CY2187B1 - Pharmaceutical compositions comprising angiotensinii receptor blocking imidazoles and diuretics - Google Patents

Pharmaceutical compositions comprising angiotensinii receptor blocking imidazoles and diuretics

Info

Publication number: CY2187B1
Authority: CY; Cyprus
Prior art keywords: angiotensinii; diuretics; pharmaceutical compositions; receptor blocking; imidazoles
Prior art date: 1988-01-07

Application number

CY9900010A

Other languages

English (en)

Inventor

David John Carini

John Jonas Vytautas Duncia

Pancras Chor Bun Wong

Original Assignee

Du Pont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-07

Filing date

1999-03-04

Publication date

2002-11-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26840231&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2187(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-12-06 Priority claimed from US07/279,194 external-priority patent/US5138069A/en

1999-03-04 Application filed by Du Pont filed Critical Du Pont

2002-11-08 Publication of CY2187B1 publication Critical patent/CY2187B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

CY9900010A 1988-01-07 1999-03-04 Pharmaceutical compositions comprising angiotensinii receptor blocking imidazoles and diuretics CY2187B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14258088A	1988-01-07	1988-01-07
US07/279,194 US5138069A (en)	1986-07-11	1988-12-06	Angiotensin II receptor blocking imidazoles

Publications (1)

Publication Number	Publication Date
CY2187B1 true CY2187B1 (en)	2002-11-08

Family

ID=26840231

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CY9900010A CY2187B1 (en)	1988-01-07	1999-03-04	Pharmaceutical compositions comprising angiotensinii receptor blocking imidazoles and diuretics
CY2004001C CY2004001I2 (el)	1988-01-07	2004-07-08	Φαρμακευτικες συνθεσεις που περιλαμβανουν ιμιδαζολια μπλοκαρισματος υποδοχεως αγγειοτασινης ιι και διουρητικα

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CY2004001C CY2004001I2 (el)	1988-01-07	2004-07-08	Φαρμακευτικες συνθεσεις που περιλαμβανουν ιμιδαζολια μπλοκαρισματος υποδοχεως αγγειοτασινης ιι και διουρητικα

Country Status (20)

Country	Link
EP (1)	EP0324377B1 (fr)
JP (1)	JPH0725738B2 (fr)
AT (2)	ATE164520T1 (fr)
AU (1)	AU617736B2 (fr)
CA (1)	CA1338238C (fr)
CY (2)	CY2187B1 (fr)
DE (3)	DE19875033I2 (fr)
DK (1)	DK174948B1 (fr)
ES (2)	ES2117463T3 (fr)
FI (1)	FI99012C (fr)
GR (1)	GR3024053T3 (fr)
HU (1)	HU211317A9 (fr)
IE (2)	IE81569B1 (fr)
IL (1)	IL88900A0 (fr)
LU (1)	LU90266I2 (fr)
NO (1)	NO177265C (fr)
NZ (1)	NZ227539A (fr)
PT (1)	PT89401B (fr)
RU (2)	RU1814646C (fr)
WO (1)	WO1989006233A1 (fr)

Families Citing this family (179)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4820843A (en) *	1987-05-22	1989-04-11	E. I. Du Pont De Nemours And Company	Tetrazole intermediates to antihypertensive compounds
US5210079A (en) *	1988-01-07	1993-05-11	E. I. Du Pont De Nemours And Company	Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
CA2003283A1 (fr) *	1988-12-05	1990-06-05	C. Anne Higley	Imidazoles pour le traitement de l'atherosclerose
US5354867A (en) *	1988-12-06	1994-10-11	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking imidazoles
US5185351A (en) *	1989-06-14	1993-02-09	Smithkline Beecham Corporation	Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
US5418250A (en) *	1989-06-14	1995-05-23	Smithkline Beecham Corporation	Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
DK0403159T3 (da) *	1989-06-14	2000-08-14	Smithkline Beecham Corp	Imidazolylalkensyrer
US5312828A (en) *	1989-06-14	1994-05-17	Finkelstein Joseph A	Substituted imidazoles having angiotensin II receptor blocking activity
EP0403158A3 (fr) *	1989-06-14	1991-12-18	Smithkline Beecham Corporation	Acides imidazolyl-alcénoiques
JP2550442B2 (ja) *	1989-06-30	1996-11-06	イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー	置換イミダゾール
EP0479892A1 (fr) *	1989-06-30	1992-04-15	E.I. Du Pont De Nemours And Company	Imidazoles a substitution aryle a anneau fusionne
ATE113281T1 (de) *	1989-08-02	1994-11-15	Takeda Chemical Industries Ltd	Pyrazol-derivate, verfahren zu deren herstellung und anwendung.
US5100897A (en) *	1989-08-28	1992-03-31	Merck & Co., Inc.	Substituted pyrimidinones as angiotensin ii antagonists
AU621245B2 (en) *	1989-10-17	1992-03-05	Boehringer Mannheim Gmbh	Hydrolase substrates, a process for the preparation thereof and agents containing them
AU640417B2 (en) *	1989-10-25	1993-08-26	Smithkline Beecham Corporation	Substituted 5-((tetrazolyl)alkenyl)imidazoles
CA2028925A1 (fr) *	1989-11-06	1991-05-07	Gerald R. Girard	Derives substitues de la n-(imidazolyl)alkylalanine
US5248689A (en) *	1989-11-06	1993-09-28	Smithkline Beecham Corporation	Substituted N-(imidazolyl)alkyl alanine derivatives
US5073566A (en) *	1989-11-30	1991-12-17	Eli Lilly And Company	Angiotensin ii antagonist 1,3-imidazoles and use thereas
US5104891A (en) *	1989-12-11	1992-04-14	G. D. Searle & Co.	Cycloheptimidazolone compounds as angiotensin ii antagonists for control of hypertension
EP0557276A1 (fr) *	1989-12-29	1993-09-01	University Technologies International Inc. (Uti)	Methodes de modelage des structures tertiaires de ligands biologiquement actifs, y compris leurs agonistes et antagonistes et nouveaux antagonistes synthetiques bases sur l'angiotensine
US5234917A (en) *	1989-12-29	1993-08-10	Finkelstein Joseph A	Substituted 5-(alkyl)carboxamide imidazoles
JPH05503691A (ja) *	1989-12-29	1993-06-17	ユニバーシティ・テクノロジーズ・インターナショナル・インコーポレイテッド	アゴニストおよびアンタゴニストを含む生物学的に活性なリガンドの３次構造モデルの設計方法およびアンギオテンシンに基づいた新規合成アンタゴニスト
US5449682A (en) *	1990-02-13	1995-09-12	Merck & Co., Inc.	Angiotensin II antagonists incorporating a substituted benzyl element
US5183810A (en) *	1990-02-13	1993-02-02	Merck & Co., Inc.	Imidazole angiotensin II antagonists incorporating a substituted benzyl element
US5240938A (en) *	1991-02-13	1993-08-31	Merck & Co., Inc.	Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring
PH30484A (en) *	1990-02-19	1997-05-28	Ciba Geigy	Acy compounds pharmaceutical composition containing said compound and method of use thereof
KR910021381A (ko) *	1990-02-20	1991-12-20	모리 히데오	4-3급 부틸이미다졸 유도체, 및 이의 제조방법 및 용도
US5140037A (en) *	1990-03-20	1992-08-18	E. I. Du Pont De Nemours And Company	Treatment of central nervous system disorders with imidazole angiotensin-ii receptor antagonists
US5270317A (en) *	1990-03-20	1993-12-14	Elf Sanofi	N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2659967B1 (fr) *	1990-03-20	1992-07-24	Sanofi Sa	Derives d'imidazolinone n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
TW201738B (fr) *	1990-03-20	1993-03-11	Sanofi Co
DE4010797A1 (de) *	1990-04-04	1991-10-10	Hoechst Ag	Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
US5039814A (en) *	1990-05-02	1991-08-13	Merck & Co., Inc.	Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
EP0527879B1 (fr) *	1990-05-11	1997-02-05	Pfizer Inc.	Compositions et procedes therapeutiques synergiques
US5821232A (en) *	1990-05-11	1998-10-13	Pfizer Inc.	Synergistic therapeutic compositions and methods
US5045540A (en) *	1990-05-25	1991-09-03	Warner-Lambert Co.	Amino acid derivatives with angiotensin II antagonist properties
FR2663028B1 (fr) *	1990-06-08	1994-10-14	Roussel Uclaf	Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
NZ238688A (en) *	1990-06-28	1992-05-26	Smithkline Beecham Corp	Substituted histidines: pharmaceutical compositions, preparation and uses thereof
IL98319A (en) *	1990-07-05	1997-04-15	Roussel Uclaf	Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
FR2664271B1 (fr) *	1990-07-05	1994-02-18	Roussel Uclaf	Nouveaux derives soufres de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR2675503B1 (fr) *	1991-04-19	1994-02-18	Roussel Uclaf	Nouveaux derives soufres de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5137902A (en) *	1990-07-13	1992-08-11	E. I. Du Pont De Nemours And Company	4-alkylimidazole derivatives and anti-hypertensive use thereof
NZ239161A (en) *	1990-07-31	1994-01-26	Smithkline Beecham Corp	Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
GB9017482D0 (en) *	1990-08-09	1990-09-26	Ici Plc	Manufacturing process
GB9017480D0 (en) *	1990-08-09	1990-09-26	Ici Plc	Chemical process
US5091390A (en) *	1990-09-20	1992-02-25	E. I. Du Pont De Nemours And Company	Treatment of CNS disorders with 4,5,6,7-tetrahydro-1H-imidazo (4,5-)-pyridines and analogs
US5210092A (en) *	1990-09-25	1993-05-11	Fujisawa Pharmaceutical Co., Ltd.	Angiotensin ii antagonizing heterocyclic derivatives
US5242939A (en) *	1990-09-28	1993-09-07	Warner-Lambert Company	Anilide derivatives with angiotensin ii antagonist properties
US5126342A (en) *	1990-10-01	1992-06-30	Merck & Co., Inc.	Imidazole angiotensin ii antagonists incorporating acidic functional groups
DE4036645A1 (de) *	1990-11-16	1992-05-21	Hoechst Ag	Substituierte azole, verfahren zu deren herstellung, deren enthaltende mittel und deren verwendung
DE4036706A1 (de) *	1990-11-17	1992-05-21	Hoechst Ag	Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
WO1992009278A1 (fr) *	1990-11-30	1992-06-11	Smithkline Beecham Corporation	Imidazoles 5-aryle substitues
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- 1989-01-06 DK DK198900051A patent/DK174948B1/da not_active IP Right Cessation
- 1989-01-09 IE IE4589A patent/IE81569B1/en not_active IP Right Cessation
- 1989-01-09 IE IE960772A patent/IE82833B1/en not_active IP Right Cessation
1992
- 1992-01-27 RU SU925010637A patent/RU2017733C1/ru active
1995
- 1995-06-30 HU HU95P/P00636P patent/HU211317A9/hu unknown
1997
- 1997-07-09 GR GR970401708T patent/GR3024053T3/el unknown
1998
- 1998-07-29 LU LU90266C patent/LU90266I2/fr unknown
1999
- 1999-03-04 CY CY9900010A patent/CY2187B1/xx unknown
2004
- 2004-07-08 CY CY2004001C patent/CY2004001I2/el unknown

Also Published As

Publication number	Publication date
NO890075L (no)	1989-07-10
NO890075D0 (no)	1989-01-06
ES2100150T3 (es)	1997-06-16
DE68928631T2 (de)	1998-10-22
FI890070A0 (fi)	1989-01-06
AU2777189A (en)	1989-07-13
IL88900A0 (en)	1989-08-15
NZ227539A (en)	1991-04-26
RU2017733C1 (ru)	1994-08-15
AU617736B2 (en)	1991-12-05
CY2004001I1 (el)	2010-07-28
JPH03501020A (ja)	1991-03-07
FI890070A (fi)	1989-07-08
JPH0725738B2 (ja)	1995-03-22
ATE164520T1 (de)	1998-04-15
CY2004001I2 (el)	2010-07-28
EP0324377A2 (fr)	1989-07-19
NO177265B (no)	1995-05-08
EP0324377A3 (fr)	1991-02-06
HU211317A9 (en)	1995-11-28
CA1338238C (fr)	1996-04-09
FI99012C (fi)	1997-09-25
DK5189A (da)	1989-07-08
GR3024053T3 (en)	1997-10-31
DE68928631D1 (de)	1998-05-07
ES2117463T3 (es)	1998-08-01
DE68927965D1 (de)	1997-05-22
ATE151755T1 (de)	1997-05-15
FI99012B (fi)	1997-06-13
PT89401B (pt)	1993-09-30
EP0324377B1 (fr)	1997-04-16
LU90266I2 (fr)	1998-10-01
DE19875033I2 (de)	2004-09-23
PT89401A (pt)	1990-02-08
WO1989006233A1 (fr)	1989-07-13
DE68927965T2 (de)	1997-07-24
DK5189D0 (da)	1989-01-06
RU1814646C (ru)	1993-05-07
DK174948B1 (da)	2004-03-15
IE82833B1 (en)	2003-04-30
NO177265C (no)	1995-08-16
IE81569B1 (en)	2001-02-21
IE960772L (en)	1989-07-07
IE890045L (en)	1989-07-07

Publication	Publication Date	Title
CY2187B1 (en)	2002-11-08	Pharmaceutical compositions comprising angiotensinii receptor blocking imidazoles and diuretics
EP0733366A3 (fr)	1996-10-09	Compositions pharmaceutiques comprenant des imidazoles comme antagonistes d'angiotensine II et des diurétiques
FI901096A0 (fi)	1990-03-02	Menetelmä farmakologisesti aktiivisten /3-(C16-C18)alkaanisulfinyyli- ja -sulfonyyli-2-metoksimetyylipropyyli/-(2-trimetyyliammonio-etyyli)fosfaattien valmistamiseksi
NO167807C (no)	1991-12-11	Analogifremgangsmaate til fremstilling av 3',4'-dinitrogensubstituerte epipodofyllotoksinglukosidderivater.
ES546866A0 (es)	1986-07-16	Procedimiento de preparar derivados antihipertensivos
ATE101139T1 (de)	1994-02-15	(alkylthio-3-propyl)-3-benzothiazolinderivate, ihre herstellung und diese enthaltende arzneimittel.
ZA872443B (en)	1987-11-25	Bis-tert.butylamino-substituted 1,3,5-triazine derivatives,processes for their preparation,medicaments containing these compounds and their use
NO167511C (no)	1991-11-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte tieno(3,4-d)imidazolderivater.
NO901302L (no)	1990-10-05	Fremgangsmaate for fremstilling av karbonfattige, finfordelte pulvere av keramisk materiale.
NO161856C (no)	1989-10-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,4-diamino-1,2,5-tiadiazol-derivater.
IL82705A0 (en)	1987-11-30	Pharmaceutical compositions containing avarone,avarol or derivatives thereof for the control of adult t-cell leukemia/lymphoma
FI890065A (fi)	1989-07-08	Foerfarande foer framstaellning av 5,8,13, 14-tetrahydrobenz/5,6/isoindolo/2,1-b/isokinolin-8,13-dionderivat.
FI894193A0 (fi)	1989-09-06	Foerfarande foer framstaellning av nya tieno (3',4'-4,5) imidazo (2,1-b)-tiazolderivat.
NO164657C (no)	1990-10-31	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,8-nafthyridinoner.
NO862648L (no)	1988-01-04	Framgangsmÿte for framstilling av farmakologisk aktive 2-substituerte-3,4-dihydroksyfenyletylamino-derivater.
IE873007L (en)	1988-05-21	New benzothiadiazine compounds, processes for the¹preparation thereof and pharmaceutical compositions¹comprising the same
ATE70840T1 (de)	1992-01-15	Benzothiepino(5,4-c>pyridazin-verbindungen und ihre pharmazeutischen wirkungen.
IT8620504A0 (it)	1986-05-21	Derivati dell'1,2,4-triazolo farmacologicamente attivi.
NO890473D0 (no)	1989-02-06	Analogifremgangsmaate for fremstilling av 6,6-ethylen-15,16-methylen-3-oxo-17alfa-pregn-4-en-21,17-carbolactoner.
NO883525L (no)	1989-02-13	Framgangsmaate for framstilling av 1,5-benzotiazepinderivater.
NO913422L (no)	1989-02-22	Framgangsmaate for framstilling av 1,5-benzotiazepinderivater.
NO883526D0 (no)	1988-08-09	Framgangsmaate for framstilling av 1,5-benzotiazepinderivater.
NO913388L (no)	1989-02-13	Framgangsmaate for framstilling av 1,5-benzotiazepinderivater.