DE2164052A1 - COSMETIC AGENTS WITH NUCLEOSIDE DERIVATIVES - Google Patents

Description

Patent attorney

HERMANN L. JUNG 757 bathe-bathe

Dipl.-Chem. Ludwig-Wilhelm-Strasse 12

Telephone (072 21) 239 33 Telegrams: JUPAT Baden-Baden

My sign day

Jg / Sch ON 758 W-81o December 15, 1971 Cosmetic agents with nucleoside derivatives

It has long been known that the aging of the uncovered Skin is mainly due to UV radiation. One could therefore protect the skin from aging achieve that they are continuously covered with sunscreens that contain UV light filter substance. But this is not possible, since all previously known light filter substances are non-physiological, chemical substances that can irritate, allergize or sensitize the skin if used daily for months. as well So far no physiological substances have been known which have such a high cell permeability that they can be used when the patient is already aged or damaged skin penetrate the cells and improve the structure of the skin.

Surprisingly, it has now been found that the nucleosides cytidine, uridine, cuanosine, inosine and their physiological Derivatives in concentrations of at least 1% have a sun protection factor of over 1.5 and thereby due to the cell permeability additionally achieve a better position of the skin structure. This effect is achieved through a single application of the cosmetic agent is achieved and lasts about 24-48 hours due to the immediate penetration of the substances.

~ ² ~ 309830/1132

Postal checking account 2290 28 Frankfurt, am Main

216405? '

That this is not a superficial covering effect acts, is proven by the fact that the effect is not lost even with frequent washing or bathing. Both Substances are physiological building blocks of the cell nucleus, which can also be administered in extremely high doses and for months show no irritating, allergic or sensitizing effect on the skin. An exception is made adenosine and its derivatives, which cannot be used in these dosages because of their vasodilating effect is. The deoxynucleosides also show a similarly positive light protection effect and improvement of the skin structure and their physiological derivatives.

With the substances claimed according to the invention, it is now possible for the first time to produce cosmetic agents which when used daily, they provide protection against aging for the skin while improving the condition of the skin Achieve damaged skin and this with absolute tolerance.

Particularly noteworthy is the mixture of the nucleosides cytidine and uridine in the ratio in which they occur as constituents of the yeast cells and obtained via nucleic acid cleavage will. As is known from cancer research, these two nucleosides have an extremely high cell permeability and are thereby absorbed very quickly by the cells, even in very high doses, even intravenously injected, no toxicity phenomena were found in animal experiments or in humans.

Accordingly, the invention consists in that cosmetic agents by a content of at least 1% of cytidine, uridine, Guanosine and / or inosine or their derivatives are labeled.

A mixture of cytidine and uridine obtained during the cleavage of yeast nucleic acid is preferably added.

-3- 3 0 9 8 3 0/1132

The invention is illustrated in the following examples:

Example 1: Day cream

Ammonium stearate.

Glycerin

stearin

low oxyethylated fatty alcohol

highly oxethylated fatty alcohol

Carboxymethyl cellulose

Cytidine, uridine (from yeast nucleic acid cleavage

Water, demineralized to 3, o 15, o 12, o o, 5

0.6

5, o Ιοο, ο

Example 2; Liquid skin care emulsion

Glycerol-mono-di-fatty acid ester fatty alcohol polyglycoether Octyldodecano1 caprylic capric acid triglyceride Paraffin oil Lanolin anhydr.

1.2-propylene glycol preservative agent1 cytidine monophosphate Na-Sa1ζ water, demineralised ad 6, o 4, ο 4, ο 4, ο 2, ο 2, ο 3 _f o

3, ο Ιοο, ο

Example 3

ffautcreme ö / w type glycerine-mono-distearate paraffin

Lanolin anhydr.

Paraffin oil Octyldodecano1 Sorbitol

Guanosine

Preservative1 water, demineralised ad 12, ο 6, o 4, ο 7, ο 6, ο 3, ο

3 0 9 8 3 ■ 0 / T 1 3 2

71B4052

Example 4: skin cream ö / w type

Sorbitan sesguueate ceresin

Beeswax

vaseline

Paraffin oil

Ribonucleic acid water, demineralized ad 5, o

6, o

7, ο

6, o

5o, o

4.0

Ιοο, ο

Example 5: facial toner

Ethyl alcohol 94% by volume sorbitol solution

Hammamelis distillate egg-white fatty acid condensate inosine

Water, demineralized ad 18, ο o, 5 I / O 2, o 2.5 Ιοο, ο

Example 6: hair lotion

Isopropyl alcohol diisopropyl adipate ■ calcium pantothenate RibonucIe in acid water, demineralized

ad

Example 7: aftershave

Ethyl alcohol 94 vol% lanolin liquid
1,2-propylene glycol hexachlorophene

Cytidine, uridine
(from yeast nucleic acid cleavage)

Water, demineralized to 50, o 2, o I / O I / O

Ιοο, ο

4o, o l, o 2, o o, 2

2, o Ιοο, ο

309830/1132

-S-

Of course, other compositions of cosmetic agents are also possible, the essential being The fact is that it contains nucleosides. The main advantage of this means is that after After months of daily use, the skin is neither irritated nor attacked in any other way. Above all, this appears to be essential, especially in the case of all well-known means for protecting the skin after a long period of time Time an irritation occurred, which could only be remedied by discontinuing the agent. Also no remedy is known which, by directly influencing the cells, can reduce their damage by light. All previously known light stabilizers act as filters and are therefore also washable. The new funds do not need to be constantly reapplied but work over a longer period of time.

309830/1132

Claims (5)

Claims 216 A O 5 1. Cosmetic agents, especially for the treatment of human skin, with particularly good long-term tolerance, consisting of a base with additives, characterized by a content of at least 1% of cytidine, uridine, guanosine and / or inosine or their derivatives. 2. Means according to claim 1, characterized by a Content of corresponding phosphoric acid derivatives or their salts. 3. Means according to claim 1, characterized by a Content of ribonucleic acids or their salts. 4. Composition according to claim 1, characterized in that one resulting from the cleavage of yeast nucleic acid Mixture of cytidine and uridine is added. 5. Composition according to claim 1 to 4, characterized in that the active ingredient is present in suspension in the base. 309830/1132