DE4207704A1 - Use of aq. emulsion of dimeticon as mouth rinse against plaque - reducing bacterial growth and adhesion of bacteria in mouth - Google Patents

Abstract

Dimeticon is used, in the form of an aq. emulsion, as a mouth rinse against plaque. The emulsion contains 0.1-5 vols.% of dimeticon. ADVANTAGE - The rinse is simple to use, physiologically acceptable and efficient in combatting plaque. It limits bacterial growth, kills microbes, and reduces the adhesion of bacteria in the mouth. It has no side effect

Description

The invention relates to the use of Dimeticon in dentistry customer.

Dimeticon is the WHO name for methyl silicone oil, which is made from polydimethyl There are siloxanes of different chain lengths:

Dimeticon is chemically inert and is not subject to corruption (so-called Rancid) and is characterized by an excellent water repellency like out.

Furthermore, Dimeticon is colorless, odorless, tasteless and temp stable against raturation. There is no absorption in the gastrointestinal area, the substance is completely non-toxic and is excreted unchanged.

According to epidemological surveys, many people suffer from one Inflammation of the gums (gingivitis). If this gingivitis becomes chronic, this leads to a pathological and irreversible change the periodontitis, with the impending loss of Teeth by loosening them in the bone.

Responsible for the development of gingivitis or periodontitis  is the plaque that forms on the teeth (miocrobial plaque). Therefore is the removal or reduction of the microbial plaque and its crystalline secondary consolidation (tartar) as the most important measure against gingivitis and periodontitis.

The most effective is the formation of plaque through a regular home Dental care as well as a periodic check by a dentist led to counter tartar removal.

In addition, there are also various preparations and chemi connections to medicinally influencing plaque (reduction by mouthwash), or in use, but in all Cases of side effects have been reported that are severely limited Condition availability of these funds. So there is when using anti biotics the risk of sensitization and resistance formation, and in ver use of hydrogen peroxide increases the risk of gas embolism more periodically Vessels. Furthermore, some have medical rinses due to it contained substances (hydroxyquinoline sulfate, phenol derivatives, guanidines, Tin chloride, chlorhexidine) taste irritation, a brown color of Teeth and tongue and effects on the mouth that have not yet been verified flora and other unpredictable risks. When using enzyma tical means, an unrealizable length of stay in the oral cavity is required necessary to have an effect.

The object of the invention is therefore to provide a mouthwash that can be used easily and easily, physiolo is harmless and enables successful plaque control.

Surprisingly, Dimeticon was found to be excellent as Mouthwash is suitable for plaque. Dimeticon gets in shape an aqueous emulsion, in which its volume fraction is preferred Is 0.1-5%. To improve the taste of the detergent, you can appropriate additives may be included.

Dimeticon rinsing liquid shows an excellent plaque-reducing Effect by restricting bacterial growth (bacteriological Effect), direct killing of microbes (bacteriocidal effect) and people  the adhesion of bacteria in the mouth area.

Because of the complete freedom from side effects, Dimeticon can be made dental perspective can be applied without restrictions. With that stands in addition to the previously known substances for inhibiting or reducing the Plaque formation is a representative of a new drug generation for ver addition.

The invention is carried out on the basis of a clinical Investigation explained:

A group of seven subjects of both types was examined poor between the ages of 24 and 47 (mean 38 years). The The total duration of the investigation was six months. This period un divided into a three-month comparison period and a three monthly flushing period. In the comparison period, the subjects operated one normal home dental care, while once in the rinsing period Day with Dimeticon. Dimeticon came in the form of an aqueous one Emulsion with a volume share of 1-2% is used.

The investigation took place over a total of nine days Basic examination at the beginning of the examination period, a start sub Search at the beginning of the comparison period, three check-ups within this period, a start examination at the beginning of the rinse period, as well as three further check-ups within this Period.

The individual findings on the various clinical para examined meters were compressed by averaging. In detail could the following results can be achieved:

• - Microbial plaque mass (plaque index according to SILNESS and LÖE)
  The relative reduction in plaque after Dimeticon application is 46.0%.
• - Gingivitis (Gingiva index according to LÖE and SILNESS)
  Dimeticon reduced these pathological changes by 24.1%.
• - Attachment level (assessment of the tooth attachment)
  A clinically detectable increase in tooth fixation as a result of the treatment was objective.
• - Tartar formation
  When using Dimeticon, a reduced formation of new tartar of 8.3% compared to the comparison phase could be found as an expression and result of the reduced plaque mass.

Claims (2)

1. Use of Dimeticon, characterized in that it is used in the form of an aqueous emulsion as a mouthwash against plaque. 2. Use of Dimeticon according to claim 1, characterized net that its volume fraction in the aqueous emulsion be 0.1-5% wearing.