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CY1110663T1 - 2-αμινοαρυλοξαζολικες ενωσεις ως παρεμποδιστες κινασων της τυροσινης - Google Patents

2-αμινοαρυλοξαζολικες ενωσεις ως παρεμποδιστες κινασων της τυροσινης

Info

Publication number
CY1110663T1
CY1110663T1 CY20101100623T CY101100623T CY1110663T1 CY 1110663 T1 CY1110663 T1 CY 1110663T1 CY 20101100623 T CY20101100623 T CY 20101100623T CY 101100623 T CY101100623 T CY 101100623T CY 1110663 T1 CY1110663 T1 CY 1110663T1
Authority
CY
Cyprus
Prior art keywords
compounds
aminoaryloxazolate
breakers
tyrosine
chinese
Prior art date
Application number
CY20101100623T
Other languages
English (en)
Inventor
Alain Moussy
Camille Wermuth
David Grierson
Abdellah Benjahad
Matine CROISY
Marco Ciufolini
Bruno Giethlen
Original Assignee
Ab Science
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04791783A external-priority patent/EP1684750B1/en
Application filed by Ab Science filed Critical Ab Science
Publication of CY1110663T1 publication Critical patent/CY1110663T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Earth Drilling (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε νέες χημικές ενώσεις επιλεγμένες από 2-αμινοαρυλοοξαζόλες του τύπου I οι οποίες επιλεκτικά ελέγχουν, ρυθμίζουν, και/ή παρεμποδίζουν τη μεταγωγή σήματος η οποία διαμεσολαβείται από ορισμένες φυσικές και/ή μεταλλαγμένες κινάσες της τυροσίνης που εμπλέκονται σε μια ποικιλία ασθενειών των ανθρώπων και των ζώων, όπως κυτταροπλαστικές, μεταβολικές, αλλεργικές και εκφυλιστικές διαταραχές. Ειδικότερα, αυτές οι ενώσεις είναι ισχυροί και εκλεκτικοί αναστολείς των c-kit, bcr-abl, FGFR3 και/ή Flt-3.
CY20101100623T 2003-10-23 2010-07-06 2-αμινοαρυλοξαζολικες ενωσεις ως παρεμποδιστες κινασων της τυροσινης CY1110663T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51321403P 2003-10-23 2003-10-23
EP04791783A EP1684750B1 (en) 2003-10-23 2004-10-22 2-aminoaryloxazole compounds as tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
CY1110663T1 true CY1110663T1 (el) 2015-06-10

Family

ID=34520080

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100623T CY1110663T1 (el) 2003-10-23 2010-07-06 2-αμινοαρυλοξαζολικες ενωσεις ως παρεμποδιστες κινασων της τυροσινης

Country Status (7)

Country Link
US (1) US7740074B2 (el)
KR (1) KR101164754B1 (el)
CY (1) CY1110663T1 (el)
DE (1) DE602004026905D1 (el)
ES (1) ES2344790T3 (el)
PT (1) PT1684750E (el)
ZA (1) ZA200604041B (el)

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GB2440940B (en) * 2006-08-18 2009-12-16 Cameron Internat Corp Us Wellhead assembly
GB0618001D0 (en) 2006-09-13 2006-10-18 Des Enhanced Recovery Ltd Method
US8196649B2 (en) * 2006-11-28 2012-06-12 T-3 Property Holdings, Inc. Thru diverter wellhead with direct connecting downhole control
CA2581581C (en) * 2006-11-28 2014-04-29 T-3 Property Holdings, Inc. Direct connecting downhole control system
GB0625526D0 (en) 2006-12-18 2007-01-31 Des Enhanced Recovery Ltd Apparatus and method
GB0625191D0 (en) 2006-12-18 2007-01-24 Des Enhanced Recovery Ltd Apparatus and method
US7596996B2 (en) 2007-04-19 2009-10-06 Fmc Technologies, Inc. Christmas tree with internally positioned flowmeter
NO340795B1 (no) * 2007-11-19 2017-06-19 Vetco Gray Inc Hjelperamme og ventiltre med slik hjelperamme
US8151890B2 (en) * 2008-10-27 2012-04-10 Vetco Gray Inc. System, method and apparatus for a modular production tree assembly to reduce weight during transfer of tree to rig
US8322442B2 (en) * 2009-03-10 2012-12-04 Vetco Gray Inc. Well unloading package
US20130098633A1 (en) * 2011-10-19 2013-04-25 Vetco Gray Inc. Recoverable production module for use with a production tree
US9284810B2 (en) 2012-08-16 2016-03-15 Vetco Gray U.K., Limited Fluid injection system and method
US9428981B2 (en) 2013-03-15 2016-08-30 Stanley Hosie Subsea test adaptor for calibration of subsea multi-phase flow meter during initial clean-up and test and methods of using same
AU2015261530B2 (en) * 2014-05-14 2018-11-15 Aker Solutions As Subsea universal Xmas tree hang-off adapter
US9702215B1 (en) * 2016-02-29 2017-07-11 Fmc Technologies, Inc. Subsea tree and methods of using the same
US20210108479A1 (en) 2017-03-28 2021-04-15 Ge Oil & Gas Uk Limited System for hydrocarbon recovery
US10669805B1 (en) * 2019-03-01 2020-06-02 Oil States Industries, Inc. Adaptor for electronic submersible pump

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US2790500A (en) * 1954-03-24 1957-04-30 Edward N Jones Pump for propelling pellets into oil wells for treating the same
US4099583A (en) * 1977-04-11 1978-07-11 Exxon Production Research Company Gas lift system for marine drilling riser
US4291772A (en) * 1980-03-25 1981-09-29 Standard Oil Company (Indiana) Drilling fluid bypass for marine riser
US4813495A (en) * 1987-05-05 1989-03-21 Conoco Inc. Method and apparatus for deepwater drilling
GB9014237D0 (en) * 1990-06-26 1990-08-15 Framo Dev Ltd Subsea pump system
GB2319795B (en) * 1996-11-22 2001-01-10 Vetco Gray Inc Abb Insert tree
US7270185B2 (en) * 1998-07-15 2007-09-18 Baker Hughes Incorporated Drilling system and method for controlling equivalent circulating density during drilling of wellbores
AU778363B2 (en) * 1998-12-21 2004-12-02 Baker Hughes Incorporated Closed loop chemical injection and monitoring system for oilfield operations
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US6460621B2 (en) * 1999-12-10 2002-10-08 Abb Vetco Gray Inc. Light-intervention subsea tree system
US6457529B2 (en) * 2000-02-17 2002-10-01 Abb Vetco Gray Inc. Apparatus and method for returning drilling fluid from a subsea wellbore
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US6457530B1 (en) * 2001-03-23 2002-10-01 Stream-Flo Industries, Ltd. Wellhead production pumping tree
US6651745B1 (en) * 2002-05-02 2003-11-25 Union Oil Company Of California Subsea riser separator system
US6966383B2 (en) * 2002-12-12 2005-11-22 Dril-Quip, Inc. Horizontal spool tree with improved porting
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US7647974B2 (en) * 2006-07-27 2010-01-19 Vetco Gray Inc. Large bore modular production tree for subsea well

Also Published As

Publication number Publication date
US20070144743A1 (en) 2007-06-28
KR101164754B1 (ko) 2012-07-12
DE602004026905D1 (de) 2010-06-10
PT1684750E (pt) 2010-07-15
ES2344790T3 (es) 2010-09-07
US7740074B2 (en) 2010-06-22
KR20060118500A (ko) 2006-11-23
ZA200604041B (en) 2007-04-25

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