Nothing Special   »   [go: up one dir, main page]

CY1116886T1 - C-met αντισωματα - Google Patents

C-met αντισωματα

Info

Publication number
CY1116886T1
CY1116886T1 CY20151100880T CY151100880T CY1116886T1 CY 1116886 T1 CY1116886 T1 CY 1116886T1 CY 20151100880 T CY20151100880 T CY 20151100880T CY 151100880 T CY151100880 T CY 151100880T CY 1116886 T1 CY1116886 T1 CY 1116886T1
Authority
CY
Cyprus
Prior art keywords
met
accessories
diseases
pathogenesis
cancers
Prior art date
Application number
CY20151100880T
Other languages
English (en)
Inventor
Julian Davies
Ling Liu
Jirong Lu
Peter Edward Vaillancourt
Mark Andrew Wortinger
Wei Zeng
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of CY1116886T1 publication Critical patent/CY1116886T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Παρέχονται μονόκλωνα αντισώματα, αντιγονο-δεσμευτικά θραύσματα αυτών, και συνδυασμοί των προαναφερθέντων, που δεσμεύονται σε, και αναστέλλουν τη δραστικότητα c-Met, και τα οποία είναι αποτελεσματικά σε αντιμετώπιση καρκίνων και άλλων νόσων, διαταραχών ή παθήσεων όπου η παθογένεση διαμεσολαβείται από c-Met.
CY20151100880T 2008-11-21 2015-10-02 C-met αντισωματα CY1116886T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11682508P 2008-11-21 2008-11-21
US21990309P 2009-06-24 2009-06-24
EP09752708.9A EP2358755B1 (en) 2008-11-21 2009-11-18 c-MET ANTIBODIES

Publications (1)

Publication Number Publication Date
CY1116886T1 true CY1116886T1 (el) 2017-04-05

Family

ID=41435259

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100880T CY1116886T1 (el) 2008-11-21 2015-10-02 C-met αντισωματα

Country Status (28)

Country Link
US (2) US8217148B2 (el)
EP (2) EP2358755B1 (el)
JP (1) JP5688027B2 (el)
KR (1) KR101334450B1 (el)
CN (1) CN102216333B (el)
AR (1) AR074360A1 (el)
AU (1) AU2009316742B2 (el)
BR (1) BRPI0922800A2 (el)
CA (1) CA2743508C (el)
CY (1) CY1116886T1 (el)
DK (1) DK2358755T3 (el)
EA (1) EA020398B1 (el)
ES (2) ES2549760T3 (el)
HK (1) HK1158229A1 (el)
HR (1) HRP20151019T1 (el)
HU (1) HUE026058T2 (el)
IL (1) IL212633A (el)
JO (1) JO3097B1 (el)
MX (1) MX2011005400A (el)
NZ (1) NZ592215A (el)
PA (1) PA8849001A1 (el)
PL (1) PL2358755T3 (el)
PT (1) PT2358755E (el)
SI (1) SI2358755T1 (el)
TR (1) TR201802841T4 (el)
TW (1) TWI477284B (el)
WO (1) WO2010059654A1 (el)
ZA (1) ZA201103586B (el)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8849001A1 (es) 2008-11-21 2010-06-28 Lilly Co Eli Anticuerpos de c-met
US9068011B2 (en) 2010-03-10 2015-06-30 Genmab A+S Monoclonal antibodies against c-Met
WO2011150454A1 (en) * 2010-06-01 2011-12-08 Monash University ANTIBODIES DIRECTED TO THE UNPROCESSED RECEPTOR TYROSINE KINASE c-MET
CN103221825A (zh) 2010-08-31 2013-07-24 基因泰克公司 生物标志物和治疗方法
KR20140019284A (ko) * 2010-09-03 2014-02-14 아카데미아 시니카 항-C-Met 항체 및 이의 이용 방법들
AU2011325098B2 (en) 2010-11-03 2016-07-14 Argen-X N.V. c-Met antibody combinations
CN102276726B (zh) * 2011-03-16 2014-02-19 常州新泉生物医药科技有限公司 肝细胞生长因子受体活性基团的融合蛋白
WO2012174529A2 (en) * 2011-06-17 2012-12-20 Indiana University Research And Technology Corporation Methods for increasing the potency and efficacy of stem cells
WO2013043715A1 (en) 2011-09-19 2013-03-28 Genentech, Inc. Combination treatments comprising c-met antagonists and b-raf antagonists
WO2013043452A1 (en) * 2011-09-20 2013-03-28 Eli Lilly And Company Anti-c-met antibodies
KR101865223B1 (ko) * 2011-10-05 2018-06-08 삼성전자주식회사 항 ｃ-Ｍｅｔ 인간화 항체 및 그의 용도
KR20130037153A (ko) * 2011-10-05 2013-04-15 삼성전자주식회사 항 ｃ-Ｍｅｔ 항체 및 그의 용도
KR20130036993A (ko) 2011-10-05 2013-04-15 삼성전자주식회사 ｃ-Ｍｅｔ의 ＳＥＭＡ 도메인 내의 에피토프에 특이적으로 결합하는 항체
US9926364B2 (en) 2011-11-03 2018-03-27 Argen-X N.V. Chimeric human-llama antigens and methods of use
BR112014012005A2 (pt) 2011-11-21 2017-12-19 Genentech Inc composições, métodos, formulação farmacêutica e artigo
US20150147274A1 (en) 2011-12-02 2015-05-28 Cancer Research Technology Limited Antibodies against hgf - receptor and uses
US9260531B2 (en) * 2012-05-09 2016-02-16 Eli Lilly And Company Anti-c-met antibodies
EP2863946A4 (en) * 2012-06-21 2016-04-13 Sorrento Therapeutics Inc ANTIGEN-BINDING PROTEINS THAT BIND TO C-MET
US9931400B2 (en) 2012-09-12 2018-04-03 Samsung Electronics Co., Ltd. Method of combination therapy for prevention or treatment of c-Met or angiogenesis factor induced diseases
ES2530968T3 (es) 2012-10-12 2015-03-09 Spirogen Sarl Pirrolobenzodiazepinas y conjugados de las mismas
CA2900097A1 (en) 2013-02-22 2014-08-28 F. Hoffmann-La Roche Ag Methods of treating cancer and preventing drug resistance
US20160031887A1 (en) 2013-03-13 2016-02-04 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
KR102049990B1 (ko) * 2013-03-28 2019-12-03 삼성전자주식회사 c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질
KR102042174B1 (ko) * 2013-03-29 2019-11-08 삼성전자주식회사 인간화 및 친화도 성숙된 항 ｃ-Ｍｅｔ 항체 및 그의 용도
EP2992019B1 (en) * 2013-04-30 2019-03-06 Agency For Science, Technology And Research Mab 2 anti-met antibody
EP3033434A2 (en) * 2013-08-14 2016-06-22 Qiagen Mansfield, Inc. Compositions and methods for multimodal analysis of cmet nucleic acids
EP3057608A4 (en) 2013-10-14 2017-10-11 Janssen Biotech, Inc. Cysteine engineered fibronectin type iii domain binding molecules
US9717715B2 (en) 2013-11-15 2017-08-01 Samsung Electronics Co., Ltd. Method of combination therapy using an anti-C-Met antibody
TW201609805A (zh) * 2013-12-23 2016-03-16 美國禮來大藥廠 結合ｅｇｆｒ及ｍｅｔ之多功能抗體
TW201622744A (zh) * 2014-03-04 2016-07-01 美國禮來大藥廠 癌症之組合療法
MA39776A (fr) 2014-03-24 2017-02-01 Hoffmann La Roche Traitement du cancer avec des antagonistes de c-met et corrélation de ces derniers avec l'expression de hgf
JP2017524371A (ja) 2014-05-23 2017-08-31 ジェネンテック， インコーポレイテッド Ｍｉｔバイオマーカーとその使用方法
CN106687141A (zh) 2014-09-10 2017-05-17 麦迪穆有限责任公司 吡咯并苯并二氮杂卓及其缀合物
ES2748295T3 (es) * 2014-09-16 2020-03-16 Symphogen As Anticuerpos anti-MET y composiciones
ES2764299T3 (es) 2014-12-09 2020-06-02 Inst Nat Sante Rech Med Anticuerpos monoclonales humanos contra AXL
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
US20180057595A1 (en) * 2015-03-16 2018-03-01 Celldex Therapeutics, Inc. Anti-MET Antibodies and Methods of Use Thereof
US10344071B2 (en) 2015-07-28 2019-07-09 Musc Foundation For Research Development Identification of novel anti-fibrotic peptide in C-terminal region of the MET receptor tyrosine kinase
CA3003759A1 (en) 2015-11-03 2017-05-11 Merck Patent Gmbh Bi-specific antibodies for enhanced tumor selectivity and inhibition and uses thereof
CN106810611A (zh) * 2015-11-30 2017-06-09 中国科学院深圳先进技术研究院 抗cMet和CD3特异性双靶向抗体及其制备方法和应用、含该双靶向抗体表达盒的微环DNA及应用
WO2017135791A1 (en) * 2016-02-05 2017-08-10 Viromed Co., Ltd. Anti-c-met antibodies and uses thereof
GB2551372A (en) * 2016-06-16 2017-12-20 Bombardier Primove Gmbh A secondary unit, a system for inductive power transfer and a method for operating a secondary unit and a system for inductive power transfer
MX2018016185A (es) 2016-06-21 2019-03-28 Janssen Biotech Inc Moléculas de unión al dominio de fibronectina tipo iii diseñadas de cisteína.
CN107556388A (zh) * 2016-06-30 2018-01-09 中国科学院深圳先进技术研究院 抗CD44v6和CD3特异性双靶向抗体、含该双靶向抗体表达盒的微环DNA及应用
CN107556386A (zh) * 2016-06-30 2018-01-09 中国科学院深圳先进技术研究院 抗EGFRvIII和CD3特异性双靶向抗体、含双靶向抗体表达盒的微环DNA及应用
CN107556387A (zh) * 2016-06-30 2018-01-09 中国科学院深圳先进技术研究院 抗gpc3和cd3特异性双靶向抗体、含该双靶向抗体表达盒的微环dna及应用
CN107573416A (zh) * 2016-06-30 2018-01-12 中国科学院深圳先进技术研究院 抗igf1r和cd3特异性双靶向抗体、含该双靶向抗体表达盒的微环dna及应用
EP3492105A4 (en) * 2016-07-26 2020-02-26 Nihon University THERAPEUTIC AGENT FOR PERIODONTITIS.
US10439449B2 (en) * 2016-08-10 2019-10-08 Microsoft Technology Licensing, Llc Coupling device modules for inductive data transmission
JP6942179B2 (ja) * 2016-09-29 2021-09-29 田辺三菱製薬株式会社 ｃＭＥＴモノクローナル結合剤、その薬物複合体およびその使用
WO2018071500A1 (en) * 2016-10-11 2018-04-19 Agenus Inc. Anti-lag-3 antibodies and methods of use thereof
CN109862919A (zh) 2016-10-11 2019-06-07 免疫医疗有限公司 抗体-药物缀合物联合免疫介导的治疗剂
TWI782930B (zh) * 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
CN109963562A (zh) 2016-11-16 2019-07-02 伊莱利利公司 用于具有外显子14跳读突变或外显子14跳读表型的癌症的组合疗法
WO2018098035A1 (en) 2016-11-23 2018-05-31 Eli Lilly And Company Met antibody drug conjugates
US10626165B2 (en) 2016-12-14 2020-04-21 Janssen Biotech, Inc. CD8a-binding fibronectin type III domains
WO2018111978A1 (en) 2016-12-14 2018-06-21 Janssen Biotech, Inc. Cd137 binding fibronectin type iii domains
EP3554535A4 (en) 2016-12-14 2020-10-21 Janssen Biotech, Inc. PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS
US20180230218A1 (en) * 2017-01-04 2018-08-16 Immunogen, Inc. Met antibodies and immunoconjugates and uses thereof
CN106986932A (zh) * 2017-04-06 2017-07-28 海口市人民医院 一种c‑Met表位肽及其应用
AU2018278730B2 (en) 2017-05-30 2021-02-04 Chong Kun Dang Pharmaceutical Corp. A novel anti-c-Met antibody and use thereof
CN109771642B (zh) 2017-11-13 2022-09-20 同济大学苏州研究院 c-MET激动型抗体及其用途
GB201803892D0 (en) * 2018-03-12 2018-04-25 Ultrahuman Six Ltd C-met binding agents
MX2020012418A (es) 2018-05-23 2021-04-28 Adc Therapeutics Sa Adyuvante molecular.
US11896682B2 (en) 2019-09-16 2024-02-13 Regeneron Pharmaceuticals, Inc. Radiolabeled MET binding proteins for immuno-PET imaging and methods of use thereof
US11628222B2 (en) 2019-10-14 2023-04-18 Aro Biotherapeutics Company CD71 binding fibronectin type III domains
US11781138B2 (en) 2019-10-14 2023-10-10 Aro Biotherapeutics Company FN3 domain-siRNA conjugates and uses thereof
WO2022079211A1 (en) 2020-10-16 2022-04-21 Adc Therapeutics Sa Glycoconjugates
EP4288456B1 (en) * 2021-02-03 2024-09-18 Mythic Therapeutics, Inc. Anti-met antibodies and uses thereof
GB202102396D0 (en) 2021-02-19 2021-04-07 Adc Therapeutics Sa Molecular adjuvant
JP2024515266A (ja) 2021-04-08 2024-04-08 ビョンディス・ビー．ブイ． 抗ｃ－ＭＥＴ抗体及び抗体薬物複合体
CA3214552A1 (en) 2021-04-14 2022-10-20 Russell C. Addis Cd71 binding fibronectin type iii domains
CN113788895B (zh) * 2021-10-14 2023-09-15 陕西健吉跃生物科技有限公司 一种兔多克隆抗体及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP3293823B2 (ja) 1991-05-10 2002-06-17 フアルマシア・エ・アツプジヨン・エツセ・ピー・アー 肝細胞成長因子（ｈｇｆ）レセプターの部分切除形態
US5686292A (en) 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US6214344B1 (en) 1995-06-02 2001-04-10 Genetech, Inc. Hepatocyte growth factor receptor antagonists and uses thereof
CN101073668A (zh) 1999-04-28 2007-11-21 德克萨斯大学董事会 用于通过选择性抑制vegf来治疗癌症的组合物和方法
EP1592713A2 (en) * 2003-02-13 2005-11-09 Pharmacia Corporation Antibodies to c-met for the treatment of cancers
US20040208876A1 (en) 2003-04-18 2004-10-21 Kim Kyung Jin Monoclonal antibodies to hepatocyte growth factor
ITMI20031127A1 (it) 2003-06-05 2004-12-06 Uni Degli Studi Del Piemont E Orientale Am Anticorpi anti-hgf-r e loro uso
HN2004000285A (es) * 2003-08-04 2006-04-27 Pfizer Prod Inc ANTICUERPOS DIRIGIDOS A c-MET
KR100556660B1 (ko) * 2003-11-11 2006-03-10 국립암센터 Ｈｇｆ의 중화가능 에피토프 및 이에 결합하는 중화 항체
EP1692178A1 (en) 2003-12-11 2006-08-23 Genentech, Inc. Methods and compositions for inhibiting c-met dimerization and activation
SI1718677T1 (sl) 2003-12-19 2012-08-31 Genentech Inc Monovalentni protitelesni fragmenti, uporabni kot zdravila
CA2575402A1 (en) * 2004-08-05 2006-02-09 Genentech, Inc. Humanized anti-cmet antagonists
CN101184506B (zh) 2005-03-25 2013-07-17 健泰科生物技术公司 用于调节超稳定化的c-met的方法和组合物
EP2192188A1 (en) 2006-02-06 2010-06-02 Metheresis Translational Research SA Anti-met monoclonal antibody, fragments and vectors thereof, for the treatment of tumors and corresponding products
WO2007101021A2 (en) * 2006-02-22 2007-09-07 Eli Lilly And Company Humanized anti-ghrelin antibodies
TW200815470A (en) * 2006-03-30 2008-04-01 Novartis Ag Compositions and methods of use for antibodies of c-Met
KR100829972B1 (ko) 2006-07-14 2008-05-16 재단법인서울대학교산학협력재단 항-ｈｇｆ/ｓｆ 인간화 항체 및 이의 제조방법
EP1914242A1 (en) * 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
BRPI0807107A2 (pt) * 2007-02-08 2014-05-06 Univ California Mutações gnaq no melanoma
EP2014681A1 (en) 2007-07-12 2009-01-14 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
PA8849001A1 (es) 2008-11-21 2010-06-28 Lilly Co Eli Anticuerpos de c-met

Also Published As

Publication number Publication date
EA020398B1 (ru) 2014-10-30
ES2549760T3 (es) 2015-11-02
PL2358755T3 (pl) 2016-01-29
AU2009316742A1 (en) 2010-05-27
ES2663825T3 (es) 2018-04-17
JO3097B1 (ar) 2017-03-15
US20100129369A1 (en) 2010-05-27
US20120263723A1 (en) 2012-10-18
IL212633A0 (en) 2011-07-31
PT2358755E (pt) 2015-11-12
TW201023885A (en) 2010-07-01
HUE026058T2 (en) 2016-05-30
JP2012509881A (ja) 2012-04-26
DK2358755T3 (en) 2015-11-16
EP2963058A1 (en) 2016-01-06
CN102216333A (zh) 2011-10-12
EP2963058B1 (en) 2018-02-21
NZ592215A (en) 2012-09-28
TWI477284B (zh) 2015-03-21
EP2358755A1 (en) 2011-08-24
KR101334450B1 (ko) 2013-12-02
CA2743508C (en) 2016-07-19
ZA201103586B (en) 2013-10-30
TR201802841T4 (tr) 2018-03-21
PA8849001A1 (es) 2010-06-28
US8217148B2 (en) 2012-07-10
CA2743508A1 (en) 2010-05-27
KR20110074612A (ko) 2011-06-30
HK1158229A1 (en) 2012-07-13
MX2011005400A (es) 2011-06-20
IL212633A (en) 2015-03-31
BRPI0922800A2 (pt) 2015-12-22
AR074360A1 (es) 2011-01-12
HRP20151019T1 (hr) 2015-10-23
JP5688027B2 (ja) 2015-03-25
AU2009316742B2 (en) 2012-06-07
CN102216333B (zh) 2014-05-21
SI2358755T1 (sl) 2015-10-30
US8398974B2 (en) 2013-03-19
EP2358755B1 (en) 2015-09-02
WO2010059654A1 (en) 2010-05-27
EA201170716A1 (ru) 2011-12-30

Similar Documents

Publication Publication Date Title
CY1116886T1 (el) C-met αντισωματα
CY1124412T1 (el) Aνti-dkk-1 αντισωματα
CY1123883T1 (el) Ανθρωποποιημενα αντισωματα κατα της liv-1 και χρηση αυτων για τη θεραπευτικη αντιμετωπιση του καρκινου
CY1122091T1 (el) Μορια δεσμευσης-cd37 και ανοσοσυζευγματα εξ αυτων
CY1117859T1 (el) Αντισωματα και ανοσοσυζευγματα anti-cd79b και μεθοδοι χρησης
CY1112739T1 (el) Αντισωματα και ανοσοσυζευγματα αντι-cd79β και μεθοδοι χρησης
CY1121148T1 (el) Παραγοντες συνδεσης vegf/dll4 και χρησεις αυτων
CY1119454T1 (el) Αντισωματα εναντι cd38 για τη θεραπεια του πολλαπλου μυελωματος
CY1120626T1 (el) Αντισωματα και αλλα μορια που δεσμευουν β7-η1 και pd-1
CY1118549T1 (el) Χρηση anti-vegf αντισωματος σε συνδυασμο με χημειοθεραπεια για τη θεραπευτικη αγωγη του καρκινου του μαστου
CY1119994T1 (el) Συνθεσεις και μεθοδοι για αυξηση της μυϊκης μαζας και της μυϊκης δυναμης ανταγωνιζοντας ειδικα ton gdf8 και/ή την ακτιβινη α
CY1115572T1 (el) Αντι cxcr4 αντισωματα και χρηση αυτων για τη θεραπεια καρκινου
CY1121742T1 (el) Αντισωματα s100a4 και θεραπευτικες χρησεις αυτων
CY1124849T1 (el) Πρωτεϊνες ειδικης συνδεσης και χρησεις αυτων
CY1119410T1 (el) Βελτιστοποιημενα μονοκλωνικα αντισωματα εναντι του αναστολεα της οδου του ιστικου παραγοντα (tfpi)
EA201100923A1 (ru) Антитела человека против тканевого фактора
EA201290727A1 (ru) Пирролбензодиазепины и их конъюгаты
CY1125102T1 (el) Αντιγονοδεσμευτικες πρωτεϊνες που ενεργοποιουν τον υποδοχεα λεπτινης
CY1112798T1 (el) Ενωσεις διαρυλυδαντοϊνης
EA201171374A1 (ru) Антитела против cd100 и способы их применения
EA201591611A1 (ru) Конъюгаты антитело-лекарственное средство
EA201401107A1 (ru) Специфические антагонисты рецептора fgf-r4
EA201070730A1 (ru) Гуманизированные антитела, специфичные к фактору фон виллебранда
CY1115349T1 (el) Εξανθρωπισμενα αντι cxcr4 αντισωματα για τη θεραπεια καρκινου
EA202091315A2 (ru) Антитела человека, связывающиеся с g-белком rsv