) * 1988-09-09 1993-09-28 Fujisawa Pharmaceutical Co., Ltd. Tricyclic compounds
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same
IL93401A (en) * 1989-03-08 1994-08-26 Kali Chemie Pharma Gmbh 1,7-fused 1h-indole-2-carboxylic acid n-(1,4-benzodiazepin-3-yl)amides, their preparation and medicaments comprising them
FR2652352A1 (en) * 1989-09-28 1991-03-29 Jouveinal Sa BENZODIAZEPINES, THEIR PROCESS AND PREPARATION INTERMEDIATES AND THEIR THERAPEUTIC APPLICATIONS.
IE904560A1 (en) * 1989-12-18 1991-06-19 Merck & Co Inc New benzodiazepine analogs
GB9018601D0 (en) * 1990-08-24 1990-10-10 Fujisawa Pharmaceutical Co Tricyclic compounds
US5206238A (en) * 1990-11-13 1993-04-27 Merck & Co., Inc. Cholecystokinin antagonists
CA2056809A1 (en) * 1990-12-07 1992-06-08 Mark G. Bock Benzodiazepine analogs
CA2157383A1 (en) * 1993-03-03 1994-09-15 Shinichi Fukuyama Optical isomerization inhibitor
IL115089A0 (en) * 1994-08-30 1995-12-08 Fujisawa Pharmaceutical Co A liposome preparation containing a tricyclic compound and process for the preparation thereof
FR2725719B1 (en) * 1994-10-14 1996-12-06 Jouveinal Inst Rech DIAZEPINO-INDOLES IV PHOSPHODIESTERASE INHIBITORS
FR2776660B1 (en) * 1998-03-27 2000-05-12 Parke Davis DIAZEPINO-INDOLES OF PHOSPHODIESTERASES IV
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
US6864092B1 (en) * 1998-08-13 2005-03-08 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
IL142816A0 (en) * 1998-12-24 2002-03-10 Du Pont Pharm Co SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
EP1218377A1 (en) * 1999-10-08 2002-07-03 Bristol-Myers Squibb Pharma Company AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION
CA2395862A1 (en) * 2000-02-17 2001-08-23 Hong Liu Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production
IL151576A0 (en) 2000-04-03 2003-04-10 Bristol Myers Squibb Pharma Co Cyclic lactams as inhibitors of a-beta protein production
US6692708B2 (en) * 2001-04-05 2004-02-17 Symyx Technologies, Inc. Parallel reactor for sampling and conducting in situ flow-through reactions and a method of using same
KR101155335B1 (en) * 2005-01-07 2012-06-11 엘지전자 주식회사 Multimedia message service operating method for mobile communication terminal

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same
FR2652352A1 (en) * 1989-09-28 1991-03-29 Jouveinal Sa BENZODIAZEPINES, THEIR PROCESS AND PREPARATION INTERMEDIATES AND THEIR THERAPEUTIC APPLICATIONS.

Also Published As

Publication number Publication date
NZ228650A (en) 1990-12-21
NO169653C (en) 1992-07-22
HK95496A (en) 1996-06-07
PT90339B (en) 1994-08-31
US4929614A (en) 1990-05-29
EP0340064B1 (en) 1993-03-17
IE891067L (en) 1989-10-25
CA1340074C (en) 1998-10-06
ZA892682B (en) 1990-12-28
JP2805634B2 (en) 1998-09-30
ATE86995T1 (en) 1993-04-15
JPH0215083A (en) 1990-01-18
PT90339A (en) 1989-11-10
KR900016158A (en) 1990-11-12
AU3302589A (en) 1989-10-26
KR0142328B1 (en) 1998-06-01
NO891692L (en) 1989-10-26
IE62663B1 (en) 1995-02-22
DK172664B1 (en) 1999-05-10
AU618086B2 (en) 1991-12-12
NO891692D0 (en) 1989-04-24
FI91409B (en) 1994-03-15
FR2630440A1 (en) 1989-10-27
EP0340064A1 (en) 1989-11-02
ES2054045T3 (en) 1994-08-01
IS3454A7 (en) 1989-10-26
FI91409C (en) 1994-06-27
FI891952A (en) 1989-10-26
DK197289A (en) 1989-10-26
DK197289D0 (en) 1989-04-24
DE68905365T2 (en) 1993-10-14
NO169653B (en) 1992-04-13
FI891952A0 (en) 1989-04-25
FR2630440B1 (en) 1991-09-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: HANSMANN & VOGESER, 81369 MUENCHEN

8339 Ceased/non-payment of the annual fee