DE60223278D1 - Nicotin- oder isonicotin benzothiazole derivaten - Google Patents

Nicotin- oder isonicotin benzothiazole derivaten

Info

Publication number: DE60223278D1
Authority: DE; Germany
Prior art keywords: isonicotin; nicotine; benzothiazole derivatives; benzothiazole; derivatives
Prior art date: 2001-11-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60223278T

Other languages

English (en)

Other versions

DE60223278T2 (de

Inventor

Alexander Flohr

Roland Jakob-Roetne

Roger David Norcross

Claus Riemer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

F Hoffmann La Roche AG

Original Assignee

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-19

Filing date

2002-11-11

Publication date

2007-12-13

2002-11-11 Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG

2007-12-13 Publication of DE60223278D1 publication Critical patent/DE60223278D1/de

2008-08-14 Application granted granted Critical

2008-08-14 Publication of DE60223278T2 publication Critical patent/DE60223278T2/de

2022-11-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE60223278T 2001-11-19 2002-11-11 Nicotin- oder isonicotin benzothiazole derivaten Expired - Lifetime DE60223278T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP01127312		2001-11-19
EP01127312		2001-11-19
PCT/EP2002/012562 WO2003043636A1 (en)	2001-11-19	2002-11-11	Nicotin-or isonicotin benzothiazole derivatives

Publications (2)

Publication Number	Publication Date
DE60223278D1 true DE60223278D1 (de)	2007-12-13
DE60223278T2 DE60223278T2 (de)	2008-08-14

Family

ID=8179263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60223278T Expired - Lifetime DE60223278T2 (de)	2001-11-19	2002-11-11	Nicotin- oder isonicotin benzothiazole derivaten

Country Status (38)

Country	Link
US (1)	US6620811B2 (de)
EP (1)	EP1448198B1 (de)
JP (1)	JP4226474B2 (de)
KR (1)	KR100577110B1 (de)
CN (1)	CN100546580C (de)
AR (1)	AR039367A1 (de)
AT (1)	ATE376831T1 (de)
AU (1)	AU2002351955B2 (de)
BR (1)	BR0214245A (de)
CA (1)	CA2467552C (de)
DE (1)	DE60223278T2 (de)
DK (1)	DK1448198T3 (de)
EA (1)	EA007502B1 (de)
EC (1)	ECSP045109A (de)
ES (1)	ES2294187T3 (de)
GT (1)	GT200200232A (de)
HR (1)	HRP20040396A2 (de)
HU (1)	HUP0402161A3 (de)
IL (2)	IL161623A0 (de)
JO (1)	JO2290B1 (de)
MA (1)	MA27083A1 (de)
MX (1)	MXPA04004684A (de)
MY (1)	MY126176A (de)
NO (1)	NO20042576L (de)
NZ (1)	NZ532802A (de)
PA (1)	PA8558001A1 (de)
PE (1)	PE20030713A1 (de)
PL (1)	PL369517A1 (de)
PT (1)	PT1448198E (de)
RS (1)	RS39904A (de)
RU (1)	RU2294933C2 (de)
SI (1)	SI1448198T1 (de)
TN (1)	TNSN04087A1 (de)
TW (1)	TW200407134A (de)
UA (1)	UA77462C2 (de)
UY (1)	UY27542A1 (de)
WO (1)	WO2003043636A1 (de)
ZA (1)	ZA200403817B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1303272T1 (sl) *	2000-06-21	2008-06-30	Hoffmann La Roche	Derivati benzotiazola za zdravljenje alzheimerjeve bolezni in parkinsonove bolezni
PT2266558T (pt) *	2001-06-07	2017-07-21	Analgesic Neuropharmaceuticals Llc	Tratamento da dor neuropática com o antagonista dos recetores de n-metil-d-aspartato (nmda) dextrometorfano
US6734179B2 (en) *	2001-12-12	2004-05-11	Hoffmann-La Roche Inc.	Benzothiazoles
US7390813B1 (en)	2001-12-21	2008-06-24	Xenon Pharmaceuticals Inc.	Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
US20050119251A1 (en) *	2001-12-21	2005-06-02	Jian-Min Fu	Nicotinamide derivatives and their use as therapeutic agents
US6872833B2 (en)	2003-04-14	2005-03-29	Hoffmann-La Roche Inc.	Adenosine receptor ligands
CN1826121B (zh) *	2003-07-23	2013-05-29	幸讬制药公司	苯基与吡啶基衍生物用于制备调控钙离子释放活化钙离子通道的药物的用途
WO2005011655A2 (en)	2003-07-30	2005-02-10	Xenon Pharmaceuticals Inc.	Pyridazine derivatives and their use as therapeutic agents
CN1871244A (zh) *	2003-09-19	2006-11-29	弗·哈夫曼-拉罗切有限公司	作为腺苷受体配体的噻唑并吡啶衍生物
CA2543707A1 (en)	2003-10-31	2005-05-19	Takeda Pharmaceutical Company Limited	Nitrogen-containing fused heterocyclic compounds
CN1902196B (zh)	2003-12-26	2010-12-29	协和发酵麒麟株式会社	噻唑衍生物
AU2004321997A1 (en) *	2004-07-06	2006-02-09	Xenon Pharmaceuticals Inc.	Nicotinamide derivatives and their use as therapeutic agents
KR100823799B1 (ko) *	2004-07-22	2008-04-21	에프. 호프만-라 로슈 아게	벤조티아졸 유도체
BRPI0513510A (pt)	2004-07-22	2008-05-06	Hoffmann La Roche	benzotiazóis substituìdos
MX2007000638A (es) *	2004-07-22	2007-03-07	Hoffmann La Roche	Derivados de benzotiazol.
JP5043668B2 (ja) *	2004-09-20	2012-10-10	ゼノン・ファーマシューティカルズ・インコーポレイテッド	複素環誘導体および治療薬としてのそれらの使用
TW200626155A (en) *	2004-09-20	2006-08-01	Xenon Pharmaceuticals Inc	Heterocyclic derivatives and their use as therapeutic agents
EP1804792A1 (de) *	2004-09-20	2007-07-11	Xenon Pharmaceuticals Inc.	Bicyclische heterocyclische derivate und ihre verwendung als hemmer von stearoyl-coa-desaturase (scd)
MX2007003318A (es)	2004-09-20	2007-05-18	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como agentes terapeuticos.
AR051093A1 (es) *	2004-09-20	2006-12-20	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de estearoil-coa desaturasa
TW200626572A (en) *	2004-09-20	2006-08-01	Xenon Pharmaceuticals Inc	Heterocyclic derivatives and their use as therapeutic agents
MX2007003330A (es) *	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como agentes terapeuticos.
WO2006034441A1 (en) *	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
WO2006034440A2 (en) *	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
WO2006048172A1 (en) *	2004-11-05	2006-05-11	F. Hoffmann-La Roche Ag	Process for preparation of isonicotinic acid derivatives
ES2400287T3 (es) *	2005-03-14	2013-04-08	High Point Pharmaceuticals, Llc	Derivados de benzazol, composiciones y procedimientos de uso como inhibidores de beta-secretasa
MX2007015216A (es) *	2005-06-03	2008-02-22	Xenon Pharmaceuticals Inc	Derivados de aminotiazol y sus usos como agentes terapeuticos.
KR20090064478A (ko) *	2006-11-13	2009-06-18	화이자 프로덕츠 인크.	디아릴, 디피리디닐 및 아릴-피리디닐 유도체, 및 이들의 용도
CA2758961A1 (en)	2009-04-27	2010-11-04	High Point Pharmaceuticals, Llc	Substituted isoquinoline derivatives, pharmaceutical compositions, and methods of use as .beta.-secretase inhibitors
TWI548411B (zh)	2009-04-28	2016-09-11	Kyowa Hakko Kirin Co Ltd	Exercise disorder treatment
UA113383C2 (xx)	2009-09-02	2017-01-25		Терапевтичний агент для лікування тривожних розладів
UA110097C2 (uk)	2009-09-02	2015-11-25		Терапевтичний агент для лікування розладів настрою
US8450354B2 (en) *	2010-03-23	2013-05-28	High Point Pharmaceuticals, Llc	Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors
JP5248585B2 (ja) *	2010-12-15	2013-07-31	ゼノン・ファーマシューティカルズ・インコーポレイテッド	治療薬としてのニコチンアミド誘導体およびそれらの使用
DE102011005232A1 (de)	2011-03-08	2012-09-13	AristoCon GmbH & Co. KG	Adenosin und seine Derivate zur Verwendung in der Schmerztherapie
CN107434803B (zh) *	2012-10-02	2020-05-05	吉利德科学公司	组蛋白去甲基化酶抑制剂
WO2020103930A1 (zh) *	2018-11-22	2020-05-28	上海科技大学	噻唑并环类化合物、其制备方法、中间体和应用
DE102019110904B4 (de) *	2019-04-26	2022-01-20	Helmholtz-Zentrum Dresden - Rossendorf E. V.	N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-acetamid-Derivate und deren Verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3374550D1 (en)	1982-12-21	1987-12-23	Johnsen Jorgensen Plastics Ltd	Dispensing container
FI91859C (fi)	1987-06-17	1994-08-25	Eisai Co Ltd	Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi
SI1303272T1 (sl)	2000-06-21	2008-06-30	Hoffmann La Roche	Derivati benzotiazola za zdravljenje alzheimerjeve bolezni in parkinsonove bolezni

2002
- 2002-11-05 US US10/288,100 patent/US6620811B2/en not_active Expired - Lifetime
- 2002-11-11 AU AU2002351955A patent/AU2002351955B2/en not_active Ceased
- 2002-11-11 DE DE60223278T patent/DE60223278T2/de not_active Expired - Lifetime
- 2002-11-11 BR BR0214245-7A patent/BR0214245A/pt not_active IP Right Cessation
- 2002-11-11 RS YU39904A patent/RS39904A/sr unknown
- 2002-11-11 AT AT02787632T patent/ATE376831T1/de active
- 2002-11-11 UA UA20040604552A patent/UA77462C2/uk unknown
- 2002-11-11 PT PT02787632T patent/PT1448198E/pt unknown
- 2002-11-11 WO PCT/EP2002/012562 patent/WO2003043636A1/en active IP Right Grant
- 2002-11-11 EP EP02787632A patent/EP1448198B1/de not_active Expired - Lifetime
- 2002-11-11 JP JP2003545317A patent/JP4226474B2/ja not_active Expired - Fee Related
- 2002-11-11 SI SI200230637T patent/SI1448198T1/sl unknown
- 2002-11-11 CN CNB028228391A patent/CN100546580C/zh not_active Expired - Fee Related
- 2002-11-11 EA EA200400598A patent/EA007502B1/ru not_active IP Right Cessation
- 2002-11-11 ES ES02787632T patent/ES2294187T3/es not_active Expired - Lifetime
- 2002-11-11 IL IL16162302A patent/IL161623A0/xx unknown
- 2002-11-11 MX MXPA04004684A patent/MXPA04004684A/es active IP Right Grant
- 2002-11-11 NZ NZ532802A patent/NZ532802A/en unknown
- 2002-11-11 HU HU0402161A patent/HUP0402161A3/hu not_active Application Discontinuation
- 2002-11-11 CA CA2467552A patent/CA2467552C/en not_active Expired - Fee Related
- 2002-11-11 PL PL02369517A patent/PL369517A1/xx not_active Application Discontinuation
- 2002-11-11 RU RU2004118425/04A patent/RU2294933C2/ru not_active IP Right Cessation
- 2002-11-11 DK DK02787632T patent/DK1448198T3/da active
- 2002-11-11 KR KR1020047007638A patent/KR100577110B1/ko not_active IP Right Cessation
- 2002-11-14 PA PA20028558001A patent/PA8558001A1/es unknown
- 2002-11-14 TW TW091133371A patent/TW200407134A/zh unknown
- 2002-11-15 PE PE2002001104A patent/PE20030713A1/es not_active Application Discontinuation
- 2002-11-18 AR ARP020104416A patent/AR039367A1/es unknown
- 2002-11-18 UY UY27542A patent/UY27542A1/es not_active Application Discontinuation
- 2002-11-18 JO JO2002114A patent/JO2290B1/en active
- 2002-11-18 GT GT200200232A patent/GT200200232A/es unknown
- 2002-11-18 MY MYPI20024303A patent/MY126176A/en unknown
2004
- 2004-04-26 IL IL161623A patent/IL161623A/en not_active IP Right Cessation
- 2004-05-05 HR HR20040396A patent/HRP20040396A2/hr not_active Application Discontinuation
- 2004-05-17 EC EC2004005109A patent/ECSP045109A/es unknown
- 2004-05-18 ZA ZA200403817A patent/ZA200403817B/en unknown
- 2004-05-18 TN TNP2004000087A patent/TNSN04087A1/en unknown
- 2004-05-18 MA MA27681A patent/MA27083A1/fr unknown
- 2004-06-18 NO NO20042576A patent/NO20042576L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TW200407134A (en)	2004-05-16
HRP20040396A2 (en)	2005-04-30
IL161623A0 (en)	2004-09-27
MY126176A (en)	2006-09-29
KR20050044535A (ko)	2005-05-12
EA200400598A1 (ru)	2005-02-24
HUP0402161A2 (hu)	2005-02-28
UA77462C2 (en)	2006-12-15
ZA200403817B (en)	2005-05-23
US20030134854A1 (en)	2003-07-17
WO2003043636A1 (en)	2003-05-30
IL161623A (en)	2010-11-30
ECSP045109A (es)	2004-06-28
MA27083A1 (fr)	2004-12-20
AU2002351955A1 (en)	2003-06-10
CA2467552A1 (en)	2003-05-30
UY27542A1 (es)	2003-05-30
SI1448198T1 (sl)	2008-02-29
RU2294933C2 (ru)	2007-03-10
EP1448198A1 (de)	2004-08-25
HUP0402161A3 (en)	2010-06-28
CN1617722A (zh)	2005-05-18
PL369517A1 (en)	2005-04-18
RS39904A (en)	2006-10-27
NZ532802A (en)	2005-07-29
ES2294187T3 (es)	2008-04-01
JP2005522413A (ja)	2005-07-28
US6620811B2 (en)	2003-09-16
BR0214245A (pt)	2004-12-14
NO20042576L (no)	2004-06-18
RU2004118425A (ru)	2006-01-10
CA2467552C (en)	2011-05-24
ATE376831T1 (de)	2007-11-15
TNSN04087A1 (en)	2006-06-01
KR100577110B1 (ko)	2006-05-10
PE20030713A1 (es)	2003-08-23
AU2002351955B2 (en)	2007-03-15
PT1448198E (pt)	2007-12-11
EA007502B1 (ru)	2006-10-27
PA8558001A1 (es)	2003-07-28
AR039367A1 (es)	2005-02-16
CN100546580C (zh)	2009-10-07
EP1448198B1 (de)	2007-10-31
MXPA04004684A (es)	2004-08-12
GT200200232A (es)	2003-06-17
JO2290B1 (en)	2005-09-12
DK1448198T3 (da)	2008-01-07
JP4226474B2 (ja)	2009-02-18
DE60223278T2 (de)	2008-08-14

Publication	Publication Date	Title
ATE376831T1 (de)	2007-11-15	Nicotin- oder isonicotin benzothiazole derivaten
NO20025978L (no)	2002-12-12	Benzotiazol-derivater
ATE391505T1 (de)	2008-04-15	Benzothiazole derivative
ATE319451T1 (de)	2006-03-15	Tetrahydrochinolin-derivate
ATE312827T1 (de)	2005-12-15	3-substituierte-4-pyrimidonderivate
NO20034439D0 (no)	2003-10-03	Benzamidinderivater
DK1292604T3 (da)	2009-06-15	2-Aminocarbonyl-9H-purinderivater
DK1458685T3 (da)	2007-09-17	Substituerede phenylderivater
ATE288437T1 (de)	2005-02-15	Tetrahydro-heterocycloazepinyl-pyrimidin-deriva e
ATE298332T1 (de)	2005-07-15	Decahydro-isochinolinderivate
DK1280809T3 (da)	2005-11-07	Antitumorecteinascidinderivater
EE200300447A (et)	2003-12-15	Asendatud bensofuraan-2-karboksamiidide derivaadid
ATE335729T1 (de)	2006-09-15	3h-chinazoline -4-on derivaten
ATE423771T1 (de)	2009-03-15	Tetrahydrochinolinderivate
DE60223031D1 (de)	2007-11-29	Arylpiperazin gebundene tetrahydroindolonderivate
ATE403646T1 (de)	2008-08-15	Aminocyclohexan-derivate
DK1322593T3 (da)	2004-10-11	O-substituerede-6-methyl-tramadol-derivater
ATE330603T1 (de)	2006-07-15	Benzothiazolderivaten
NO20042980L (no)	2004-07-14	3,4-dihydro-1H-isokinolin-2-yl-derivater
DK1246791T3 (da)	2005-02-14	Aminomethyl-phenyl-cyklohexanonderivater
ATE346045T1 (de)	2006-12-15	Heteroaryl-substituierte aminocyclohexan-derivate
DE50211466D1 (de)	2008-02-14	Substituierte 4-aminocyclohexanolderivate
DK1392670T3 (da)	2005-08-08	Substituerede C-furan-2-yl-methylamin- og C-thiophen-2-yl-methylamin-derivater
DE60202381D1 (de)	2005-01-27	Paroxetin-n-formyl-derivate
ATE374776T1 (de)	2007-10-15	Pyrrolotriazolopyrimidinonderivate

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2008-11-20	8364	No opposition during term of opposition