DE60208180D1 - Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung - Google Patents

Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung

Info

Publication number: DE60208180D1
Authority: DE; Germany
Prior art keywords: applicable; medicament preparation; modified cyclosporin; cyclosporin; modified
Prior art date: 2001-04-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60208180T

Other languages

English (en)

Other versions

DE60208180T2 (de

Inventor

Roland Wenger

Manfred Mutter

Arnaud Hamel

Francis Hubler

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ophthalmopharma Ag Sarnen Ch

Original Assignee

Debiopharm SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-20

Filing date

2002-04-22

Publication date

2006-01-26

2002-04-22 Application filed by Debiopharm SA filed Critical Debiopharm SA

2006-01-26 Application granted granted Critical

2006-01-26 Publication of DE60208180D1 publication Critical patent/DE60208180D1/de

2006-08-17 Publication of DE60208180T2 publication Critical patent/DE60208180T2/de

2022-04-23 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
229940126601 medicinal product Drugs 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Virology (AREA)
Transplantation (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE60208180T 2001-04-20 2002-04-22 Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung Expired - Lifetime DE60208180T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CH7202001		2001-04-20
CH72001		2001-04-20
PCT/CH2002/000222 WO2002085928A2 (fr)	2001-04-20	2002-04-22	Cyclosporine modifiee utilisable en tant que pro-drogue et son utilisation

Publications (2)

Publication Number	Publication Date
DE60208180D1 true DE60208180D1 (de)	2006-01-26
DE60208180T2 DE60208180T2 (de)	2006-08-17

Family

ID=4531478

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60208180T Expired - Lifetime DE60208180T2 (de)	2001-04-20	2002-04-22	Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung

Country Status (17)

Country	Link
US (1)	US6995139B2 (de)
EP (1)	EP1379547B1 (de)
JP (1)	JP4588979B2 (de)
KR (1)	KR100932859B1 (de)
CN (1)	CN1507451A (de)
AT (1)	ATE313557T1 (de)
AU (1)	AU2002245996B8 (de)
BR (1)	BR0208923A (de)
CA (1)	CA2444278C (de)
DE (1)	DE60208180T2 (de)
ES (1)	ES2256450T3 (de)
IL (1)	IL158385A0 (de)
MX (1)	MXPA03009586A (de)
RU (1)	RU2290196C2 (de)
UA (1)	UA75136C2 (de)
WO (1)	WO2002085928A2 (de)
ZA (1)	ZA200307794B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8048917B2 (en)	2005-04-06	2011-11-01	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en)	2001-06-11	2007-03-06	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US7354574B2 (en) *	2002-11-07	2008-04-08	Advanced Ocular Systems Limited	Treatment of ocular disease
US7083803B2 (en)	2003-09-19	2006-08-01	Advanced Ocular Systems Limited	Ocular solutions
US7087237B2 (en)	2003-09-19	2006-08-08	Advanced Ocular Systems Limited	Ocular solutions
CA2571710A1 (en)	2004-06-24	2006-11-02	Nicholas Valiante	Small molecule immunopotentiators and assays for their detection
EP1904056B1 (de)	2005-07-18	2009-04-29	Minu, L.L.C.	Verwendung von Makroliden zur Wiederherstellung der Kornealempfindungen
US7696165B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7531572B2 (en)	2006-07-28	2009-05-12	Xenoport, Inc.	Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use
US8394763B2 (en)	2007-09-26	2013-03-12	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009098533A1 (en) *	2008-02-08	2009-08-13	Debiopharm Sa	Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
GB0912584D0 (en) *	2009-07-20	2009-08-26	Ucl Business Plc	Cyclosporin conjugates
RU2630690C9 (ru)	2010-12-15	2017-12-28	КонтраВир Фармасьютикалз, Инк.	МОЛЕКУЛЫ АНАЛОГОВ ЦИКЛОСПОРИНА, МОДИФИЦИРОВАННЫЕ ПО 1 и 3 АМИНОКИСЛОТЕ
AR090964A1 (es) *	2012-05-09	2014-12-17	Novartis Ag	Proceso para la elaboracion de undecapeptidos ciclicos
CN113388002A (zh) *	2021-06-10	2021-09-14	梯尔希（南京）药物研发有限公司	一种环孢菌素相关化合物的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4396542A (en) *	1980-02-14	1983-08-02	Sandoz Ltd.	Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
ATE43335T1 (de) *	1980-02-14	1989-06-15	Sandoz Ag	Peptide die einen (1s,2r,3r)- oder (1r,2s,3s)-1nitrilo-1-carbonyl-3-methyl-2-oxyheptan oder hept-5-en-rest enthalten brauchbar in totaler synsthese von cyclosporinen, und verfahren zu ihrer herstellung.
US5169773A (en) *	1984-10-04	1992-12-08	Sandoz Ltd.	Monoclonal antibodies to cyclosporins
ATE43499T1 (de) *	1984-10-10	1989-06-15	Ile De France	Synergistische empfaengnisverhuetende mischung.
US4764503A (en) *	1986-11-19	1988-08-16	Sandoz Ltd.	Novel cyclosporins
DK0484281T4 (da) *	1990-11-02	2001-02-05	Novartis Ag	Cyclosporiner
US6187547B1 (en) *	1993-09-08	2001-02-13	Novartis Ag	Assay kit
GB9624038D0 (en) *	1996-11-19	1997-01-08	Sandoz Ltd	Organic compounds
US6017879A (en) *	1998-04-03	2000-01-25	B.M.R.A. Corporation B.V.	Template associated NPY Y2-receptor agonists
DE69928938T2 (de)	1998-07-01	2006-08-17	Debiopharm S.A.	Neues cyclosporin mit verbesserter wirkung
US6204257B1 (en) *	1998-08-07	2001-03-20	Universtiy Of Kansas	Water soluble prodrugs of hindered alcohols
DE60028936T2 (de) *	1999-02-05	2007-01-11	Debiopharm S.A.	Cyclosporin-derivate und verfahren zu deren herstellung
US6765019B1 (en) *	1999-05-06	2004-07-20	University Of Kentucky Research Foundation	Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
WO2001005819A1 (en) *	1999-07-15	2001-01-25	Kuhnil Pharm. Co., Ltd.	Novel water soluble-cyclosporine conjugated compounds
MXPA02001857A (es) *	1999-08-24	2003-07-14	Cellgate Inc	Composiciones y metodos para incrementar la entrega de drogas a traves y dentro de tejidos epiteliales.

2002
- 2002-04-22 CA CA2444278A patent/CA2444278C/en not_active Expired - Fee Related
- 2002-04-22 UA UA20031110436A patent/UA75136C2/uk unknown
- 2002-04-22 JP JP2002583454A patent/JP4588979B2/ja not_active Expired - Fee Related
- 2002-04-22 MX MXPA03009586A patent/MXPA03009586A/es active IP Right Grant
- 2002-04-22 ES ES02713992T patent/ES2256450T3/es not_active Expired - Lifetime
- 2002-04-22 AT AT02713992T patent/ATE313557T1/de not_active IP Right Cessation
- 2002-04-22 WO PCT/CH2002/000222 patent/WO2002085928A2/fr active IP Right Grant
- 2002-04-22 BR BR0208923-8A patent/BR0208923A/pt active Search and Examination
- 2002-04-22 EP EP02713992A patent/EP1379547B1/de not_active Expired - Lifetime
- 2002-04-22 CN CNA028094050A patent/CN1507451A/zh active Pending
- 2002-04-22 AU AU2002245996A patent/AU2002245996B8/en not_active Ceased
- 2002-04-22 RU RU2003133742/15A patent/RU2290196C2/ru not_active IP Right Cessation
- 2002-04-22 IL IL15838502A patent/IL158385A0/xx not_active IP Right Cessation
- 2002-04-22 US US10/474,396 patent/US6995139B2/en not_active Expired - Fee Related
- 2002-04-22 DE DE60208180T patent/DE60208180T2/de not_active Expired - Lifetime
2003
- 2003-10-06 ZA ZA200307794A patent/ZA200307794B/en unknown
- 2003-10-17 KR KR1020037013666A patent/KR100932859B1/ko not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE60208180T2 (de)	2006-08-17
CA2444278C (en)	2011-11-22
KR100932859B1 (ko)	2009-12-23
EP1379547A2 (de)	2004-01-14
ZA200307794B (en)	2004-07-19
UA75136C2 (en)	2006-03-15
AU2002245996B2 (en)	2005-06-30
JP4588979B2 (ja)	2010-12-01
IL158385A0 (en)	2004-05-12
KR20030094357A (ko)	2003-12-11
RU2003133742A (ru)	2005-03-20
CA2444278A1 (en)	2002-10-31
AU2002245996B8 (en)	2005-07-14
US20040138108A1 (en)	2004-07-15
US6995139B2 (en)	2006-02-07
CN1507451A (zh)	2004-06-23
ES2256450T3 (es)	2006-07-16
ATE313557T1 (de)	2006-01-15
MXPA03009586A (es)	2004-05-24
EP1379547B1 (de)	2005-12-21
JP2004536051A (ja)	2004-12-02
RU2290196C2 (ru)	2006-12-27
WO2002085928A2 (fr)	2002-10-31
BR0208923A (pt)	2004-04-27
WO2002085928A3 (fr)	2003-04-17

Publication	Publication Date	Title
DE60208180D1 (de)	2006-01-26	Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung
ATE300306T1 (de)	2005-08-15	Pharmazeutische zusammensetzung zur ophtalmologischen und rhinologischen anwendung
ATE502633T1 (de)	2011-04-15	Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
NO20015584L (no)	2002-01-03	Langtidsvarende insulintropiske peptider og konjugater samt anvendelse for fremstilling av medikamenter for behandling
NO20042161L (no)	2004-08-17	Inhibitorer av 11-beta-hydroksysteroid dehydrogenase type 1
IL159087A0 (en)	2004-05-12	Bridged bicyclic compounds and pharmaceutical compositions containing the same
HK1085667A1 (en)	2006-09-01	Non-nucleoside reverse transcriptase inhibitors
EA200500782A1 (ru)	2005-10-27	Лечение геморрагического шока
HK1080459A1 (en)	2006-04-28	Novel pyrimidineamide derivatives and the use thereof
MY144318A (en)	2011-08-29	Methods of treating hiv infection.
CA2583764A1 (en)	2006-05-04	Thrombopoietin activity modulating compounds and methods
NO20073176L (no)	2007-09-17	Nye medikamenter for behandling av luftveissykdommer
IL157540A0 (en)	2004-03-28	N-(aryl)-2-arylethenesulphonamides and therapeutic uses thereof
SG162614A1 (en)	2010-07-29	Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors
ATE554753T1 (de)	2012-05-15	2,2'-dithio-bis(ethansulfonat) für den einsatz zur hemmung paclitaxel-induzierter abnormer thermoesthesia
GEP20063869B (en)	2006-07-10	Novel cyclohexyl sulphones
NO20044550L (no)	2005-01-28	Heterotrisyklyl 6-alkaliden-penemer som beta-laktamaseinhibitorer
HK1068606A1 (en)	2005-04-29	Novel aminobenzoephenones
MXPA02011533A (es)	2003-04-25	Nuevas formulaciones de alfa-2,4-disulfofenil-n-terc-butilnitrona.
MY128529A (en)	2007-02-28	Use of cilobradine or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
DK1268522T3 (da)	2009-01-12	LH-RH-antagonister samt fremstilling deraf og anvendelse deraf som lægemidler
DE60227008D1 (de)	2008-07-17	Neue thiophenacylhydrazinoderivate, verfahren zu deren herstellung, deren verwendung als arzneimittel, pharmazeutische zusammensetzungen und neue anwendungen
ATE425741T1 (de)	2009-04-15	Arzneizubereitung und deren anwendung zur behandlung von erkrankungen des inneren ohres
DE50206173D1 (de)	2006-05-11	Antiglaukomatoses mittel und dessen verwendung
ITFI20030238A1 (it)	2005-03-12	Peptidi ciclici antagonisti dell'urotensina-ii

Legal Events

Date	Code	Title	Description
2007-01-11	8364	No opposition during term of opposition
2008-08-14	8327	Change in the person/name/address of the patent owner	Owner name: OPHTHALMOPHARMA AG, SARNEN, CH