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CU20130072A7 - 1 h-pirazol-5-olato sódico sustituido - Google Patents

1 h-pirazol-5-olato sódico sustituido

Info

Publication number
CU20130072A7
CU20130072A7 CU2013000072A CU20130072A CU20130072A7 CU 20130072 A7 CU20130072 A7 CU 20130072A7 CU 2013000072 A CU2013000072 A CU 2013000072A CU 20130072 A CU20130072 A CU 20130072A CU 20130072 A7 CU20130072 A7 CU 20130072A7
Authority
CU
Cuba
Prior art keywords
pirazol
olato
diseases
substituted sodium
prophylaxis
Prior art date
Application number
CU2013000072A
Other languages
English (en)
Inventor
Hans-Christian Militzer
Jörg Gries
Stefan Koep
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of CU20130072A7 publication Critical patent/CU20130072A7/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

La presente solicitud se refiere a 1-[6-(morfolin-4-il]-4-(1 H-1,2,3-triazol-1-il)-1 H -pirazol-5-olato sódico, a procedimientos para su preparación, su uso para el tratamiento y/o la profilazis de enfermedades como también su uso para la preparación de medicamentos para el tratamiento y/o la profilaxis de enfermedades, especialmente de enfermedades cardiovasculares y hematológicas, de enfermedades renales como también para ayudar a la curación de heridas.
CU2013000072A 2010-11-18 2013-05-16 1 h-pirazol-5-olato sódico sustituido CU20130072A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010044131A DE102010044131A1 (de) 2010-11-18 2010-11-18 Substituiertes Natrium-1H-pyrazol-5-olat
PCT/EP2011/070099 WO2012065967A1 (de) 2010-11-18 2011-11-15 Substítuiertes natrium-1h-pyrazol-5-olat

Publications (1)

Publication Number Publication Date
CU20130072A7 true CU20130072A7 (es) 2013-09-27

Family

ID=44999768

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2013000072A CU20130072A7 (es) 2010-11-18 2013-05-16 1 h-pirazol-5-olato sódico sustituido

Country Status (45)

Country Link
US (2) US8653074B2 (es)
EP (1) EP2640718B8 (es)
JP (1) JP5918779B2 (es)
KR (2) KR20180023043A (es)
CN (2) CN104650047A (es)
AP (1) AP3429A (es)
AR (1) AR083887A1 (es)
AU (1) AU2011331305B2 (es)
BR (1) BR112013012223B1 (es)
CA (1) CA2818002C (es)
CL (1) CL2013001390A1 (es)
CO (1) CO6741155A2 (es)
CR (1) CR20130196A (es)
CU (1) CU20130072A7 (es)
CY (1) CY1120375T1 (es)
DE (1) DE102010044131A1 (es)
DK (1) DK2640718T3 (es)
DO (1) DOP2013000096A (es)
EA (1) EA023103B1 (es)
EC (1) ECSP13012627A (es)
ES (1) ES2675580T3 (es)
GT (1) GT201300125A (es)
HK (2) HK1188782A1 (es)
HR (1) HRP20180993T1 (es)
HU (1) HUE038024T2 (es)
IL (1) IL226192A (es)
JO (1) JOP20110347B1 (es)
LT (1) LT2640718T (es)
MA (1) MA34671B1 (es)
MX (1) MX347670B (es)
MY (1) MY167219A (es)
NZ (1) NZ610614A (es)
PE (2) PE20140391A1 (es)
PL (1) PL2640718T3 (es)
PT (1) PT2640718T (es)
RS (1) RS57599B1 (es)
SG (1) SG189975A1 (es)
SI (1) SI2640718T1 (es)
TN (1) TN2013000215A1 (es)
TR (1) TR201806652T4 (es)
TW (1) TWI516485B (es)
UA (1) UA112422C2 (es)
UY (1) UY33736A (es)
WO (1) WO2012065967A1 (es)
ZA (1) ZA201304430B (es)

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DE102006050516A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dihydropyrazolone und ihre Verwendung
DE102010044131A1 (de) * 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituiertes Natrium-1H-pyrazol-5-olat
CA2872726C (en) * 2012-05-08 2020-07-07 Hans-Christian Militzer Method for the preparation of triazole compounds
WO2015055564A1 (de) * 2013-10-17 2015-04-23 Bayer Pharma Aktiengesellschaft Pharmazeutische darreichungsformen enthaltend natrium-1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1h-1,2,3-triazol-1-yl)-1h-pyrazol-5-olat
US20160089386A1 (en) 2014-09-26 2016-03-31 The Cleveland Clinic Foundation Treating and preventing disease with tma and tmao lowering agents
CL2015003047A1 (es) * 2015-10-15 2016-06-17 Univ Chile Método ex vivo para detectar precozmente injuria renal aguda en pacientes críticos, que comprende la mediciom en una muestra de tres proteinas como biomarcadores, factor de crecimiento fibroblástico 23, klotho y eritropoyetina
WO2018149929A1 (en) * 2017-02-16 2018-08-23 Bayer Pharma Aktiengesellschaft Combination of reporter gene assays and transcriptional analysis
EP3888684A1 (en) * 2020-03-31 2021-10-06 Bayer Animal Health GmbH Composition having improved voluntary acceptance

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DE102010044131A1 (de) 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituiertes Natrium-1H-pyrazol-5-olat

Also Published As

Publication number Publication date
EA023103B1 (ru) 2016-04-29
WO2012065967A1 (de) 2012-05-24
PE20180324A1 (es) 2018-02-13
SG189975A1 (en) 2013-06-28
RS57599B1 (sr) 2018-11-30
PL2640718T3 (pl) 2018-08-31
HK1210776A1 (en) 2016-05-06
SI2640718T1 (en) 2018-08-31
CN104650047A (zh) 2015-05-27
NZ610614A (en) 2015-05-29
AU2011331305A1 (en) 2013-06-06
PE20140391A1 (es) 2014-03-29
IL226192A (en) 2016-06-30
HUE038024T2 (hu) 2018-09-28
EP2640718B1 (de) 2018-03-28
HRP20180993T1 (hr) 2018-08-10
US9533972B2 (en) 2017-01-03
AU2011331305B2 (en) 2016-06-02
GT201300125A (es) 2017-07-26
CN103270031A (zh) 2013-08-28
EP2640718A1 (de) 2013-09-25
KR20130131335A (ko) 2013-12-03
ZA201304430B (en) 2014-12-23
DOP2013000096A (es) 2013-06-15
UY33736A (es) 2012-06-29
MX2013004797A (es) 2013-06-28
AP3429A (en) 2015-09-30
MX347670B (es) 2017-05-03
EP2640718B8 (de) 2018-06-27
IL226192A0 (en) 2013-07-31
TN2013000215A1 (en) 2014-11-10
LT2640718T (lt) 2018-07-10
UA112422C2 (uk) 2016-09-12
CA2818002C (en) 2019-01-15
AR083887A1 (es) 2013-03-27
KR20180023043A (ko) 2018-03-06
TW201307328A (zh) 2013-02-16
HK1188782A1 (en) 2014-05-16
DE102010044131A1 (de) 2012-05-24
JP5918779B2 (ja) 2016-05-18
KR101984317B1 (ko) 2019-05-30
DK2640718T3 (da) 2018-07-16
CR20130196A (es) 2013-08-06
US8653074B2 (en) 2014-02-18
ES2675580T3 (es) 2018-07-11
CL2013001390A1 (es) 2014-04-04
BR112013012223A2 (pt) 2020-03-10
CY1120375T1 (el) 2019-07-10
MA34671B1 (fr) 2013-11-02
JP2014500877A (ja) 2014-01-16
CO6741155A2 (es) 2013-08-30
PT2640718T (pt) 2018-07-04
MY167219A (en) 2018-08-14
JOP20110347B1 (ar) 2021-08-17
TR201806652T4 (tr) 2018-06-21
TWI516485B (zh) 2016-01-11
CA2818002A1 (en) 2012-05-24
EA201390703A1 (ru) 2013-12-30
US20130310381A1 (en) 2013-11-21
ECSP13012627A (es) 2013-07-31
AP2013006922A0 (en) 2013-06-30
BR112013012223B1 (pt) 2021-06-29
CN103270031B (zh) 2015-06-17
US20120129857A1 (en) 2012-05-24

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