CN110559086B - Surgical mammary gland nuclear magnetic resonance examination accurate positioning auxiliary device and method - Google Patents
Surgical mammary gland nuclear magnetic resonance examination accurate positioning auxiliary device and method Download PDFInfo
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- 210000005075 mammary gland Anatomy 0.000 title claims abstract description 52
- 238000005481 NMR spectroscopy Methods 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims abstract description 17
- 210000000481 breast Anatomy 0.000 claims abstract description 36
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 34
- 239000011229 interlayer Substances 0.000 claims abstract description 13
- 208000026310 Breast neoplasm Diseases 0.000 claims abstract description 11
- 206010006187 Breast cancer Diseases 0.000 claims abstract description 9
- 239000003026 cod liver oil Substances 0.000 claims description 20
- 235000012716 cod liver oil Nutrition 0.000 claims description 20
- 238000002347 injection Methods 0.000 claims description 19
- 239000007924 injection Substances 0.000 claims description 19
- 230000005291 magnetic effect Effects 0.000 claims description 14
- 210000002445 nipple Anatomy 0.000 claims description 10
- 238000010146 3D printing Methods 0.000 claims description 7
- 210000002417 xiphoid bone Anatomy 0.000 claims description 4
- 239000000853 adhesive Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 3
- 239000003302 ferromagnetic material Substances 0.000 claims description 3
- 238000005498 polishing Methods 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 239000012780 transparent material Substances 0.000 claims description 3
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 229960000907 methylthioninium chloride Drugs 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005865 ionizing radiation Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000007639 printing Methods 0.000 description 2
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 1
- 241000402754 Erythranthe moschata Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 238000012938 design process Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
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- 230000008569 process Effects 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
- A61B2090/3908—Soft tissue, e.g. breast tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3937—Visible markers
- A61B2090/395—Visible markers with marking agent for marking skin or other tissue
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- High Energy & Nuclear Physics (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The invention discloses a surgical mammary gland nuclear magnetic resonance examination accurate positioning auxiliary device and a method for accurate positioning based on the device, wherein the surgical mammary gland nuclear magnetic resonance examination accurate positioning auxiliary device comprises: positioning cup with central hole, braces and shoulder straps connecting two cups; wherein the positioning cup is round, the diameter of the central hole is 2-3 cm, the inner ring of the cup is provided with a round interlayer, an adjusting belt is penetrated in the interlayer, and two ends of the adjusting belt extend out of the interlayer; three marking holes are arranged on the positioning cup, three small Kong Chengzheng triangular distribution holes are arranged, and the distance between the small holes is 2cm. The invention is simple, easy, economical and practical, does not increase the pain of the extra patient, reduces the operation time of the operation and ensures the accurate excision of the tumor. Can lay a foundation for accurately guiding positioning in breast tumor operation and for breast care operation.
Description
Technical Field
The invention belongs to the technical field of surgical clinical medicine, and particularly relates to a surgical mammary gland nuclear magnetic resonance examination accurate positioning auxiliary device and a method for accurate positioning based on the device.
Background
The breast mainly comprises fat and connective tissue, so that the structure is softer, the gravity effect easily deforms the breast, the shape change of the breast in the supine position and the prone position of the human body is larger, breast tumors often deform, the breast tumors cannot be positioned accurately during breast protection operation, and the enlarged excision or residual focus is often caused. At present, a positioning guide wire puncture method is conventionally adopted, namely, a pre-operation is carried out under the mammary gland perspective (X-ray or ultrasonic), a mammary gland focus is positioned, and an imaging doctor firstly uses a mammary gland positioning needle to put a guide wire into the mammary gland focus before the mammary gland operation, so that the position of the mammary gland focus is positioned; and then the focus is accurately found by the surgeon according to the guide of the guide wire. The defects are as follows: x-rays have ionizing radiation and are harmful to the body. X-ray is prone to missing lesions for dense breast. B ultrasonic treatment is not easy to find focus of infection for smaller tumor, and causes difficult positioning. 4. Both methods of lancing can add additional pain and additional expense to the patient. 5. The puncture method can only find the center of the tumor, and cannot accurately position the edge of the tumor.
Nuclear magnetic resonance is increasingly used in breast examinations because of its lack of ionizing radiation hazard, multiparameter imaging, and high soft tissue contrast imaging. In order to obtain high-quality breast images, a conventional breast coil is designed into a prone position examination mode, but the breast position is a supine position during B-ultrasonic examination and operation, and the prone position images of magnetic resonance have great change of tumor positions in the supine position due to soft texture, so that the operation range cannot be accurately judged by using the magnetic resonance images. Some students use supine magnetic resonance examination to solve the problem, but still have the following disadvantages: 1. the special breast coil for supine position examination is not available, so that the image quality is low, and the accurate tumor positioning is affected. 2. The surface coils used also deform the breast further under their own weight. 3. The supine position examination is usually performed by changing the coil after the standard prone position is enhanced and scanning after the body position, and the coil changing needs to take a long time, so that the contrast agent flowing out effect is obvious, and inaccuracy of tumor positioning is aggravated.
Disclosure of Invention
The invention aims at overcoming the defects of the prior art and provides a surgical mammary gland nuclear magnetic resonance examination accurate positioning auxiliary device and a method for accurate positioning based on the device.
In order to achieve the above purpose, the present invention adopts the following technical scheme: a surgical breast nmr check accurate positioning assistance device, comprising: positioning cup with central hole, braces and shoulder straps connecting two cups; wherein the positioning cup is round, the diameter of the central hole is 2-3 cm, the inner ring of the cup is provided with a round interlayer, an adjusting belt is penetrated in the interlayer, and two ends of the adjusting belt extend out of the interlayer; three marking holes are arranged on the positioning cup, three small Kong Chengzheng triangular distribution holes are arranged, and the distance between the small holes is 2cm.
Further, two ends of the braces are fixed through adhesive pieces arranged at the ends.
Further, a back buckle for adjusting the length is arranged on the shoulder strap.
Further, the positioning cup is made of elastic composite materials with moderate hardness.
Further, the auxiliary positioning device is made of non-ferromagnetic materials.
A method for accurately positioning breast tumor based on an accurate positioning auxiliary device and 3D printing comprises the following steps: (1) Wearing an accurate positioning auxiliary device by a patient, fixing one cod liver oil at three marking holes of a positioning cup, and performing nuclear magnetic resonance examination;
(2) After the magnetic resonance examination is completed, pasting positioning labels on the surfaces of the mammary glands corresponding to the three marking holes of the positioning cup;
(3) Introducing MIMICS a mammary gland nuclear magnetic resonance image into MIMICS software for three-dimensional reconstruction, and reconstructing a cod liver oil image at three positions of locating cod liver oil on the surface of the reconstructed mammary gland;
(4) The obtained three-dimensional reconstructed breast, tumor and positioning cod liver oil images are imported into 3-MATIC software for processing, the design of a precise positioning device is carried out, the shape of the precise positioning device is consistent with that of a breast of a patient, a round hole is arranged in the center of the precise positioning device, three identical small holes are arranged at the position of positioning cod liver oil, 3-5 cylindrical injection holes are arranged at the position 5mm away from the edge of the tumor, and the precise positioning device is printed by a 3D printer;
(5) The accurate positioning device is placed at the corresponding mammary gland part of a patient, the positions of the three small holes correspond to the positions of the mammary gland surface positioning label marks one by one, and after the accurate positioning device for the tumor is matched with the mammary gland, the disposable injector is used for injecting methylene blue at the cylindrical injection hole of the accurate positioning device for accurately positioning the tumor of the mammary gland.
Furthermore, in the step 1, the patient wears the accurate positioning auxiliary device, so that the nipple of the patient is exposed out of the center hole of the positioning cup; the circular adjustable belt of the inner ring of the cup is adjusted according to the size of the mammary gland, so that the cup is attached to the surface of the mammary gland; the length of the shoulder straps at two sides is adjusted, and the strap magic tape is adjusted, so that the positioning cup is attached to the body to better fix the mammary gland.
Further, the accurate positioning device in the step 3 is provided with two direction marks at the round hole edge, wherein the first direction mark points to the opposite nipple, and the second direction mark points to the xiphoid process
Furthermore, the precise positioning device in step 4 needs polishing and disinfection treatment before use.
Further, the cylindrical injection hole is made of transparent material, the inner diameter is 5.5mm, and the height is 5cm; the outer surface of the cylindrical injection hole is provided with a graduated scale, and the graduated scale is used for marking the distance from the position corresponding to the cylindrical injection hole to the edge of the tumor; the inner surface of the cylindrical injection hole is provided with a clamping groove.
Firstly, a self-made accurate positioning auxiliary device for surgical mammary gland nuclear magnetic resonance examination is used for fixing the mammary gland morphology of a patient to a certain extent, MIMICS software is used for dividing tumors and reconstructing the surface of the mammary gland in a three-dimensional way, and mammary gland and tumor models are established; the 3-MATIC software is applied to design a personalized positioning device according to the three-dimensional mammary gland and tumor model; printing a personalized accurate positioning device by using a 3D printer and performing post-treatment such as disinfection; finally, after the patient is anesthetized, a 3D printed accurate positioning device is arranged, and methylene blue is injected into the 5mm position of the tumor edge through a cylindrical injection hole of the accurate positioning device, so that the edge of the tumor to be resected is marked. According to the technology, cod liver oil is pasted at three different positions on the surface of a mammary gland during magnetic resonance examination, positioning labels are pasted on the surface of the mammary gland at the three same positions, the three positions for pasting the cod liver oil can be displayed when MIMICS software reconstructs the surface of the mammary gland in a three-dimensional mode, three small holes are respectively designed at the three positions for pasting the cod liver oil when 3-MATIC software processes the surface of the mammary gland, and the three marks of a sign pen on the surface of the mammary gland are corresponding to the three small holes when the 3D printing positioning device is applied to a patient operation, so that the 3D printing positioning device is completely attached to the shape of the mammary gland. The invention is simple, easy, economical and practical, does not increase the pain of the extra patient, reduces the operation time of the operation and ensures the accurate excision of the tumor. Can lay a foundation for accurately guiding positioning in breast tumor operation and for breast care operation.
Drawings
Fig. 1 is a schematic structural view of an embodiment of an auxiliary device for accurate positioning for nuclear magnetic resonance examination of external mammary glands.
Fig. 2 is a schematic structural diagram of an embodiment accurate positioning device.
Detailed Description
In order that those skilled in the art will better understand the present application, a technical solution in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in which it is apparent that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present application without making any inventive effort, shall fall within the scope of the present application.
(One) surgical mammary gland nuclear magnetic resonance examination accurate positioning auxiliary device, including: a positioning cup 1 with a hole at the center, a brace 2 and a shoulder strap 3 for connecting the two cups. The used materials are free of ferromagnetic materials, so that the influence on images in magnetic resonance examination is avoided.
Wherein the positioning cup is round, the diameter of the central hole is 3cm, the inner ring of the cup is provided with a round interlayer 4, an adjusting belt 5 is penetrated in the interlayer, and two ends of the adjusting belt extend out of the interlayer. Three marking holes 6 are arranged on the positioning cup, three small Kong Chengzheng are distributed in a triangular mode, and the distance between the small holes is 2cm. The positioning cup is made of elastic composite material with moderate hardness.
The two ends of the braces are fixed through adhesive pieces arranged at the ends, and the shoulder straps are provided with a back buckle 7 for adjusting the length.
(II) accurate positioner of preparation
(1) The patient was prepared for routine breast nmr scanning (additive plain scan enhancement) with all metal removed, and then a precision positioning aid was applied: the nipple is exposed out of the middle hole of the positioning cup; the adjustable band in the circular interlayer of the inner ring of the cup is adjusted according to the size of the mammary gland, so that the cup can be well attached to the surface of the mammary gland; the length of the shoulder straps at two sides is adjusted, and the strap magic tape is adjusted, so that the positioning cup is well attached to the body to better fix the mammary gland.
(2) The positioning cup is reserved with three small holes A, B, C of regular triangle, the corresponding breast surface is marked by a sign pen, three cod liver oil particles are fixed at the three small holes A, B, C, and after the magnetic resonance examination is finished, positioning labels A ', B ', C ' are stuck at the cross mark position of the sign pen on the breast surface, so that the mark can be accurately stored until the operation is performed.
(3) The patient with the fixed positioning auxiliary device is sent into a magnetic resonance examination room (the conventional breast nuclear magnetic resonance examination is prone), the positioning cod liver oil in the magnetic resonance image is clearly displayed, and the obtained DICOM-format magnetic resonance image is imported into MIMICS software to carry out tumor segmentation and breast surface three-dimensional reconstruction, so as to establish breast and tumor models. The functions of MUSK, hollow and the like of 3-MATIC are applied to obtain the surface of the breast of the personalized patient, and the tumor positioning device is completely attached to the breast model, so that a foundation is laid for accurately positioning tumors. In the design process of the accurate positioning device in the mammary gland tumor operation, three small holes a, b and c are respectively designed at three positions of the positioning cod liver oil A, B, C. The nipple position of the accurate positioning device is designed to be a round hole 8 with a diameter slightly larger than that of the nipple, two direction marks are designed on the round hole, a first direction mark 9 points to the opposite nipple, and a second direction mark 10 points to the xiphoid process. 3-5 (number is determined according to the tumor size and shape) cylinder injection holes 11 are designed at intervals of 5mm at the edge of the tumor of the patient, the inner diameter of each cylinder injection hole is designed to be 5.5mm, the height of each cylinder injection hole is 5cm, a graduated scale accurate to millimeter is designed, the cylinder injection holes are made of transparent materials, clamping grooves 12 are designed at the bottom of each cylinder hole, and the clamping grooves are used for being beneficial to fixing the positions of the syringes. And after the application 3-MATIC is designed, storing the STL 3D printing format file.
(4) And selecting a proper 3D printer and printing materials to print the accurate positioning device in the mammary tumor operation, and polishing and sterilizing the positioning device for application in an operating room.
Method for precisely positioning breast tumor by using precise positioning device
Special attention should be paid to applying the accurate positioning device in breast tumor operation to the surface of the breast of a patient: first, the nipple exposes the middle hole of the accurate positioning device; secondly, the mammary gland positioning device is characterized in that a first direction mark points to the opposite nipple, and a second direction mark points to the xiphoid process; thirdly, the three small holes a, B and C designed by the mammary gland positioning device are in one-to-one correspondence with the positions of positioning labels A ', B ' and C ' at the position where the sign pen on the surface of the mammary gland makes a cross mark. Therefore, consistency of the prone position breast shape and the supine position breast shape of the accurate positioning device in the operation room for applying the 3D printing breast tumor during magnetic resonance examination by using the auxiliary device is realized, and a foundation is laid for applying the prone position magnetic resonance image design to produce the supine position 3D printing tumor accurate positioning device.
(1) After the accurate tumor positioning device is matched with the mammary gland, the disposable injector is used for injecting methylene blue at the cylindrical injection hole of the accurate tumor positioning device, the injection depth is set according to the distance from the surface of the mammary gland corresponding to each cylindrical hole in the magnetic resonance image to the edge of the tumor, and the graduated scale on the cylindrical hole can ensure the accuracy of the injection depth.
(2) The surgeon performs the operation, and the scope within the blue display at the edge of the tumor is the part needing to be excised. The method is simple and easy to implement, reduces pain of patients, saves treatment cost of the patients, shortens treatment period, and most importantly, reduces false positive and false negative results of tumor resection, greatly reduces recurrence rate after operation, and can lay foundation for accurately guiding positioning in breast tumor operation and for breast conservation operation.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. A surgical breast nuclear magnetic resonance examination accurate positioning auxiliary device, characterized by comprising: positioning cup with central hole, braces and shoulder straps connecting two cups; wherein the positioning cup is round, the diameter of the central hole is 2-3 cm, the inner ring of the cup is provided with a round interlayer, an adjusting belt is penetrated in the interlayer, and two ends of the adjusting belt extend out of the interlayer; three marking holes are formed in the positioning cup, three small Kong Chengzheng triangular holes are distributed, and the distance between the small holes is 2cm; the method comprises the steps that when nuclear magnetic resonance examination is carried out on breast tumors, one cod liver oil is fixed in each marking hole, when a breast nuclear magnetic resonance image is reconstructed in a three-dimensional mode, cod liver oil images are reconstructed at three positions of the reconstructed breast surface for positioning the cod liver oil, positioning labels are adhered to the breast surfaces corresponding to the three marking holes of the positioning cup, when the precise positioning device is designed, the shape of the precise positioning device is consistent with the shape of a breast of a patient, a round hole is formed in the center, three identical small holes are formed in the position of positioning the cod liver oil, and the positions of the three small holes correspond to the marking positions of the positioning labels on the breast surface one by one, so that precise positioning is achieved; the two ends of the braces are fixed through adhesive pieces arranged at the ends;
the shoulder straps are provided with a eight buckle for adjusting the length.
2. The accurate positioning assistance apparatus according to claim 1, wherein: the positioning cup is made of elastic composite materials with moderate hardness.
3. The accurate positioning assistance apparatus according to claim 1, wherein: the accurate positioning auxiliary device is made of a non-ferromagnetic material.
4. The method for accurately positioning the breast tumor based on the accurate positioning auxiliary device and the 3D printing is characterized by comprising the following steps of:
(1) Wearing an accurate positioning auxiliary device by a patient, fixing one cod liver oil at three marking holes of a positioning cup, and performing nuclear magnetic resonance examination;
(2) After the magnetic resonance examination is completed, pasting positioning labels on the surfaces of the mammary glands corresponding to the three marking holes of the positioning cup;
(3) Introducing MIMICS a mammary gland nuclear magnetic resonance image into MIMICS software for three-dimensional reconstruction, and reconstructing a cod liver oil image at three positions of locating cod liver oil on the surface of the reconstructed mammary gland;
(4) The obtained three-dimensional reconstructed breast, tumor and positioning cod liver oil images are imported into 3-MATIC software for processing, the design of a precise positioning device is carried out, the shape of the precise positioning device is consistent with that of a breast of a patient, a round hole is arranged in the center of the precise positioning device, three identical small holes are arranged at the position of positioning cod liver oil, 3-5 cylindrical injection holes are arranged at the position 5mm away from the edge of the tumor, and the precise positioning device is printed by a 3D printer;
(5) The accurate positioning device is placed at the corresponding mammary gland part of the patient, and the positions of the three small holes correspond to the positions of the mammary gland surface positioning label marks one by one.
5. The method according to claim 4, wherein: the patient wears the accurate positioning auxiliary device in the step 1, namely, the nipple of the patient is exposed out of the center hole of the positioning cup; the circular adjustable belt of the inner ring of the cup is adjusted according to the size of the mammary gland, so that the cup is attached to the surface of the mammary gland; the length of the shoulder straps at two sides is adjusted, and the strap magic tape is adjusted, so that the positioning cup is attached to the body to better fix the mammary gland.
6. The method according to claim 4, wherein: the accurate positioning device in the step 3 is provided with two direction marks at the edge of the round hole, wherein the first direction mark points to the opposite nipple, and the second direction mark points to the xiphoid process.
7. The method according to claim 4, wherein: the accurate positioning device in the step 4 needs polishing and disinfection treatment before use.
8. The method according to claim 4, wherein: the cylindrical injection hole is made of transparent materials, the inner diameter is 5.5mm, and the height is 5cm; the outer surface of the cylindrical injection hole is provided with a graduated scale, and the graduated scale is used for marking the distance from the position corresponding to the cylindrical injection hole to the edge of the tumor; the inner surface of the cylindrical injection hole is provided with a clamping groove.
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| KR20130142275A (en) * | 2012-06-19 | 2013-12-30 | 주식회사 빅앤빅 | Structure for adjustment brassiere cup size |
| CN209499912U (en) * | 2018-06-05 | 2019-10-18 | 江苏省人民医院（南京医科大学第一附属医院） | Accurate positioning auxiliary device for surgical breast nuclear magnetic resonance examination |
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| DE4225001C1 (en) * | 1992-07-29 | 1993-11-18 | Siemens Ag | Stereo-tactic additional device for nuclear spin tomography for investigation of mammary disorders - has two compression plates parallel and displaceable towards one another, between which object for investigation e.g breast is positioned |
| US20060009693A1 (en) * | 2004-04-08 | 2006-01-12 | Techniscan, Inc. | Apparatus for imaging and treating a breast |
| US7708751B2 (en) * | 2004-05-21 | 2010-05-04 | Ethicon Endo-Surgery, Inc. | MRI biopsy device |
| EP1741469A1 (en) * | 2005-07-08 | 2007-01-10 | Engineers & Doctors Wallstén Medical A/S | Method of guiding an irradiation equipment |
| CA2648277C (en) * | 2006-04-04 | 2016-06-21 | University Health Network | A coil electrode apparatus for thermal therapy |
| US20070276229A1 (en) * | 2006-05-23 | 2007-11-29 | Accuray Incorporated | Breast restraint |
| PL381431A1 (en) * | 2006-12-29 | 2008-07-07 | Jacek Stępień | Thermomastographic apparatus for differentiating diagnostics for detection of breast pathology in women and application of thermomastographic apparatus for differentiating apparatus |
| US7752768B2 (en) * | 2008-07-23 | 2010-07-13 | Bodyaesthetic Research Center, Inc. | Marker template for breast reduction surgery |
| CN101428166A (en) * | 2008-09-13 | 2009-05-13 | 郑奇 | Fixation method and device for breast in prostrate radiotheraphy of human body breast |
| CN202568287U (en) * | 2012-04-14 | 2012-12-05 | 张颖颖 | Mammary gland CT (Computed Tomography) scanning supporting bracket |
| CN104306386A (en) * | 2014-09-25 | 2015-01-28 | 江苏省人民医院 | Application of paclitaxel combined Shenyi capsule and EGFR-TKIs in preparation of medicines for treating EGFR mutation positive NSCLC |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130142275A (en) * | 2012-06-19 | 2013-12-30 | 주식회사 빅앤빅 | Structure for adjustment brassiere cup size |
| CN209499912U (en) * | 2018-06-05 | 2019-10-18 | 江苏省人民医院（南京医科大学第一附属医院） | Accurate positioning auxiliary device for surgical breast nuclear magnetic resonance examination |
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