CN110302140A - A kind of picria fel tarrae gel and preparation method thereof - Google Patents
A kind of picria fel tarrae gel and preparation method thereof Download PDFInfo
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- CN110302140A CN110302140A CN201910480306.4A CN201910480306A CN110302140A CN 110302140 A CN110302140 A CN 110302140A CN 201910480306 A CN201910480306 A CN 201910480306A CN 110302140 A CN110302140 A CN 110302140A
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- picria fel
- fel tarrae
- carbomer
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- 241001375216 Picria Species 0.000 title claims abstract description 71
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 238000001879 gelation Methods 0.000 title abstract description 4
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 44
- 229960001631 carbomer Drugs 0.000 claims abstract description 44
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 35
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 10
- 239000008213 purified water Substances 0.000 claims abstract description 10
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000000084 colloidal system Substances 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 238000004090 dissolution Methods 0.000 claims description 3
- 208000020670 canker sore Diseases 0.000 abstract description 14
- 230000035876 healing Effects 0.000 abstract description 5
- 230000000202 analgesic effect Effects 0.000 abstract description 4
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 2
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 208000030961 allergic reaction Diseases 0.000 abstract description 2
- 239000003937 drug carrier Substances 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 230000008719 thickening Effects 0.000 abstract 1
- 241000700159 Rattus Species 0.000 description 14
- 241000219109 Citrullus Species 0.000 description 6
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 6
- 208000025865 Ulcer Diseases 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 231100000397 ulcer Toxicity 0.000 description 5
- 210000000214 mouth Anatomy 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 241000219112 Cucumis Species 0.000 description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 2
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 208000002399 aphthous stomatitis Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- FPVRUILUEYSIMD-RPRRAYFGSA-N [(8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(OC(C)=O)[C@@]1(C)C[C@@H]2O FPVRUILUEYSIMD-RPRRAYFGSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000005178 buccal mucosa Anatomy 0.000 description 1
- 229960003657 dexamethasone acetate Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 238000007157 ring contraction reaction Methods 0.000 description 1
- 210000001584 soft palate Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000001720 vestibular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The technical program discloses a kind of picria fel tarrae gel and preparation method thereof, and the Traditional Chinese medicine gel includes the raw material of following mass parts: 50~80 parts of powder, 50~100 parts of carbomer, 100~150 parts of purified water, 15~40 parts of triethanolamine, 10~35 parts of hydrochloric acid is concentrated in picria fel tarrae extract.Picria fel tarrae gel described in the technical program has outstanding anti-inflammation and sterilization, analgesic activity, and picria fel tarrae extract can accelerate affected part healing；Carbomer has good adhesion, thickening property, emulsibility, suspending and film forming, and carbomer safety and stability, non-stimulated and allergic reaction, so that carbomer becomes outstanding pharmaceutical carrier, picria fel tarrae gel described in the technical program can completely cut off affected part well, conducive to the self-healing of canker sore；Picria fel tarrae preparation method described in the technical program can be made easily while active principle is not destroyed in guaranteeing picria fel tarrae extract and have no bubble, finer and smoother gel.
Description
Technical field
The technical program belongs to technical field of traditional Chinese medicines, in particular to a kind of picria fel tarrae gel and preparation method thereof.
Background technique
Canker sore is commonly called as " aphtha ", is a kind of common ulcerative damages illness for betiding cavity mucous membrane, is more common in
The mucous membrane at the positions such as lip inside, tongue, tongue abdomen, buccal mucosa, vestibular ditch, soft palate, these positions lacks keratinization or angling is poor.
Canker sore is a kind of self-limited disease, and not medication can also fully recover.But severe pain allows people's sleeping and eating difficulty to pacify, ulcer
It is easy to induce infection；Medication is primarily to analgesic and anti-infection.The product for treating canker sore on the market at present has: 1) watermelon
White spray, but some local sprays are difficult to be sprayed onto oral cavity, patient needs repeatedly to carry out medicament spraying, and west to affected part
The taste of melon frost spray is bitter, and spray can very bitterly when touching affected part；2) Dobell, Dobell are imitated with good anti-inflammatory
Fruit, but need for this piece to be contained in affected part, the curative effect just having had, therefore inconvenient to use；3) dexamethasone acetate plaster, this
Medicament has good analgesic effect, but inconvenient to use, is easy to paste askew or patch less than affected part, is easy, can not cover
Big ulcer, and this medicament contains hormone, cannot use for a long time.
Summary of the invention
The technical program provides a kind of picria fel tarrae gel, and the picria fel tarrae gel is easy to use, can stop in affected part enough
The long time, and the picria fel tarrae gel is hormone-free, has good therapeutic effect to canker sore.
To achieve the above object, the technical program adopts the following technical solutions.
A kind of picria fel tarrae gel, the Traditional Chinese medicine gel include the raw material of following mass parts: powder 50 is concentrated in picria fel tarrae extract
~80 parts, 50~100 parts of carbomer, 100~150 parts of purified water, 15~40 parts of triethanolamine, 10~35 parts of hydrochloric acid.
Further, the concentration of the hydrochloric acid is 0.1mol/L.
A kind of preparation method of picria fel tarrae gel, comprising the following steps:
(1) it takes purified water to be put into container according to mass parts described above, and quickly stirs purified water, quickly stirring
During, it is slowly added to carbomer, is swollen carbomer, carbomer colloid is made；A container separately is taken, purifying is added to it
Then water is inwardly added picria fel tarrae extract and powder is concentrated, and stirring makes picria fel tarrae extract that powder dissolution be concentrated, and picria fel tarrae is made
Extract solution；
(2) hydrochloric acid solution is added into carbomer colloid made from step (1), adjusts the pH value of carbomer colloid；
(3) picria fel tarrae extract solution is added in the carbomer colloid for completing step (2), and makes picria fel tarrae extract
Solution is uniformly mixed, and picria fel tarrae-carbomer mixture is made；
(4) triethanolamine is added into picria fel tarrae made from step (3)-carbomer mixture, adjusts picria fel tarrae-carbomer
The pH value of mixture obtains picria fel tarrae gel.
Further, the pH value of carbomer colloid is adjusted to 2 in step (2).
Further, in step (3), picria fel tarrae-carbomer colloid pH value is adjusted to 8.
The technical program has the beneficial effect that picria fel tarrae bitter, cold in nature, picria fel tarrae have anti-inflammatory antipyretic, analgesia, maincenter suppression
System, antibacterial, influence thoracic aortic ring contraction, it is antitumor the effects of；Therefore picria fel tarrae gel described in the technical program has excellent
Anti-inflammation and sterilization, the analgesic activity of show, and picria fel tarrae extract can accelerate affected part healing；Carbomer has good adhesion, increasing
Consistence, emulsibility, suspending and film forming, and carbomer safety and stability, non-stimulated and allergic reaction, so that carbomer becomes
Outstanding pharmaceutical carrier, therefore picria fel tarrae gel described in the technical program is not easily to fall off, can cover affected part well, and block
Wave nurse also has film forming well, therefore picria fel tarrae gel described in the technical program can completely cut off affected part well, be conducive to
The self-healing of canker sore；
Picria fel tarrae preparation method described in the technical program, active principle is not destroyed in guaranteeing picria fel tarrae extract
Meanwhile can be made easily and have no bubble, finer and smoother gel.
Specific embodiment
Embodiment 1
A kind of picria fel tarrae gel, the Traditional Chinese medicine gel include the raw material of following mass parts: powder 70 is concentrated in picria fel tarrae extract
Part, 50 parts of carbomer, 100 parts of purified water, 15 parts of triethanolamine, 10 parts of hydrochloric acid.
Further, the concentration of the hydrochloric acid is 0.1mol/L.
A kind of preparation method of picria fel tarrae gel, comprising the following steps:
(1) it takes purified water to be put into container according to mass parts described above, and quickly stirs purified water, quickly stirring
During, it is slowly added to carbomer, is swollen carbomer, carbomer colloid is made；A container separately is taken, purifying is added to it
Then water is inwardly added picria fel tarrae extract and powder is concentrated, and stirring makes picria fel tarrae extract that powder dissolution be concentrated, and picria fel tarrae is made
Extract solution；
(2) hydrochloric acid solution is added into carbomer colloid made from step (1), adjusts the pH value of carbomer colloid；
(3) picria fel tarrae extract solution is added in the carbomer colloid for completing step (2), and makes picria fel tarrae extract
Solution is uniformly mixed, and picria fel tarrae-carbomer mixture is made；
(4) triethanolamine is added into picria fel tarrae made from step (3)-carbomer mixture, adjusts picria fel tarrae-carbomer
The pH value of mixture obtains picria fel tarrae gel.
Further, the pH value of carbomer colloid is adjusted to 2 in step (2).
Further, picria fel tarrae-carbomer colloid pH value is adjusted to 8 in step (3).
32 rats are chosen, and this 32 rats are carried out glacial acetic acid modeling 24 hours, then by this 32 rats point
For control group, water melon frost group, picria fel tarrae group, carbomer group；It is not administered to rat canker sore affected part in control group wherein；To west
The canker sore successive administration of the rat of melon frost group 6 days, institute's medication are spraying for water melon frost；To the oral cavity of the rat in picria fel tarrae group
Ulcer successive administration 6 days, institute's medication was picria fel tarrae gel obtained in embodiment 1；It bursts to the oral cavity of the rat in carbomer group
Successive administration 6 days at ulcer, institute's medication are carbomer gel；Guarantee water melon frost group, the dosage of picria fel tarrae group and carbomer group with
Administration time is identical, and the living environment of the rat in 4 groups and food are just the same；It bursts daily to the oral cavity of rat in 4 groups
Ulcer diameter measures, and the results are shown in Table 1；The results are shown in Table 2 for each group rat canker sore healing rate.
The variation of rat oral ulcer surface diameter in 14 groups of table
Note: each group is compared with model group on the same day, P < 0.05**P < 0.01 *
Each group compared with gel group on the same day,▲P<0.05▲▲P<0.01
Diameter of the rat canker sore diameter than first day has dropped in the 6th day in picria fel tarrae group as can be seen from Table 1
81.94%, and diameter of the rat canker sore diameter than first day has dropped 80.9% in the 6th day in water melon frost group, it is seen that this
Picria fel tarrae gel described in technical solution can effectively reduce canker sore diameter.
Rat canker sore healing rate changes with time in 24 groups of table
Note: each group is compared with model group on the same day, P < 0.05**P < 0.01 *
Each group compared with gel group on the same day,▲P<0.05▲▲P<0.01
As can be known from Table 2, the 6th day, model group, water melon frost group, picria fel tarrae gel group and carbomer gel group healing rate
Difference has height statistical significance (P < 0.01)；And know that picria fel tarrae gel described in the technical program can be effectively cured
Close canker sore.
Claims (5)
1. a kind of picria fel tarrae gel, which is characterized in that the Traditional Chinese medicine gel includes the raw material of following mass parts: picria fel tarrae extract
50~80 parts of powder, 50~100 parts of carbomer, 100~150 parts of purified water, 15~40 parts of triethanolamine, hydrochloric acid 10~35 is concentrated
Part.
2. a kind of picria fel tarrae gel according to claim 1, which is characterized in that the concentration of the hydrochloric acid is 0.1mol/L.
3. a kind of preparation method of picria fel tarrae gel, which comprises the following steps:
(1) it takes purified water to be put into container according to the mass parts of the picria fel tarrae gel described in claim 1, and quickly stirs pure
Change water, during quick stirring, be slowly added to carbomer, be swollen carbomer, carbomer colloid is made；Separately take an appearance
Purified water is added to it in device, picria fel tarrae extract is then inwardly added, powder is concentrated, and stirring makes picria fel tarrae extract that powder be concentrated
Picria fel tarrae extract solution is made in dissolution；
(2) hydrochloric acid solution is added into carbomer colloid made from step (1), adjusts the pH value of carbomer colloid；
(3) picria fel tarrae extract solution is added in the carbomer colloid for completing step (2), and makes picria fel tarrae extract solution
It is uniformly mixed, picria fel tarrae-carbomer mixture is made；
(4) triethanolamine is added into picria fel tarrae made from step (3)-carbomer mixture, adjusts picria fel tarrae-carbomer mixing
The pH value of object obtains picria fel tarrae gel.
4. a kind of preparation method of picria fel tarrae gel according to claim 3, which is characterized in that will card in step (2)
The pH value of wave nurse colloid is adjusted to 2.
5. a kind of preparation method of picria fel tarrae gel according to claim 3, which is characterized in that, will be bitter in step (3)
Radix scrophulariae-carbomer colloid pH value is adjusted to 8.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910480306.4A CN110302140A (en) | 2019-06-04 | 2019-06-04 | A kind of picria fel tarrae gel and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910480306.4A CN110302140A (en) | 2019-06-04 | 2019-06-04 | A kind of picria fel tarrae gel and preparation method thereof |
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| Publication Number | Publication Date |
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| CN110302140A true CN110302140A (en) | 2019-10-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910480306.4A Pending CN110302140A (en) | 2019-06-04 | 2019-06-04 | A kind of picria fel tarrae gel and preparation method thereof |
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| CN (1) | CN110302140A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641376A (en) * | 2012-05-08 | 2012-08-22 | 广西壮族自治区中国科学院广西植物研究所 | Application of Picria fel-terrae Lour extract in pharmacy |
| CN103446294A (en) * | 2013-09-18 | 2013-12-18 | 海南华拓天涯制药有限公司 | Murrayae folium ET Cacumen extract preparation method, Murrayae folium ET Cacumen extract obtained thereby and application thereof |
| CN103877132A (en) * | 2014-02-19 | 2014-06-25 | 合肥海大生物医药科技有限公司 | Sunset abelmoschus flower general flavone gel for treating dental ulcer and preparation method of gel |
| AU2017261372A1 (en) * | 2016-05-05 | 2018-11-22 | Triastek, Inc. | Controlled release dosage form |
-
2019
- 2019-06-04 CN CN201910480306.4A patent/CN110302140A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641376A (en) * | 2012-05-08 | 2012-08-22 | 广西壮族自治区中国科学院广西植物研究所 | Application of Picria fel-terrae Lour extract in pharmacy |
| CN103446294A (en) * | 2013-09-18 | 2013-12-18 | 海南华拓天涯制药有限公司 | Murrayae folium ET Cacumen extract preparation method, Murrayae folium ET Cacumen extract obtained thereby and application thereof |
| CN103877132A (en) * | 2014-02-19 | 2014-06-25 | 合肥海大生物医药科技有限公司 | Sunset abelmoschus flower general flavone gel for treating dental ulcer and preparation method of gel |
| AU2017261372A1 (en) * | 2016-05-05 | 2018-11-22 | Triastek, Inc. | Controlled release dosage form |
Non-Patent Citations (2)
| Title |
|---|
| 陈红风，等: "《中医外科学》", 31 August 2016, 中国中医药出版社 * |
| 马丽华，等: "《中国秘方大全 临床实用验方》", 31 October 2003, 军事医学科学出版社 * |
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