CN110123682A - A kind of personal care articles preparation method with inhibition propionibacterium acnes - Google Patents
A kind of personal care articles preparation method with inhibition propionibacterium acnes Download PDFInfo
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- CN110123682A CN110123682A CN201910267112.6A CN201910267112A CN110123682A CN 110123682 A CN110123682 A CN 110123682A CN 201910267112 A CN201910267112 A CN 201910267112A CN 110123682 A CN110123682 A CN 110123682A
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- personal care
- propionibacterium acnes
- care articles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/87—Polyurethanes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Birds (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
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- Microbiology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Cosmetics (AREA)
Abstract
The disclosure of the invention of this composite skin care product preparation technical field is a kind of with the personal care articles preparation method for inhibiting propionibacterium acnes, this has, and to inhibit the personal care articles composition of propionibacterium acnes include: Fermentation in Pichia Pastoris lysis object filtrate by weight percentage: 80%；PEG-240/HDI copolymer pair--20 ether of decyl alkanol polyethers: 0.5%；Butanediol and water: 0.5%；1,2 hexylene glycol: 0.3%；Propylene glycol: 2%；Water: 17.2%; the present invention inhibits propionibacterium acnes ability to be better than salicylic acid; linear relationship is presented to various fungistatic effects; additive amount is bigger, and bacteriostatic level is stronger; and present invention can apply in skin care item facial mask essence, Essence, lotion and cream maintenance skin effect object addition, and protect product stability.
Description
Technical field
The present invention relates to skin care field more particularly to a kind of personal care articles preparations with inhibition propionibacterium acnes
Method.
Background technique
Skin care item are many kinds of on the market at present, and effect is different, including whitening, moisturizing, nti-freckle and anti-aging etc..But it is very much
Product is more or less added to some chemical substances being harmful to the human body, although these substances have short-term beauty to the skin of people
The skin care effects such as white, anti-aging can make skin severely damaged, long acne, color spot and oil occur instead but if being used for a long time
Rouge dyssecretosis etc.；The personal-care supplies raw material for resisting propionibacterium acnes on the market at present is selected as salicylic acid, but because of it
Irritation and cutin to skin, which peel off degree, to generate a possibility that uncomfortable to consumer skin, in recent, skin surface benefit
Raw bacterium colony is increasing for the generation research of acne, it is believed that and the bacterium colony of propionibacterium acnes can be effectively suppressed in prebiotic bacterium colony, because
This, we have proposed a kind of with the personal care articles preparation method for inhibiting propionibacterium acnes.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and the one kind proposed has inhibition acne third
The personal care articles preparation method of acidfast bacilli.
To achieve the goals above, present invention employs following technical solutions: a kind of with inhibiting propionibacterium acnes
Personal care articles preparation method, this have inhibit propionibacterium acnes personal care articles composition include: by weight percentage
Preferably, described a kind of with the personal care articles preparation method for inhibiting propionibacterium acnes, this has inhibition Cuo
The personal care articles preparation method of sore Propionibacterium includes the following steps:
S1: raw material screening: with raw material by the percentage of composition in claim 1: pichia pastoris yeast is sent out
Ferment lysis object filtrate: 80%；PEG-240/HDI copolymer pair--20 ether of decyl alkanol polyethers: 0.5%；Butanediol and
Water: 0.5%；1,2 hexylene glycol: 0.3%；Propylene glycol: 2%；Water: 17.2%；
S2: it stirs for the first time: by Fermentation in Pichia Pastoris lysis object filtrate: 80%；PEG-240/HDI copolymer
Double--20 ether of decyl alkanol polyethers: 0.5%；Butanediol and water: 0.5% is sufficiently stirred in ultrasonic oscillator, revolving speed
It is 500 turns per minute, stirs 10 minutes, then pour the mixture into homogeneous 5 minutes in homogenizer, it is spare to obtain mixture；
S3: second stirs: will be added again 1,2 hexylene glycols in the resulting mixture of above-mentioned steps S1: 0.3%；The third two
Alcohol: 2%；Water: 17.2%, it is stirred in ultrasonic oscillator, obtains composition finished product after ten minutes.
Preferably, homogenizer model RX-200l in the step S2.
Preferably, composition finished product obtained in the step S3 is applied to face pack prescription addition 3-8%, is applied to essence
Liquid aqua adds 5-10%, is applied to cream emulsion and adds 5-10%.
It is provided by the invention a kind of with the personal care articles preparation method for inhibiting propionibacterium acnes, it is intended to be directed to existing
The technological deficiency of technology provides a kind of can add with the personal care articles for inhibiting propionibacterium acnes, to solve using bigcatkin willow
Acid can feel the offer another kind formula design alternative of excitement, inhibit propionibacterium acnes ability to be better than salicylic acid, to various
Linear relationship is presented in fungistatic effect, and additive amount is bigger, and bacteriostatic level is stronger, and present invention can apply to the facial masks in skin care item
Essence, Essence, lotion and cream maintenance skin effect object addition, and protect product stability.
Detailed description of the invention
Fig. 1 is preparation flow figure of the present invention；
Fig. 2 is inhibition zone comparative diagram of the present invention；
Fig. 3 is that linear relationship table is presented to various fungistatic effects in the present invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with specific embodiment, to this
Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not
For limiting the present invention.
A kind of personal care articles preparation method with inhibition propionibacterium acnes, this, which has, inhibits propionibacterium acnes
Personal care articles composition includes: by weight percentage
There is the personal care articles preparation method for inhibiting propionibacterium acnes to include the following steps: for this
S1: raw material screening: with raw material by the percentage of composition in claim 1: pichia pastoris yeast is sent out
Ferment lysis object filtrate: 80%；PEG-240/HDI copolymer pair--20 ether of decyl alkanol polyethers: 0.5%；Butanediol and
Water: 0.5%；1,2 hexylene glycol: 0.3%；Propylene glycol: 2%；Water: 17.2%；
S2: it stirs for the first time: by Fermentation in Pichia Pastoris lysis object filtrate: 80%；PEG-240/HDI copolymer
Double--20 ether of decyl alkanol polyethers: 0.5%；Butanediol and water: 0.5% is sufficiently stirred in ultrasonic oscillator, revolving speed
It is 500 turns per minute, stirs 10 minutes, then pour the mixture into homogeneous 5 minutes in homogenizer, it is spare to obtain mixture；
S3: second stirs: will be added again 1,2 hexylene glycols in the resulting mixture of above-mentioned steps S1: 0.3%；The third two
Alcohol: 2%；Water: 17.2%, it is stirred in ultrasonic oscillator, obtains composition finished product after ten minutes.
Wherein, homogenizer model RX-200l in the step S2；Composition finished product application obtained in the step S3
3-8% is added in face pack prescription, is applied to Essence aqua and adds 5-10%, is applied to cream emulsion and adds 5-10%.
According to fig. 2, it can be found to inhibit propionibacterium acnes ability better than salicylic acid by inhibition zone；According to Fig. 3, to various suppressions
Linear relationship is presented in bacterium effect, and additive amount is bigger, and bacteriostatic level is stronger.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (4)
1. a kind of with the personal care articles preparation method for inhibiting propionibacterium acnes, it is characterised in that: this has inhibition acne
The personal care articles composition of Propionibacterium includes: by weight percentage
2. a kind of have the personal care articles preparation method for inhibiting propionibacterium acnes as described in claim 1, feature exists
In: there is the personal care articles preparation method for inhibiting propionibacterium acnes to include the following steps: for this
S1: raw material screening: with raw material by the percentage of composition in claim 1: Fermentation in Pichia Pastoris is molten
Born of the same parents' object filtrate: 80%；PEG-240/HDI copolymer pair--20 ether of decyl alkanol polyethers: 0.5%；Butanediol and water:
0.5%；1,2 hexylene glycol: 0.3%；Propylene glycol: 2%；Water: 17.2%；
S2: it stirs for the first time: by Fermentation in Pichia Pastoris lysis object filtrate: 80%；The PEG-240/HDI copolymer pair-last of the ten Heavenly stems
- 20 ether of base tetradecanol polyethers: 0.5%；Butanediol and water: 0.5% is sufficiently stirred in ultrasonic oscillator, and revolving speed is every point
It 500 turns of clock, stirs 10 minutes, then pours the mixture into homogeneous 5 minutes in homogenizer, it is spare to obtain mixture；
S3: second stirs: will be added again 1,2 hexylene glycols in the resulting mixture of above-mentioned steps S1: 0.3%；Propylene glycol:
2%；Water: 17.2%, it is stirred in ultrasonic oscillator, obtains composition finished product after ten minutes.
3. according to claim 2 a kind of with the personal care articles preparation method for inhibiting propionibacterium acnes, feature
It is: homogenizer model RX-200l in the step S2.
4. according to claim 2 a kind of with the personal care articles preparation method for inhibiting propionibacterium acnes, feature
Be: composition finished product obtained in the step S3 is applied to face pack prescription and adds 3-8%, is applied to Essence aqua and adds
5-10% is applied to cream emulsion and adds 5-10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910267112.6A CN110123682A (en) | 2019-04-03 | 2019-04-03 | A kind of personal care articles preparation method with inhibition propionibacterium acnes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910267112.6A CN110123682A (en) | 2019-04-03 | 2019-04-03 | A kind of personal care articles preparation method with inhibition propionibacterium acnes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110123682A true CN110123682A (en) | 2019-08-16 |
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ID=67569044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910267112.6A Pending CN110123682A (en) | 2019-04-03 | 2019-04-03 | A kind of personal care articles preparation method with inhibition propionibacterium acnes |
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| Country | Link |
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| CN (1) | CN110123682A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705428A (en) * | 2014-01-10 | 2014-04-09 | 上海相宜本草化妆品股份有限公司 | Non-ionic composition used for removing keratin and preparation method of non-ionic composition |
| CN109276485A (en) * | 2018-09-26 | 2019-01-29 | 伯德创研(广州)生物科技有限公司 | A kind of acne-removing sheet and preparation method thereof |
-
2019
- 2019-04-03 CN CN201910267112.6A patent/CN110123682A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705428A (en) * | 2014-01-10 | 2014-04-09 | 上海相宜本草化妆品股份有限公司 | Non-ionic composition used for removing keratin and preparation method of non-ionic composition |
| CN109276485A (en) * | 2018-09-26 | 2019-01-29 | 伯德创研(广州)生物科技有限公司 | A kind of acne-removing sheet and preparation method thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190816 |