CN217688681U - Sample analyzer - Google Patents

Abstract

The present application provides a sample analyzer, the sample analyzer comprising: the kit comprises a box body and a plurality of impedance detection cells arranged on the box body, wherein the impedance detection cells are used for matching to carry out impedance detection; the detection seat is used for accommodating a reagent box; the micro-fluidic chip detection module is arranged on the box body and/or the detection seat and comprises at least one of a blood coagulation detection module, a microorganism detection module, a luminous immunity detection module, a urinary sediment detection module and an insect egg and excrement detection module. The sample analyzer has the advantages that the structure is simple, the impedance detection can be performed on the sample through the impedance detection pool, the detection of other items can be performed on the sample through the micro-fluidic chip detection module, the functions are more, and the use by a user is convenient.

Description

Sample analyzer

Technical Field

The application relates to the technical field of medical equipment, in particular to a sample analyzer.

Background

The sample analyzer is widely used in hospitals of all levels, medical inspection laboratories and regional detection centers due to high measurement speed, high accuracy and small reagent consumption. With the wide application of sample analyzers, the diversified functional requirements of the sample analyzers are also increased.

Most sample analyzers at present have single functions, and bring inconvenience to users.

SUMMERY OF THE UTILITY MODEL

The application provides a sample analyzer to among the solution prior art, sample analyzer's function singleness, the technical problem who brings inconvenience for user's use.

In order to solve the technical problem, the application adopts a technical scheme that: there is provided a sample analyzer comprising: the kit comprises a box body and a plurality of impedance detection pools arranged on the box body, wherein the impedance detection pools are used for matching impedance detection; a test seat for accommodating a reagent cartridge; the micro-fluidic chip detection module is arranged on the box body and/or the detection seat and comprises at least one of a blood coagulation detection module, a microorganism detection module, a luminous immunity detection module, a urinary sediment detection module and an insect egg excrement detection module.

Furthermore, the sample analyzer also comprises an image recognition device, and the image recognition device is used for recognizing and detecting the microfluidic chip detection module.

Furthermore, the microfluidic chip detection module and the box body are integrally formed, or the microfluidic chip detection module is detachably connected with the box body and/or the detection seat.

Furthermore, a clamping groove is formed in the box body and/or the detection seat, and the micro-fluidic chip detection module is clamped in the clamping groove.

Further, the microorganism detection module comprises a microfluidic chip, the microfluidic chip comprises a cavity with a preset thickness, and the cavity is used for placing a sample.

Further, the blood coagulation detection module comprises a micro-fluidic chip, the micro-fluidic chip comprises a micro-channel, and the micro-channel is arranged to enable different samples to flow in different heights or distances in the micro-channel due to different blood coagulation times.

Furthermore, the urinary sediment detection module comprises a micro-fluidic chip, wherein the micro-fluidic chip comprises a micro-channel, and the micro-channel is used for enabling the sample to flow in the micro-channel at a constant speed by virtue of capillary action.

Further, the sample analyzer further comprises a shielding cover assembly, the shielding cover assembly is movably arranged on one side of the detection seat, the shielding cover assembly is used for covering the opening of the detection seat so as to seal the reagent box in a cavity formed by the detection seat and the shielding cover assembly, and the image recognition device is fixed on the shielding cover assembly.

Furthermore, an image recognition base is arranged on the detection base and used for bearing the microfluidic chip detection module and providing light source irradiation for the microfluidic chip detection module.

Furthermore, the impedance detection cell comprises a front cell and a rear cell communicated with the front cell, a microporous sheet is arranged between the front cell and the rear cell, a front cell electrode is arranged in the front cell, and a rear cell electrode is arranged in the rear cell.

The beneficial effect of this application is: unlike the prior art, the sample analyzer of the present application includes: the kit comprises a plurality of impedance detection tanks, the impedance detection tanks are used for carrying out impedance detection on a sample, the microfluidic chip detection module is arranged on the kit body and/or the detection seat and comprises a coagulation detection module, a microorganism detection module, a luminous immunity detection module, a urinary sediment detection module and at least one of an insect egg and excrement detection module, and the microfluidic chip detection module can be used for carrying out coagulation detection, microorganism detection, immunity detection, urinary sediment detection or excrement and excrement detection and the like on the sample. The sample analyzer has the advantages of simple structure, simultaneous multiple detection and convenience for users to use.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:

FIG. 1 is a schematic block diagram of one embodiment of a sample analyzer provided herein;

fig. 2 is a schematic structural diagram of an embodiment of a cartridge in a sample analyzer provided herein.

Detailed Description

The technical solutions in the embodiments of the present application will be described clearly and completely with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only some embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It should be noted that if directional indications (such as up, down, left, right, front, back, 8230; \8230;) are referred to in the embodiments of the present application, the directional indications are only used to explain the relative positional relationship between the components, the motion situation, etc. in a specific posture (as shown in the attached drawings), and if the specific posture is changed, the directional indications are correspondingly changed.

In addition, if there is a description relating to "first", "second", etc. in the embodiments of the present application, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present application.

The application provides a sample analyzer, this sample analyzer's simple structure, the cost is lower, can carry out impedance detection to the sample through the impedance detection pond, and can carry out the detection of items such as blood coagulation, microorganism, luminous immunity, urinary sediment or excrement and urine worm egg to the sample through micro-fluidic chip detection module, and the function is more, and the user of being convenient for uses.

Referring to fig. 1 and fig. 2, fig. 1 is a schematic structural diagram of an embodiment of a sample analyzer provided in the present application, and fig. 2 is a schematic structural diagram of an embodiment of a kit in the sample analyzer provided in the present application, where the sample analyzer 100 includes: the device comprises a shell 10, a reagent kit 11, a detection seat 12 and a microfluidic chip detection module 13.

The casing 10 forms an accommodating space, and the reagent kit 11, the detection seat 12 and the microfluidic chip detection module 13 are all positioned in the accommodating space. In other embodiments, the housing 10 may not be provided.

Specifically, as shown in fig. 2, the reagent kit 11 includes a box body 111 and a plurality of impedance detection cells (not labeled in the figure) disposed on the box body 111, and the plurality of impedance detection cells are used for matching impedance detection.

The impedance detection cell comprises a front cell (not shown) and a rear cell (not shown), the front cell is provided with a front cell electrode (not shown), the rear cell is provided with a rear cell electrode (not shown), a microporous sheet (not shown) is arranged between the front cell and the rear cell, and one end of each of the front cell electrode and the rear cell electrode is exposed on the surface of the cell body to form an electrode contact point. As shown in fig. 2, in the present embodiment, two impedance detection cells are provided, which are a WBC (white blood cell) detection cell 112 and a RBC (red blood cell) detection cell 113. The rear pool is communicated with a cavity, the bottom of the cavity is closed, the upper opening of the cavity is a pressure plug jack 105, the pressure plug jack is connected with a negative pressure connecting device when measurement is carried out, and under the action of negative pressure, a sample in the front pool enters the rear pool through the micro-porous sheet so as to count cells.

Optionally, the front cell of the WBC detection cell 112 is provided with an optically transparent window (not shown) having an outer surface recessed into the outer surface of the front cell, and the detection window is slightly recessed to prevent wear and contamination.

As shown in fig. 2, the box body 111 may further be provided with a diluent tank 114, a hemolytic agent tank 115, a cleaning tank 116, and a pre-dilution tank 117 for cooperating with WBC detection. The hemolytic agent reservoir 115 is used for containing hemolytic agent, the cleaning reservoir 116 is used for containing cleaning liquid, and the diluent reservoir 115 is used for containing diluent.

In other embodiments, one or more optical detection cells may be disposed on the box 111 for performing photoelectric detection of transmitted light and/or photoelectric detection of scattered light, and the optical detection cells may be made of optical plastic, transparent plastic, or glass.

The various tanks can be integrally formed with the box body 111, and can also be detachably connected with the box body 111. The tank body is sealed by a film or a rubber plug after being filled with liquid.

It is understood that the cartridge 111 may further be provided with a reagent pool matched with the microfluidic chip detection module 13, and may be specifically configured as required.

Further, in the embodiment shown in fig. 2, a sample placing hole 101 is further provided on the box body 111, and the sample placing hole 101 is used for placing a sample tube. The cassette 111 is further provided with a first pipette tip placement hole 102 and a second pipette tip placement hole 103, the first pipette tip placement hole 102 being used for placing a first pipette tip (not shown) for inserting a pipette 15 described below, and the second pipette tip placement hole 103 being used for placing a second pipette tip (not shown) for inserting the pipette 15. The box body 111 is also provided with a puncture tube placing hole 104, and if the tank body provided with liquid on the kit 11 adopts a membrane sealing scheme, the puncture tube placing hole 104 is used for placing a puncture tube for a pipette 15 to be inserted and connected to puncture a membrane sealing. In other embodiments, the sealing membrane may be directly pierced by a pipette tip of pipette 15.

It is understood that the type and number of the wells and the holes on the box 111 can be set according to the actual requirement, and are not limited specifically herein.

The test seat 12 is used for accommodating the reagent cartridge 11. Specifically, as shown in fig. 1, a detection tray assembly 120 is disposed in the housing 10, the detection tray assembly 120 is used for carrying the detection seat 12, and the detection tray assembly 120 can move in one or two dimensions. The detection seat 12 is a semi-closed cavity with an opening at the upper end, and the exterior of the detection seat is made of metal materials, so that external electromagnetic interference can be shielded for electrical impedance detection. The detection seat 12 is mounted on the detection tray assembly 120 and can move with the detection tray assembly 120 in one or two dimensions, so as to facilitate placing and taking out the reagent kit 11 and/or the microfluidic chip detection module 13 and liquid transferring operation.

The test socket 12 is provided with a plurality of impedance testing components (not shown) and/or temperature control components (not shown) and an image recognition base 121.

Further, the component for impedance detection includes an electrode conducting device (not shown), and when the reagent cartridge 11 is installed in the detection seat 12, the electrode conducting device is electrically contacted with an electrode on the reagent cartridge, so as to perform electrical impedance detection on the sample in the reagent cartridge 11. The image recognition base 121 is used for supporting the microfluidic chip detection module 13 and providing light source irradiation for the microfluidic chip detection module 13.

As shown in fig. 1, the sample analyzer 100 further includes a shielding cover assembly 16, the shielding cover assembly 16 is disposed in the housing 10, the shielding cover assembly 16 includes a metal cover and is capable of moving up and down, and the size of the metal cover can fully cover the upper opening of the detection seat 12, when the shielding cover assembly 16 descends to the detection seat 12, the reagent kit 11 can be enclosed in a cavity formed by the detection seat 12 and the shielding cover assembly 16, and the reagent kit 11 is shielded from external electromagnetic interference during the electrical impedance method test, the shielding cover assembly 16 is provided with a negative pressure connection device 161, the negative pressure connection device 161 is used for connecting the reagent kit 11, so that the negative pressure in the air path system acts on the reagent kit 11, and provides a driving force for the sample flow detected by the electrical impedance method.

Further, in this embodiment, as shown in fig. 2, the microfluidic chip detection module 13 is disposed on the box body 111, and the microfluidic chip detection module 13 may be detachably connected to the box body 111. Specifically, a clamping groove (not shown) is disposed on the box body 111, and the microfluidic chip detection module 13 is disposed in the clamping groove. In another embodiment, the card slot may also be a stand-alone card slot. In other embodiments, the microfluidic chip detection module 13 and the cartridge 111 may be integrally formed, for example, the microfluidic chip detection module 13 may be integrally formed with the cartridge 111.

Optionally, the microfluidic chip detection module 13 may also be disposed on the detection seat 12, and the microfluidic chip detection module 13 may be detachably connected to the detection seat 12, for example, the microfluidic chip detection module 13 may be directly disposed on the image recognition base 121, or a clamping groove (not shown) is disposed on the detection seat 12, and the microfluidic chip detection module 13 is clamped in the clamping groove of the detection seat 12, which can simplify the overall structure of the kit 11.

Further, the microfluidic chip detection module 13 includes at least one of a blood coagulation detection module, a microorganism detection module, a luminescence immunoassay detection module, a urinary sediment detection module, and an insect egg and feces detection module. For example, the microfluidic chip detection module 13 includes a blood coagulation detection module, or the microfluidic chip detection module 13 includes a microorganism detection module and a luminescence immunoassay detection module. Specifically, the selection setting can be performed according to the items to be detected.

The blood coagulation detection module is used for carrying out blood coagulation project detection on a blood sample, the microorganism detection module is used for carrying out microorganism detection on body fluid, the luminescence immunoassay detection module is used for carrying out immunoassay on the blood sample, the urine sediment detection module is used for detecting sediment (formed components in urine) of urine, and the worm egg excrement detection module is used for carrying out worm egg detection on the excrement sample.

Further, the sample analyzer 100 further includes an image recognition device 14, the image recognition device 14 is located at one side of the detection seat 12, and the image recognition device 14 is configured to perform recognition detection on the microfluidic chip detection module 13 to obtain a detection result of the sample.

The image recognition device 14 may be located right above the image recognition base 121, that is, right above the microfluidic chip detection module 13, and is used for performing recognition detection on the microfluidic chip detection module 13.

In a specific embodiment, the image recognition device 14 can be fixed above the image recognition base 121 and keep a suitable distance for performing recognition detection on the microfluidic chip detection module 13. In another embodiment, as shown in FIG. 1, the image recognition device 14 may be combined with the shield cover assembly 16 described above and capable of up and down movement.

In a specific embodiment, the image recognition device includes a lens, and the microfluidic chip detection module 13 performs image acquisition through the lens to obtain a detection result of the sample according to the acquired image.

When the microfluidic chip detection module 13 includes a plurality of detection modules, the plurality of detection modules may share the same lens to perform image acquisition, for example, the microfluidic chip detection module 13 includes a blood coagulation detection module and a microorganism detection module, and the blood coagulation detection module and the microorganism detection module perform image acquisition through the shared lens. In this way, the overall structure of the sample analyzer 100 can be simplified, saving costs.

In other embodiments, the lenses of the microfluidic chip detection modules 13 may not be shared by multiple detection modules, but each detection module may be provided with a separate lens. For example, the microfluidic chip detection module 13 includes a blood coagulation detection module and a microorganism detection module, the image recognition device 14 includes a first lens and a second lens, the blood coagulation detection module performs image acquisition through the first lens, and the microorganism detection module performs image acquisition through the second lens. By the mode, different detection modules use different lenses to acquire images, so that interference between different detection modules can be avoided, and the reliability of sample detection is improved.

In particular, the coagulation detection module may comprise a microfluidic chip comprising a microchannel on which different samples may flow at different heights or distances due to different coagulation times. After the sample enters the micro-channel, the image recognition device acquires an image of the detection area of the micro-fluidic chip, and the blood coagulation time is calculated according to the flowing distance or height of the sample.

Specifically, the microorganism detection module comprises a microfluidic chip, wherein the microfluidic chip in the microorganism detection module comprises a cavity with a specific thickness, a processed body fluid sample is added into the cavity, a microscopic image of a detection area of the microfluidic chip is directly obtained through an image recognition device, and then the type of microorganism is detected and recognized through a feature recognition algorithm.

Specifically, the urinary sediment detection module comprises a micro-fluidic chip, the micro-fluidic chip of the urinary sediment detection module comprises a micro-channel, a urine sample flows in the micro-channel at a constant speed by virtue of capillary action, a sample image in a detection area of the micro-fluidic chip is obtained by an image recognition device, and then the form of the urinary sediment can be detected by a feature recognition algorithm.

Specifically, the luminescence immunoassay module comprises a micro-fluidic chip, a processed sample is placed in the micro-fluidic chip, a luminescence intensity image is collected on the sample through an image recognition device, and the concentration of the sample is calculated according to the gray value, so that the immunoassay result of the sample is obtained.

Specifically, worm's ovum excrement and urine detection module includes micro-fluidic chip, and this micro-fluidic chip includes the cavity of a fixed thickness, and the cavity is used for placing the excrement and urine sample of handling, and the excrement and urine sample can be spread in the cavity, and image recognition device gathers many pictures of detection zone, then detects the worm's ovum in the excrement and urine through the feature recognition algorithm. The treatment of the fecal sample before detection mainly comprises: adding the diluent for dilution, mixing evenly, and then filtering.

Further, as shown in fig. 1, the sample analyzer 100 further includes a pipette 15, the pipette 15 is disposed in the housing 10 and located above the detection seat 12, the pipette 15 can perform one-dimensional or two-dimensional movement, and the pipette 15 is matched with the movement of the detection tray assembly 120 for performing three-dimensional pipetting operation on the reagent kit 11; the pipettor 15 may include components such as solenoid valves, syringes or dosing pumps, tubing, pipette tip adapters, and the like. Alternatively, the pipettor 15 may be a set of movable quantitative liquid-transferring and liquid-separating systems, or may be a set of integrated air quantitative pumps driven by a driving device.

Further, the sample analyzer 100 may further include a control module (not shown) which may be disposed on the back of the housing 10, and to which all of the components within the housing 10 are powered and signal processed, and data analysis is connected. The output end of the control module can be connected with a display device and a printing device.

To sum up, the simple structure of sample analysis appearance 100 that this application provided can carry out impedance detection to the sample through the impedance detection pond, also can carry out the detection of other projects to the sample through micro-fluidic chip detection module, and the function is more, and convenience of customers uses, has stronger practicality.

The above description is only an embodiment of the present application, and is not intended to limit the scope of the present application, and all equivalent structures or equivalent processes performed by the present application and the contents of the attached drawings, which are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.

Claims (10)

1. A sample analyzer, the sample analyzer comprising:

the kit comprises a kit body and a plurality of impedance detection cells arranged on the kit body, wherein the impedance detection cells are used for matching impedance detection;

a test seat for accommodating the reagent cartridge;

the micro-fluidic chip detection module is arranged on the box body and/or the detection seat and comprises at least one of a blood coagulation detection module, a microorganism detection module, a luminous immunity detection module, a urinary sediment detection module and an insect egg and excrement detection module.

2. The sample analyzer of claim 1, further comprising an image recognition device for recognizing and detecting the microfluidic chip detection module.

3. The sample analyzer as claimed in claim 1, wherein the microfluidic chip detection module is integrally formed with the cartridge body, or the microfluidic chip detection module is detachably connected with the cartridge body and/or the detection seat.

4. The sample analyzer as claimed in claim 1, wherein a clamping groove is arranged on the box body and/or the detection seat, and the microfluidic chip detection module is clamped in the clamping groove.

5. The sample analyzer of any of claims 1-4, wherein the microorganism detection module comprises a microfluidic chip comprising a cavity of a predetermined thickness for placement of the sample.

6. The sample analyzer of any of claims 1-4 wherein the coagulation detection module comprises a microfluidic chip comprising microchannels configured to allow different samples to flow at different heights or distances within the microchannels due to different coagulation times.

7. The sample analyzer of any of claims 1-4, wherein the urinary sediment detection module comprises a microfluidic chip containing micro channels for enabling the sample to flow therein at a uniform rate by capillary action.

8. The sample analyzer of claim 2, further comprising a shield cover assembly movably disposed on one side of the test seat, the shield cover assembly being configured to cover the opening of the test seat to enclose the reagent cartridge in a cavity formed by the test seat and the shield cover assembly, the image recognition device being secured to the shield cover assembly.

9. The sample analyzer as claimed in claim 1, wherein the detection base is provided with an image recognition base, and the image recognition base is used for bearing the microfluidic chip detection module and providing light source irradiation for the microfluidic chip detection module.

10. The sample analyzer of claim 1, wherein the impedance detection cell comprises a front cell and a rear cell in communication with the front cell, a microporous sheet is disposed between the front cell and the rear cell, a front cell electrode is disposed in the front cell, and a rear cell electrode is disposed in the rear cell.

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