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DE3923638C2 - Salze aus Ranitidin und einem Komplex von Bismut mit einer Carbonsäure, Verfahren zu deren Herstellung und diese Salze enthaltende pharmazeutische Präparate - Google Patents

Salze aus Ranitidin und einem Komplex von Bismut mit einer Carbonsäure, Verfahren zu deren Herstellung und diese Salze enthaltende pharmazeutische Präparate

Info

Publication number
DE3923638C2
DE3923638C2 DE3923638A DE3923638A DE3923638C2 DE 3923638 C2 DE3923638 C2 DE 3923638C2 DE 3923638 A DE3923638 A DE 3923638A DE 3923638 A DE3923638 A DE 3923638A DE 3923638 C2 DE3923638 C2 DE 3923638C2
Authority
DE
Germany
Prior art keywords
bismuth
methyl
complex
ranitidine
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3923638A
Other languages
German (de)
English (en)
Other versions
DE3923638A1 (de
Inventor
John Watson Clitherow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888817098A external-priority patent/GB8817098D0/en
Priority claimed from GB898904686A external-priority patent/GB8904686D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE3923638A1 publication Critical patent/DE3923638A1/de
Application granted granted Critical
Publication of DE3923638C2 publication Critical patent/DE3923638C2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE3923638A 1988-07-18 1989-07-17 Salze aus Ranitidin und einem Komplex von Bismut mit einer Carbonsäure, Verfahren zu deren Herstellung und diese Salze enthaltende pharmazeutische Präparate Expired - Fee Related DE3923638C2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888817098A GB8817098D0 (en) 1988-07-18 1988-07-18 Chemical compounds
GB898904686A GB8904686D0 (en) 1989-03-01 1989-03-01 Chemical compounds

Publications (2)

Publication Number Publication Date
DE3923638A1 DE3923638A1 (de) 1990-03-01
DE3923638C2 true DE3923638C2 (de) 1995-11-23

Family

ID=26294175

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3923638A Expired - Fee Related DE3923638C2 (de) 1988-07-18 1989-07-17 Salze aus Ranitidin und einem Komplex von Bismut mit einer Carbonsäure, Verfahren zu deren Herstellung und diese Salze enthaltende pharmazeutische Präparate

Country Status (35)

Country Link
US (1) US5008256A (da)
JP (1) JP2523185B2 (da)
KR (1) KR0122598B1 (da)
CN (1) CN1022626C (da)
AT (1) AT398200B (da)
AU (1) AU632052B2 (da)
BE (1) BE1003254A5 (da)
CA (1) CA1332610C (da)
CH (1) CH679582A5 (da)
CY (1) CY1650A (da)
DE (1) DE3923638C2 (da)
DK (1) DK168381B1 (da)
EG (1) EG19368A (da)
ES (1) ES2014175A6 (da)
FI (1) FI90538C (da)
FR (1) FR2634122B1 (da)
GB (1) GB2220937B (da)
GR (1) GR1000431B (da)
HK (1) HK61392A (da)
HU (2) HU206104B (da)
IE (1) IE61076B1 (da)
IL (1) IL91005A (da)
IT (1) IT1231481B (da)
LU (2) LU88722I2 (da)
MX (1) MX174145B (da)
MY (1) MY104055A (da)
NL (2) NL192604C (da)
NO (2) NO176319C (da)
NZ (1) NZ229958A (da)
PL (1) PL162391B1 (da)
PT (1) PT91188B (da)
SE (1) SE468715B (da)
SG (1) SG51992G (da)
YU (1) YU47021B (da)
ZW (1) ZW8689A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0282132B1 (en) * 1987-03-09 1992-09-30 The Procter & Gamble Company Compositions and their use for treating gastrointestinal disorders
IL85472A (en) * 1987-03-09 1991-06-30 Procter & Gamble Pharmaceutical compositions for treating gastrointestinal disorders
AU641903B2 (en) * 1988-10-26 1993-10-07 Glaxo Group Limited Carboxylic acid derivatives
GB9004328D0 (en) * 1990-02-27 1990-04-25 Glaxo Group Ltd Chemical compounds
GB9009240D0 (en) * 1990-04-25 1990-06-20 Glaxo Group Ltd Chemical compounds
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds
DK0540613T3 (da) * 1990-07-20 1996-04-01 Tillotts Pharma Ag Produkter og fremgangsmåder til behandling af fordøjelseskanalen
GB9019875D0 (en) * 1990-09-11 1990-10-24 Glaxo Group Ltd Pharmaceutical compositions
US5192752A (en) * 1991-01-14 1993-03-09 The Procter & Gamble Company Swallowable pharmaceutical compositions containing colloidal bismuth subcitrate
US5128140A (en) * 1991-01-14 1992-07-07 The Procter & Gamble Company Swallowable pharmaceutical compositions
GB9120131D0 (en) * 1991-09-20 1991-11-06 Glaxo Group Ltd Medicaments
ES2130152T3 (es) * 1991-12-06 1999-07-01 Glaxo Group Ltd Medicamentos para tratar dolencias inflamatorias o para analgesia que contienen un nsaid y ranitidina/citrato de bismuto.
AU1671295A (en) * 1994-12-19 1996-07-10 Lauteral Limited Combinations of ranitidine hydrochloride-form 1 and bismuth compounds
GB9501560D0 (en) 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
EP0805815B1 (en) * 1995-01-26 2002-04-10 Nycomed Imaging A/S Use of bismuth compounds for the manufacture of medicaments for the treatment of gastric disorders caused by Helicobacter pylori
EP1035192A1 (de) * 1999-01-26 2000-09-13 Stefan Graichen Additiv für einen Kühlschmierstoff
CN1102585C (zh) * 1999-04-28 2003-03-05 常州兰陵制药有限公司 雷尼替丁枸橼酸铋盐的制备方法
US20060100271A1 (en) * 2004-11-08 2006-05-11 Keith Whitehead Stabilized aqueous ranitidine compositions
CN100402514C (zh) * 2006-08-01 2008-07-16 丽珠医药集团股份有限公司 一种制备枸橼酸铋雷尼替丁的方法
CN101484132A (zh) * 2007-07-09 2009-07-15 柏树制药公司 具有合意口味的雷尼替丁制剂
CN102408398B (zh) * 2011-09-20 2012-12-05 江苏汉斯通药业有限公司 枸橼酸铋雷尼替丁的制备方法
US9731999B2 (en) 2011-09-23 2017-08-15 Iqbal Gill Chemical admixtures for hydraulic cements
ES2426539B1 (es) * 2012-04-18 2014-09-09 Dr Healthcare España, S. L. Uso de la diaminooxidasa para el tratamiento o la prevención del trastorno por deficit de atencion con hiperactividad (adhd)
CN103896888B (zh) * 2014-03-28 2015-11-18 常州兰陵制药有限公司 枸橼酸铋雷尼替丁的制备方法
WO2015155297A1 (en) 2014-04-11 2015-10-15 Sanovel Ilac Sanayi Ve Ticaret A.S. Pharmaceutical combinations of dabigatran and h2-receptor antagonists
EP2942058A1 (en) 2014-05-09 2015-11-11 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and H2-receptor antagonists
CN107382921A (zh) * 2017-07-28 2017-11-24 常州兰陵制药有限公司 制备枸橼酸铋雷尼替丁的方法
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
FR2531706A1 (fr) * 1982-08-13 1984-02-17 Sanofi Sa Benzamides, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant
BE905235A (fr) * 1986-08-05 1986-12-01 Hasunor Ag Ascorbates antagonistes des recepteurs h2 et leur procede de preparation.
IT1215325B (it) * 1987-01-07 1990-02-08 Barisintex Sa Composti antagonisti di recettori -h2 e procedimento per la loro preparazione.
IL85472A (en) * 1987-03-09 1991-06-30 Procter & Gamble Pharmaceutical compositions for treating gastrointestinal disorders
EP0282132B1 (en) * 1987-03-09 1992-09-30 The Procter & Gamble Company Compositions and their use for treating gastrointestinal disorders
DE3710462A1 (de) * 1987-03-30 1988-10-13 Heumann Pharma Gmbh & Co Pharmazeutische zubereitung zur behandlung von erkrankungen des magen-darm-traktes
GB9004328D0 (en) * 1990-02-27 1990-04-25 Glaxo Group Ltd Chemical compounds
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
ES2014175A6 (es) 1990-06-16
IT8948196A0 (it) 1989-07-17
FR2634122B1 (fr) 1993-11-19
GB8916288D0 (en) 1989-08-31
AU3817889A (en) 1990-01-18
YU47021B (sh) 1994-11-15
CH679582A5 (da) 1992-03-13
FI90538B (fi) 1993-11-15
NL192604B (nl) 1997-07-01
CN1022626C (zh) 1993-11-03
MY104055A (en) 1993-10-30
CY1650A (en) 1992-12-11
ZW8689A1 (en) 1990-02-21
GR1000431B (el) 1992-07-30
DE3923638A1 (de) 1990-03-01
ATA172889A (de) 1994-02-15
HK61392A (en) 1992-08-21
FI893448A (fi) 1990-01-19
NO176319B (no) 1994-12-05
NL970046I2 (nl) 1998-04-01
BE1003254A5 (fr) 1992-02-11
FI893448A0 (fi) 1989-07-17
DK351789D0 (da) 1989-07-17
DK168381B1 (da) 1994-03-21
NL192604C (nl) 1997-11-04
CN1039419A (zh) 1990-02-07
MX174145B (es) 1994-04-25
MX16829A (es) 1993-10-01
HU211173A9 (en) 1995-11-28
CA1332610C (en) 1994-10-18
NO892936D0 (no) 1989-07-17
EG19368A (en) 1995-02-28
SE468715B (sv) 1993-03-08
PL162391B1 (pl) 1993-10-30
GR890100454A (en) 1990-06-27
IE892309L (en) 1990-01-18
YU142789A (en) 1991-04-30
KR910002826A (ko) 1991-02-26
HU206104B (en) 1992-08-28
JP2523185B2 (ja) 1996-08-07
AU632052B2 (en) 1992-12-17
LU87557A1 (fr) 1990-07-24
GB2220937B (en) 1991-11-27
PT91188B (pt) 1995-03-01
SE8902550L (sv) 1990-01-19
IE61076B1 (en) 1994-09-21
US5008256A (en) 1991-04-16
NL8901840A (nl) 1990-02-16
IL91005A0 (en) 1990-02-09
IL91005A (en) 1994-10-07
NO176319C (no) 1995-03-15
FR2634122A1 (fr) 1990-01-19
IT1231481B (it) 1991-12-07
NZ229958A (en) 1991-09-25
JPH02117684A (ja) 1990-05-02
NO1998007I1 (no) 1998-02-05
GB2220937A (en) 1990-01-24
NL970046I1 (nl) 1998-03-02
SE8902550D0 (sv) 1989-07-17
NO892936L (no) 1990-01-19
AT398200B (de) 1994-10-25
DK351789A (da) 1990-01-19
HUT52082A (en) 1990-06-28
PT91188A (pt) 1990-02-08
LU88722I2 (fr) 1996-08-23
KR0122598B1 (ko) 1997-11-13
FI90538C (fi) 1994-02-25
SG51992G (en) 1992-07-24

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee